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1965 …2018
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Research Output 1965 2018

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Article
1989
16 Citations (Scopus)

Spermidine uptake by type II pulmonary epithelial cells in primary culture

Kameji, R., Rannels, S. R., Pegg, A. & Rannels, D. E., Jan 1 1989, In : American Journal of Physiology - Cell Physiology. 256, 1

Research output: Contribution to journalArticle

Spermidine
Epithelial Cells
Polyamines
Lung
Mitoguazone
33 Citations (Scopus)

Synthesis and Biological Evaluation of S-Adenosyl-l,12-diamino-3-thio-9-azadodecane, a Multisubstrate Adduct Inhibitor of Spermine Synthase

Woster, P. M., Black, A. Y., Duff, K. J., Coward, J. K. & Pegg, A., Jun 1 1989, In : Journal of Medicinal Chemistry. 32, 6, p. 1300-1307 8 p.

Research output: Contribution to journalArticle

Spermine Synthase
Spermidine Synthase
Polyamines
Enzyme Inhibitors
Biosynthetic Pathways
1988
62 Citations (Scopus)

Cell specific differences in o-methylguanine-dna methyltransferase activity and removal of o-methylguanine in rat pulmonary cells

Belinsky, S. A., Dolan, M. E., White, C. M., Maronpot, R. R., Pegg, A. E. & Anderson, M. W., Nov 1 1988, In : Carcinogenesis. 9, 11, p. 2053-2058 6 p.

Research output: Contribution to journalArticle

Methyltransferases
Lung
DNA
Alveolar Epithelial Cells
Macrophages
58 Citations (Scopus)

Control of ornithine decarboxylase activity in α-difluoromethylornithine-resistant L1210 cells by polyamines and synthetic analogues

Pegg, A., Madhubala, R., Kameji, T. & Bergeron, R. J., Jan 1 1988, In : Journal of Biological Chemistry. 263, 22, p. 11008-11014 7 p.

Research output: Contribution to journalArticle

Eflornithine
Artificial Cells
Ornithine Decarboxylase
Polyamines
Messenger RNA
17 Citations (Scopus)

Detection of proenzyme form of S-adenosylmethionine decarboxylase in extracts from rat prostate

Pegg, A., Wiest, L. & Pajunen, A., Jan 29 1988, In : Biochemical and Biophysical Research Communications. 150, 2, p. 788-793 6 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Enzyme Precursors
Putrescine
Rats
Prostate
34 Citations (Scopus)

Effect of Inhibitors of S-Adenosylmethionine Decarboxylase on Polyamine Content and Growth of L1210 Cells

Pegg, A., Jones, D. B. & Secrist, J. A., Mar 1 1988, In : Biochemistry. 27, 5, p. 1408-1415 8 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Polyamines
Adenosine
Spermidine
Growth
34 Citations (Scopus)

Effect of O6-Methylguanine on DNA Interstrand Cross-Link Formation by Chloroethylnitrosoureas and 2-Chloroethyl(methylsulfonyl)methanesulfonate

Dolan, M. E., Pegg, A. E., Hora, N. K. & Erickson, L. C., Jan 1 1988, In : Cancer Research. 48, 13, p. 3603-3606 4 p.

Research output: Contribution to journalArticle

clomesone
DNA
HT29 Cells
O-(6)-methylguanine
8 Citations (Scopus)

Gene sequences coding for s-adenosylmethionine decarboxylase are present on human chromosome 6 and the x and are not amplified in colon neoplasia

Radford, D. M., Eddy, R., Haley, L., Henry, W. M., Pegg, A. E., Pajunen, A. & Shows, T. B., Jan 1 1988, In : Cytogenetic and Genome Research. 49, 4, p. 285-288 4 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
S-Adenosylmethionine
Chromosomes, Human, Pair 6
Polyamines
Human Chromosomes
13 Citations (Scopus)

Investigation of the specificity of O6-alkylguanine-DNA-alkyltransferase

Pegg, A., Morimoto, K. & Dolan, M. E., Jan 1 1988, In : Chemico-Biological Interactions. 65, 3, p. 275-281 7 p.

Research output: Contribution to journalArticle

RNA
Repair
Alkyl and Aryl Transferases
DNA
Substrates
5 Citations (Scopus)

Mechanisms of Differential Strain Sensitivity in Gastric Carcinogenesis

Weisburger, J. H., Jones, R. C., Barnes, W. S. & Pegg, A. E., Dec 1988, In : Japanese Journal of Cancer Research. 79, 12, p. 1304-1310 7 p.

Research output: Contribution to journalArticle

Methylnitronitrosoguanidine
Sulfhydryl Compounds
Stomach
Carcinogenesis
Buffaloes
1468 Citations (Scopus)

Polyamine Metabolism and Its Importance in Neoplastic Growth and as a Target for Chemotherapy

Pegg, A. E., Jan 1 1988, In : Cancer Research. 48, 4, p. 759-774 16 p.

Research output: Contribution to journalArticle

Polyamines
Drug Therapy
Growth
Antineoplastic Agents
Carcinogenesis
22 Citations (Scopus)

Properties of L1210 Cells Resistant to α-Difluoro Methyl Or Nithine

Pegg, A. E., Secrist, J. A. & Madhubala, R., Mar 1988, In : Cancer Research. 48, 10, p. 2678-2682 5 p.

Research output: Contribution to journalArticle

Spermidine
Spermine
Ornithine Decarboxylase
Adenosylmethionine Decarboxylase
Putrescine
4 Citations (Scopus)

Regulation of mammalian S-Adenosylmethionine decarboxylase

Pegg, A., Kameji, T., Shirahata, A., Stanley, B., Madhubala, R. & Pajunen, A., Jan 1 1988, In : Advances in enzyme regulation. 27, C

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Polyamines
Prostate
Putrescine
Protein Biosynthesis
29 Citations (Scopus)

Regulation of mammalian S-adenosylmethionine decarboxylase.

Pegg, A. E., Kameji, T., Shirahata, A., Stanley, B., Madhubala, R. & Pajunen, A., 1988, In : Advances in enzyme regulation. 27, p. 43-55 13 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Polyamines
Prostate
Putrescine
Messenger RNA
115 Citations (Scopus)

Repair of O-alkylpyrimidines in mammalian cells: A present consensus

Brent, T. P., Dolan, M. E., Fraenkel-Conrat, H., Hall, J., Karran, P., Laval, F., Margison, G. P., Montesano, R., Pegg, A. E., Potter, P. M., Singer, B., Swenberg, J. A. & Yarosh, D. B., Dec 1 1988, In : Proceedings of the National Academy of Sciences of the United States of America. 85, 6, p. 1759-1762 4 p.

Research output: Contribution to journalArticle

3-methyladenine-DNA glycosylase
Methyltransferases
Biochemical Phenomena
Escherichia coli
Escherichia coli Proteins
93 Citations (Scopus)

Sequence specificity of guanine alkylation and repair

Dolan, M. E., Oplinger, M. & Pegg, A. E., Nov 1 1988, In : Carcinogenesis. 9, 11, p. 2139-2143 5 p.

Research output: Contribution to journalArticle

Guanine
Alkylation
Methylation
Thymine
Adenine
96 Citations (Scopus)

Structure and regulation of mammalian s-adenosylmethionine decarboxylase

Pajunen, A., Crozat, A., Jänne, O. A., Ihalainen, R., Laitinen, P. H., Stanley, B., Madhubala, R. & Pegg, A., Jan 1 1988, In : Journal of Biological Chemistry. 263, 32, p. 17040-17049 10 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Complementary DNA
Rats
Enzyme Precursors
Enzymes
19 Citations (Scopus)

Studies of non-metabolizable polyamines that support growth of SV-3T3 cells depleted of natural polyamines by exposure to α-difluoromethylornithine

Nagarajan, S., Ganem, B. & Pegg, A. E., Jan 1 1988, In : Biochemical Journal. 254, 2, p. 373-378 6 p.

Research output: Contribution to journalArticle

Eflornithine
3T3 Cells
Polyamines
Spermidine
Spermine
11 Citations (Scopus)

The effects of chronic ethanol administration on polyamine content during dimethylhydrazine-induced colorectal carcinogenesis in the rat

Mcgarrity, T. J., Peiffer, L. P., Colony, P. C. & Pegg, A. E., Nov 1 1988, In : Carcinogenesis. 9, 11, p. 2093-2098 6 p.

Research output: Contribution to journalArticle

Dimethylhydrazines
1,2-Dimethylhydrazine
Polyamines
Putrescine
Carcinogenesis
22 Citations (Scopus)

Use of a dodecadeoxynucleotide to study repair of the O4-methylthymine lesion

Dolan, M. E., Oplinger, M. & Pegg, A. E., Mar 1988, In : Mutation Research DNA Repair Reports. 193, 2, p. 131-137 7 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
Liver Extracts
Polynucleotide 5'-Hydroxyl-Kinase
HT29 Cells
Adenosine Monophosphate
33 Citations (Scopus)

Use of oligodeoxynucleotides containing o6-alkylguanine for the assay of o6-alkylguanine-dna-alkyl transferase activity

Eileez Dolan, M., Scicchitano, D. & Pegg, A., Jan 1 1988, In : Cancer Research. 48, 5, p. 1184-1188 5 p.

Research output: Contribution to journalArticle

Oligodeoxyribonucleotides
Transferases
Polynucleotide 5'-Hydroxyl-Kinase
Reverse-Phase Chromatography
Cell Extracts
1987
47 Citations (Scopus)

Decarboxylation of α-difluoromethylornithine by ornithine decarboxylase

Pegg, A. E., McGovern, K. A. & Wiest, L., Jan 1 1987, In : Biochemical Journal. 241, 1, p. 305-307 3 p.

Research output: Contribution to journalArticle

Eflornithine
Decarboxylation
Ornithine Decarboxylase
Enzymes
Imines
42 Citations (Scopus)

Effect of putrescine on the synthesis of S-adenosylmethionine decarboxylase

Kameji, T. & Pegg, A., Jan 1 1987, In : Biochemical Journal. 243, 1, p. 285-288 4 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Putrescine
Enzymes
Mitoguazone
S-Adenosylmethionine
57 Citations (Scopus)

Increased efficiency of translation of ornithine decarboxylase mRNA in mitogen‐activated lymphocytes

WHITE, M. W., KAMEJI, T., PEGG, A. E. & MORRIS, D. R., Dec 1987, In : European Journal of Biochemistry. 170, 1-2, p. 87-92 6 p.

Research output: Contribution to journalArticle

Ornithine Decarboxylase
Lymphocytes
Messenger RNA
Polyribosomes
Biosynthesis
29 Citations (Scopus)

Increase in S-adenosylmethionine decarboxylase in SV-3T3 cells treated with S-methyl-5'-methylthioadenosine

Pegg, A., Wechter, R. & Pajunen, A., Jan 1 1987, In : Biochemical Journal. 244, 1, p. 49-54 6 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
3T3 Cells
Spermine
Spermine Synthase
Proteins
39 Citations (Scopus)

Inhibition of O6-alkylguanine-DNA-alkyltransferase by metals

Scicchitano, D. A. & Pegg, A., Jan 1 1987, In : Mutation Research Letters. 192, 3, p. 207-210 4 p.

Research output: Contribution to journalArticle

DNA Repair
Metals
Arsenicals
Proteins
Dithiothreitol
82 Citations (Scopus)

Inhibition of translation of mRNAs for ornithine decarboxylase and S-adenosylmethionine decarboxylase by polyamines.

Kameji, T. & Pegg, A., Feb 25 1987, In : Journal of Biological Chemistry. 262, 6, p. 2427-2430 4 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Ornithine Decarboxylase
Polyamines
Protein Biosynthesis
Messenger RNA
51 Citations (Scopus)

Multiple pathways for uptake of paraquat, methylglyoxal bis(guanylhydrazone), and polyamines

Byers, T. L., Kameji, R., Rannels, D. E. & Pegg, A. E., Jan 1 1987, In : American Journal of Physiology - Cell Physiology. 252, 6, p. 21/6

Research output: Contribution to journalArticle

Mitoguazone
Paraquat
Polyamines
Spermidine
Cricetulus
35 Citations (Scopus)

Polyamine administration reduces ornithine decarboxylase activity without affecting its mRNA content

Sertich, G. J. & Pegg, A. E., Mar 13 1987, In : Biochemical and Biophysical Research Communications. 143, 2, p. 424-430 7 p.

Research output: Contribution to journalArticle

Ornithine Decarboxylase
Polyamines
Enzyme activity
Messenger RNA
Enzymes
53 Citations (Scopus)

Properties and assay of mammalian O6-alkyguanine-DNA alkyltransferase

Pegg, A. E. & Eileen Dolan, M., 1987, In : Pharmacology and Therapeutics. 34, 2, p. 167-179 13 p.

Research output: Contribution to journalArticle

O(6)-Methylguanine-DNA Methyltransferase
Methyltransferases
Substrate Specificity
DNA alkyltransferase
44 Citations (Scopus)

Regulation of ornithine decarboxylase activity by spermidine and the spermidine analogue N1N8-bis(ethyl)spermidine

Porter, C. W., Berger, F. G., Pegg, A. E., Ganis, B. & Bergeron, R. J., Jan 1 1987, In : Biochemical Journal. 242, 2, p. 433-440 8 p.

Research output: Contribution to journalArticle

Ornithine Decarboxylase
Spermidine
Polyamines
Biosynthesis
Messenger RNA
12 Citations (Scopus)

Regulation of ovarian ornithine decarboxylase by human chorionic gonadotrophin

Sertich, G. J., Persson, L. & Pegg, A. E., Dec 1 1987, In : American Journal of Physiology - Cell Physiology. 253, 5, p. 22/5

Research output: Contribution to journalArticle

Ornithine Decarboxylase
Chorionic Gonadotropin
Ovary
Putrescine
Polyamines
11 Citations (Scopus)

Specificity of O6-alkylguanine-DNA alkyltransferase.

Pegg, A., Scicchitano, D., Morimoto, K. & Dolan, M. E., Jan 1 1987, In : IARC scientific publications. 84, p. 30-34 5 p.

Research output: Contribution to journalArticle

Oligodeoxyribonucleotides
Alkyl and Aryl Transferases
Proteins
Escherichia coli Proteins
Cultured Cells
23 Citations (Scopus)
Spermidine Synthase
Polyamines
Cultured Cells
Biosynthetic Pathways
Enzymes
1986
20 Citations (Scopus)

Acetylation of Decarboxylated S-Adenosylmethionine by Mammalian Cells

Pegg, A., Wechter, R. S., Clark, R. S., Wiest, L. & Erwin, B. G., Jan 1 1986, In : Biochemistry. 25, 2, p. 379-384 6 p.

Research output: Contribution to journalArticle

Acetylation
Cells
Histones
Eflornithine
Spermidine
7 Citations (Scopus)
Spermine
Polyamines
Cell growth
Metabolism
Spermidine
88 Citations (Scopus)

Effect of O6-Alkylguanine Pretreatment on the Sensitivity of Human Colon Tumor Cells to the Cytotoxic Effects of Chloroethylating Agents

Dolan, M. E., Young, G. S. & Pegg, A. E., Sep 1986, In : Cancer Research. 46, 9, p. 4500-4504 5 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
HT29 Cells
Colon
Neoplasms
Poisons
24 Citations (Scopus)

Effects of Certain 5'-Substituted Adenosines on Polyarnine Synthesis: Selective Inhibitors of Spermine Synthase

Pegg, A., Coward, J. K., Talekar, R. R. & Secrist, J. A., Jan 1 1986, In : Biochemistry. 25, 14, p. 4091-4097 7 p.

Research output: Contribution to journalArticle

Spermine Synthase
Spermidine Synthase
Adenosine
Spermine
Polyamines
33 Citations (Scopus)
Adenosylmethionine Decarboxylase
Eflornithine
RNA Precursors
Rats
Prostate
49 Citations (Scopus)

Regulation of spermidine/spermine N1-acetyltransferase in L6 cells by polyamines and related compounds

Erwin, B. G. & Pegg, A., Jan 1 1986, In : Biochemical Journal. 238, 2, p. 581-587 7 p.

Research output: Contribution to journalArticle

Acetyltransferases
Spermidine
Spermine
Polyamines
Putrescine
31 Citations (Scopus)

Repair of oligodeoxynucleotides containing o-methylguanine by o-alkylguanine-dna-alkyltransferase

Scicchitano, D., Jones, R. A., Kuzmich, S., Gaffney, B., Lasko, D. D., Essigmann, J. M. & Pegg, A. E., Dec 1 1986, In : Carcinogenesis. 7, 8, p. 1383-1386 4 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
Oligodeoxyribonucleotides
Proteins
DNA
Guanine
1985
7 Citations (Scopus)

Carrier-mediated uptake of methylglyoxal bis(guanylhydrazone) by rat lungs perfused in situ

Rannels, D. E., Addison, J. L. & Pegg, A. E., Jan 1 1985, In : American Journal of Physiology - Endocrinology and Metabolism. 11, 3, p. E292-E298

Research output: Contribution to journalArticle

Mitoguazone
Lung
Spermidine
Polyamines
Pulmonary Circulation
17 Citations (Scopus)

Comparison of ornithine decarboxylase from rat liver, rat hepatoma and mouse kidney

Seely, J. E., Persson, L., Sertich, G. J. & Pegg, A., Jan 1 1985, In : Biochemical Journal. 226, 2, p. 577-586 10 p.

Research output: Contribution to journalArticle

Ornithine Decarboxylase
Liver
Rats
Hepatocellular Carcinoma
Kidney
40 Citations (Scopus)

Depletion of o-methylguanine-dna-methyltransferase in human fibroblasts increases the mutagenic response to n-methyl-n'-nitro-n-nitrosoguanidine

Domoradzki, J., Pegg, A. E., Dolan, M. E., Maher, V. M. & Mccormick, J. J., Dec 1 1985, In : Carcinogenesis. 6, 12, p. 1823-1826 4 p.

Research output: Contribution to journalArticle

Nitrosoguanidines
Methyltransferases
Transferases
Methylnitronitrosoguanidine
Fibroblasts
63 Citations (Scopus)

Escherichia coli S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase. Purification, substrate specificity and mechanism of action

della Ragione, F., Porcelli, M., Carteni-Farina, M., Zappia, V. & Pegg, A., Jan 1 1985, In : Biochemical Journal. 232, 2, p. 335-341 7 p.

Research output: Contribution to journalArticle

adenosylhomocysteine nucleosidase
Substrate Specificity
Escherichia coli
57 Citations (Scopus)

Exposure of HeLa cells to 06-alkylguanines increases sensitivity to the cytotoxic effects of alkylating agents

Dolan, M. E., Corsico, C. D. & Pegg, A. E., Oct 15 1985, In : Biochemical and Biophysical Research Communications. 132, 1, p. 178-185 8 p.

Research output: Contribution to journalArticle

Alkylating Agents
HeLa Cells
Methylnitronitrosoguanidine
Cytoprotection
Repair
33 Citations (Scopus)
Methylnitrosourea
Liver
DNA
Alkyl and Aryl Transferases
DNA alkyltransferase
24 Citations (Scopus)

Growth of mammalian cells in the absence of the accumulation of spermine

Pegg, A. E. & Coward, J. K., Nov 27 1985, In : Biochemical and Biophysical Research Communications. 133, 1, p. 82-89 8 p.

Research output: Contribution to journalArticle

Spermine
Cells
Spermine Synthase
Growth
Cell Physiological Phenomena
29 Citations (Scopus)

Induction of spermidine/spermine N1-acetyltransferase by methylglyoxal bis(guanylhydrazone)

Pegg, A. E., Erwin, B. G. & Persson, L., Oct 17 1985, In : BBA - General Subjects. 842, 2-3, p. 111-118 8 p.

Research output: Contribution to journalArticle

Mitoguazone
Acetyltransferases
Spermidine
Spermine
Polyamines
32 Citations (Scopus)

Induction of spermidine/spermine N1-acetyltransferase in rat tissues by polyamines

Pegg, A. & Erwin, B. G., Jan 1 1985, In : Biochemical Journal. 231, 2, p. 285-289 5 p.

Research output: Contribution to journalArticle

Acetyltransferases
Spermidine
Spermine
Polyamines
Rats