• 2856 Citations
  • 26 h-Index
20032020

Research output per year

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Personal profile

Research interests

Dr. Arati Sharma’s research is focused on melanoma, the most aggressive and metastatic form of skin cancer. Despite one American dying of melanoma every hour, there is no effective long-term treatment for patients' suffering from the advanced stages of the disease.

To be able to effectively treat melanomas, one must understand the biology of melanoma, proteins and signaling pathways involved in melanoma progression and development. In this respect, very few globally important melanoma causing genes or pathways have been identified, and it is only with this knowledge that more effective treatments to repair the defects that are seen in melanoma cells can be tailored and developed.

Dr. Sharma's laboratory has been focused on process of target identification and validation, chemopreventive and chemotherapeutic agent development and elucidating the mechanism of action.

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Projects

  • Research Output

    • 2856 Citations
    • 26 h-Index
    • 41 Article
    • 2 Chapter (peer-reviewed)
    • 2 Review article
    • 1 Letter

    Ceramide analogue SACLAC modulates sphingolipid levels and MCL-1 splicing to induce apoptosis in acute myeloid leukemia

    Pearson, J. M., Tan, S. F., Sharma, A., Annageldiyev, C., Fox, T. E., Abad, J. L., Fabrias, G., Desai, D., Amin, S., Wang, H. G., Cabot, M. C., Claxton, D. F., Kester, M., Feith, D. J. & Loughran, T. P., Jan 1 2020, In : Molecular Cancer Research. 18, 3, p. 352-363 12 p.

    Research output: Contribution to journalArticle

  • Regulation of small GTPase Rab20 by ikaros in B-cell acute lymphoblastic leukemia

    Payne, J. L., Song, C., Ding, Y., Dhanyamraju, P. K., Bamme, Y., Schramm, J. W., Desai, D., Sharma, A., Gowda, C. & Dovat, S., Mar 1 2020, In : International journal of molecular sciences. 21, 5, 1718.

    Research output: Contribution to journalArticle

    Open Access
  • The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia

    Annageldiyev, C., Gowda, K., Patel, T., Bhattacharya, P., Tan, S. F., Iyer, S., Desai, D., Dovat, S., Feith, D. J., Loughran, T. P., Amin, S., Claxton, D. & Sharma, A., Mar 1 2020, In : Haematologica. 105, 3, p. 687-696 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • Animal (mouse) models of melanoma

    Madhunapantula, S. R. V., Patel, T. N., Annageldiyev, C. & Sharma, A., 2019, Animal Models in Cancer Drug Discovery. Azmi, A. & Mohammad, R. M. (eds.). Academic Press, p. 401-417

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  • Animal mouse models of acute myeloid leukemia

    Patel, T. N., Madhunapantula, S. R. V., Annageldiyev, C., Claxton, D. & Sharma, A., 2019, Animal Models in Cancer Drug Discovery. Azmi, A. & Mohammad, R. M. (eds.). Academic Press, p. 419-438

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)