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Research Output 1993 2019

  • 2398 Citations
  • 28 h-Index
  • 96 Article
  • 3 Review article
2019

ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells

Narayan, S., Ramisetti, S., Jaiswal, A. S., Law, B. K., Singh-Pillay, A., Singh, P., Amin, S. & Sharma, A., Jan 1 2019, In : European Journal of Medicinal Chemistry. 161, p. 456-467 12 p.

Research output: Contribution to journalArticle

oxaliplatin
Bioactivity
Stem cells
Fluorouracil
Antineoplastic Agents
1 Citation (Scopus)

Development of Isoselenocyanate Compounds' Syntheses and Biological Applications

Frieben, E. E., Amin, S. & Sharma, A., Jun 13 2019, In : Journal of Medicinal Chemistry. 62, 11, p. 5261-5275 15 p.

Research output: Contribution to journalArticle

Sulfur
Isothiocyanates
Neoplasms
Organoselenium Compounds
Glucosinolates

Identification of a novel quinoxaline-isoselenourea targeting the STAT3 pathway as a potential melanoma therapeutic

Alcolea, V., Karelia, D. N., Pandey, M. K., Plano, D., Singh, P., Palop, J. A., Amin, S., Sanmartín, C. & Sharma, A., Feb 1 2019, In : International journal of molecular sciences. 20, 3, 521.

Research output: Contribution to journalArticle

quinoxalines
STAT3 Transcription Factor
Quinoxalines
Transcription
Transducers
1 Citation (Scopus)

Leishmanicidal activity of isoselenocyanate derivatives

Fernández-Rubio, C., Larrea, E., Guerrero, J. P., Herrero, E. S., Gamboa, I., Berrio, C., Plano, D., Amin, S., Sharma, A. & Nguewa, P. A., Feb 1 2019, In : Antimicrobial agents and chemotherapy. 63, 2, e00904-18.

Research output: Contribution to journalArticle

Leishmania major
Leishmaniasis
Leishmania
Amphotericin B
Cell Cycle
2018
2 Citations (Scopus)

Cationic amphiphilic bolaamphiphile-based delivery of antisense oligonucleotides provides a potentially microbiome sparing treatment for C. difficile

Sharma, A., Krzeminski, J., Weissig, V., Hegarty, J. P. & Stewart, D. B., Aug 1 2018, In : Journal of Antibiotics. 71, 8, p. 713-721 9 p.

Research output: Contribution to journalArticle

Antisense Oligonucleotides
Microbiota
Escherichia coli
Infection
Dysbiosis
4 Citations (Scopus)

Design and synthesis of novel thiobarbituric acid derivatives targeting both wild-type and BRAF-mutated melanoma cells

Ramisetti, S. R., Pandey, M. K., Lee, S., Karelia, D., Narayan, S., Amin, S. & Sharma, A., Jan 1 2018, In : European Journal of Medicinal Chemistry. 143, p. 1919-1930 12 p.

Research output: Contribution to journalArticle

Melanoma
Assays
Cells
Derivatives
Cell death
1 Citation (Scopus)

Novel selenadiazole derivatives as selective antitumor and radical scavenging agents

Ruberte, A. C., Plano, D., Encío, I., Aydillo, C., Sharma, A. & Sanmartín, C., Sep 5 2018, In : European Journal of Medicinal Chemistry. 157, p. 14-27 14 p.

Research output: Contribution to journalArticle

Scavenging
Cells
Derivatives
Cell Line
Neoplasms
3 Citations (Scopus)
Androgen Receptors
Reactive Oxygen Species
Prostatic Neoplasms
Apoptosis
Prostate-Specific Antigen
4 Citations (Scopus)

Suppression of Notch1 and AKT mediated epithelial to mesenchymal transition by Verrucarin J in metastatic colon cancer

Pal, D., Tyagi, A., Chandrasekaran, B., Alattasi, H., Ankem, M. K., Sharma, A. & Damodaran, C., Aug 1 2018, In : Cell Death and Disease. 9, 8, 798.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Colonic Neoplasms
Colorectal Neoplasms
Down-Regulation
Cell Proliferation
1 Citation (Scopus)

The chemopreventive effect of withaferin A on spontaneous and inflammation-associated colon carcinogenesis models

Chandrasekaran, B., Pal, D., Kolluru, V., Tyagi, A., Baby, B., Dahiya, N. R., Youssef, K., Alatassi, H., Ankem, M. K., Sharma, A. & Damodaran, C., Dec 31 2018, In : Carcinogenesis. 39, 12, p. 1537-1547 11 p.

Research output: Contribution to journalArticle

Colon
Carcinogenesis
Azoxymethane
Inflammation
Dextran Sulfate
2017

An Efficient Synthesis of Dibenzo[a,l]tetracene and Dibenzo[a,j]tetracene and Their Identification in a Coal Tar Extract

Ramisetti, S. R., Oña-Ruales, J. O., Wise, S. A., Amin, S. & Sharma, A., Sep 8 2017, (Accepted/In press) In : Polycyclic Aromatic Compounds. p. 1-11 11 p.

Research output: Contribution to journalArticle

Coal Tar
Coal tar
Aromatization
Polycyclic Aromatic Hydrocarbons
Liquid chromatography
8 Citations (Scopus)

Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity

Karelia, D. N., Sk, U. H., Singh, P., Gowda, A. S. P., Pandey, M. K., Ramisetti, S. R., Amin, S. & Sharma, A., Jan 1 2017, In : European Journal of Medicinal Chemistry. 135, p. 282-295 14 p.

Research output: Contribution to journalArticle

Naphthalimides
Type II DNA Topoisomerase
Melanoma
Cells
Growth
2 Citations (Scopus)

Methods of selecting combination therapy for colorectal cancer patients: a patent evaluation of US20160025730A1

Plano, D., Alcolea, V., Sanmartín, C. & Sharma, A., May 4 2017, In : Expert Opinion on Therapeutic Patents. 27, 5, p. 527-538 12 p.

Research output: Contribution to journalArticle

Growth Factor Receptors
Colorectal Neoplasms
Therapeutics
Mitogen-Activated Protein Kinase Kinases
Expert Testimony
3 Citations (Scopus)

Molecular insights: Suppression of EGFR and AKT activation by a small molecule in non-small cell lung cancer

Chandrasekaran, B., Tyagi, A., Sharma, A., Cai, L., Ankem, M. & Damodaran, C., Sep 1 2017, In : Genes and Cancer. 8, 9-10, p. 713-724 12 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Cell Line
Down-Regulation
Catenins
3 Citations (Scopus)

NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations

Narayan, S., Jaiswal, A. S., Sharma, R., Nawab, A., Duckworth, L. V., Law, B. K., Zajac-Kaye, M., George, T. J., Sharma, J., Sharma, A. & Hromas, R. A., Jan 1 2017, In : Oncotarget. 8, 34, p. 57246-57264 19 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Fluorouracil
Colorectal Neoplasms
Population
DNA Damage
2016
9 Citations (Scopus)

Bolaamphiphile-based nanocomplex delivery of phosphorothioate gapmer antisense oligonucleotides as a treatment for Clostridium difficile

Hegarty, J. P., Krzeminski, J., Sharma, A., Guzman-Villanueva, D., Weissig, V. & Stewart, D., Aug 1 2016, In : International Journal of Nanomedicine. 11, p. 3607-3619 13 p.

Research output: Contribution to journalArticle

Clostridium
Clostridium difficile
Antisense Oligonucleotides
Oligonucleotides
Dequalinium
15 Citations (Scopus)

Chalcogen containing heterocyclic scaffolds: New hybrids with antitumoral activity

Alcolea, V., Plano, D., Encío, I., Palop, J. A., Sharma, A. & Sanmartín, C., Jan 1 2016, In : European Journal of Medicinal Chemistry. 123, p. 407-418 12 p.

Research output: Contribution to journalArticle

Chalcogens
Scaffolds
Cells
Selenium
Sulfur
9 Citations (Scopus)

Design, synthesis, and anti-breast cancer evaluation of new triarylethylene analogs bearing short alkyl- and polar amino-/amido-ethyl chains

Kaur, G., Mahajan, M. P., Pandey, M. K., Singh, P., Ramisetti, S. R. & Sharma, A., Apr 15 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 8, p. 1963-1969 7 p.

Research output: Contribution to journalArticle

Bearings (structural)
Estrogen Receptors
Breast Neoplasms
Cells
Tamoxifen
44 Citations (Scopus)

Design, Synthesis, and Biological Evaluation of Novel Selenium (Se-NSAID) Molecules as Anticancer Agents

Plano, D., Karelia, D. N., Pandey, M. K., Spallholz, J. E., Amin, S. & Sharma, A., Mar 10 2016, In : Journal of Medicinal Chemistry. 59, 5, p. 1946-1959 14 p.

Research output: Contribution to journalArticle

Selenium
Antineoplastic Agents
Colorectal Neoplasms
Anti-Inflammatory Agents
Cell Cycle
4 Citations (Scopus)

Interaction between APC and Fen1 during breast carcinogenesis

Narayan, S., Jaiswal, A. S., Law, B. K., Kamal, M. A., Sharma, A. & Hromas, R. A., May 1 2016, In : DNA Repair. 41, p. 54-62 9 p.

Research output: Contribution to journalReview article

Flap Endonucleases
Adenomatous Polyposis Coli
Carcinogenesis
Breast
DNA Repair
16 Citations (Scopus)

Novel seleno- and thio-urea derivatives with potent in vitro activities against several cancer cell lines

Alcolea, V., Plano, D., Karelia, D. N., Palop, J. A., Amin, S., Sanmartín, C. & Sharma, A., May 4 2016, In : European Journal of Medicinal Chemistry. 113, p. 134-144 11 p.

Research output: Contribution to journalArticle

Urea
Cells
Derivatives
Cell Line
Carcinoma
2015
11 Citations (Scopus)
Coal Tar
Polycyclic Aromatic Hydrocarbons
Polycyclic aromatic hydrocarbons
Complex Mixtures
Liquid Chromatography
17 Citations (Scopus)

The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines

Dick, T. E., Hengst, J., Fox, T. E., Colledge, A. L., Kale, V. P., Sung, S., Sharma, A., Amin, S., Loughran, T. P., Kester, M., Wang, H-G. & Yun, J., Mar 1 2015, In : Journal of Pharmacology and Experimental Therapeutics. 352, 3, p. 494-508 15 p.

Research output: Contribution to journalArticle

Myeloid Cells
Acute Myeloid Leukemia
Cell Line
CDC2 Protein Kinase
Cyclin-Dependent Kinases
2014
13 Citations (Scopus)

Design, synthesis and evaluation of Ospemifene analogs as anti-breast cancer agents

Kaur, G., Mahajan, M. P., Pandey, M. K., Singh, P., Ramisetti, S. R. & Sharma, A., Oct 30 2014, In : European Journal of Medicinal Chemistry. 86, p. 211-218 8 p.

Research output: Contribution to journalArticle

Tamoxifen
Breast Neoplasms
Cells
Cell Line
Selective Estrogen Receptor Modulators
23 Citations (Scopus)

Gambogic acid inhibits multiple myeloma mediated osteoclastogenesis through suppression of chemokine receptor CXCR4 signaling pathways

Pandey, M. K., Kale, V. P., Song, C., Sung, S., Sharma, A., Talamo, G., Dovat, S. & Amin, S., Oct 1 2014, In : Experimental Hematology. 42, 10, p. 883-896 14 p.

Research output: Contribution to journalArticle

CXCR4 Receptors
Chemokine Receptors
Multiple Myeloma
Osteogenesis
Chemokine CXCL12
45 Citations (Scopus)
Sphingolipids
Neoplasms
Therapeutics
Diabetic Nephropathies
Metabolic Networks and Pathways
11 Citations (Scopus)
Deoxyguanosine
Tongue
Tissue
Estuaries
Environmental Pollutants
34 Citations (Scopus)

Synthesis and biological evaluation of some 2-(3,5-dimethyl-1H-pyrazol-1- yl)-1-arylethanones: Antibacterial, DNA photocleavage, and anticancer activities

Kumar, V., Kaur, K., Karelia, D. N., Beniwal, V., Gupta, G. K., Sharma, A. & Gupta, A. K., Jun 23 2014, In : European Journal of Medicinal Chemistry. 81, p. 267-276 10 p.

Research output: Contribution to journalArticle

Cells
DNA
Cell Line
Lung Neoplasms
Escherichia coli
2013
3 Citations (Scopus)

Adenine-DNA adduct derived from the nitroreduction of 6-nitrochrysene is more resistant to nucleotide excision repair than guanine-DNA adducts

Krzeminski, J., Kropachev, K., Reeves, D., Kolbanovskiy, A., Kolbanovskiy, M., Chen, K-M., Sharma, A., Geacintov, N., Amin, S. & El-Bayoumy, K., Nov 18 2013, In : Chemical Research in Toxicology. 26, 11, p. 1746-1754 9 p.

Research output: Contribution to journalArticle

DNA Adducts
Guanine
Adenine
DNA Repair
Repair
16 Citations (Scopus)

Impact of pregnancy on the pharmacokinetics of Dibenzo[def,p]chrysene in mice

Crowell, S. R., Sharma, A., Amin, S., Soelberg, J. J., Sadler, N. C., Wright, A. T., Baird, W. M., Williams, D. E. & Corley, R. A., Sep 1 2013, In : Toxicological Sciences. 135, 1, p. 48-62 15 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Blood
Polycyclic Aromatic Hydrocarbons
Pregnancy
Metabolites
20 Citations (Scopus)

Mechanisms of oral carcinogenesis induced by dibenzo[a,l]pyrene: An environmental pollutant and a tobacco smoke constituent

Chen, K-M., Guttenplan, J. B., Zhang, S. M., Aliaga, C., Cooper, T., Sun, Y-W., Deltondo, J., Kosinska, W., Sharma, A., Jiang, K., Bruggeman, R., Ahn, K., Amin, S. & El-Bayoumy, K., Sep 15 2013, In : International Journal of Cancer. 133, 6, p. 1300-1309 10 p.

Research output: Contribution to journalArticle

Environmental Pollutants
Smoke
Tobacco
Carcinogenesis
Tongue
16 Citations (Scopus)

Post SELECT: Selenium on trial

Sharma, A. & Amin, S., Feb 1 2013, In : Future Medicinal Chemistry. 5, 2, p. 163-174 12 p.

Research output: Contribution to journalReview article

Selenium Compounds
Selenium
Selenomethionine
Trace Elements
Pharmaceutical Preparations
25 Citations (Scopus)

Proteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the efficacy of ABT-737 in melanoma cells

Pandey, M. K., Gowda, K., Doi, K., Sharma, A., Wang, H-G. & Amin, S., Nov 4 2013, In : PloS one. 8, 11, e78570.

Research output: Contribution to journalArticle

melanoma
Melanoma
apoptosis
Apoptosis
Degradation
9 Citations (Scopus)

The Akt Inhibitor ISC-4 Synergizes with Cetuximab in 5-FU-Resistant Colon Cancer

Allen, J. E., Gallant, J. N., Dicker, D. T., Amin, S., Irby, R., Sharma, A. & El-Deiry, W. S., Mar 12 2013, In : PLoS One. 8, 3, e59380.

Research output: Contribution to journalArticle

colorectal neoplasms
Fluorouracil
Colonic Neoplasms
Cells
Tumors
2012
182 Citations (Scopus)

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

Young, M. M., Takahashi, Y., Khan, O., Park, S., Hori, T., Yun, J., Sharma, A., Amin, S., Hu, C. D., Zhang, J., Kester, M. & Wang, H-G., Apr 6 2012, In : Journal of Biological Chemistry. 287, 15, p. 12455-12468 14 p.

Research output: Contribution to journalArticle

Death Domain Receptor Signaling Adaptor Proteins
Caspase 8
Chemical activation
Apoptosis
Membranes
25 Citations (Scopus)

In vitro growth inhibition of human cancer cells by novel honokiol analogs

Lin, J. M., Prakasha Gowda, A. S., Sharma, A. & Amin, S., May 15 2012, In : Bioorganic and Medicinal Chemistry. 20, 10, p. 3202-3211 10 p.

Research output: Contribution to journalArticle

Cells
Growth
Cyclin B1
Neoplasms
Cell Cycle Resting Phase
27 Citations (Scopus)

Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity: A potential new model for oral cancer

Guttenplan, J. B., Kosinska, W., Zhao, Z. L., Chen, K-M., Aliaga, C., Deltondo, J., Cooper, T., Sun, Y-W., Zhang, S. M., Jiang, K., Bruggeman, R., Sharma, A., Amin, S., Ahn, K. & El-Bayoumy, K., Jun 15 2012, In : International Journal of Cancer. 130, 12, p. 2783-2790 8 p.

Research output: Contribution to journalArticle

Mouth Neoplasms
Mutagenesis
Mouth
Carcinogenesis
Squamous Cell Carcinoma
21 Citations (Scopus)

Phenylalkyl isoselenocyanates vs phenylalkyl isothiocyanates: Thiol reactivity and its implications

Crampsie, M. A., Pandey, M. K., Desai, D., Spallholz, J., Amin, S. & Sharma, A., Oct 25 2012, In : Chemico-Biological Interactions. 200, 1, p. 28-37 10 p.

Research output: Contribution to journalArticle

Isothiocyanates
Sulfhydryl Compounds
Chain length
Oxidation-Reduction
Reactive Oxygen Species
23 Citations (Scopus)

Rational incorporation of selenium into temozolomide elicits superior antitumor activity associated with both apoptotic and autophagic cell death

Cheng, Y., Sk, U. H., Zhang, Y., Ren, X., Zhang, L., Huber-Keener, K. J., Sun, Y-W., Liao, J. J., Amin, S., Sharma, A. & Yang, J-M., Apr 5 2012, In : PloS one. 7, 4, e35104.

Research output: Contribution to journalArticle

temozolomide
autophagy
Autophagy
Cell death
Selenium
122 Citations (Scopus)

Selenium compounds, apoptosis and other types of cell death: An overview for cancer therapy

Sanmartín, C., Plano, D., Sharma, A. & Palop, J. A., Jan 1 2012, In : International journal of molecular sciences. 13, 8, p. 9649-9672 24 p.

Research output: Contribution to journalReview article

Selenium compounds
selenium compounds
Selenium Compounds
apoptosis
Cell death
2011
8 Citations (Scopus)

Characterization of dibenzo[ a,l pyrene- trans -11,12-diol (dibenzo[ def,p chrysene) glucuronidation by UDP-glucuronosyltransferases

Olson, K. C., Sun, D., Chen, G., Sharma, A., Amin, S., Ropson, I., Spratt, T. & Lazarus, P., Sep 19 2011, In : Chemical Research in Toxicology. 24, 9, p. 1549-1559 11 p.

Research output: Contribution to journalArticle

Glucuronosyltransferase
Glucuronides
Uridine Diphosphate
Enantiomers
Diphosphates
20 Citations (Scopus)

Development of novel naphthalimide derivatives and their evaluation as potential melanoma therapeutics

Sk, U. H., Prakasha Gowda, A. S., Crampsie, M. A., Yun, J., Spratt, T., Amin, S. & Sharma, A., Aug 1 2011, In : European Journal of Medicinal Chemistry. 46, 8, p. 3331-3338 8 p.

Research output: Contribution to journalArticle

Naphthalimides
Melanoma
Thiourea
Derivatives
Tumors
26 Citations (Scopus)
Environmental Carcinogens
DNA Adducts
Tobacco
High Pressure Liquid Chromatography
Tissue
40 Citations (Scopus)

Melanoma chemoprevention in skin reconstructs and mouse xenografts using isoselenocyanate-4

Nguyen, N., Sharma, A., Nguyen, N., Sharma, A., Desai, D., Huh, S. J., Amin, S., Meyers, C. & Robertson, G., Feb 1 2011, In : Cancer Prevention Research. 4, 2, p. 248-258 11 p.

Research output: Contribution to journalArticle

Chemoprevention
Heterografts
Melanoma
Skin
Incidence
16 Citations (Scopus)
Glucuronosyltransferase
DNA Adducts
Glutathione Transferase
Lung Neoplasms
Protein Isoforms
20 Citations (Scopus)

Preliminary physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents

Crowell, S. R., Amin, S., Anderson, K. A., Gowda, K., Sharma, A., Soelberg, J. J., Williams, D. E. & Corley, R. A., Dec 15 2011, In : Toxicology and Applied Pharmacology. 257, 3, p. 365-376 12 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Benzo(a)pyrene
Polycyclic Aromatic Hydrocarbons
Rodentia
Metabolites
15 Citations (Scopus)

Sphingo-guanidines and their use as inhibitors of sphingosine kinase (WO2010078247)

Sharma, A., May 1 2011, In : Expert Opinion on Therapeutic Patents. 21, 5, p. 807-812 6 p.

Research output: Contribution to journalArticle

Guanidines
Ceramidases
Sphingosine
Sphingolipids
Ceramides
36 Citations (Scopus)

Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3′,4′-dimethoxy- α-naphthoflavone

Murray, I. A., Flaveny, C. A., Chiaro, C. R., Sharma, A., Tanos, R. S., Schroeder, J. C., Amin, S., Bisson, W. H., Kolluri, S. K. & Perdew, G. H., Mar 1 2011, In : Molecular Pharmacology. 79, 3, p. 508-519 12 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Response Elements
Cytokines
Gene Expression
Dioxins
41 Citations (Scopus)

Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway

Gowda, K., Prakasha Gowda, A. S., Tagaram, H. R. S., Carroll, K. F. S. O., Irby, R., Sharma, A. & Amin, S., Oct 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 20, p. 6006-6014 9 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Isatin
Phosphorylation
Vinblastine
Cells