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Research Output

  • 2751 Citations
  • 26 h-Index
  • 65 Article
  • 9 Review article
  • 1 Chapter
  • 1 Comment/debate
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Article
2020

CD8 T cells and STAT1 signaling are essential codeterminants in protection from polyomavirus encephalopathy

Mockus, T. E., Netherby-Winslow, C. S., Atkins, H. M., Lauver, M. D., Jin, G., Ren, H. M. & Lukacher, A. E., Mar 1 2020, In : Journal of virology. 94, 8, e02038-19.

Research output: Contribution to journalArticle

Serine phosphorylation of the STAT1 transactivation domain promotes autoreactive B cell and systemic autoimmunity development

Chodisetti, S. B., Fike, A. J., Domeier, P. P., Schell, S. L., Mockus, T. E., Choi, N. M., Corradetti, C., Hou, B., Atkins, H. M., Caricchio, R., Decker, T., Lukacher, A., Olsen, N. & Rahman, Z. S. M., May 15 2020, In : Journal of Immunology. 204, 10, p. 2641-2650 10 p.

Research output: Contribution to journalArticle

2019

Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors

Desai, D., Lauver, M., Ostman, A., Cruz, L., Ferguson, K., Jin, G., Roper, B., Brosius, D., Lukacher, A., Amin, S. & Buchkovich, N., May 1 2019, In : Bioorganic and Medicinal Chemistry. 27, 9, p. 1795-1803 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

PD-1 dynamically regulates inflammation and development of brain-resident memory CD8 T cells during persistent viral encephalitis

Shwetank, Frost, E. L., Mockus, T. E., Ren, H. M., Toprak, M., Lauver, M. D., Netherby-Winslow, C. S., Jin, G., Cosby, J. M., Evavold, B. D. & Lukacher, A. E., Jan 1 2019, In : Frontiers in immunology. 10, MAR, 783.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

CD4 T cells control development and maintenance of brain-resident CD8 T cells during polyomavirus infection

Mockus, T. E., Shwetank, Lauver, M. D., Ren, H. M., Netherby, C. S., Salameh, T., Kawasawa, Y. I., Yue, F., Broach, J. R. & Lukacher, A. E., Oct 2018, In : PLoS pathogens. 14, 10, e1007365.

Research output: Contribution to journalArticle

4 Scopus citations

Combined sublethal irradiation and agonist anti-CD40 enhance donor T cell accumulation and control of autochthonous murine pancreatic tumors

Ward-Kavanagh, L. K., Kokolus, K. M., Cooper, T., Lukacher, A. E. & Schell, T. D., Apr 1 2018, In : Cancer Immunology, Immunotherapy. 67, 4, p. 639-652 14 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Inhibition of retrograde transport limits polyomavirus infection in vivo

Maru, S., Jin, G., Desai, D., Amin, S., Shwetank, Lauver, M. D. & Lukacher, A. E., Nov 1 2017, In : mSphere. 2, 6, e00494-17.

Research output: Contribution to journalArticle

8 Scopus citations

Maintenance of PD-1 on brain-resident memory CD8 T cells is antigen independent

Shwetank, Abdelsamed, H. A., Frost, E. L., Schmitz, H. M., Mockus, T. E., Youngblood, B. A. & Lukacher, A. E., Nov 1 2017, In : Immunology and Cell Biology. 95, 10, p. 953-959 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Reducing persistent polyomavirus infection increases functionality of virus-specific memory CD8 T cells

Qin, Q., Lauver, M., Maru, S., Lin, E. & Lukacher, A. E., Feb 1 2017, In : Virology. 502, p. 198-205 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
11 Scopus citations
2016

Type I interferons regulate the magnitude and functionality of mouse polyomavirus-specific CD8 T cells in a virus strain- dependent manner

Qin, Q., Shwetank, Frost, E. L., Maru, S. & Lukacher, A. E., May 1 2016, In : Journal of virology. 90, 10, p. 5187-5199 13 p.

Research output: Contribution to journalArticle

7 Scopus citations
2015

Cutting edge: Resident memory CD8 T cells express high-affinity TCRs

Frost, E. L., Kersh, A. E., Evavold, B. D. & Lukacher, A. E., Oct 15 2015, In : Journal of Immunology. 195, 8, p. 3520-3524 5 p.

Research output: Contribution to journalArticle

34 Scopus citations

Distinct and synergistic roles of FcγRIIB deficiency and 129 strain-derived SLAM family proteins in the development of spontaneous germinal centers and autoimmunity

Soni, C., Domeier, P. P., Wong, E. B., Shwetank, Khan, T. N., Elias, M. J., Schell, S. L., Lukacher, A. E., Cooper, T. K. & Rahman, Z. S. M., Sep 1 2015, In : Journal of Autoimmunity. 63, p. 31-46 16 p.

Research output: Contribution to journalArticle

16 Scopus citations

Pathogen stimulation history impacts donor-specific CD8+ T cell susceptibility to costimulation/integrin blockade-based therapy

Badell, I. R., Kitchens, W. H., Wagener, M. E., Lukacher, A. E., Larsen, C. P. & Ford, M. L., Dec 2015, In : American Journal of Transplantation. 15, 12, p. 3081-3094 14 p.

Research output: Contribution to journalArticle

9 Scopus citations
2013

Peptide immunization elicits polyomavirus-specific MHC class Ib-restricted CD8 T cells in MHC class ia allogeneic mice

Hofstetter, A. R., Evavold, B. D. & Lukacher, A. E., Feb 1 2013, In : Viral Immunology. 26, 1, p. 109-113 5 p.

Research output: Contribution to journalArticle

1 Scopus citations
2012

Adaptive immunity rather than viral cytopathology mediates polyomavirus-associated nephropathy in mice

Albrecht, J. A., Dong, Y., Wang, J., Breeden, C., Farris, A. B., Lukacher, A. E. & Newell, K. A., Jun 1 2012, In : American Journal of Transplantation. 12, 6, p. 1419-1428 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

CD8 T cells recruited early in mouse polyomavirus infection undergo exhaustion

Wilson, J. J., Pack, C. D., Lin, E., Frost, E. L., Albrecht, J. A., Hadley, A., Hofstetter, A. R., Tevethia, S. S., Schell, T. D. & Lukacher, A. E., May 1 2012, In : Journal of Immunology. 188, 9, p. 4340-4348 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

MHC class Ib-restricted CD8 T cells differ in dependence on CD4 T cell help and CD28 costimulation over the course of mouse polyomavirus infection

Hofstetter, A. R., Ford, M. L., Sullivan, L. C., Wilson, J. J., Hadley, A., Brooks, A. G. & Lukacher, A. E., Apr 1 2012, In : Journal of Immunology. 188, 7, p. 3071-3079 9 p.

Research output: Contribution to journalArticle

5 Scopus citations
2011

Gamma interferon controls mouse polyomavirus infection in vivo

Wilson, J. J., Lin, E., Pack, C. D., Frost, E. L., Hadley, A., Swimm, A. I., Wang, J., Dong, Y., Breeden, C. P., Kalman, D., Newell, K. A. & Lukacher, A. E., Oct 1 2011, In : Journal of virology. 85, 19, p. 10126-10134 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Minor antigens on transfused RBCs crossprime CD8 T cells but do not induce full effector function

Desmarets, M., Mylvaganam, G., Waller, E. K., Josephson, C. D., Pack, C., Lukacher, A. E. & Zimring, J. C., Sep 1 2011, In : American Journal of Transplantation. 11, 9, p. 1825-1834 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

The carboxypeptidase ACE shapes the MHC class i peptide repertoire

Shen, X. Z., Billet, S., Lin, C., Okwan-Duodu, D., Chen, X., Lukacher, A. E. & Bernstein, K. E., Nov 1 2011, In : Nature Immunology. 12, 11, p. 1078-1085 8 p.

Research output: Contribution to journalArticle

47 Scopus citations
2010

Abl family tyrosine kinases regulate sialylated ganglioside receptors for polyomavirus

Swimm, A. I., Bornmann, W., Jiang, M., Imperiale, M. J., Lukacher, A. E. & Kalman, D., May 2010, In : Journal of virology. 84, 9, p. 4243-4251 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Heterogeneity among viral antigen-specific CD4+ T cells and their de novo recruitment during persistent polyomavirus infection

Lin, E., Kemball, C. C., Hadley, A., Wilson, J. J., Hofstetter, A. R., Pack, C. D. & Lukacher, A. E., Aug 1 2010, In : Journal of Immunology. 185, 3, p. 1692-1700 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Persistence of viral infection despite similar killing efficacy of antiviral CD8+ T cells during acute and chronic phases of infection

Ganusov, V. V., Lukacher, A. E. & Byers, A. M., Sep 1 2010, In : Virology. 405, 1, p. 193-200 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Regulation of primary alloantibody response through antecedent exposure to a microbial T-cell epitope

Hudson, K. E., Lin, E., Hendrickson, J. E., Lukacher, A. E. & Zimring, J. C., May 13 2010, In : Blood. 115, 19, p. 3989-3996 8 p.

Research output: Contribution to journalArticle

41 Scopus citations
2009

Cutting edge: Shift in antigen dependence by an antiviral MHC class Ib-restricted CD8 T cell response during persistent viral infection

Swanson, P. A., Hofstetter, A. R., Wilson, J. J. & Lukacher, A. E., May 1 2009, In : Journal of Immunology. 182, 9, p. 5198-5202 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Murine Polyomavirus encodes a microRNA that cleaves early RNA transcripts but is not essential for experimental infection

Sullivan, C. S., Sung, C. K., Pack, C. D., Grundhoff, A., Lukacher, A. E., Benjamin, T. L. & Ganem, D., Apr 25 2009, In : Virology. 387, 1, p. 157-167 11 p.

Research output: Contribution to journalArticle

78 Scopus citations
2008

An MHC class Ib-restricted CD8 T cell response confers antiviral immunity

Swanson, P. A., Pack, C. D., Hadley, A., Wang, C. R., Stroynowski, I., Jensen, P. E. & Lukacher, A. E., Jul 7 2008, In : Journal of Experimental Medicine. 205, 7, p. 1647-1657 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Expression of angiotensin-converting enzyme changes major histocompatibility complex class I peptide presentation by modifying C termini of peptide precursors

Shen, X. Z., Lukacher, A. E., Billet, S., Williams, I. R. & Bernstein, K. E., Apr 11 2008, In : Journal of Biological Chemistry. 283, 15, p. 9957-9965 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Generation of antiviral major histocompatibility complex class I-restricted T cells in the absence of CD8 coreceptors

Andrews, N. P., Pack, C. D. & Lukacher, A. E., May 1 2008, In : Journal of virology. 82, 10, p. 4697-4705 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
2007

Allogeneic differences in the dependence on CD4+ T-cell help for virus-specific CD8+ T-cell differentiation

Kemball, C. C., Szomolanyi-Tsuda, E. & Lukacher, A. E., Dec 1 2007, In : Journal of virology. 81, 24, p. 13743-13753 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Early virus-associated bystander events affect the fitness of the CD8 T cell response to persistent virus infection

Andrews, N. P., Pack, C. D., Vezys, V., Barber, G. N. & Lukacher, A. E., Jun 1 2007, In : Journal of Immunology. 178, 11, p. 7267-7275 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Protection against polyoma virus-induced tumors is perforin-independent

Byers, A. M., Hadley, A. & Lukacher, A. E., Feb 20 2007, In : Virology. 358, 2, p. 485-492 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

The antiviral CD8+ T cell response is differentially dependent on CD4+ T cell help over the course of persistent infection

Kemball, C. C., Pack, C. D., Guay, H. M., Li, Z. N., Steinhauer, D. A., Szomolanyi-Tsuda, E. & Lukacher, A. E., Jul 15 2007, In : Journal of Immunology. 179, 2, p. 1113-1121 9 p.

Research output: Contribution to journalArticle

26 Scopus citations
2006

A mouse model for polyomavirus-associated nephropathy of kidney transplants

Han Lee, E. D., Kemball, C. C., Wang, J., Dong, Y., Stapler, D. C., Hamby, K. M., Gangappa, S., Newell, K. A., Pearson, T. C., Lukacher, A. & Larsen, C. P., May 1 2006, In : American Journal of Transplantation. 6, 5 I, p. 913-922 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

CD94/NKG2A expression is associated with proliferative potential of CD8 T cells during persistent polyoma virus infection

Byers, A. M., Andrews, N. P. & Lukacher, A. E., May 15 2006, In : Journal of Immunology. 176, 10, p. 6121-6129 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection

Vezys, V., Masopust, D., Kemball, C. C., Barber, D. L., O'Mara, L. A., Larsen, C. P., Pearson, T. C., Ahmed, R. & Lukacher, A. E., Oct 9 2006, In : Journal of Experimental Medicine. 203, 10, p. 2263-2269 7 p.

Research output: Contribution to journalArticle

157 Scopus citations

Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infection

Kemball, C. C., Lee, E. D. H., Szomolanyi-Tsuda, E., Pearson, T. C., Larsen, C. P. & Lukacher, A. E., Feb 1 2006, In : Journal of Immunology. 176, 3, p. 1814-1824 11 p.

Research output: Contribution to journalArticle

34 Scopus citations
2005

A cytokine promoter/yellow fluorescent protein reporter transgene serves as an early activation marker of lymphocyte subsets

Kumar, S., Skeen, M. J., Adiri, Y., Yoon, H., Vezys, V. D., Lukacher, A., Evavold, B. D., Ziegler, H. K. & Boss, J. M., Oct 1 2005, In : Cellular Immunology. 237, 2, p. 131-140 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Late priming and variability of epitope-specific CD8+ T cell responses during a persistent virus infection

Kemball, C. C., Lee, E. D. H., Vezys, V., Pearson, T. C., Larsen, C. P. & Lukacher, A. E., Jun 15 2005, In : Journal of Immunology. 174, 12, p. 7950-7960 11 p.

Research output: Contribution to journalArticle

64 Scopus citations
2003

Cutting edge: Rapid in vivo CTL activity by polyoma virus-specific effector and memory CD8+ T cells

Byers, A. M., Kemball, C. C., Moser, J. M. & Lukacher, A. E., Jul 1 2003, In : Journal of Immunology. 171, 1, p. 17-21 5 p.

Research output: Contribution to journalArticle

90 Scopus citations

Memory CD8+ T cells provide an early source of IFN-γ

Kambayashi, T., Assarsson, E., Lukacher, A. E., Ljunggren, H. G. & Jensen, P. E., Mar 1 2003, In : Journal of Immunology. 170, 5, p. 2399-2408 10 p.

Research output: Contribution to journalArticle

Open Access
109 Scopus citations
2002

CD94-NKG2A receptors regulate antiviral CD8+ T cell responses

Moser, J. M., Gibbs, J., Jensen, P. E. & Lukacher, A., Jan 1 2002, In : Nature Immunology. 3, 2, p. 189-195 7 p.

Research output: Contribution to journalArticle

172 Scopus citations

Prevention of chronic rejection in murine cardiac allografts: A comparison of chimerism- and nonchimerism-inducing costimulation blockade-based tolerance induction regimens

Shirasugi, N., Adams, A. B., Durham, M. M., Lukacher, A. E., Xu, H., Rees, P., Cowan, S. R., Williams, M. A., Pearson, T. C. & Larsen, C. P., Sep 1 2002, In : Journal of Immunology. 169, 5, p. 2677-2684 8 p.

Research output: Contribution to journalArticle

57 Scopus citations
2001
71 Scopus citations

CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation

Daniels, M. A., Devine, L., Miller, J. D., Moser, J. M., Lukacher, A. E., Altman, J. D., Kavathas, P., Hogquist, K. A. & Jameson, S. C., Jan 1 2001, In : Immunity. 15, 6, p. 1051-1061 11 p.

Research output: Contribution to journalArticle

136 Scopus citations

Induction of polyomavirus-specific CD8+ T lymphocytes by distinct dendritic cell subpopulations

Drake, D. R., Shawver, M. L., Hadley, A., Butz, E., Maliszewski, C. & Lukacher, A. E., Jan 1 2001, In : Journal of virology. 75, 1, p. 544-547 4 p.

Research output: Contribution to journalArticle

8 Scopus citations
2000

Patterns of expression of viral and cytokine gene transcripts during mouse polyoma virus infection

Drake, D. R., Knoepp, L., Actor, J. K. & Lukacher, A. E., Jan 1 2000, In : Combinatorial Chemistry and High Throughput Screening. 3, 4, p. 329-341 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Polyomavirus-infected dendritic cells induce antiviral CD8+ T lymphocytes

Drake, D. R., Moser, J. M., Hadley, A., Altman, J. D., Maliszewski, C., Butz, E. & Lukacher, A. E., May 2 2000, In : Journal of virology. 74, 9, p. 4093-4101 9 p.

Research output: Contribution to journalArticle

30 Scopus citations
1999

Cross-recognition of two middle T protein epitopes by immunodominant polyoma virus-specific CTL

Wilson, C. S., Moser, J. M., Altman, J. D., Jensen, P. E. & Lukacher, A., Apr 1 1999, In : Journal of Immunology. 162, 7, p. 3933-3941 9 p.

Research output: Contribution to journalArticle

25 Scopus citations