• 10084 Citations
  • 57 h-Index
1995 …2023
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Research Output 1995 2020

2006
10 Citations (Scopus)
Inositol Oxygenase
Electron Spin Resonance Spectroscopy
Inositol
Spectrum Analysis
Demonstrations
228 Citations (Scopus)

Direct spectroscopic detection of a C-H-cleaving high-spin Fe(IV) complex in a prolyl-4-hydroxylase

Hoffart, L. M., Barr, E. W., Guyer, R. B., Bollinger, Jr., J. M. & Krebs, C., Oct 3 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 40, p. 14738-14743 6 p.

Research output: Contribution to journalArticle

Prolyl Hydroxylases
Dioxygenases
Taurine
Hydroxylation
Enzymes
76 Citations (Scopus)

Evidence for basic ferryls in cytochromes P450

Behan, R. K., Hoffart, L. M., Stone, K. L., Krebs, C. & Green, M. T., Sep 6 2006, In : Journal of the American Chemical Society. 128, 35, p. 11471-11474 4 p.

Research output: Contribution to journalArticle

Camphor 5-Monooxygenase
Cytochrome P-450 Enzyme System
Density functional theory
Enzymes
Protonation
86 Citations (Scopus)

Evidence for C-H cleavage by an iron-superoxide complex in the glycol cleavage reaction catalyzed by myo-inositol oxygenase

Xing, G., Diao, Y., Hoffart, L. M., Barr, E. W., Prabhu, K. S., Arner, R. J., Reddy, C. C., Krebs, C. & Bollinger, J. M., Apr 18 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 16, p. 6130-6135 6 p.

Research output: Contribution to journalArticle

Inositol Oxygenase
Glycols
Inositol
Superoxides
Iron
68 Citations (Scopus)

Evidence for two ferryl species in chloroperoxidase compound II

Stone, K. L., Hoffart, L. M., Behan, R. K., Krebs, C. & Green, M. T., May 10 2006, In : Journal of the American Chemical Society. 128, 18, p. 6147-6153 7 p.

Research output: Contribution to journalArticle

Chloride Peroxidase
Density functional theory
Cryogenics
Absorption spectra
Spectrum Analysis
33 Citations (Scopus)

Identification of FX in the heliobacterial reaction center as a [4Fe-4S] cluster with an S = 3/2 ground spin state

Heinnickel, M., Agalarov, R., Svensen, N., Krebs, C. & Golbeck, J. H., May 30 2006, In : Biochemistry. 45, 21, p. 6756-6764 9 p.

Research output: Contribution to journalArticle

Dithionite
Genetic Recombination
Paramagnetic resonance
Electrons
Azotobacter vinelandii
38 Citations (Scopus)

Oxygen activation by a mixed-valent, diiron(II/III) cluster in the glycol cleavage reaction catalyzed by myo-inositol oxygenase

Xing, G., Barr, E. W., Diao, Y., Hoffart, L. M., Prabhu, K. S., Arner, R. J., Reddy, C. C., Krebs, C. & Bollinger, J. M., May 2 2006, In : Biochemistry. 45, 17, p. 5402-5412 11 p.

Research output: Contribution to journalArticle

Inositol Oxygenase
Glycols
Inositol
Chemical activation
Oxygen
101 Citations (Scopus)

Stalking intermediates in oxygen activation by iron enzymes: Motivation and method

Bollinger, J. M. & Krebs, C., Apr 1 2006, In : Journal of Inorganic Biochemistry. 100, 4, p. 586-605 20 p.

Research output: Contribution to journalReview article

Stalking
Enzyme Activation
Motivation
Iron
Chemical activation
2007
139 Citations (Scopus)

A manganese(IV)/iron(III) cofactor in Chlamydia trachomatis ribonucleotide reductase

Jiang, W., Yun, D., Saleh, L., Barr, E. W., Xing, G., Hoffart, L. M., Maslak, M. A., Krebs, C. & Bollinger, Jr., J. M., May 25 2007, In : Science. 316, 5828, p. 1188-1191 4 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Chlamydia trachomatis
Manganese
Iron
Cysteine
57 Citations (Scopus)

A manganese(IV)/iron(IV) intermediate in assembly of the manganese(IV)/iron(III) cofactor of Chlamydia trachomatis ribonucleotide reductase

Jiang, W., Hoffart, L. M., Krebs, C. & Bollinger, Jr., J. M., Jul 31 2007, In : Biochemistry. 46, 30, p. 8709-8716 8 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Chlamydia trachomatis
Reducing Agents
Pathogens
Manganese
28 Citations (Scopus)

AurF from Streptomyces thioluteus and a possible new family of manganese/iron oxygenases

Krebs, C., Matthews, M. L., Jiang, W. & Bollinger, Jr., J. M., Sep 18 2007, In : Biochemistry. 46, 37, p. 10413-10418 6 p.

Research output: Contribution to journalArticle

Oxygenases
Streptomyces
Manganese
Iron
Chlamydia trachomatis
61 Citations (Scopus)

CD and MCD of CytC3 and taurine dioxygenase: Role of the facial triad in α-KG-dependent oxygenases

Neidig, M. L., Brown, C. D., Light, K. M., Fujimori, D. G., Nolan, E. M., Price, J. C., Barr, E. W., Bollinger, Jr., J. M., Krebs, C., Walsh, C. T. & Solomon, E. I., Nov 21 2007, In : Journal of the American Chemical Society. 129, 46, p. 14224-14231 8 p.

Research output: Contribution to journalArticle

Dioxygenases
Oxygenases
Taurine
Catalytic Domain
Hydroxylation
128 Citations (Scopus)

Direct spectroscopic evidence for a high-spin Fe(IV) intermediate in tyrosine hydroxylase

Eser, B. E., Barr, E. W., Frantom, P. A., Saleh, L., Bollinger, Jr., J. M., Krebs, C. & Fitzpatrick, P. F., Sep 19 2007, In : Journal of the American Chemical Society. 129, 37, p. 11334-11335 2 p.

Research output: Contribution to journalArticle

Hydroxylation
Tyrosine 3-Monooxygenase
Aromatic Amino Acids
Dihydroxyphenylalanine
Mixed Function Oxygenases
106 Citations (Scopus)

Enzymatic C-H activation by metal-superoxo intermediates

Bollinger, Jr., J. M. & Krebs, C., Apr 1 2007, In : Current Opinion in Chemical Biology. 11, 2, p. 151-158 8 p.

Research output: Contribution to journalReview article

Metalloids
Metals
Chemical activation
Arsenals
Oxidation
18 Citations (Scopus)

Further insights into the spectroscopic properties, electronic structure, and kinetics of formation of the heme-peroxo-copper complex [(F 8TPP)FeIII-(O22-)-Cu II(TMPA)]+

Ghiladi, R. A., Chufán, E. E., Del Río, D., Solomon, E. I., Krebs, C., Boi, H. H., Huang, H. W., Moënne-Loccoz, P., Kaderli, S., Honecker, M., Zuberbühler, A. D., Marzilli, L., Cotter, R. J. & Karlin, K. D., May 14 2007, In : Inorganic chemistry. 46, 10, p. 3889-3902 14 p.

Research output: Contribution to journalArticle

Heme
Electronic structure
Copper
peroxides
electronic structure
566 Citations (Scopus)

Non-heme Fe(IV)-oxo intermediates

Krebs, C., Fujimori, D. G., Walsh, C. T. & Bollinger, Jr., J. M., Jul 1 2007, In : Accounts of Chemical Research. 40, 7, p. 484-492 9 p.

Research output: Contribution to journalArticle

Hydroxylation
Halogenation
Substrates
Iron
Oxygenases
26 Citations (Scopus)

Reaction of cytochrome P450BM3 and peroxynitrite yields nitrosyl complex

Behan, R. K., Hoffart, L. M., Stone, K. L., Krebs, C. & Green, M. T., May 9 2007, In : Journal of the American Chemical Society. 129, 18, p. 5855-5859 5 p.

Research output: Contribution to journalArticle

Peroxynitrous Acid
Cytochromes
Proteins
Nitration
Density functional theory
128 Citations (Scopus)
Dioxygenases
Taurine
Escherichia coli
Ligands
Density functional theory
90 Citations (Scopus)

Spectroscopic evidence for a high-spin Br-Fe(IV)-OxO intermediate in the α-ketoglutarate-dependent halogenase CytC3 from Streptomyces

Fujimori, D. G., Barr, E. W., Matthews, M. L., Koch, G. M., Yonce, J. R., Walsh, C. T., Bollinger, J. M., Krebs, C. & Riggs-Gelasco, P. J., Nov 7 2007, In : Journal of the American Chemical Society. 129, 44, p. 13408-13409 2 p.

Research output: Contribution to journalArticle

X-Ray Absorption Spectroscopy
Dioxygenases
Reaction intermediates
X ray absorption spectroscopy
Streptomyces
49 Citations (Scopus)

SufR coordinates two [4Fe-4S]2+,1+ clusters and functions as a transcriptional repressor of the sufBCDS operon and an autoregulator of sufR in cyanobacteria

Shen, G., Balasubramanian, R., Wang, T., Wu, Y., Hoffart, L. M., Krebs, C., Bryant, D. A. & Golbeck, J. H., Nov 2 2007, In : Journal of Biological Chemistry. 282, 44, p. 31909-31919 11 p.

Research output: Contribution to journalArticle

Cyanobacteria
Operon
Binding Sites
Genes
Synechocystis
41 Citations (Scopus)
Ribonucleotide Reductases
Chlamydia trachomatis
Ground state
Proteins
Nucleotides
219 Citations (Scopus)

Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3

Galonić, D. P., Barr, E. W., Walsh, C. T., Bollinger, Jr., J. M. & Krebs, C., Jan 1 2007, In : Nature Chemical Biology. 3, 2, p. 113-116 4 p.

Research output: Contribution to journalArticle

Halogenation
Iron
Halogens
Streptomyces
Enzymes
39 Citations (Scopus)

YfaE, a ferredoxin involved in diferric-tyrosyl radical maintenance in Escherichia coli ribonucleotide reductase

Wu, C. H., Jiang, W., Krebs, C. & Stubbe, J., Oct 16 2007, In : Biochemistry. 46, 41, p. 11577-11588 12 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Ferredoxins
Biosynthetic Pathways
Titration
Escherichia coli
2008
70 Citations (Scopus)

A catalytic di-heme bis-Fe(IV) intermediate, alternative to an Fe(IV)=0 porphyrin radical

Li, X., Fu, R., Lee, S., Krebs, C., Davidson, V. L. & Liu, A., Jun 24 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 25, p. 8597-8600 4 p.

Research output: Contribution to journalArticle

Porphyrins
Heme
Tryptophan
Protein Precursors
Protein Biosynthesis
26 Citations (Scopus)
Synechococcus
Photosystem I Protein Complex
Cyanobacteria
Sulfur
Iron
40 Citations (Scopus)

Branched activation- and catalysis-specific pathways for electron relay to the manganese/iron cofactor in ribonucleotide reductase from Chlamydia trachomatis

Jiang, W., Saleh, L., Barr, E. W., Xie, J., Gardner, M. M., Krebs, C. & Bollinger, Jr., J. M., Aug 19 2008, In : Biochemistry. 47, 33, p. 8477-8484 8 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Chlamydia trachomatis
Manganese
Catalysis
Iron
18 Citations (Scopus)

Characterization of quinolinate synthases from Escherichia coli, Mycobacterium tuberculosis, and Pyrococcus horikoshii indicates that [4Fe-4S] clusters are common cofactors throughout this class of enzymes

Saunders, A. H., Griffiths, A. E., Lee, K. H., Cicchillo, R. M., Tu, L., Stromberg, J. A., Krebs, C. & Booker, S. J., Oct 14 2008, In : Biochemistry. 47, 41, p. 10999-11012 14 p.

Research output: Contribution to journalArticle

Pyrococcus horikoshii
Quinolinic Acid
Mycobacterium tuberculosis
Escherichia coli
Enzymes
40 Citations (Scopus)

Formation and function of the manganese(iv)/iron(iii) cofactor in chlamydia trachomatis ribonucleotide reductase

Jiang, W., Yun, D., Saleh, L., Martin Bollinger, J. & Krebs, C., Dec 30 2008, In : Biochemistry. 47, 52, p. 13736-13744 9 p.

Research output: Contribution to journalReview article

Ribonucleotide Reductases
Chlamydia trachomatis
Manganese
Iron
Electrons
24 Citations (Scopus)

Importance of the maintenance pathway in the regulation of the activity of Escherichia coli ribonucleotide reductase

Hristova, D., Wu, C. H., Jiang, W., Krebs, C. & Stubbe, J., Apr 1 2008, In : Biochemistry. 47, 13, p. 3989-3999 11 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Escherichia coli
Maintenance
Arabinose
Titration

Intermediates in oxygen activation reactions of diiron enzymes

Krebs, C. & Huynh, B. H., Jan 2 2008, Iron Metabolism: Inorganic Biochemistry and Regulatory Mechanisms. wiley, p. 253-273 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

methane monooxygenase
Ribonucleotide Reductases
Ferritins
Chemical activation
Oxygen
74 Citations (Scopus)

In vitro characterization of AtsB, a radical SAM formylglycine-generating enzyme that contains three [4Fe-4S] clusters

Grove, T. L., Lee, K. H., St. Clair, J., Krebs, C. & Booker, S. J., Jul 15 2008, In : Biochemistry. 47, 28, p. 7523-7538 16 p.

Research output: Contribution to journalArticle

Sulfatases
Sulfides
Peptides
Enzymes
Proteins
28 Citations (Scopus)

Rapid and quantitative activation of Chlamydia trachomatis ribonucleotide reductase by hydrogen peroxide

Jiang, W., Xie, J., Nørgaard, H., Bollinger, Jr., J. M. & Krebs, C., Apr 15 2008, In : Biochemistry. 47, 15, p. 4477-4483 7 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Chlamydia trachomatis
Hydrogen Peroxide
Biochemistry
Chemical activation
99 Citations (Scopus)

Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily

Chatterjee, A., Li, Y., Zhang, Y., Grove, T. L., Lee, M., Krebs, C., Booker, S. J., Begley, T. P. & Ealick, S. E., Dec 2008, In : Nature Chemical Biology. 4, 12, p. 758-765 8 p.

Research output: Contribution to journalArticle

Thiamine
Phosphates
Ribonucleotides
pyrimidine
4-amino-5-hydroxymethyl-2-methylpyrimidine
48 Citations (Scopus)
Extended X ray absorption fine structure spectroscopy
Ribonucleotide Reductases
Chlamydia trachomatis
Structural analysis
Density functional theory
48 Citations (Scopus)
Ribonucleotide Reductases
Chlamydia trachomatis
Manganese
Protons
Iron
2009
50 Citations (Scopus)

A long-lived, substrate-hydroxylating peroxodiiron(III/III) intermediate in the amine oxygenase, AurF, from Streptomyces thioluteus

Korboukh, V. K., Li, N., Barr, E. W., Bollinger, Jr., J. M. & Krebs, C., Oct 13 2009, In : Journal of the American Chemical Society. 131, 38, p. 13608-13609 2 p.

Research output: Contribution to journalArticle

para-Aminobenzoates
Oxygenases
Streptomyces
Nitrobenzoates
Amines
62 Citations (Scopus)

Characterization of RimO, a new member of the methylthiotransferase subclass of the radical SAM superfamily

Lee, K. H., Saleh, L., Anton, B. P., Madinger, C. L., Benner, J. S., Iwig, D. F., Roberts, R. J., Krebs, C. & Booker, S. J., Oct 27 2009, In : Biochemistry. 48, 42, p. 10162-10174 13 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Escherichia coli
Enzymes
Transfer RNA
Sulfur
10 Citations (Scopus)

Freeze-quench 57Fe-Mössbauer spectroscopy: Trapping reactive intermediates

Krebs, C. & Bollinger, J. M., Nov 1 2009, In : Photosynthesis research. 102, 2, p. 295-304 10 p.

Research output: Contribution to journalReview article

trapping
spectroscopy
Spectrum Analysis
Iron
Spectroscopy
52 Citations (Scopus)

Myo-Inositol oxygenase: A radical new pathway for O2 and C-H activation at a nonheme diiron cluster

Bollinger, Jr., J. M., Diao, Y., Matthews, M. L., Xing, G. & Krebs, C., Mar 24 2009, In : Dalton Transactions. 6, p. 905-914 10 p.

Research output: Contribution to journalArticle

Inositol Oxygenase
Inositol
Chemical activation
Cell signaling
Glucuronic Acid
124 Citations (Scopus)

Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2

Matthews, M. L., Neumann, C. S., Miles, L. A., Grove, T. L., Booker, S. J., Krebs, C., Walsh, C. T. & Bollinger, J. M., Oct 20 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 42, p. 17723-17728 6 p.

Research output: Contribution to journalArticle

Halogenation
Hydroxylation
Halogens
Mixed Function Oxygenases
Ligands
144 Citations (Scopus)

Substrate-triggered formation and remarkable stability of the C-H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2

Matthews, M. L., Krest, C. M., Barr, E. W., Vaillancourt, F. H., Walsh, C. T., Green, M. T., Krebs, C. & Bollinger, J. M., May 26 2009, In : Biochemistry. 48, 20, p. 4331-4343 13 p.

Research output: Contribution to journalArticle

Carrier Proteins
Amino Acids
Peptide Synthases
Substrates
Extended X ray absorption fine structure spectroscopy
2010
51 Citations (Scopus)

A consensus mechanism for radical SAM-dependent dehydrogenation? BtrN contains two [4Fe-4S] clusters

Grove, T. L., Ahlum, J. H., Sharma, P., Krebs, C. & Booker, S. J., May 11 2010, In : Biochemistry. 49, 18, p. 3783-3785 3 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Dehydrogenation
Electrons
Oxidation
Enzymes
23 Citations (Scopus)

Active site threonine facilitates proton transfer during dioxygen activation at the diiron center of toluene/o-xylene monooxygenase hydroxylase

Song, W. J., McCormick, M. S., Behan, R. K., Sazinsky, M. H., Jiang, W., Lin, J., Krebs, C. & Lippard, S. J., Oct 6 2010, In : Journal of the American Chemical Society. 132, 39, p. 13582-13585 4 p.

Research output: Contribution to journalArticle

Proton transfer
Threonine
Xylene
Toluene
Protons
40 Citations (Scopus)

Cryoreduction of the NO-Adduct of Taurine: α-Ketoglutarate Dioxygenase (TauD) Yields an Elusive {FeNO}8 Species

Ye, S., Price, J. C., Barr, E. W., Green, M. T., Bollinger, J. M., Krebs, C. & Neese, F., Apr 7 2010, In : Journal of the American Chemical Society. 132, 13, p. 4739-4751 13 p.

Research output: Contribution to journalArticle

Dioxygenases
Taurine
Reaction intermediates
Enzymes
Ground state
122 Citations (Scopus)

Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme

Zhang, Y., Zhu, X., Torelli, A. T., Lee, M., Dzikovski, B., Koralewski, R. M., Wang, E., Freed, J., Krebs, C., Ealick, S. E. & Lin, H., Jun 17 2010, In : Nature. 465, 7300, p. 891-896 6 p.

Research output: Contribution to journalArticle

Sulfur
Methionine
Pyrococcus horikoshii
Iron
Enzymes
48 Citations (Scopus)

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen

Flashman, E., Hoffart, L. M., Hamed, R. B., Bollinger, J. M., Krebs, C. & Schofield, C. J., Oct 2010, In : FEBS Journal. 277, 19, p. 4089-4099 11 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor-Proline Dioxygenases
Prolyl Hydroxylases
Oxygenases
Oxygen
Oxygen sensors
41 Citations (Scopus)
Nitrobenzoates
Streptomyces
Electrons
Oxygenases
para-Aminobenzoates
83 Citations (Scopus)

Substrate activation by iron superoxo intermediates

van der Donk, W. A., Krebs, C. & Bollinger, Jr., J. M., Dec 1 2010, In : Current Opinion in Structural Biology. 20, 6, p. 673-683 11 p.

Research output: Contribution to journalReview article

Iron
Oxygenases
Superoxides
Hydrogen
Oxidoreductases
19 Citations (Scopus)
Ribonucleotide Reductases
Hydroxyurea
Chlamydia trachomatis
Electrons
Proteins
2011
141 Citations (Scopus)

A radically different mechanism for S-adenosylmethionine-dependent methyltransferases

Grove, T. L., Benner, J. S., Radle, M. I., Ahlum, J. H., Landgraf, B. J., Krebs, C. & Booker, S. J., Apr 29 2011, In : Science. 332, 6029, p. 604-607 4 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Methyltransferases
Methylation
23S Ribosomal RNA
Carbon