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Research Output 1980 2019

  • 2660 Citations
  • 25 h-Index
  • 63 Article
  • 8 Review article
  • 1 Chapter
  • 1 Comment/debate
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Article
2019

Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors

Desai, D., Lauver, M., Ostman, A., Cruz, L., Ferguson, K., Jin, G., Roper, B., Brosius, D., Lukacher, A., Amin, S. & Buchkovich, N., May 1 2019, In : Bioorganic and Medicinal Chemistry. 27, 9, p. 1795-1803 9 p.

Research output: Contribution to journalArticle

Viruses
Polyomavirus
Stem Cell Transplantation
Stem cells
Cytomegalovirus

PD-1 dynamically regulates inflammation and development of brain-resident memory CD8 T cells during persistent viral encephalitis

Shwetank, Frost, E. L., Mockus, T. E., Ren, H. M., Toprak, M., Lauver, M. D., Netherby-Winslow, C. S., Jin, G., Cosby, J. M., Evavold, B. D. & Lukacher, A., Jan 1 2019, In : Frontiers in immunology. 10, MAR, 783.

Research output: Contribution to journalArticle

Open Access
Viral Encephalitis
Encephalitis
Polyomavirus
Cell Death
T-Lymphocytes
2018
2 Citations (Scopus)

CD4 T cells control development and maintenance of brain-resident CD8 T cells during polyomavirus infection

Mockus, T. E., Shwetank, Lauver, M. D., Ren, H. M., Netherby, C. S., Salameh, T., Imamura, Y., Yue, F., Broach, J. & Lukacher, A., Oct 1 2018, In : PLoS Pathogens. 14, 10, e1007365.

Research output: Contribution to journalArticle

Polyomavirus Infections
Maintenance
T-Lymphocytes
Brain
JC Virus
2 Citations (Scopus)

Combined sublethal irradiation and agonist anti-CD40 enhance donor T cell accumulation and control of autochthonous murine pancreatic tumors

Ward-Kavanagh, L. K., Kokolus, K. M., Cooper, T. K., Lukacher, A. & Schell, T., Apr 1 2018, In : Cancer Immunology, Immunotherapy. 67, 4, p. 639-652 14 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Neoplasms
Whole-Body Irradiation
Pancreas
Neuroendocrine Tumors
2017
4 Citations (Scopus)

Inhibition of retrograde transport limits polyomavirus infection in vivo

Maru, S., Jin, G., Desai, D., Amin, S., Shwetank, Lauver, M. D. & Lukacher, A., Nov 1 2017, In : mSphere. 2, 6, e00494-17.

Research output: Contribution to journalArticle

Polyomavirus Infections
Polyomavirus
BK Virus
JC Virus
Kidney
20 Citations (Scopus)

Maintenance of PD-1 on brain-resident memory CD8 T cells is antigen independent

Shwetank, Abdelsamed, H. A., Frost, E. L., Schmitz, H. M., Mockus, T. E., Youngblood, B. A. & Lukacher, A., Nov 1 2017, In : Immunology and Cell Biology. 95, 10, p. 953-959 7 p.

Research output: Contribution to journalArticle

Polyomavirus
Maintenance
Programmed Cell Death 1 Receptor
T-Lymphocytes
Antigens
1 Citation (Scopus)

Reducing persistent polyomavirus infection increases functionality of virus-specific memory CD8 T cells

Qin, Q., Lauver, M., Maru, S., Lin, E. & Lukacher, A., Feb 1 2017, In : Virology. 502, p. 198-205 8 p.

Research output: Contribution to journalArticle

Polyomavirus Infections
Polyomavirus
Viruses
T-Lymphocytes
Viral Load
7 Citations (Scopus)
Virus Diseases
T-Lymphocytes
Brain
Antigens
Epitopes
2016
6 Citations (Scopus)

Type I interferons regulate the magnitude and functionality of mouse polyomavirus-specific CD8 T cells in a virus strain- dependent manner

Qin, Q., Shwetank, Frost, E. L., Maru, S. & Lukacher, A., May 1 2016, In : Journal of virology. 90, 10, p. 5187-5199 13 p.

Research output: Contribution to journalArticle

Murine polyomavirus
Polyomavirus
Interferon Type I
interferons
varespladib methyl
2015
28 Citations (Scopus)

Cutting edge: Resident memory CD8 T cells express high-affinity TCRs

Frost, E. L., Kersh, A. E., Evavold, B. D. & Lukacher, A., Oct 15 2015, In : Journal of Immunology. 195, 8, p. 3520-3524 5 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Polyomavirus
Brain
Spleen
Epithelium
12 Citations (Scopus)

Distinct and synergistic roles of FcγRIIB deficiency and 129 strain-derived SLAM family proteins in the development of spontaneous germinal centers and autoimmunity

Soni, C., Domeier, P. P., Wong, E. B., Shwetank, Khan, T. N., Elias, M. J., Schell, S. L., Lukacher, A., Cooper, T. & Rahman, Z., Sep 1 2015, In : Journal of Autoimmunity. 63, p. 31-46 16 p.

Research output: Contribution to journalArticle

Germinal Center
Autoimmunity
B-Lymphocytes
Lymphocyte Activation
T-Lymphocytes
7 Citations (Scopus)

Pathogen stimulation history impacts donor-specific CD8+ T cell susceptibility to costimulation/integrin blockade-based therapy

Badell, I. R., Kitchens, W. H., Wagener, M. E., Lukacher, A., Larsen, C. P. & Ford, M. L., Dec 1 2015, In : American Journal of Transplantation. 15, 12, p. 3081-3094 14 p.

Research output: Contribution to journalArticle

Integrins
Tissue Donors
T-Lymphocytes
Heterologous Immunity
Immunosuppression
2013
1 Citation (Scopus)

Peptide immunization elicits polyomavirus-specific MHC class Ib-restricted CD8 T cells in MHC class ia allogeneic mice

Hofstetter, A. R., Evavold, B. D. & Lukacher, A., Feb 1 2013, In : Viral Immunology. 26, 1, p. 109-113 5 p.

Research output: Contribution to journalArticle

Polyomavirus
Immunization
T-Lymphocytes
Peptides
Capsid
2012
9 Citations (Scopus)

Adaptive immunity rather than viral cytopathology mediates polyomavirus-associated nephropathy in mice

Albrecht, J. A., Dong, Y., Wang, J., Breeden, C., Farris, A. B., Lukacher, A. & Newell, K. A., Jun 1 2012, In : American Journal of Transplantation. 12, 6, p. 1419-1428 10 p.

Research output: Contribution to journalArticle

Polyomavirus
Adaptive Immunity
Allografts
Kidney
Polyomavirus Infections
12 Citations (Scopus)

CD8 T cells recruited early in mouse polyomavirus infection undergo exhaustion

Wilson, J. J., Pack, C. D., Lin, E., Frost, E. L., Albrecht, J. A., Hadley, A., Hofstetter, A. R., Tevethia, S. S., Schell, T. & Lukacher, A., May 1 2012, In : Journal of Immunology. 188, 9, p. 4340-4348 9 p.

Research output: Contribution to journalArticle

Polyomavirus Infections
T-Lymphocytes
Viruses
Infection
Polyomavirus
5 Citations (Scopus)

MHC class Ib-restricted CD8 T cells differ in dependence on CD4 T cell help and CD28 costimulation over the course of mouse polyomavirus infection

Hofstetter, A. R., Ford, M. L., Sullivan, L. C., Wilson, J. J., Hadley, A., Brooks, A. G. & Lukacher, A., Apr 1 2012, In : Journal of Immunology. 188, 7, p. 3071-3079 9 p.

Research output: Contribution to journalArticle

Polyomavirus Infections
T-Lymphocytes
Maintenance
CD40 Ligand
Polyomavirus
2011
17 Citations (Scopus)

Gamma interferon controls mouse polyomavirus infection in vivo

Wilson, J. J., Lin, E., Pack, C. D., Frost, E. L., Hadley, A., Swimm, A. I., Wang, J., Dong, Y., Breeden, C. P., Kalman, D., Newell, K. A. & Lukacher, A., Oct 1 2011, In : Journal of virology. 85, 19, p. 10126-10134 9 p.

Research output: Contribution to journalArticle

Murine polyomavirus
Polyomavirus Infections
interferon-gamma
Interferon-gamma
interferons
2 Citations (Scopus)

Minor antigens on transfused RBCs crossprime CD8 T cells but do not induce full effector function

Desmarets, M., Mylvaganam, G., Waller, E. K., Josephson, C. D., Pack, C., Lukacher, A. & Zimring, J. C., Sep 1 2011, In : American Journal of Transplantation. 11, 9, p. 1825-1834 10 p.

Research output: Contribution to journalArticle

Bone Marrow Transplantation
T-Lymphocytes
Graft Rejection
Antigens
Blood Transfusion
41 Citations (Scopus)

The carboxypeptidase ACE shapes the MHC class i peptide repertoire

Shen, X. Z., Billet, S., Lin, C., Okwan-Duodu, D., Chen, X., Lukacher, A. & Bernstein, K. E., Nov 1 2011, In : Nature Immunology. 12, 11, p. 1078-1085 8 p.

Research output: Contribution to journalArticle

Carboxypeptidases
Peptidyl-Dipeptidase A
Major Histocompatibility Complex
Peptides
Proteasome Endopeptidase Complex
2010
20 Citations (Scopus)

Abl family tyrosine kinases regulate sialylated ganglioside receptors for polyomavirus

Swimm, A. I., Bornmann, W., Jiang, M., Imperiale, M. J., Lukacher, A. & Kalman, D., May 1 2010, In : Journal of virology. 84, 9, p. 4243-4251 9 p.

Research output: Contribution to journalArticle

Polyomavirus
gangliosides
Protein-Tyrosine Kinases
tyrosine
phosphotransferases (kinases)
18 Citations (Scopus)

Heterogeneity among viral antigen-specific CD4+ T cells and their de novo recruitment during persistent polyomavirus infection

Lin, E., Kemball, C. C., Hadley, A., Wilson, J. J., Hofstetter, A. R., Pack, C. D. & Lukacher, A., Aug 1 2010, In : Journal of Immunology. 185, 3, p. 1692-1700 9 p.

Research output: Contribution to journalArticle

Polyomavirus Infections
Viral Antigens
T-Lymphocytes
Polyomavirus
Virus Diseases
14 Citations (Scopus)

Persistence of viral infection despite similar killing efficacy of antiviral CD8+ T cells during acute and chronic phases of infection

Ganusov, V. V., Lukacher, A. & Byers, A. M., Sep 1 2010, In : Virology. 405, 1, p. 193-200 8 p.

Research output: Contribution to journalArticle

Polyomavirus
Virus Diseases
Antiviral Agents
T-Lymphocytes
Lymphocytic choriomeningitis virus
40 Citations (Scopus)

Regulation of primary alloantibody response through antecedent exposure to a microbial T-cell epitope

Hudson, K. E., Lin, E., Hendrickson, J. E., Lukacher, A. & Zimring, J. C., May 13 2010, In : Blood. 115, 19, p. 3989-3996 8 p.

Research output: Contribution to journalArticle

Isoantibodies
T-Lymphocyte Epitopes
Blood
Polyomavirus
Erythrocytes
2009
7 Citations (Scopus)

Cutting edge: Shift in antigen dependence by an antiviral MHC class Ib-restricted CD8 T cell response during persistent viral infection

Swanson, P. A., Hofstetter, A. R., Wilson, J. J. & Lukacher, A., May 1 2009, In : Journal of Immunology. 182, 9, p. 5198-5202 5 p.

Research output: Contribution to journalArticle

Virus Diseases
Antiviral Agents
T-Lymphocytes
Antigens
Polyomavirus
77 Citations (Scopus)

Murine Polyomavirus encodes a microRNA that cleaves early RNA transcripts but is not essential for experimental infection

Sullivan, C. S., Sung, C. K., Pack, C. D., Grundhoff, A., Lukacher, A., Benjamin, T. L. & Ganem, D., Apr 25 2009, In : Virology. 387, 1, p. 157-167 11 p.

Research output: Contribution to journalArticle

Polyomavirus
MicroRNAs
RNA
Infection
Cultured Cells
2008
25 Citations (Scopus)

An MHC class Ib-restricted CD8 T cell response confers antiviral immunity

Swanson, P. A., Pack, C. D., Hadley, A., Wang, C. R., Stroynowski, I., Jensen, P. E. & Lukacher, A., Jul 7 2008, In : Journal of Experimental Medicine. 205, 7, p. 1647-1657 11 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
Antiviral Agents
Immunity
Polyomavirus
T-Lymphocytes
23 Citations (Scopus)

Expression of angiotensin-converting enzyme changes major histocompatibility complex class I peptide presentation by modifying C termini of peptide precursors

Shen, X. Z., Lukacher, A., Billet, S., Williams, I. R. & Bernstein, K. E., Apr 11 2008, In : Journal of Biological Chemistry. 283, 15, p. 9957-9965 9 p.

Research output: Contribution to journalArticle

Peptidyl-Dipeptidase A
Major Histocompatibility Complex
Peptides
Macrophages
Antigens
14 Citations (Scopus)

Generation of antiviral major histocompatibility complex class I-restricted T cells in the absence of CD8 coreceptors

Andrews, N. P., Pack, C. D. & Lukacher, A., May 1 2008, In : Journal of virology. 82, 10, p. 4697-4705 9 p.

Research output: Contribution to journalArticle

major histocompatibility complex
Major Histocompatibility Complex
Antiviral Agents
T-lymphocytes
Polyomavirus
2007
1 Citation (Scopus)

Allogeneic differences in the dependence on CD4+ T-cell help for virus-specific CD8+ T-cell differentiation

Kemball, C. C., Szomolanyi-Tsuda, E. & Lukacher, A., Dec 1 2007, In : Journal of Virology. 81, 24, p. 13743-13753 11 p.

Research output: Contribution to journalArticle

cell differentiation
Cell Differentiation
T-lymphocytes
Viruses
T-Lymphocytes
16 Citations (Scopus)

Early virus-associated bystander events affect the fitness of the CD8 T cell response to persistent virus infection

Andrews, N. P., Pack, C. D., Vezys, V., Barber, G. N. & Lukacher, A., Jun 1 2007, In : Journal of Immunology. 178, 11, p. 7267-7275 9 p.

Research output: Contribution to journalArticle

Virus Diseases
Viruses
T-Lymphocytes
Polyomavirus
Antiviral Agents
7 Citations (Scopus)

Protection against polyoma virus-induced tumors is perforin-independent

Byers, A. M., Hadley, A. & Lukacher, A., Feb 20 2007, In : Virology. 358, 2, p. 485-492 8 p.

Research output: Contribution to journalArticle

Polyomavirus
Perforin
T-Lymphocytes
Neoplasms
Granzymes
25 Citations (Scopus)

The antiviral CD8+ T cell response is differentially dependent on CD4+ T cell help over the course of persistent infection

Kemball, C. C., Pack, C. D., Guay, H. M., Li, Z. N., Steinhauer, D. A., Szomolanyi-Tsuda, E. & Lukacher, A., Jul 15 2007, In : Journal of Immunology. 179, 2, p. 1113-1121 9 p.

Research output: Contribution to journalArticle

Antiviral Agents
T-Lymphocytes
Infection
Polyomavirus
Virus Diseases
2006
33 Citations (Scopus)

A mouse model for polyomavirus-associated nephropathy of kidney transplants

Han Lee, E. D., Kemball, C. C., Wang, J., Dong, Y., Stapler, D. C., Hamby, K. M., Gangappa, S., Newell, K. A., Pearson, T. C., Lukacher, A. & Larsen, C. P., May 1 2006, In : American Journal of Transplantation. 6, 5 I, p. 913-922 10 p.

Research output: Contribution to journalArticle

Polyomavirus
Transplants
Kidney
T-Lymphocytes
BK Virus
13 Citations (Scopus)

CD94/NKG2A expression is associated with proliferative potential of CD8 T cells during persistent polyoma virus infection

Byers, A. M., Andrews, N. P. & Lukacher, A., May 15 2006, In : Journal of Immunology. 176, 10, p. 6121-6129 9 p.

Research output: Contribution to journalArticle

Polyomavirus
Virus Diseases
T-Lymphocytes
Interleukin-2
Natural Killer Cell Receptors
155 Citations (Scopus)

Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection

Vezys, V., Masopust, D., Kemball, C. C., Barber, D. L., O'Mara, L. A., Larsen, C. P., Pearson, T. C., Ahmed, R. & Lukacher, A., Oct 9 2006, In : Journal of Experimental Medicine. 203, 10, p. 2263-2269 7 p.

Research output: Contribution to journalArticle

Antiviral Agents
T-Lymphocytes
Infection
CD8 Antigens
Antigens
33 Citations (Scopus)

Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infection

Kemball, C. C., Lee, E. D. H., Szomolanyi-Tsuda, E., Pearson, T. C., Larsen, C. P. & Lukacher, A., Feb 1 2006, In : Journal of Immunology. 176, 3, p. 1814-1824 11 p.

Research output: Contribution to journalArticle

Polyomavirus
Virus Diseases
Antiviral Agents
CD40 Ligand
T-Lymphocytes
2005
5 Citations (Scopus)

A cytokine promoter/yellow fluorescent protein reporter transgene serves as an early activation marker of lymphocyte subsets

Kumar, S., Skeen, M. J., Adiri, Y., Yoon, H., Vezys, V. D., Lukacher, A., Evavold, B. D., Ziegler, H. K. & Boss, J. M., Oct 1 2005, In : Cellular Immunology. 237, 2, p. 131-140 10 p.

Research output: Contribution to journalArticle

Lymphocyte Subsets
Transgenes
Cytokines
Lymphocyte Activation
Proteins
64 Citations (Scopus)

Late priming and variability of epitope-specific CD8+ T cell responses during a persistent virus infection

Kemball, C. C., Lee, E. D. H., Vezys, V., Pearson, T. C., Larsen, C. P. & Lukacher, A., Jun 15 2005, In : Journal of Immunology. 174, 12, p. 7950-7960 11 p.

Research output: Contribution to journalArticle

Virus Diseases
Epitopes
T-Lymphocytes
Polyomavirus
Infection
2003
88 Citations (Scopus)

Cutting edge: Rapid in vivo CTL activity by polyoma virus-specific effector and memory CD8+ T cells

Byers, A. M., Kemball, C. C., Moser, J. M. & Lukacher, A., Jul 1 2003, In : Journal of Immunology. 171, 1, p. 17-21 5 p.

Research output: Contribution to journalArticle

Polyomavirus
T-Lymphocytes
Antiviral Agents
Viruses
Immunologic Monitoring
107 Citations (Scopus)

Memory CD8+ T cells provide an early source of IFN-γ

Kambayashi, T., Assarsson, E., Lukacher, A., Ljunggren, H. G. & Jensen, P. E., Mar 1 2003, In : Journal of Immunology. 170, 5, p. 2399-2408 10 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Natural Killer T-Cells
Natural Killer Cells
Spleen
Lymph Nodes
2002
168 Citations (Scopus)

CD94-NKG2A receptors regulate antiviral CD8+ T cell responses

Moser, J. M., Gibbs, J., Jensen, P. E. & Lukacher, A., Jan 1 2002, In : Nature Immunology. 3, 2, p. 189-195 7 p.

Research output: Contribution to journalArticle

NK Cell Lectin-Like Receptor Subfamily C
Antiviral Agents
T-Lymphocytes
Natural Killer Cell Receptors
Viruses
56 Citations (Scopus)

Prevention of chronic rejection in murine cardiac allografts: A comparison of chimerism- and nonchimerism-inducing costimulation blockade-based tolerance induction regimens

Shirasugi, N., Adams, A. B., Durham, M. M., Lukacher, A., Xu, H., Rees, P., Cowan, S. R., Williams, M. A., Pearson, T. C. & Larsen, C. P., Sep 1 2002, In : Journal of Immunology. 169, 5, p. 2677-2684 8 p.

Research output: Contribution to journalArticle

Chimerism
Allografts
Transplants
Busulfan
Skin
2001
71 Citations (Scopus)
Polyomavirus
Viral Antigens
Antiviral Agents
T-Lymphocytes
Neoplasms
133 Citations (Scopus)

CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation

Daniels, M. A., Devine, L., Miller, J. D., Moser, J. M., Lukacher, A., Altman, J. D., Kavathas, P., Hogquist, K. A. & Jameson, S. C., Jan 1 2001, In : Immunity. 15, 6, p. 1051-1061 11 p.

Research output: Contribution to journalArticle

Glycosylation
T-Lymphocytes
Thymocytes
Cell Adhesion
Ligands
8 Citations (Scopus)

Induction of polyomavirus-specific CD8+ T lymphocytes by distinct dendritic cell subpopulations

Drake, D. R., Shawver, M. L., Hadley, A., Butz, E., Maliszewski, C. & Lukacher, A., Jan 1 2001, In : Journal of virology. 75, 1, p. 544-547 4 p.

Research output: Contribution to journalArticle

Polyomavirus
dendritic cells
Dendritic Cells
T-lymphocytes
T-Lymphocytes
2000
6 Citations (Scopus)

Patterns of expression of viral and cytokine gene transcripts during mouse polyoma virus infection

Drake, D. R., Knoepp, L., Actor, J. K. & Lukacher, A., Jan 1 2000, In : Combinatorial Chemistry and High Throughput Screening. 3, 4, p. 329-341 13 p.

Research output: Contribution to journalArticle

Polyomavirus
Viral Genes
Virus Diseases
Viruses
Tumors
30 Citations (Scopus)

Polyomavirus-infected dendritic cells induce antiviral CD8+ T lymphocytes

Drake, D. R., Moser, J. M., Hadley, A., Altman, J. D., Maliszewski, C., Butz, E. & Lukacher, A., May 2 2000, In : Journal of virology. 74, 9, p. 4093-4101 9 p.

Research output: Contribution to journalArticle

Polyomavirus
dendritic cells
Dendritic Cells
Antiviral Agents
T-lymphocytes
1999
25 Citations (Scopus)

Cross-recognition of two middle T protein epitopes by immunodominant polyoma virus-specific CTL

Wilson, C. S., Moser, J. M., Altman, J. D., Jensen, P. E. & Lukacher, A., Apr 1 1999, In : Journal of Immunology. 162, 7, p. 3933-3941 9 p.

Research output: Contribution to journalArticle

Immunodominant Epitopes
Polyomavirus
Peptides
Epitopes
Proteins
48 Citations (Scopus)

Visualization of polyoma virus-specific CD8+ T cells in vivo during infection and tumor rejection

Lukacher, A., Moser, J. M., Hadley, A. & Altman, J. D., Sep 15 1999, In : Journal of Immunology. 163, 6, p. 3369-3378 10 p.

Research output: Contribution to journalArticle

Polyomavirus
T-Lymphocytes
Infection
Neoplasms
Peptides
1998
26 Citations (Scopus)

A europium fluoroimmunoassay for measuring peptide binding to MHC class I molecules

Jensen, P. E., Moore, J. C. & Lukacher, A., Jun 1 1998, In : Journal of Immunological Methods. 215, 1-2, p. 71-80 10 p.

Research output: Contribution to journalArticle

Fluoroimmunoassay
Europium
Biotin
Peptide T
Fluorometry