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Personal profile

Research interests

Dr. Arati Sharma’s research is focused on melanoma, the most aggressive and metastatic form of skin cancer. Despite one American dying of melanoma every hour, there is no effective long-term treatment for patients' suffering from the advanced stages of the disease.

To be able to effectively treat melanomas, one must understand the biology of melanoma, proteins and signaling pathways involved in melanoma progression and development. In this respect, very few globally important melanoma causing genes or pathways have been identified, and it is only with this knowledge that more effective treatments to repair the defects that are seen in melanoma cells can be tailored and developed.

Dr. Sharma's laboratory has been focused on process of target identification and validation, chemopreventive and chemotherapeutic agent development and elucidating the mechanism of action.

Fingerprint Dive into the research topics where Arati Sharma is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 7 Similar Profiles
Melanoma Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Celecoxib Medicine & Life Sciences
Small Interfering RNA Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Nanoparticles Medicine & Life Sciences
Mitogen-Activated Protein Kinases Medicine & Life Sciences
Neoplasm Metastasis Medicine & Life Sciences

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Projects 2009 2012

Melanoma
Apoptosis
plumbagin
Sunscreening Agents
Skin Neoplasms

Research Output 2003 2019

  • 2757 Citations
  • 26 h-Index
  • 36 Article
  • 2 Review article
  • 1 Letter
1 Citation (Scopus)

Downregulation of CD73 associates with T cell exhaustion in AML patients

Kong, Y., Jia, B., Zhao, C., Claxton, D., Sharma, A., Annageldiyev, C., Fotos, J., Zeng, H., Paulson, R., Prabhu, K. S. & Zheng, H., Apr 24 2019, In : Journal of Hematology and Oncology. 12, 1, 40.

Research output: Contribution to journalArticle

Open Access
Acute Myeloid Leukemia
Down-Regulation
T-Lymphocytes
Adenosine
Neoplasms

Optimizing live-animal bioluminescence imaging prediction of tumor burden in human prostate cancer xenograft models in SCID-NSG mice

Kim, S., Zhang, Y., Tang, S., Qin, C., Karelia, D., Sharma, A., Jiang, C. & Lu, J., Jun 15 2019, In : Prostate. 79, 9, p. 949-960 12 p.

Research output: Contribution to journalArticle

SCID Mice
Tumor Burden
Luciferases
Heterografts
Prostatic Neoplasms

Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity

Kokolus, K. M., Haley, J. S., Koubek, E. J., Gowda, R., Dinavahi, S. S., Sharma, A., Claxton, D., Helm, K., Drabick, J., Robertson, G., Neighbors, J., Hohl, R. & Schell, T., Feb 1 2019, In : OncoImmunology. 8, 2, e1539614.

Research output: Contribution to journalArticle

Biological Products
Immunity
Melanoma
Immunotherapy
Neoplasms
5 Citations (Scopus)

Identification of WEE1 as a target to make AKT inhibition more effective in melanoma

Kuzu, O. F., Gowda, R., Sharma, A., Noory, M. A., Kardos, G., Madhunapantula, S. R. V., Drabick, J. & Robertson, G., Jan 2 2018, In : Cancer Biology and Therapy. 19, 1, p. 53-62 10 p.

Research output: Contribution to journalArticle

Melanoma
RNA Interference
Cell Cycle Checkpoints
DNA Repair
DNA Damage
2 Citations (Scopus)

Improving pharmacological targeting of AKT in melanoma

Kuzu, O. F., Gowda, R., Sharma, A., Noory, M. A., Dinavahi, S. S., Kardos, G., Drabick, J. & Robertson, G., Sep 28 2017, In : Cancer Letters. 404, p. 29-36 8 p.

Research output: Contribution to journalArticle

Melanoma
Pharmacology
Proteins
Drug Combinations
Growth