Barbara Miller, MD

    • 2920 Citations
    • 34 h-Index
    1979 …2020
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    Personal profile

    Research interests

    Dr. Barbara Miller is internationally recognized for her work on the superfamily of TRP ion channels. Her lab is currently studying an ion channel called TRPM2. This channel is found on many cell types and has an important role in cell proliferation and survival. Dr. Miller’s lab recently demonstrated that TRPM2 channels are highly expressed in neuroblastoma, the most common pediatric solid tumor outside the brain, as well as other cancers including melanoma, lung, breast cancer and leukemia.  

    Full-length TRPM2 channels allow ion (calcium/sodium) entry into a cell. The channel isoform TRPM2-S (S for short), which is missing the pore, inhibits ion entry through the channel. Using mouse models, Dr. Miller’s lab found that neuroblastomas expressing full-length TRPM2 channels grow much larger than tumors in which TRPM2 is inhibited, either by depleting it by cutting it out with a technique called CRISPR or by inhibiting it with the short isoform, TRPM2-S, that has no pore function. 

    Leukemia growth is also significantly reduced by TRPM2 inhibition. Inhibition of calcium entry through TRPM2 reduces energy production in both neuroblastoma and leukemia, increases the levels of harmful oxidants (ROS), blocks the growth of tumors and leukemia and increases sensitivity to chemotherapy.  

    Research currently focuses on better understanding the mechanisms through which TRPM2 modulates cell growth and survival through cellular bioenergetics, and new projects are underway to study its role in metastasis and leukemia. Dr. Miller’s lab is utilizing a drug discovery approach to identify a TRPM2 inhibitor that can be used as a novel anti-cancer agent in clinical trials. 

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    Projects 1979 2020

    Focal Adhesion Kinase 2
    Cell Survival
    Mitochondria
    Cell Proliferation
    Neuroblastoma

    EXERCISE TRAINING IN POSTINFARCT HEART

    Miller, B. & Cheung, J.

    National Institutes of Health

    7/1/981/31/14

    Project: Research project

    Muscle Cells
    Exercise
    Myocardial Infarction
    Cicatrix
    Cytophotometry

    GENERAL CLINICAL RESEARCH CENTER

    Boehmer, J., Ettinger, S., Eyster, M. E., Kenney, Jr., W. L., Miller, B., Mastro, A. M., Ahluwalia, N., Lloyd, T., Sinoway, L., Williams, N., Legro, R., Dong, C., Vgontzas, A., Leuenberger, U., Mulfinger, L., Rolls, B. J., Floros, J., Bixler, E., Ulbrecht, J., Simmons, Z., Paul, I., Latash, M., Ettinger, S., West, S. G., Lee, P., Rolls, B. J., Eslinger, P., Kenney, Jr., W. L., Pawelczyk, J. A., Klein, L., Ouyang, A., Bixler, E., Thiboutot, D., Harvey, H., Hartman, T. J., Ulbrecht, J., Proctor, D. N., Floros, J., Janicki, P., Conroy, D. E., Yang, Q., Challis, J. H., Thomas, N., Dodson, W., Downs, D. S., Wilson, R., Simmons, Z., Cui, J., Alexander, L. M., Ross, A. C., Francis, L. A., Latash, M., West, S. G., Lee, P., Graff, G., Paul, I., Zaenglein, A., De Souza, M. J., Liao, D., Wilson, R., Corwin, R. L., Sinoway, L., Huang, X., Gao, Z., Dunaif, A., Rodichok, L., Eggli, D., Holman, M., Watterberg, K., Campbell, W., Gaumond, R., McGarrity, T., Kulin, H., Streufert, S., Gordon, R., Blosser, S., Manni, A., McCabe, P., Evarts, C., Kirwan, J. P., Craig, T., MacLean, D., Beard, J. L., Pritchard, T. C., Loomis, J., Cavanagh, P. R., Koch, K., Shoemaker, J. K., Hankey, P., Jones, B., Reynolds, H. Y., Granger, D., Corwin, E., Powers, S., Khan, M., Page, M., Daley, J., Lallos, C., Larsson, L., MacNeill, C., Ultman, J., Kirch, D., Farrell, P., Finkelstein, J., Vesell, E., Luck, J., Gardner, T. W., Ambrose, A., Ahsan, N., Kraemer, W., Lipton, A., Ramirez, M., Consevage, M., Phelps, D. S., Cronin, A., Lanoue, K. F., Lathrop, M., Gardner, T. W., Holtzclaw, B. J., Farrell, P., Ayannusi, O., Davis, W., Thorndyke, L., Gardner, T. W., Reeves, W. C., Lihua, X., Pallone, M., Barrett, A. M., Flood, W., Eyster, E., Gilchrist, I., Ramer, J., Leong, S., Imadojemu, V., Rosales, F., Pu, M. I. N., Lott, M., Susman, E. J., Chuang, C., Burks, E., McNulty, P. H., Galka, E. V. A., Rodrigues, I., Erickson, D., Wilson, T. R., Raja-Khan, N. T., Loughran, T. P., Stauffer, L., Miller, C., Fitzgerald, E., Sieverling, E., Podskalny, G. P., Torgerson, C., Trussel, J., Florian, J., Parker, B., Boustred, A. M., O'Bryan, T., Miraliakbari, R., Xiong, N. A., Molenaar, P. C. M., Muscat, J., Ridout, S. J., Baker, L., Spiller, E., Hillary, F. G., Sinha, R., Imadojemu, V., Weinstein, J., Dougherty, K., Demers, L., Han, D., Evans, W., Smith, J., Ray, C., Kris-Etherton, P., [No Value], H. L., Craig, T. J., Ehmann, C., Rybka, W. B., Koltun, W. A., Birch, L. L., Petit, M. A., Connor, J., Monahan, K., Momen, A., Singareddy, R., Cooney, R., Subramanian, T., Curry, W., Ramer, J., Farace, E., Jarvis, S., Flaherty-Craig, C., Scott, K., Aronson, K. R., Scalzi, L., Cavener, D. R., Lang, J., Goldenberg, D. N., MacNeill, C., Elavsky, S., Lohse, B., Selan, J., McBrier, N., Claxton, D., Giampetro, D., Rauh, E., Skulas-Ray, A. N. N., Graham-Engeland, J. E., Kimchi, E. T., Belani, C., Betterman, K., Vender, R. L., Albaugh, V., Sciamanna, C. N., Cheng, K., Joshi, R., Gill, D., Ehman, C., Bascom, R. & Green, M. J.

    National Institutes of Health

    8/15/955/31/11

    Project: Research project

    Research
    Outpatients
    Research Personnel
    Polycystic Ovary Syndrome
    Medicine
    Erythropoietin
    Signal Transduction
    Calcium
    Calcium Channels
    Erythroid Cells

    Research Output 1982 2019

    Trpm2 enhances physiological bioenergetics and protects against pathological oxidative cardiac injury: Role of Pyk2 phosphorylation

    Miller, B., Wang, J. F., Song, J., Zhang, X. Q., Hirschler-Laszkiewicz, I., Shanmughapriya, S., Tomar, D., Rajan, S., Feldman, A. M., Madesh, M., Sheu, S. S. & Cheung, J. Y., Sep 1 2019, In : Journal of Cellular Physiology. 234, 9, p. 15048-15060 13 p.

    Research output: Contribution to journalArticle

    Focal Adhesion Kinase 2
    Phosphorylation
    Energy Metabolism
    Muscle Cells
    Wounds and Injuries
    1 Citation (Scopus)

    TRPM2 in Cancer

    Miller, B., Jun 1 2019, In : Cell Calcium. 80, p. 8-17 10 p.

    Research output: Contribution to journalReview article

    Cell Survival
    Neoplasms
    Neuroblastoma
    Autophagy
    Breast Neoplasms
    4 Citations (Scopus)

    Targeted inhibition of ULK1 promotes apoptosis and suppresses tumor growth and metastasis in neuroblastoma

    Dower, C. M., Bhat, N., Gebru, M. T., Chen, L., Wills, C. A., Miller, B. & Wang, H-G., Nov 1 2018, In : Molecular cancer therapeutics. 17, 11, p. 2365-2376 12 p.

    Research output: Contribution to journalArticle

    Autophagy
    Neuroblastoma
    Apoptosis
    Neoplasm Metastasis
    Growth
    5 Citations (Scopus)

    The human ion channel TRPM2 modulates neuroblastoma cell survival and mitochondrial function through Pyk2, CREB, and MCU activation

    Hirschler-Laszkiewicz, I., Chen, S., Bao, L., Wang, J., Zhang, X. Q., Shanmughapriya, S., Keefer, K., Madesh, M., Cheung, J. Y. & Miller, B., Oct 6 2018, In : American Journal of Physiology - Cell Physiology. 315, 4, p. C571-C586

    Research output: Contribution to journalArticle

    Focal Adhesion Kinase 2
    Transient Receptor Potential Channels
    Neuroblastoma
    Ion Channels
    Cell Survival

    Transient Receptor Potential-Melastatin Channel Family Member 2: Friend or Foe

    Cheung, J. Y. & Miller, B., Jan 1 2017, In : Transactions of the American Clinical and Climatological Association. 128, p. 308-329 22 p.

    Research output: Contribution to journalReview article

    Transient Receptor Potential Channels
    Reactive Oxygen Species
    Cell Respiration
    Monovalent Cations
    Neoplasms