• 34343 Citations
  • 87 h-Index
1965 …2018
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1965 2018

Filter
Review article
2018
4 Citations (Scopus)

Introduction to the thematic minireview series: Sixty plus years of polyamine research

Pegg, A. E., Jan 1 2018, In : Journal of Biological Chemistry. 293, 48, p. 18681-18692 12 p.

Research output: Contribution to journalReview article

Polyamines
Research
Biochemical Phenomena
Protozoa
Biochemistry
44 Citations (Scopus)

Polyamine metabolism and cancer: treatments, challenges and opportunities

Casero, R. A., Murray Stewart, T. & Pegg, A., Nov 1 2018, In : Nature Reviews Cancer. 18, 11, p. 681-695 15 p.

Research output: Contribution to journalReview article

Polyamines
Neoplasms
Therapeutics
Carcinogenesis
Clinical Trials
2016
117 Citations (Scopus)

Functions of polyamines in mammals

Pegg, A. E., Jul 15 2016, In : Journal of Biological Chemistry. 291, 29, p. 14904-14912 9 p.

Research output: Contribution to journalReview article

Mammals
Spermidine
Polyamines
Spermine
Spermine Synthase
2014
77 Citations (Scopus)

The function of spermine

Pegg, A. E., Jan 1 2014, In : IUBMB Life. 66, 1, p. 8-18 11 p.

Research output: Contribution to journalReview article

Spermine
Spermine Synthase
Spermidine
Polyamines
Proteins
2013
84 Citations (Scopus)

Toxicity of polyamines and their metabolic products

Pegg, A. E., Dec 16 2013, In : Chemical research in toxicology. 26, 12, p. 1782-1800 19 p.

Research output: Contribution to journalReview article

Polyamines
Toxicity
Cellular Structures
Cells
Acrolein
2011
118 Citations (Scopus)

Current status of the polyamine research field.

Pegg, A. & Casero, R. A., May 24 2011, In : Methods in molecular biology (Clifton, N.J.). 720, p. 3-35 33 p.

Research output: Contribution to journalReview article

Polyamines
Research
Drug Delivery Systems
Therapeutics
104 Citations (Scopus)
Alkyl and Aryl Transferases
Chemotherapy
DNA Repair
DNA Damage
Repair
2010
75 Citations (Scopus)

Spermine synthase

Pegg, A. & Michael, A. J., Jan 1 2010, In : Cellular and Molecular Life Sciences. 67, 1, p. 113-121 9 p.

Research output: Contribution to journalReview article

Spermine Synthase
Spermine
Catalytic Domain
Spermidine Synthase
Adenosylmethionine Decarboxylase
2009
355 Citations (Scopus)

Mammalian polyamine metabolism and function

Pegg, A. E., Dec 1 2009, In : IUBMB Life. 61, 9, p. 880-894 15 p.

Research output: Contribution to journalReview article

Polyamines
Metabolism
Physiology
Molecules
Pharmaceutical Preparations
223 Citations (Scopus)

Polyamine catabolism and disease

Casero, R. A. & Pegg, A. E., Aug 1 2009, In : Biochemical Journal. 421, 3, p. 323-338 16 p.

Research output: Contribution to journalReview article

Polyamines
Acetyltransferases
Spermidine
Spermine
Oxidoreductases
2008
174 Citations (Scopus)

Spermidine/spermine-N1-acetyltransferase: A key metabolic regulator

Pegg, A. E., Jun 1 2008, In : American Journal of Physiology - Endocrinology and Metabolism. 294, 6, p. E995-E1010

Research output: Contribution to journalReview article

Spermine
Polyamines
Acetyl Coenzyme A
Proteins
Acetylation
2007
51 Citations (Scopus)

Human variants of O6-alkylguanine-DNA alkyltransferase

Pegg, A., Fang, Q. & Loktionova, N. A., Aug 1 2007, In : DNA Repair. 6, 8, p. 1071-1078 8 p.

Research output: Contribution to journalReview article

Chemotherapy
Alkylation
Recombinant Proteins
Epidemiologic Studies
Neoplasms
2003
25 Citations (Scopus)

Drugs affecting the cell cycle via actions on the polyamine metabolic pathway.

Ackermann, J. M., Pegg, A. & McCloskey, D. E., Jan 1 2003, In : Progress in cell cycle research. 5, p. 461-468 8 p.

Research output: Contribution to journalReview article

Polyamines
Metabolic Networks and Pathways
Cell Cycle
Pharmaceutical Preparations
Ornithine Decarboxylase
1999
97 Citations (Scopus)
Ornithine Decarboxylase
Adenosylmethionine Decarboxylase
Polyamines
Enzymes
Open Reading Frames
1997
214 Citations (Scopus)

O6-Benzylguanine and its role in chemotherapy

Dolan, M. E. & Pegg, A., Jun 1 1997, In : Clinical Cancer Research. 3, 6, p. 837-847 11 p.

Research output: Contribution to journalReview article

Alkyl and Aryl Transferases
Drug Therapy
Carmustine
Clinical Trials, Phase I
Proteins
1995
679 Citations (Scopus)

Polyamines as targets for therapeutic intervention

Marton, L. J. & Pegg, A. E., Jan 1 1995, In : Annual Review of Pharmacology and Toxicology. 35, p. 55-91 37 p.

Research output: Contribution to journalReview article

Polyamines
Therapeutic Uses
Therapeutics
Protozoa
African Trypanosomiasis
69 Citations (Scopus)

Use of aminopropyltransferase inhibitors and of non-metabolizable analogs to study polyamine regulation and function

Pegg, A. E., Poulin, R. & Coward, J. K., May 1995, In : International Journal of Biochemistry and Cell Biology. 27, 5, p. 425-442 18 p.

Research output: Contribution to journalReview article

Spermidine Synthase
Polyamines
Spermidine
Spermine
Growth
1993
374 Citations (Scopus)

Spermidine/spermine N1-acetyltransferase - The turning point in polyamine metabolism

Casero, R. A. & Pegg, A. E., Jan 1 1993, In : FASEB Journal. 7, 8, p. 653-661 9 p.

Research output: Contribution to journalReview article

Acetyltransferases
Spermidine
Spermine
Polyamines
Metabolism
1992
220 Citations (Scopus)

Ornithine decarboxylase as an enzyme target for therapy

McCann, P. P. & Pegg, A., Jan 1 1992, In : Pharmacology and Therapeutics. 54, 2, p. 195-215 21 p.

Research output: Contribution to journalReview article

Enzyme Therapy
Ornithine Decarboxylase
Polyamines
African Trypanosomiasis
Eflornithine
249 Citations (Scopus)

Repair of DNA containing O6-alkylguanine

Pegg, A. E. & Byers, T. L., Jan 1 1992, In : FASEB Journal. 6, 6, p. 2302-2310 9 p.

Research output: Contribution to journalReview article

Alkyl and Aryl Transferases
DNA Repair
Repair
Alkylating Agents
DNA
94 Citations (Scopus)

S-adenosylmenthionine decarboxylase as an enzyme target for therapy

Pegg, A. E. & McCann, P. P., 1992, In : Pharmacology and Therapeutics. 56, 3, p. 359-377 19 p.

Research output: Contribution to journalReview article

Enzyme Therapy
Carboxy-Lyases
Polyamines
Enzyme Inhibitors
Putrescine
1991
1 Citation (Scopus)
Alkylating Agents
DNA Repair
Carcinogenesis
Mutation
DNA
1988
8 Citations (Scopus)

Properties of human and rodent S-adenosylmethionine decarboxylase.

Pegg, A., Stanley, B., Pajunen, A., Crozat, A. & Jänne, O. A., Dec 1 1988, In : Advances in Experimental Medicine and Biology. 250, p. 101-109 9 p.

Research output: Contribution to journalReview article

Adenosylmethionine Decarboxylase
Species Specificity
Carboxy-Lyases
Rodentia
1986
1397 Citations (Scopus)

Recent advances in the biochemistry of polyamines in eukaryocytes

Pegg, A., Jan 1 1986, In : Biochemical Journal. 234, 2, p. 249-262 14 p.

Research output: Contribution to journalReview article

Biochemistry
Polyamines
1 Citation (Scopus)

Short-term assays to predict carcinogenicity. DNA damage and repair.

Venitt, S., Bartsch, H., Becking, G., Fuchs, R. P., Hofnung, M., Malaveille, C., Matsushima, T., Pegg, A., Rajewsky, M. R. & Roberfroid, M., Dec 1 1986, In : IARC scientific publications. 83, p. 129-142 14 p.

Research output: Contribution to journalReview article

Short-term assays to predict carcinogenicity. Metabolic activation.

Venitt, S., Bartsch, H., Becking, G., Fuchs, R. P., Hofnung, M., Malaveille, C., Matsushima, T., Mendelsohn, M. L., Pegg, A. & Roberfroid, M., Dec 1 1986, In : IARC scientific publications. 83, p. 439-455 17 p.

Research output: Contribution to journalReview article

1980
40 Citations (Scopus)

Metabolism of N-nitrosodimethylamine

Pegg, A., Jan 1 1980, In : IARC (International Agency for Research on Cancer) Scientific Publications. VOL. 27, p. 3-22 20 p.

Research output: Contribution to journalReview article

Dimethylnitrosamine
Kidney Neoplasms
Intestinal Absorption
Methyltransferases
Liver Neoplasms