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1965 …2018
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Research Output 1965 2018

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Article
1993
49 Citations (Scopus)
Ornithine Decarboxylase
Spermidine
Putrescine
Polyamines
Osmotic Pressure
33 Citations (Scopus)

Investigations of the mechanism by which mammalian cell growth is inhibited by N1N12-bis(ethyl)spermine

Albanese, L., Bergeron, R. J. & Pegg, A. E., Jan 1 1993, In : Biochemical Journal. 291, 1, p. 131-137 7 p.

Research output: Contribution to journalArticle

Spermine
Polyamines
Cell growth
Ornithine Decarboxylase
Growth
168 Citations (Scopus)

Mechanism of Inactivation of Human O6-Alkylguanine-DNA Alkyltransferase by O6-Benzylguanine

Pegg, A. E., Byers, T. L., Swenn, K., Boosalis, M., Samson, L., Moschel, R. C. & Dolan, M. E., Jan 1 1993, In : Biochemistry. 32, 45, p. 11998-12006 9 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
Guanine
Proteins
Substrates
Yeast
37 Citations (Scopus)

Repair of 06-Methylguanine and 04-Methylthymidine in F344 Rat Liver following Treatment with 1,2-Dimethylhydrazine and 06-Benzylguanine

O'Toole, S. M., wenberg, J. A. & Pegg, A., Jan 1 1993, In : Cancer Research. 53, 17, p. 3895-3898 4 p.

Research output: Contribution to journalArticle

1,2-Dimethylhydrazine
Alkyl and Aryl Transferases
Inbred F344 Rats
Thymidine
Liver
20 Citations (Scopus)

The effects of O6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells

Sarkar, A., Dolan, M. E., Gonzalez, G. G., Marton, L. J., Pegg, A. E. & Deen, D. F., Nov 1 1993, In : Cancer Chemotherapy and Pharmacology. 32, 6, p. 477-481 5 p.

Research output: Contribution to journalArticle

Carmustine
Cytotoxicity
Ornithine Decarboxylase
Polyamines
Cells
1992
74 Citations (Scopus)
Leukemia L1210
S-Adenosylmethionine
Spermidine
Spermine
Growth
123 Citations (Scopus)

Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme

Friedman, H. S., Dolan, M. E., Moschel, R. C., Pegg, A., Felker, G. M., Rich, J., Bigner, D. D. & Schold, S. C., Dec 16 1992, In : Journal of the National Cancer Institute. 84, 24, p. 1926-1931 6 p.

Research output: Contribution to journalArticle

Carmustine
Medulloblastoma
Glioblastoma
Heterografts
Streptozocin
5 Citations (Scopus)
Adenosylmethionine Decarboxylase
Ornithine Decarboxylase
Oligodeoxyribonucleotides
Messenger RNA
Ornithine
16 Citations (Scopus)

Irreversible inhibition of S-adenosylmethionine decarboxylase of trypanosoma bru cei bru cei by S-adenosylmethionine analogues

Tekwani, B. L., Bacchi, C. J., Secrist, J. A. & Pegg, A. E., Sep 1 1992, In : Biochemical Pharmacology. 44, 5, p. 905-911 7 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Trypanosoma
S-Adenosylmethionine
Adenosine
Inhibitory Concentration 50
173 Citations (Scopus)
Eflornithine
Ornithine Decarboxylase
Coenzymes
Pyridoxal Phosphate
Lysine
10 Citations (Scopus)

Nucleotide sequence of hamster S-adenosylmethionine decarboxylase cDNA

Tekwani, B. L., Stanley, B. & Pegg, A., Mar 24 1992, In : BBA - Gene Structure and Expression. 1130, 2, p. 221-223 3 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Enzyme Precursors
5' Untranslated Regions
Cricetinae
Nucleotides
14 Citations (Scopus)

Nucleotide sequence of hamster spermidine/spermine-N1-acetyltransferase cDNA

Pegg, A. E., Stanley, B. A., Wiest, L. & Casero, R. A., Nov 15 1992, In : BBA - Gene Structure and Expression. 1171, 1, p. 106-108 3 p.

Research output: Contribution to journalArticle

Acetyltransferases
Spermidine
Spermine
Cricetinae
Nucleotides
24 Citations (Scopus)

Putrescine activated S-adenosylmethionine decarboxylase from Trypanosoma brucei brucei

Tekwani, B. L., Bacchi, C. J. & Pegg, A., Mar 1 1992, In : Molecular and Cellular Biochemistry. 117, 1, p. 53-61 9 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
S-Adenosylmethionine
Trypanosoma brucei brucei
Putrescine
Mitoguazone
47 Citations (Scopus)

Regulation of S-adenosylmethionine decarboxylase activity by alterations in the intracellular polyamine content

Shantz, L. M., Holm, I., Janne, O. A. & Pegg, A. E., Jan 1 1992, In : Biochemical Journal. 288, 2, p. 511-518 8 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Polyamines
Spermidine
Spermine
COS Cells
9 Citations (Scopus)

Sequence specificity of DNA repair by escherichia coli fpg protein

Graves, R., Laval, J. & Pegg, A. E., Aug 1 1992, In : Carcinogenesis. 13, 8, p. 1455-1459 5 p.

Research output: Contribution to journalArticle

Escherichia coli Proteins
Guanine
DNA Repair
Methylation
DNA-Formamidopyrimidine Glycosylase
111 Citations (Scopus)

Structural Features of Substituted Purine Derivatives Compatible with Depletion of Human O6-Alkylguanine-DNA Alkyltransferase

Moschel, R. C., McDougall, M. G., Dolan, M. E., Stine, L. & Pegg, A., Nov 1 1992, In : Journal of Medicinal Chemistry. 35, 23, p. 4486-4491 6 p.

Research output: Contribution to journalArticle

2-Aminopurine
S 6
HT29 Cells
Deoxyguanosine
Guanosine
54 Citations (Scopus)

α-Methyl Polyamines: Metabolically Stable Spermidine and Spermine Mimics Capable of Supporting Growth in Cells Depleted of Polyamines

Lakanen, J. R., Coward, J. K. & Pegg, A. E., Feb 1 1992, In : Journal of Medicinal Chemistry. 35, 4, p. 724-734 11 p.

Research output: Contribution to journalArticle

Spermidine
Spermine
Polyamines
Spermine Synthase
Growth
1991
54 Citations (Scopus)
Adenosylmethionine Decarboxylase
Enzyme Precursors
Putrescine
Catalyst activity
Amino Acids
22 Citations (Scopus)

An early enlargement of the putrescine pool is required for growth in L1210 mouse leukemia cells under hypoosmotic stress

Poulin, R., Wechter, R. S. & Pegg, A. E., Jul 23 1991, In : Journal of Biological Chemistry. 266, 10, p. 6142-6151 10 p.

Research output: Contribution to journalArticle

Leukemia L1210
Putrescine
Growth
Ornithine Decarboxylase
Osmotic Pressure
33 Citations (Scopus)

Characterization of a full-length cDNA which codes for the human spermidine/spermine N1-acetyltransferase

Xiao, L., Celano, P., Mank, A. R., Pegg, A. E. & Casero, R. A., Aug 30 1991, In : Biochemical and Biophysical Research Communications. 179, 1, p. 407-415 9 p.

Research output: Contribution to journalArticle

Acetyltransferases
Spermidine
Spermine
Complementary DNA
Polyamines
71 Citations (Scopus)

Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine

Dolan, M. E., Pegg, A., Dumenco, L. L., Moschel, R. C. & Gerson, S. L., Dec 1 1991, In : Carcinogenesis. 12, 12, p. 2305-2309 5 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
DNA
Proteins
Protein
Cell
77 Citations (Scopus)

Effect of O6-alkylguanine-DNA alkyltransferase on the frequency and spectrum of mutations induced by N-methyl-N′-nitro-N-nitrosoguanidine in the HPRT gene of diploid human fibroblasts

Lukash, L. L., Boldt, J., Pegg, A. E., Eileen Dolan, M., Maher, V. M. & Justin McCormick, J., Jan 1 1991, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 250, 1-2, p. 397-409 13 p.

Research output: Contribution to journalArticle

Hypoxanthine Phosphoribosyltransferase
Methylnitronitrosoguanidine
Mutation Rate
Diploidy
Fibroblasts
57 Citations (Scopus)

Identification of residues in ornithine decarboxylase essential for enzymic activity and for rapid protein turnover

Lu, L., Stanley, B. & Pegg, A., Jan 1 1991, In : Biochemical Journal. 277, 3, p. 671-675 5 p.

Research output: Contribution to journalArticle

Ornithine Decarboxylase
Alanine
Reticulocytes
Proteins
Serine
97 Citations (Scopus)

Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase

Casero, R. A., Celano, P., Ervin, S. J., Applegren, N. B., Wiest, L. & Pegg, A. E., Feb 19 1991, In : Journal of Biological Chemistry. 266, 2, p. 810-814 5 p.

Research output: Contribution to journalArticle

Acetyltransferases
Spermidine
Spermine
Polyamines
Complementary DNA
24 Citations (Scopus)

Production of antibodies to peptide sequences present in human O6-alkylguanine-DNA alkyltransferase and their use to detect this protein in cell extracts

Pegg, A. E., Wiest, L., Mummert, C. & Dolan, M. E., Sep 1 1991, In : Carcinogenesis. 12, 9, p. 1671-1677 7 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
Cell Extracts
Antibody Formation
Peptides
Immune Sera
11 Citations (Scopus)

Role of unsaturated derivatives of spermidine as substrates for spermine synthase and in supporting growth of SV-3T3 cells

Pegg, A. E., Nagarajan, S., Naficy, S. & Ganem, B., Jan 1 1991, In : Biochemical Journal. 274, 1, p. 167-171 5 p.

Research output: Contribution to journalArticle

Spermine Synthase
3T3 Cells
Spermidine
Polyamines
Derivatives
67 Citations (Scopus)

Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-n'-nitro-N-nitrosoguanidine

Pegg, A. E., Wiest, L., Mummert, C., Stine, L., Moschel, R. C. & Dolan, M. E., Sep 1 1991, In : Carcinogenesis. 12, 9, p. 1679-1683 5 p.

Research output: Contribution to journalArticle

Nitrosoguanidines
Alkyl and Aryl Transferases
Antibodies
Proteins
Cysteine
1990
37 Citations (Scopus)

Colonic polyamine content and ornithine decarboxylase activity as markers for adenomas

McGarrity, T., Peiffer, L. P., Bartholomew, M. J. & Pegg, A., Jan 1 1990, In : Cancer. 66, 7, p. 1539-1543 5 p.

Research output: Contribution to journalArticle

Ornithine Decarboxylase
Adenomatous Polyps
Polyamines
Adenoma
Putrescine
55 Citations (Scopus)

Combined regulation of ornithine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N1N12-bis(ethyl)spermine

Porter, C. W., Pegg, A. E., Ganis, B., Madhabala, R. & Bergeron, R. J., Jan 1 1990, In : Biochemical Journal. 268, 1, p. 207-212 6 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Ornithine
Spermine
Ornithine Decarboxylase
Spermidine
472 Citations (Scopus)
Alkylating Agents
Alkyl and Aryl Transferases
Proteins
HT29 Cells
Therapeutics
74 Citations (Scopus)

High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma.

Casero, R. A., Celano, P., Ervin, S. J., Wiest, L. & Pegg, A. E., Sep 15 1990, In : The Biochemical journal. 270, 3, p. 615-620 6 p.

Research output: Contribution to journalArticle

Large Cell Carcinoma
Acetyltransferases
Spermidine
Spermine
Cells
33 Citations (Scopus)

Induction of spermidine/spermine N1-acetyltransferase activity in Chinese-hamster ovary cells by N1N11-bis(ethyl)norspermidine and related compounds

Pegg, A. E., Pakala, R. & Bergeron, R. J., Jan 1 1990, In : Biochemical Journal. 267, 2, p. 331-338 8 p.

Research output: Contribution to journalArticle

Acetyltransferases
Spermidine
Spermine
Putrescine
Cricetulus
804 Citations (Scopus)
O(6)-Methylguanine-DNA Methyltransferase
Enzyme Induction
Alkylating Agents
Methyltransferases
Alkylation
113 Citations (Scopus)
Neoplasm Transplantation
Drug Dose Response Relationship
O(6)-Methylguanine-DNA Methyltransferase
Semustine
Cultured Tumor Cells
55 Citations (Scopus)

Properties of mammalian O6-alkylguanine-DNA transferases

Pegg, A. E., Jan 1 1990, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 233, 1-2, p. 165-175 11 p.

Research output: Contribution to journalArticle

O(6)-Methylguanine-DNA Methyltransferase
Species Specificity
Organ Specificity
Alkylating Agents
Methyltransferases
36 Citations (Scopus)

Regulation of ornithine decarboxylase expression by anisosmotic shock in α-difluoromethylornithine-resistant L1210 cells

Poulin, R. & Pegg, A., Apr 2 1990, In : Journal of Biological Chemistry. 265, 7, p. 4025-4032 8 p.

Research output: Contribution to journalArticle

Eflornithine
Ornithine Decarboxylase
Shock
Osmolar Concentration
Osmotic Pressure
48 Citations (Scopus)

Regulation of polyamine transport in Chinese hamster ovary cells

Byers, T. L. & Pegg, A. E., Jun 1990, In : Journal of Cellular Physiology. 143, 3, p. 460-467 8 p.

Research output: Contribution to journalArticle

Polyamines
Cricetulus
Ovary
Cells
Ornithine Decarboxylase
1989

Administration of Ethylnitrosourea to Neonate Hamsters Increases Growth and Frequency of SV40-Induced Fibrosarcomas

Choudhury, S., Pegg, A. E., Kreider, J. W., Mayo, D. R. & Howett, M. K., Oct 1989, In : Proceedings of the Society for Experimental Biology and Medicine. 192, 1, p. 72-77 6 p.

Research output: Contribution to journalArticle

Ethylnitrosourea
Simian virus 40
Fibrosarcoma
Viruses
Cricetinae
37 Citations (Scopus)

Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine

Dolan, M. E., Larkin, G. L., English, H. F. & Pegg, A. E., Mar 1 1989, In : Cancer Chemotherapy and Pharmacology. 25, 2, p. 103-108 6 p.

Research output: Contribution to journalArticle

Heterografts
Nude Mice
Tumors
Tissue
Neoplasms
16 Citations (Scopus)

Effect of 1-amino-oxy-3-aminopropane on polyamine metabolism and growth of L1210 cells

Poulin, R., Secrist, J. A. & Pegg, A., Jan 1 1989, In : Biochemical Journal. 263, 1, p. 215-221 7 p.

Research output: Contribution to journalArticle

Ornithine Decarboxylase
Putrescine
Spermidine
Polyamines
Adenosylmethionine Decarboxylase
85 Citations (Scopus)

Effect of N1,N12-bis(ethyl)spermine and related compounds on growth and polyamine acetylation, content, and excretion in human colon tumor cells

Pegg, A., Wechter, R., Pakala, R. & Bergeron, R. J., Jan 1 1989, In : Journal of Biological Chemistry. 264, 20, p. 11744-11749 6 p.

Research output: Contribution to journalArticle

Acetylation
Spermine
Polyamines
Spermidine
Tumors
51 Citations (Scopus)

Effect of S'-Adenosyl-1,12-diamino-3-thio-9-azadodecane, a Multisubstrate Adduct Inhibitor of Spermine Synthase, on Polyamine Metabolism in Mammalian Cells

Pegg, A. E., Wechter, R., Poulin, R., Woster, P. M. & Coward, J. K., Jan 1 1989, In : Biochemistry. 28, 21, p. 8446-8453 8 p.

Research output: Contribution to journalArticle

Spermine Synthase
Polyamines
Metabolism
Cells
Biosynthesis
27 Citations (Scopus)

Effects of S-adenosyl-1,8-diamino-3-thio-octane and S-methyl-5'-methylthioadenosine on polyaine synthesis in Ehrlich ascites-tumour cells

Holm, I., Persson, L., Pegg, A. E. & Heby, O., Jan 1 1989, In : Biochemical Journal. 261, 1, p. 205-210 6 p.

Research output: Contribution to journalArticle

Ehrlich Tumor Carcinoma
Ornithine Decarboxylase
Spermine
Tumors
Spermidine
49 Citations (Scopus)

Expression of a human gene for polyamine transport in Chinese-hamster ovary cells

Byers, T. L., Wechter, R., Nuttall, M. E. & Pegg, A., Jan 1 1989, In : Biochemical Journal. 263, 3, p. 745-752 8 p.

Research output: Contribution to journalArticle

Polyamines
Cricetulus
Ovary
Genes
Cells
37 Citations (Scopus)

Expression of mammalian (O6-alkylguanine-DNA alkyltransferase in a cell line sensitive to alkylating agents

Dolan, M. E., Norbeck, L., Clyde, C., Hora, N. K., Erickson, L. C. & Pegg, A. E., Sep 1 1989, In : Carcinogenesis. 10, 9, p. 1613-1619 7 p.

Research output: Contribution to journalArticle

Alkylating Agents
Cell Line
DNA
Transfection
clomesone
6 Citations (Scopus)

Production of N1-acetyl spermidine by renal cell tumors

Pine, M. J., Huben, R. P. & Pegg, A., Jan 1 1989, In : Journal of Urology. 141, 3 I, p. 651-655 5 p.

Research output: Contribution to journalArticle

Spermidine
Kidney
Neoplasms
Polyamines
Growth
39 Citations (Scopus)

Properties and physiological function of the polyamine transport system

Byers, T. L. & Pegg, A., Jan 1 1989, In : American Journal of Physiology - Cell Physiology. 257, 3

Research output: Contribution to journalArticle

Polyamines
Spermine
Cricetulus
Ovary
Mitoguazone
71 Citations (Scopus)

Site of pyruvate formation and processing of mammalian S-adenosylmethionine decarboxylase proenzyme

Stanley, B. A., Pegg, A. E. & Holm, I., Dec 1 1989, In : Journal of Biological Chemistry. 264, 35, p. 21073-21079 7 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Enzyme Precursors
Pyruvic Acid
Serine
Alanine
24 Citations (Scopus)

Spermidine uptake by type II pneumocytes: Interactions of amine uptake pathways

Rannels, D. E., Kameji, R., Pegg, A. & Rannels, S. R., Dec 1 1989, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 257, 6

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Putrescine
Spermidine
Amines
Paraquat