• 9401 Citations
  • 55 h-Index
1995 …2023
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  • 7 Similar Profiles
Iron Medicine & Life Sciences
Ribonucleotide Reductases Chemical Compounds
Escherichia coli Chemical Compounds
Enzymes Medicine & Life Sciences
Oxygenases Medicine & Life Sciences
Oxygen Chemical Compounds
Electrons Medicine & Life Sciences
Mossbauer Spectroscopy Medicine & Life Sciences

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Projects 1997 2023

Mechanisms of Iron-Containing Enzymes

Krebs, C.

National Institutes of Health

5/1/184/30/23

Project: Research projectOutstanding Investigator Award

Iron
Enzymes
Biosynthesis
S-Adenosylmethionine
Glutarates
Oxygenases
Iron
Carbon
Glutarates
Halogenation
Glutarates
Oxygenases
Alkenes
Iron
Dehydrogenation
Carbon
Atoms
Enzymes
Oxygenases
Hydroxylation
Bioinorganic Chemistry
Education
Molecular Biology
Biochemistry
Students

Research Output 1995 2019

Synthetic Model Complex of the Key Intermediate in Cytochrome P450 Nitric Oxide Reductase

McQuarters, A. B., Blaesi, E. J., Kampf, J. W., Alp, E. E., Zhao, J., Hu, M., Krebs, C. & Lehnert, N., Jan 22 2019, In : Inorganic Chemistry. 58, 2, p. 1398-1413 16 p.

Research output: Contribution to journalArticle

cytochromes
nitric oxide
Cytochrome P-450 Enzyme System
Electronic structure
Oxidoreductases
2 Citations

Installation of the Ether Bridge of Lolines by the Iron- and 2-Oxoglutarate-Dependent Oxygenase, LolO: Regio- and Stereochemistry of Sequential Hydroxylation and Oxacyclization Reactions

Pan, J., Bhardwaj, M., Zhang, B., Chang, W. C., Schardl, C. L., Krebs, C., Grossman, R. B. & Bollinger, Jr., J. M., Apr 10 2018, In : Biochemistry. 57, 14, p. 2074-2083 10 p.

Research output: Contribution to journalArticle

Oxygenases
Hydroxylation
Stereochemistry
Ether
Iron
1 Citations

Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosinederived dihydroxyphenylalanine radical

Blaesi, E. J., Palowitch, G. M., Hu, K., Kim, A. J., Rose, H. R., Alapati, R., Lougee, M. G., Kim, H. J., Taguchi, A. T., Tan, K. O., Laremore, T. N., Griffin, R. G., Krebs, C., Matthews, M. L., Silakov, A., Bollinger, Jr., J. M., Allen, B. D. & Boal, A. K., Oct 2 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 40, p. 10022-10027 6 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Dihydroxyphenylalanine
Catalysis
Metals
Tissue Plasminogen Activator
2 Citations

Non-Heme Diiron Model Complexes Can Mediate Direct NO Reduction: Mechanistic Insight into Flavodiiron NO Reductases

Dong, H. T., White, C. J., Zhang, B., Krebs, C. & Lehnert, N., Oct 17 2018, In : Journal of the American Chemical Society. 140, 41, p. 13429-13440 12 p.

Research output: Contribution to journalArticle

Nitric oxide
Nitric Oxide
Bacteria
Gases
Mossbauer Spectroscopy

Non-heme High-Spin {FeNO}6-8 Complexes: One Ligand Platform Can Do It All

Speelman, A. L., White, C. J., Zhang, B., Alp, E. E., Zhao, J., Hu, M., Krebs, C., Penner-Hahn, J. & Lehnert, N., Sep 12 2018, In : Journal of the American Chemical Society. 140, 36, p. 11341-11359 19 p.

Research output: Contribution to journalArticle

Ligands
Iron
Oxidation-Reduction
Heme
Oxidation