• 10342 Citations
  • 59 h-Index
1995 …2023

Research output per year

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Research Output

Enzymatic C-H activation by metal-superoxo intermediates

Bollinger, J. M. & Krebs, C., Apr 1 2007, In : Current Opinion in Chemical Biology. 11, 2, p. 151-158 8 p.

Research output: Contribution to journalReview article

108 Scopus citations

Erratum: A role for iron in an ancient carbonic anhydrase (Journal of Biological Chemistry (2004) 279 (6683-6687)

Tripp, B. C., Bell, C. B., Cruz, F., Krebs, C. & Ferry, J. G., May 14 2004, In : Journal of Biological Chemistry. 279, 20, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Escherichia coli lipoyl synthase binds two distinct [4Fe-4S] clusters per polypeptide

Cicchillo, R. M., Lee, K. H., Baleanu-Gogonea, C., Nesbitt, N. M., Krebs, C. & Booker, S. J., Sep 21 2004, In : Biochemistry. 43, 37, p. 11770-11781 12 p.

Research output: Contribution to journalArticle

101 Scopus citations

Escherichia coli L-serine deaminase requires a [4Fe-4S] cluster in catalysis

Cicchillo, R. M., Baker, M. A., Schnitzer, E. J., Newman, E. B., Krebs, C. & Booker, S. J., Jul 30 2004, In : Journal of Biological Chemistry. 279, 31, p. 32418-32425 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Escherichia coli quinolinate synthetase does indeed harbor a [4Fe-4S] cluster

Cicchillo, R. M., Tu, L., Stromberg, J. A., Hoffart, L. M., Krebs, C. & Booker, S. J., May 25 2005, In : Journal of the American Chemical Society. 127, 20, p. 7310-7311 2 p.

Research output: Contribution to journalArticle

31 Scopus citations

Evidence for a catalytically and kinetically competent enzyme-substrate cross-linked intermediate in catalysis by lipoyl synthase

Lanz, N. D., Pandelia, M. E., Kakar, E. S., Lee, K. H., Krebs, C. & Booker, S. J., Jul 22 2014, In : Biochemistry. 53, 28, p. 4557-4572 16 p.

Research output: Contribution to journalArticle

32 Scopus citations

Evidence for a Di-μ-oxo diamond core in the Mn(IV)/Fe(IV) activation intermediate of ribonucleotide reductase from chlamydia trachomatis

Martinie, R. J., Blaesi, E. J., Krebs, C., Bollinger, Jr., J. M., Silakov, A. & Pollock, C. J., Feb 8 2017, In : Journal of the American Chemical Society. 139, 5, p. 1950-1957 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Evidence for a high-Spin Fe(IV) species in the catalytic cycle of a bacterial phenylalanine hydroxylase

Panay, A. J., Lee, M., Krebs, C., Bollinger, Jr., J. M. & Fitzpatrick, P. F., Mar 22 2011, In : Biochemistry. 50, 11, p. 1928-1933 6 p.

Research output: Contribution to journalArticle

59 Scopus citations

Evidence for basic ferryls in cytochromes P450

Behan, R. K., Hoffart, L. M., Stone, K. L., Krebs, C. & Green, M. T., Sep 6 2006, In : Journal of the American Chemical Society. 128, 35, p. 11471-11474 4 p.

Research output: Contribution to journalArticle

77 Scopus citations

Evidence for C-H cleavage by an iron-superoxide complex in the glycol cleavage reaction catalyzed by myo-inositol oxygenase

Xing, G., Diao, Y., Hoffart, L. M., Barr, E. W., Prabhu, K. S., Arner, R. J., Reddy, C. C., Krebs, C. & Bollinger, J. M., Apr 18 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 16, p. 6130-6135 6 p.

Research output: Contribution to journalArticle

86 Scopus citations
286 Scopus citations

Evidence for Modulation of Oxygen Rebound Rate in Control of Outcome by Iron(II)- And 2-Oxoglutarate-Dependent Oxygenases

Pan, J., Wenger, E. S., Matthews, M. L., Pollock, C. J., Bhardwaj, M., Kim, A. J., Allen, B. D., Grossman, R. B., Krebs, C. & Martin Bollinger, J., Sep 25 2019, In : Journal of the American Chemical Society. 141, 38, p. 15153-15165 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Evidence for only oxygenative cleavage of aldehydes to alk(a/e)nes and formate by cyanobacterial aldehyde decarbonylases

Li, N., Chang, W. C., Warui, D., Booker, S. J., Krebs, C. & Bollinger, Jr., J. M., Oct 9 2012, In : Biochemistry. 51, 40, p. 7908-7916 9 p.

Research output: Contribution to journalArticle

91 Scopus citations

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen

Flashman, E., Hoffart, L. M., Hamed, R. B., Bollinger, J. M., Krebs, C. & Schofield, C. J., Oct 2010, In : FEBS Journal. 277, 19, p. 4089-4099 11 p.

Research output: Contribution to journalArticle

50 Scopus citations

Evidence for two ferryl species in chloroperoxidase compound II

Stone, K. L., Hoffart, L. M., Behan, R. K., Krebs, C. & Green, M. T., May 10 2006, In : Journal of the American Chemical Society. 128, 18, p. 6147-6153 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

Evidence that the fosfomycin-producing epoxidase, HppE, is a non-heme-iron peroxidase

Wang, C., Chang, W. C., Guo, Y., Huang, H., Peck, S. C., Pandelia, M. E., Lin, G. M., Liu, H. W., Krebs, C. & Bollinger, Jr., J. M., Jan 1 2013, In : Science. 342, 6161, p. 991-995 5 p.

Research output: Contribution to journalArticle

37 Scopus citations
33 Scopus citations

EXAFS spectroscopic evidence for an Fe=O unit in the Fe(IV) intermediate observed during oxygen activation by taurine:α-ketoglutarate dioxygenase

Riggs-Gelasco, P. J., Price, J. C., Guyer, R. B., Brehm, J. H., Barr, E. W., Bollinger, Jr., J. M. & Krebs, C., Jul 7 2004, In : Journal of the American Chemical Society. 126, 26, p. 8108-8109 2 p.

Research output: Contribution to journalArticle

226 Scopus citations

Exchange and double-exchange phenomena in linear homo- and heteronuclear nickel(II,III,IV) complexes containing six μ2-phenolato or μ2-thiophenolato bridging ligands

Beissel, T., Birkelbach, F., Bill, E., Glaser, T., Kesting, F., Krebs, C., Weyhermüller, T., Wieghardt, K., Butzlaff, C. & Trautwein, A. X., Dec 1 1996, In : Journal of the American Chemical Society. 118, 49, p. 12376-12390 15 p.

Research output: Contribution to journalArticle

90 Scopus citations

Exchange coupling constant J of peroxodiferric reaction intermediates determined by Mössbauer spectroscopy

Krebs, C., Bollinger, Jr., J. M., Theil, E. C. & Huynh, B. H., Dec 1 2002, In : Journal of Biological Inorganic Chemistry. 7, 7-8, p. 863-869 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Exchange Coupling in an Isostructural Series of Face-Sharing Bioctahedral Complexes [LMII(μ-X)3MIIL]BPh4 M = Mn, Fe, Co, Ni, Zn; X = Cl, Br; L = 1,4,7-Trimethyl-1,4,7-triazacyclononane

Bossek, U., Nühlen, D., Bill, E., Glaser, T., Krebs, C., Weyhermüller, T., Wieghardt, K., Lengen, M. & Trautwein, A. X., Dec 1 1997, In : Inorganic chemistry. 36, 13, p. 2834-2843 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

Experimental correlation of substrate position with reaction outcome in the aliphatic halogenase, SyrB2

Martinie, R. J., Livada, J., Chang, W. C., Green, M. T., Krebs, C., Bollinger, J. M. & Silakov, A., Jun 3 2015, In : Journal of the American Chemical Society. 137, 21, p. 6912-6919 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Facile electron transfer during formation of cluster X and kinetic competence of X for tyrosyl radical production in protein R2 of ribonucleotide reductase from mouse

Yun, D., Krebs, C., Gupta, G. P., Iwig, D. F., Huynh, B. H. & Bollinger, J. M., Jan 22 2002, In : Biochemistry. 41, 3, p. 981-990 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

First Step in Catalysis of the Radical S-Adenosylmethionine Methylthiotransferase MiaB Yields an Intermediate with a [3Fe-4S]0-Like Auxiliary Cluster

Zhang, B., Arcinas, A. J., Radle, M. I., Silakov, A., Booker, S. J. & Krebs, C., Jan 29 2020, In : Journal of the American Chemical Society. 142, 4, p. 1911-1924 14 p.

Research output: Contribution to journalArticle

Formation and function of the manganese(iv)/iron(iii) cofactor in chlamydia trachomatis ribonucleotide reductase

Jiang, W., Yun, D., Saleh, L., Martin Bollinger, J. & Krebs, C., Dec 30 2008, In : Biochemistry. 47, 52, p. 13736-13744 9 p.

Research output: Contribution to journalReview article

41 Scopus citations

Formation of a pterin radical in the reaction of the heme domain of inducible nitric oxide synthase with oxygen

Hurshman, A. R., Krebs, C., Edmondson, D. E., Huynh, B. H. & Marletta, M. A., Nov 30 1999, In : Biochemistry. 38, 48

Research output: Contribution to journalArticle

Formation of a pterin radical in the reaction of the heme domain of inducible nitric oxide synthase with oxygen

Hurshman, A. R., Krebs, C., Edmondson, D. E., Huynh, B. H. & Marletta, M. A., Nov 30 1999, In : Biochemistry. 38, 48, p. 15689-15696 8 p.

Research output: Contribution to journalArticle

204 Scopus citations

Formation of Fe(III)Fe(IV) species from the reaction between a diiron(II) complex and dioxygen: Relevance to ribonucleotide reductase intermediate X [12]

Lee, D., Du Bois, J., Petasis, D., Hendrich, M. P., Krebs, C., Huynh, B. H. & Lippard, S. J., Oct 27 1999, In : Journal of the American Chemical Society. 121, 42, p. 9893-9894 2 p.

Research output: Contribution to journalLetter

86 Scopus citations
41 Scopus citations

Freeze-quench 57Fe-Mössbauer spectroscopy: Trapping reactive intermediates

Krebs, C. & Bollinger, J. M., Nov 1 2009, In : Photosynthesis research. 102, 2, p. 295-304 10 p.

Research output: Contribution to journalReview article

11 Scopus citations

Functional mimic of dioxygen-activating centers in non-heme diiron enzymes: Mechanistic implications of paramagnetic intermediates in the reactions between diiron(II) complexes and dioxygen

Lee, D., Pierce, B., Krebs, C., Hendrich, M. P., Huynh, B. H. & Lippard, S. J., Apr 17 2002, In : Journal of the American Chemical Society. 124, 15, p. 3993-4007 15 p.

Research output: Contribution to journalArticle

53 Scopus citations

Function of the diiron cluster of Escherichia coli class Ia ribonucleotide reductase in proton-coupled electron transfer

Wörsdörfer, B., Conner, D. A., Yokoyama, K., Livada, J., Seyedsayamdost, M., Jiang, W., Silakov, A., Stubbe, J., Bollinger, J. M. & Krebs, C., Jun 12 2013, In : Journal of the American Chemical Society. 135, 23, p. 8585-8593 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Further characterization of Cys-type and Ser-type anaerobic sulfatase maturating enzymes suggests a commonality in the mechanism of catalysis

Grove, T. L., Ahlum, J. H., Qin, R. M., Lanz, N. D., Radle, M. I., Krebs, C. & Booker, S. J., Apr 30 2013, In : Biochemistry. 52, 17, p. 2874-2887 14 p.

Research output: Contribution to journalArticle

31 Scopus citations

Further insights into the spectroscopic properties, electronic structure, and kinetics of formation of the heme-peroxo-copper complex [(F 8TPP)FeIII-(O22-)-Cu II(TMPA)]+

Ghiladi, R. A., Chufán, E. E., Del Río, D., Solomon, E. I., Krebs, C., Boi, H. H., Huang, H. W., Moënne-Loccoz, P., Kaderli, S., Honecker, M., Zuberbühler, A. D., Marzilli, L., Cotter, R. J. & Karlin, K. D., May 14 2007, In : Inorganic chemistry. 46, 10, p. 3889-3902 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

Generation of a mixed-valent Fe(III)Fe(IV) form of intermediate Q in the reaction cycle of soluble methane monooxygenase, an analog of intermediate X in ribonucleotide reductase R2 assembly [10]

Valentine, A. M., Tavares, P., Pereira, A. S., Davydov, R., Krebs, C., Hoffman, B. M., Edmondson, D. E., Boi Hanh Huynh, H. H. & Lippard, S. J., Mar 11 1998, In : Journal of the American Chemical Society. 120, 9, p. 2190-2191 2 p.

Research output: Contribution to journalLetter

53 Scopus citations

Geometric and electronic structure of the Mn(IV)Fe(III) cofactor in class Ic ribonucleotide reductase: Correlation to the class ia binuclear non-heme iron enzyme

Kwak, Y., Jiang, W., Dassama, L. M. K., Park, K., Bell, C. B., Liu, L. V., Wong, S. D., Saito, M., Kobayashi, Y., Kitao, S., Seto, M., Yoda, Y., Alp, E. E., Zhao, J., Bollinger, J. M., Krebs, C. & Solomon, E. I., Nov 20 2013, In : Journal of the American Chemical Society. 135, 46, p. 17573-17584 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Ground spin state variation in carboxylate-bridged tetranuclear [Fe2Mn2O2]8+ cores and a comparison with their [Fe4O2]8+ and [Mn4O2]18+ congeners

Chaudhuri, P., Rentschler, E., Birkelbach, F., Krebs, C., Bill, E., Weyhermüller, T. & Flörke, U., Feb 2003, In : European Journal of Inorganic Chemistry. 3, p. 541-555 15 p.

Research output: Contribution to journalArticle

46 Scopus citations

Highly variable π-bonding in the interaction of iron(II) porphyrinates with nitrite

Nasri, H., Ellison, M. K., Krebs, C., Huynh, B. H. & Scheidt, W. R., Nov 8 2000, In : Journal of the American Chemical Society. 122, 44, p. 10795-10804 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

High-resolution iron X-ray absorption spectroscopic and computational studies of non-heme diiron peroxo intermediates

Cutsail, G. E., Blaesi, E. J., Pollock, C. J., Bollinger, J. M., Krebs, C. & DeBeer, S., Feb 2020, In : Journal of Inorganic Biochemistry. 203, 110877.

Research output: Contribution to journalArticle

Open Access

Human calprotectin is an iron-sequestering host-defense protein

Nakashige, T. G., Zhang, B., Krebs, C. & Nolan, E. M., Oct 19 2015, In : Nature Chemical Biology. 11, 10, p. 765-771 7 p.

Research output: Contribution to journalArticle

90 Scopus citations

Hydrogen Donation but not Abstraction by a Tyrosine (Y68) during Endoperoxide Installation by Verruculogen Synthase (FtmOx1)

Dunham, N. P., Del Río Pantoja, J. M., Zhang, B., Rajakovich, L. J., Allen, B. D., Krebs, C., Boal, A. K. & Bollinger, J. M., Jun 26 2019, In : Journal of the American Chemical Society. 141, 25, p. 9964-9979 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

Identification of FX in the heliobacterial reaction center as a [4Fe-4S] cluster with an S = 3/2 ground spin state

Heinnickel, M., Agalarov, R., Svensen, N., Krebs, C. & Golbeck, J. H., May 30 2006, In : Biochemistry. 45, 21, p. 6756-6764 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Importance of the maintenance pathway in the regulation of the activity of Escherichia coli ribonucleotide reductase

Hristova, D., Wu, C. H., Jiang, W., Krebs, C. & Stubbe, J., Apr 1 2008, In : Biochemistry. 47, 13, p. 3989-3999 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Installation of the Ether Bridge of Lolines by the Iron- and 2-Oxoglutarate-Dependent Oxygenase, LolO: Regio- and Stereochemistry of Sequential Hydroxylation and Oxacyclization Reactions

Pan, J., Bhardwaj, M., Zhang, B., Chang, W. C., Schardl, C. L., Krebs, C., Grossman, R. B. & Martin Bollinger, J., Apr 10 2018, In : Biochemistry. 57, 14, p. 2074-2083 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Intermediates in oxygen activation reactions of diiron enzymes

Krebs, C. & Huynh, B. H., Jan 2 2008, Iron Metabolism: Inorganic Biochemistry and Regulatory Mechanisms. wiley, p. 253-273 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

In vitro characterization of AtsB, a radical SAM formylglycine-generating enzyme that contains three [4Fe-4S] clusters

Grove, T. L., Lee, K. H., St. Clair, J., Krebs, C. & Booker, S. J., Jul 15 2008, In : Biochemistry. 47, 28, p. 7523-7538 16 p.

Research output: Contribution to journalArticle

75 Scopus citations

Iron-sulfur cluster engineering provides insight into the evolution of substrate specificity among sulfonucleotide reductases

Bhave, D. P., Hong, J. A., Keller, R. L., Krebs, C. & Carroll, K. S., Feb 17 2012, In : ACS chemical biology. 7, 2, p. 306-315 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

IscA, an alternate scaffold for Fe-S cluster biosynthesis

Krebs, C., Agar, J. N., Smith, A. D., Frazzon, J., Dean, D. R., Huynh, B. H. & Johnson, M. K., Nov 20 2001, In : Biochemistry. 40, 46, p. 14069-14080 12 p.

Research output: Contribution to journalArticle

190 Scopus citations

IscU as a scaffold for iron-sulfur cluster biosynthesis: Sequential assembly of [2Fe-2S] and [4Fe-4S] clusters in IscU

Agar, J. N., Krebs, C., Frazzon, J., Huynh, B. H., Dean, D. R. & Johnson, M. K., Jul 11 2000, In : Biochemistry. 39, 27, p. 7856-7862 7 p.

Research output: Contribution to journalArticle

340 Scopus citations