• 10342 Citations
  • 59 h-Index
1995 …2023

Research output per year

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Research Output

2020

First Step in Catalysis of the Radical S-Adenosylmethionine Methylthiotransferase MiaB Yields an Intermediate with a [3Fe-4S]0-Like Auxiliary Cluster

Zhang, B., Arcinas, A. J., Radle, M. I., Silakov, A., Booker, S. J. & Krebs, C., Jan 29 2020, In : Journal of the American Chemical Society. 142, 4, p. 1911-1924 14 p.

Research output: Contribution to journalArticle

High-resolution iron X-ray absorption spectroscopic and computational studies of non-heme diiron peroxo intermediates

Cutsail, G. E., Blaesi, E. J., Pollock, C. J., Bollinger, J. M., Krebs, C. & DeBeer, S., Feb 2020, In : Journal of Inorganic Biochemistry. 203, 110877.

Research output: Contribution to journalArticle

Open Access
2019

Analysis of RNA Methylation by Phylogenetically Diverse Cfr Radical S-Adenosylmethionine Enzymes Reveals an Iron-Binding Accessory Domain in a Clostridial Enzyme

Gumkowski, J. D., Martinie, R. J., Corrigan, P. S., Pan, J., Bauerle, M. R., Almarei, M., Booker, S. J., Silakov, A., Krebs, C. & Boal, A. K., Jun 27 2019, In : Biochemistry. 58, 29, p. 3169-3184 16 p.

Research output: Contribution to journalArticle

A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases

Rajakovich, L. J., Pandelia, M. E., Mitchell, A. J., Chang, W. C., Zhang, B., Boal, A. K., Krebs, C. & Bollinger, J. M., Mar 26 2019, In : Biochemistry. 58, 12, p. 1627-1647 21 p.

Research output: Contribution to journalArticle

2 Scopus citations

Evidence for Modulation of Oxygen Rebound Rate in Control of Outcome by Iron(II)- And 2-Oxoglutarate-Dependent Oxygenases

Pan, J., Wenger, E. S., Matthews, M. L., Pollock, C. J., Bhardwaj, M., Kim, A. J., Allen, B. D., Grossman, R. B., Krebs, C. & Martin Bollinger, J., Sep 25 2019, In : Journal of the American Chemical Society. 141, 38, p. 15153-15165 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Hydrogen Donation but not Abstraction by a Tyrosine (Y68) during Endoperoxide Installation by Verruculogen Synthase (FtmOx1)

Dunham, N. P., Del Río Pantoja, J. M., Zhang, B., Rajakovich, L. J., Allen, B. D., Krebs, C., Boal, A. K. & Bollinger, J. M., Jun 26 2019, In : Journal of the American Chemical Society. 141, 25, p. 9964-9979 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

Molecular basis for enantioselective herbicide degradation imparted by aryloxyalkanoate dioxygenases in transgenic plants

Chekan, J. R., Ongpipattanakul, C., Wright, T. R., Zhang, B., Martin Bollinger, J., Rajakovich, L. J., Krebs, C., Cicchillo, R. M. & Nair, S. K., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13299-13304 6 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Steric Enforcement of cis-Epoxide Formation in the Radical C-O-Coupling Reaction by Which (S)-2-Hydroxypropylphosphonate Epoxidase (HppE) Produces Fosfomycin

Zhou, S., Pan, J., Davis, K. M., Schaperdoth, I., Wang, B., Boal, A. K., Krebs, C. & Bollinger, J. M., Dec 26 2019, In : Journal of the American Chemical Society. 141, 51, p. 20397-20406 10 p.

Research output: Contribution to journalArticle

Structure of a Ferryl Mimic in the Archetypal Iron(II)- And 2-(Oxo)-glutarate-Dependent Dioxygenase, TauD

Davis, K. M., Altmyer, M., Martinie, R. J., Schaperdoth, I., Krebs, C., Bollinger, J. M. & Boal, A. K., Oct 15 2019, In : Biochemistry. 58, 41, p. 4218-4223 6 p.

Research output: Contribution to journalArticle

Substrate-Triggered Formation of a Peroxo-Fe2(III/III) Intermediate during Fatty Acid Decarboxylation by UndA

Zhang, B., Rajakovich, L. J., Van Cura, D., Blaesi, E. J., Mitchell, A. J., Tysoe, C. R., Zhu, X., Streit, B. R., Rui, Z., Zhang, W., Boal, A. K., Krebs, C. & Bollinger, J. M., Sep 18 2019, In : Journal of the American Chemical Society. 141, 37, p. 14510-14514 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Synthetic Model Complex of the Key Intermediate in Cytochrome P450 Nitric Oxide Reductase

McQuarters, A. B., Blaesi, E. J., Kampf, J. W., Alp, E. E., Zhao, J., Hu, M., Krebs, C. & Lehnert, N., Jan 22 2019, In : Inorganic chemistry. 58, 2, p. 1398-1413 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

The Fe2(NO)2 Diamond Core: A Unique Structural Motif In Non-Heme Iron–NO Chemistry

Dong, H. T., Speelman, A. L., Kozemchak, C. E., Sil, D., Krebs, C. & Lehnert, N., Dec 2 2019, In : Angewandte Chemie - International Edition. 58, 49, p. 17695-17699 5 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Installation of the Ether Bridge of Lolines by the Iron- and 2-Oxoglutarate-Dependent Oxygenase, LolO: Regio- and Stereochemistry of Sequential Hydroxylation and Oxacyclization Reactions

Pan, J., Bhardwaj, M., Zhang, B., Chang, W. C., Schardl, C. L., Krebs, C., Grossman, R. B. & Martin Bollinger, J., Apr 10 2018, In : Biochemistry. 57, 14, p. 2074-2083 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosinederived dihydroxyphenylalanine radical

Blaesi, E. J., Palowitch, G. M., Hu, K., Kim, A. J., Rose, H. R., Alapati, R., Lougee, M. G., Kim, H. J., Taguchi, A. T., Tan, K. O., Laremore, T. N., Griffin, R. G., Krebs, C., Matthews, M. L., Silakov, A., Bollinger, J. M., Allen, B. D. & Boal, A. K., Oct 2 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 40, p. 10022-10027 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Non-Heme Diiron Model Complexes Can Mediate Direct NO Reduction: Mechanistic Insight into Flavodiiron NO Reductases

Dong, H. T., White, C. J., Zhang, B., Krebs, C. & Lehnert, N., Oct 17 2018, In : Journal of the American Chemical Society. 140, 41, p. 13429-13440 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Non-heme High-Spin {FeNO}6-8 Complexes: One Ligand Platform Can Do It All

Speelman, A. L., White, C. J., Zhang, B., Alp, E. E., Zhao, J., Hu, M., Krebs, C., Penner-Hahn, J. & Lehnert, N., Sep 12 2018, In : Journal of the American Chemical Society. 140, 36, p. 11341-11359 19 p.

Research output: Contribution to journalArticle

8 Scopus citations

Stereochemical and Mechanistic Investigation of the Reaction Catalyzed by Fom3 from Streptomyces fradiae, a Cobalamin-Dependent Radical S-Adenosylmethionine Methylase

Wang, B., Blaszczyk, A. J., Knox, H. L., Zhou, S., Blaesi, E. J., Krebs, C., Wang, R. X. & Booker, S. J., Aug 21 2018, In : Biochemistry. 57, 33, p. 4972-4984 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Structural and spectroscopic analyses of the sporulation killing factor biosynthetic enzyme SkfB, a bacterial AdoMet radical sactisynthase

Grell, T. A. J., Kincannon, W. M., Bruender, N. A., Blaesi, E. J., Krebs, C., Bandarian, V. & Drennan, C. L., Jan 1 2018, In : Journal of Biological Chemistry. 293, 45, p. 17349-17361 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Structural Basis for Superoxide Activation of Flavobacterium johnsoniae Class i Ribonucleotide Reductase and for Radical Initiation by Its Dimanganese Cofactor

Rose, H. R., Ghosh, M. K., Maggiolo, A. O., Pollock, C. J., Blaesi, E. J., Hajj, V., Wei, Y., Rajakovich, L. J., Chang, W. C., Han, Y., Hajj, M., Krebs, C., Silakov, A., Pandelia, M. E., Bollinger, J. M. & Boal, A. K., May 8 2018, In : Biochemistry. 57, 18, p. 2679-2693 15 p.

Research output: Contribution to journalArticle

14 Scopus citations

The biosynthesis of methanobactin

Kenney, G. E., Dassama, L. M. K., Pandelia, M. E., Gizzi, A. S., Martinie, R. J., Gao, P., DeHart, C. J., Schachner, L. F., Skinner, O. S., Ro, S. Y., Zhu, X., Sadek, M., Thomas, P. M., Almo, S. C., Bollinger, J. M., Krebs, C., Kelleher, N. L. & Rosenzweig, A. C., Mar 23 2018, In : Science. 359, 6382, p. 1411-1416 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Toward a mechanistic and physiological understanding of a ferredoxin:disulfide reductase from the domains Archaea and Bacteria

Prakash, D., Walters, K. A., Martinie, X. R. J., McCarver, A. C., Kumar, A. K., Lessner, D. J., Krebs, C., Golbeck, J. H. & Ferry, J. G., Jan 1 2018, In : Journal of Biological Chemistry. 293, 24, p. 9198-9209 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Two-Color Valence-to-Core X-ray Emission Spectroscopy Tracks Cofactor Protonation State in a Class I Ribonucleotide Reductase

Martinie, R. J., Blaesi, E. J., Bollinger, J. M., Krebs, C., Finkelstein, K. D. & Pollock, C. J., Sep 24 2018, In : Angewandte Chemie - International Edition. 57, 39, p. 12754-12758 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance

Dunham, N. P., Chang, W. C., Mitchell, A. J., Martinie, R. J., Zhang, B., Bergman, J. A., Rajakovich, L. J., Wang, B., Silakov, A., Krebs, C., Boal, A. K. & Bollinger, Jr., J. M., Jun 13 2018, In : Journal of the American Chemical Society. 140, 23, p. 7116-7126 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

α-Amine Desaturation of d -Arginine by the Iron(II)- and 2-(Oxo)glutarate-Dependent l -Arginine 3-Hydroxylase, VioC

Dunham, N. P., Mitchell, A. J., Del Río Pantoja, J. M., Krebs, C., Bollinger, J. M. & Boal, A. K., Nov 20 2018, In : Biochemistry. 57, 46, p. 6479-6488 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers

Fuller, F. D., Gul, S., Chatterjee, R., Sethe Burgie, E., Young, I. D., Lebrette, H., Srinivas, V., Brewster, A. S., Michels-Clark, T., Clinger, J. A., Andi, B., Ibrahim, M., Pastor, E., De Lichtenberg, C., Hussein, R., Pollock, C. J., Zhang, M., Stan, C. A., Kroll, T., Fransson, T. & 36 others, Weninger, C., Kubin, M., Aller, P., Lassalle, L., Bräuer, P., Miller, M. D., Amin, M., Koroidov, S., Roessler, C. G., Allaire, M., Sierra, R. G., Docker, P. T., Glownia, J. M., Nelson, S., Koglin, J. E., Zhu, D., Chollet, M., Song, S., Lemke, H., Liang, M., Sokaras, D., Alonso-Mori, R., Zouni, A., Messinger, J., Bergmann, U., Boal, A. K., Martin Bollinger, J., Krebs, C., Högbom, M., Phillips, G. N., Vierstra, R. D., Sauter, N. K., Orville, A. M., Kern, J., Yachandra, V. K. & Yano, J., Feb 27 2017, In : Nature methods. 14, 4, p. 443-449 7 p.

Research output: Contribution to journalArticle

54 Scopus citations

Evidence for a Di-μ-oxo diamond core in the Mn(IV)/Fe(IV) activation intermediate of ribonucleotide reductase from chlamydia trachomatis

Martinie, R. J., Blaesi, E. J., Krebs, C., Bollinger, Jr., J. M., Silakov, A. & Pollock, C. J., Feb 8 2017, In : Journal of the American Chemical Society. 139, 5, p. 1950-1957 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

O-H activation by an unexpected ferryl intermediate during catalysis by 2-hydroxyethylphosphonate dioxygenase

Peck, S. C., Wang, C., Dassama, L. M. K., Zhang, B., Guo, Y., Rajakovich, L. J., Martin Bollinger, J., Krebs, C. & Van Der Donk, W. A., Feb 8 2017, In : Journal of the American Chemical Society. 139, 5, p. 2045-2052 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Peroxide Activation for Electrophilic Reactivity by the Binuclear Non-heme Iron Enzyme AurF

Park, K., Li, N., Kwak, Y., Srnec, M., Bell, C. B., Liu, L. V., Wong, S. D., Yoda, Y., Kitao, S., Seto, M., Hu, M., Zhao, J., Krebs, C., Bollinger, J. M. & Solomon, E. I., May 24 2017, In : Journal of the American Chemical Society. 139, 20, p. 7062-7070 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

The RicAFT (YmcA-YlbF-YaaT) complex carries two [4Fe-4S]2+ clusters and may respond to redox changes

Tanner, A. W., Carabetta, V. J., Martinie, R. J., Mashruwala, A. A., Boyd, J. M., Krebs, C. & Dubnau, D., Jun 2017, In : Molecular Microbiology. 104, 5, p. 837-850 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Vanadyl as a Stable Structural Mimic of Reactive Ferryl Intermediates in Mononuclear Nonheme-Iron Enzymes

Martinie, R. J., Pollock, C. J., Matthews, M. L., Bollinger, J. M., Krebs, C. & Silakov, A., Nov 6 2017, In : Inorganic chemistry. 56, 21, p. 13382-13389 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Visualizing the reaction cycle in an Iron(II)- and 2-(Oxo)-glutarate-dependent hydroxylase

Mitchell, A. J., Dunham, N. P., Martinie, R. J., Bergman, J. A., Pollock, C. J., Hu, K., Allen, B. D., Chang, W. C., Silakov, A., Bollinger, J. M., Krebs, C. & Boal, A. K., Jan 1 2017, In : Journal of the American Chemical Society. 139, 39, p. 13830-13836 7 p.

Research output: Contribution to journalArticle

32 Scopus citations
2016

Aromatic C-F Hydroxylation by Nonheme Iron(IV)-Oxo Complexes: Structural, Spectroscopic, and Mechanistic Investigations

Sahu, S., Zhang, B., Pollock, C. J., Dürr, M., Davies, C. G., Confer, A. M., Ivanović-Burmazović, I., Siegler, M. A., Jameson, G. N. L., Krebs, C. & Goldberg, D. P., Oct 5 2016, In : Journal of the American Chemical Society. 138, 39, p. 12791-12802 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Characterization of Lipoyl Synthase from Mycobacterium tuberculosis

Lanz, N. D., Lee, K. H., Horstmann, A. K., Pandelia, M. E., Cicchillo, R. M., Krebs, C. & Booker, S. J., Mar 8 2016, In : Biochemistry. 55, 9, p. 1372-1383 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Electronic Structure of the Ferryl Intermediate in the α-Ketoglutarate Dependent Non-Heme Iron Halogenase SyrB2: Contributions to H Atom Abstraction Reactivity

Srnec, M., Wong, S. D., Matthews, M. L., Krebs, C., Bollinger, J. M. & Solomon, E. I., May 4 2016, In : Journal of the American Chemical Society. 138, 15, p. 5110-5122 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Organometallic Complex Formed by an Unconventional Radical S-Adenosylmethionine Enzyme

Dong, M., Horitani, M., Dzikovski, B., Pandelia, M. E., Krebs, C., Freed, J. H., Hoffman, B. M. & Lin, H., Aug 10 2016, In : Journal of the American Chemical Society. 138, 31, p. 9755-9758 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Spectroscopic and Electrochemical Characterization of the Iron-Sulfur and Cobalamin Cofactors of TsrM, an Unusual Radical S-Adenosylmethionine Methylase

Blaszczyk, A. J., Silakov, A., Zhang, B., Maiocco, S. J., Lanz, N. D., Kelly, W. L., Elliott, S. J., Krebs, C. & Booker, S. J., Mar 16 2016, In : Journal of the American Chemical Society. 138, 10, p. 3416-3426 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Spectroscopic Evidence for the Two C-H-Cleaving Intermediates of Aspergillus nidulans Isopenicillin N Synthase

Tamanaha, E., Zhang, B., Guo, Y., Chang, W. C., Barr, E. W., Xing, G., St Clair, J., Ye, S., Neese, F., Bollinger, J. M. & Krebs, C., Jul 20 2016, In : Journal of the American Chemical Society. 138, 28, p. 8862-8874 13 p.

Research output: Contribution to journalArticle

51 Scopus citations

Structural and Spectroscopic Characterization of a High-Spin {FeNO}6 Complex with an Iron(IV)-NO- Electronic Structure

Speelman, A. L., Zhang, B., Krebs, C. & Lehnert, N., Jun 1 2016, In : Angewandte Chemie - International Edition. 55, 23, p. 6685-6688 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

Unusual Synthetic Pathway for an {Fe(NO)2}9 Dinitrosyl Iron Complex (DNIC) and Insight into DNIC Electronic Structure via Nuclear Resonance Vibrational Spectroscopy

Speelman, A. L., Zhang, B., Silakov, A., Skodje, K. M., Alp, E. E., Zhao, J., Hu, M. Y., Kim, E., Krebs, C. & Lehnert, N., Jun 6 2016, In : Inorganic Chemistry. 55, 11, p. 5485-5501 17 p.

Research output: Contribution to journalArticle

30 Scopus citations
2015

Direct Measurement of the Radical Translocation Distance in the Class i Ribonucleotide Reductase from Chlamydia trachomatis

Livada, J., Martinie, R. J., Dassama, L. M. K., Krebs, C., Bollinger, J. M. & Silakov, A., Oct 29 2015, In : Journal of Physical Chemistry B. 119, 43, p. 13777-13784 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
15 Scopus citations

Experimental correlation of substrate position with reaction outcome in the aliphatic halogenase, SyrB2

Martinie, R. J., Livada, J., Chang, W. C., Green, M. T., Krebs, C., Bollinger, J. M. & Silakov, A., Jun 3 2015, In : Journal of the American Chemical Society. 137, 21, p. 6912-6919 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Human calprotectin is an iron-sequestering host-defense protein

Nakashige, T. G., Zhang, B., Krebs, C. & Nolan, E. M., Oct 19 2015, In : Nature Chemical Biology. 11, 10, p. 765-771 7 p.

Research output: Contribution to journalArticle

90 Scopus citations

Mechanisms of 2-oxoglutarate-dependent oxygenases: The hydroxylation paradigm and beyond

Bollinger, Jr., J. M., Chang, W. C., Matthews, M. L., Martinie, R. J., Boal, A. K. & Krebs, C., Jan 1 2015, 2-Oxoglutarate-Dependent Oxygenases. Hausinger, R. P. & Schofield, C. J. (eds.). 3 ed. Royal Society of Chemistry, p. 95-122 28 p. (RSC Metallobiology; vol. 2015-January, no. 3).

Research output: Chapter in Book/Report/Conference proceedingChapter

35 Scopus citations

Mössbauer spectroscopy of Fe/S proteins

Pandelia, M. E., Lanz, N. D., Booker, S. J. & Krebs, C., Jun 1 2015, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1853, 6, p. 1395-1405 11 p.

Research output: Contribution to journalReview article

43 Scopus citations

Rapid Reduction of the Diferric-Peroxyhemiacetal Intermediate in Aldehyde-Deformylating Oxygenase by a Cyanobacterial Ferredoxin: Evidence for a Free-Radical Mechanism

Rajakovich, L. J., Nørgaard, H., Warui, D. M., Chang, W. C., Li, N., Booker, S. J., Krebs, C., Bollinger, J. M. & Pandelia, M. E., Sep 16 2015, In : Journal of the American Chemical Society. 137, 36, p. 11695-11709 15 p.

Research output: Contribution to journalArticle

29 Scopus citations
2014

ChlR protein of Synechococcus sp. PCC 7002 is a transcription activator that uses an oxygen-sensitive [4Fe-4S] cluster to control genes involved in pigment biosynthesis

Ludwig, M., Pandelia, M. E., Chew, C. Y., Zhang, B., Golbeck, J. H., Krebs, C. & Bryant, D. A., Jun 13 2014, In : Journal of Biological Chemistry. 289, 24, p. 16624-16639 16 p.

Research output: Contribution to journalArticle

14 Scopus citations

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase

Matthews, M. L., Chang, W. C., Layne, A. P., Miles, L. A., Krebs, C. & Bollinger, J. M., Mar 2014, In : Nature Chemical Biology. 10, 3, p. 209-215 7 p.

Research output: Contribution to journalArticle

58 Scopus citations

Evidence for a catalytically and kinetically competent enzyme-substrate cross-linked intermediate in catalysis by lipoyl synthase

Lanz, N. D., Pandelia, M. E., Kakar, E. S., Lee, K. H., Krebs, C. & Booker, S. J., Jul 22 2014, In : Biochemistry. 53, 28, p. 4557-4572 16 p.

Research output: Contribution to journalArticle

32 Scopus citations

Mechanism of the C5 stereoinversion reaction in the biosynthesis of carbapenem antibiotics

Chang, W. C., Guo, Y., Wang, C., Butch, S. E., Rosenzweig, A. C., Boal, A. K., Krebs, C. & Bollinger, J. M., Jan 1 2014, In : Science. 343, 6175, p. 1140-1144 5 p.

Research output: Contribution to journalArticle

62 Scopus citations