• 9973 Citations
  • 57 h-Index
1995 …2023
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Research Output 1995 2019

Article
23 Citations (Scopus)

A 2.8 Å Fe-Fe separation in the Fe 2 III/IV intermediate, X, from Escherichia coli ribonucleotide reductase

Dassama, L. M. K., Silakov, A., Krest, C. M., Calixto, J. C., Krebs, C., Bollinger, Jr., J. M. & Green, M. T., Nov 13 2013, In : Journal of the American Chemical Society. 135, 45, p. 16758-16761 4 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
X ray absorption
Escherichia coli
chlorite dismutase
X-Rays
48 Citations (Scopus)

Ability of Tetrahydrobiopterin Analogues to Support Catalysis by Inducible Nitric Oxide Synthase: Formation of a Pterin Radical is Required for Enzyme Activity

Hurshman, A. R., Krebs, C., Edmondson, D. E. & Marletta, M. A., Nov 18 2003, In : Biochemistry. 42, 45, p. 13287-13303 17 p.

Research output: Contribution to journalArticle

Pterins
Enzyme activity
Nitric Oxide Synthase Type II
Catalysis
Catalyst supports
69 Citations (Scopus)

A catalytic di-heme bis-Fe(IV) intermediate, alternative to an Fe(IV)=0 porphyrin radical

Li, X., Fu, R., Lee, S., Krebs, C., Davidson, V. L. & Liu, A., Jun 24 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 25, p. 8597-8600 4 p.

Research output: Contribution to journalArticle

Porphyrins
Heme
Tryptophan
Protein Precursors
Protein Biosynthesis
51 Citations (Scopus)

A consensus mechanism for radical SAM-dependent dehydrogenation? BtrN contains two [4Fe-4S] clusters

Grove, T. L., Ahlum, J. H., Sharma, P., Krebs, C. & Booker, S. J., May 11 2010, In : Biochemistry. 49, 18, p. 3783-3785 3 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Dehydrogenation
Electrons
Oxidation
Enzymes
38 Citations (Scopus)

A coupled dinuclear iron cluster that is perturbed by substrate binding in myo-inositol oxygenase

Xing, G., Hoffart, L. M., Diao, Y., Prabhu, K. S., Arner, R. J., Reddy, C. C., Krebs, C. & Bollinger, Jr., J. M., May 2 2006, In : Biochemistry. 45, 17, p. 5393-5401 9 p.

Research output: Contribution to journalArticle

Inositol Oxygenase
Inositol
acyl-(acyl-carrier-protein)desaturase
Iron
methane monooxygenase
23 Citations (Scopus)

Active site threonine facilitates proton transfer during dioxygen activation at the diiron center of toluene/o-xylene monooxygenase hydroxylase

Song, W. J., McCormick, M. S., Behan, R. K., Sazinsky, M. H., Jiang, W., Lin, J., Krebs, C. & Lippard, S. J., Oct 6 2010, In : Journal of the American Chemical Society. 132, 39, p. 13582-13585 4 p.

Research output: Contribution to journalArticle

Proton transfer
Threonine
Xylene
Toluene
Protons
49 Citations (Scopus)

A long-lived, substrate-hydroxylating peroxodiiron(III/III) intermediate in the amine oxygenase, AurF, from Streptomyces thioluteus

Korboukh, V. K., Li, N., Barr, E. W., Bollinger, Jr., J. M. & Krebs, C., Oct 13 2009, In : Journal of the American Chemical Society. 131, 38, p. 13608-13609 2 p.

Research output: Contribution to journalArticle

para-Aminobenzoates
Oxygenases
Streptomyces
Nitrobenzoates
Amines
139 Citations (Scopus)

A manganese(IV)/iron(III) cofactor in Chlamydia trachomatis ribonucleotide reductase

Jiang, W., Yun, D., Saleh, L., Barr, E. W., Xing, G., Hoffart, L. M., Maslak, M. A., Krebs, C. & Bollinger, Jr., J. M., May 25 2007, In : Science. 316, 5828, p. 1188-1191 4 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Chlamydia trachomatis
Manganese
Iron
Cysteine
57 Citations (Scopus)

A manganese(IV)/iron(IV) intermediate in assembly of the manganese(IV)/iron(III) cofactor of Chlamydia trachomatis ribonucleotide reductase

Jiang, W., Hoffart, L. M., Krebs, C. & Bollinger, Jr., J. M., Jul 31 2007, In : Biochemistry. 46, 30, p. 8709-8716 8 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Chlamydia trachomatis
Reducing Agents
Pathogens
Manganese

Analysis of RNA Methylation by Phylogenetically Diverse Cfr Radical S-Adenosylmethionine Enzymes Reveals an Iron-Binding Accessory Domain in a Clostridial Enzyme

Gumkowski, J. D., Martinie, R. J., Corrigan, P. S., Pan, J., Bauerle, M. R., Almarei, M., Booker, S. J., Silakov, A., Krebs, C. & Boal, A. K., Jun 27 2019, In : Biochemistry. 58, 29, p. 3169-3184 16 p.

Research output: Contribution to journalArticle

tRNA Methyltransferases
S-Adenosylmethionine
Methylation
Accessories
Rubredoxins
1 Citation (Scopus)

A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases

Rajakovich, L. J., Pandelia, M. E., Mitchell, A. J., Chang, W. C., Zhang, B., Boal, A. K., Krebs, C. & Bollinger, J. M., Mar 26 2019, In : Biochemistry. 58, 12, p. 1627-1647 21 p.

Research output: Contribution to journalArticle

Organophosphonates
Oxygenases
Iron
Degradation
gamma-Butyrobetaine Dioxygenase
39 Citations (Scopus)

A paramagnetic copper(III) complex containing an octahedral Cu(III)S6 coordination polyhedron

Krebs, C., Glaser, T., Bill, E., Weyhermüller, T., Meyer-Klaucke, W. & Wieghardt, K., Feb 1 1999, In : Angewandte Chemie - International Edition. 38, 3, p. 359-361 3 p.

Research output: Contribution to journalArticle

Copper
Ligands
Electrons
Paramagnetic resonance
Metals
140 Citations (Scopus)

A radically different mechanism for S-adenosylmethionine-dependent methyltransferases

Grove, T. L., Benner, J. S., Radle, M. I., Ahlum, J. H., Landgraf, B. J., Krebs, C. & Booker, S. J., Apr 29 2011, In : Science. 332, 6029, p. 604-607 4 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Methyltransferases
Methylation
23S Ribosomal RNA
Carbon
109 Citations (Scopus)

A Role for Iron in an Ancient Carbonic Anhydrase

Tripp, B. C., Bell, C. B., Cruz, F., Krebs, C. & Ferry, J. G., Feb 20 2004, In : Journal of Biological Chemistry. 279, 8, p. 6683-6687 5 p.

Research output: Contribution to journalArticle

Carbonic Anhydrases
Cams
Iron
Enzymes
Methanosarcina
21 Citations (Scopus)

Aromatic C-F Hydroxylation by Nonheme Iron(IV)-Oxo Complexes: Structural, Spectroscopic, and Mechanistic Investigations

Sahu, S., Zhang, B., Pollock, C. J., Dürr, M., Davies, C. G., Confer, A. M., Ivanović-Burmazović, I., Siegler, M. A., Jameson, G. N. L., Krebs, C. & Goldberg, D. P., Oct 5 2016, In : Journal of the American Chemical Society. 138, 39, p. 12791-12802 12 p.

Research output: Contribution to journalArticle

Hydroxylation
Iron
Activation Analysis
ferryl iron
X-Ray Diffraction
47 Citations (Scopus)

A triangular iron(III) complex potentially relevant to iron(III)-binding sites in ferreascidin

Bill, E., Krebs, C., Winter, M., Gerdan, M., Trautwein, A. X., Flörke, U., Haupt, H. J. & Chaudhuri, P., Jan 1 1997, In : Chemistry - A European Journal. 3, 2, p. 193-201 9 p.

Research output: Contribution to journalArticle

Binding sites
Iron
Binding Sites
Ions
Magnetic susceptibility
28 Citations (Scopus)

AurF from Streptomyces thioluteus and a possible new family of manganese/iron oxygenases

Krebs, C., Matthews, M. L., Jiang, W. & Bollinger, Jr., J. M., Sep 18 2007, In : Biochemistry. 46, 37, p. 10413-10418 6 p.

Research output: Contribution to journalArticle

Oxygenases
Streptomyces
Manganese
Iron
Chlamydia trachomatis
8 Citations (Scopus)

Biochemical and spectroscopic characterization of overexpressed fuscoredoxin from Escherichia coli

Pereira, A. S., Tavares, P., Krebs, C., Huynh, B. H., Rusnak, F., Moura, I. & Moura, J. J. G., Jun 24 1999, In : Biochemical and Biophysical Research Communications. 260, 1, p. 209-215 7 p.

Research output: Contribution to journalArticle

Escherichia coli
Iron
Genes
Desulfovibrio
Proteins
26 Citations (Scopus)
Synechococcus
Photosystem I Protein Complex
Cyanobacteria
Sulfur
Iron
40 Citations (Scopus)

Branched activation- and catalysis-specific pathways for electron relay to the manganese/iron cofactor in ribonucleotide reductase from Chlamydia trachomatis

Jiang, W., Saleh, L., Barr, E. W., Xie, J., Gardner, M. M., Krebs, C. & Bollinger, Jr., J. M., Aug 19 2008, In : Biochemistry. 47, 33, p. 8477-8484 8 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Chlamydia trachomatis
Manganese
Catalysis
Iron
61 Citations (Scopus)

CD and MCD of CytC3 and taurine dioxygenase: Role of the facial triad in α-KG-dependent oxygenases

Neidig, M. L., Brown, C. D., Light, K. M., Fujimori, D. G., Nolan, E. M., Price, J. C., Barr, E. W., Bollinger, Jr., J. M., Krebs, C., Walsh, C. T. & Solomon, E. I., Nov 21 2007, In : Journal of the American Chemical Society. 129, 46, p. 14224-14231 8 p.

Research output: Contribution to journalArticle

Dioxygenases
Oxygenases
Taurine
Catalytic Domain
Hydroxylation
43 Citations (Scopus)
S-Adenosylmethionine
Proteins
Iron
Cysteine
Carbon
6 Citations (Scopus)

Characterization of Lipoyl Synthase from Mycobacterium tuberculosis

Lanz, N. D., Lee, K. H., Horstmann, A. K., Pandelia, M. E., Cicchillo, R. M., Krebs, C. & Booker, S. J., Mar 8 2016, In : Biochemistry. 55, 9, p. 1372-1383 12 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Escherichia coli
Biosynthesis
Glycine Decarboxylase Complex H-Protein
Salvaging
17 Citations (Scopus)

Characterization of quinolinate synthases from Escherichia coli, Mycobacterium tuberculosis, and Pyrococcus horikoshii indicates that [4Fe-4S] clusters are common cofactors throughout this class of enzymes

Saunders, A. H., Griffiths, A. E., Lee, K. H., Cicchillo, R. M., Tu, L., Stromberg, J. A., Krebs, C. & Booker, S. J., Oct 14 2008, In : Biochemistry. 47, 41, p. 10999-11012 14 p.

Research output: Contribution to journalArticle

Pyrococcus horikoshii
Quinolinic Acid
Mycobacterium tuberculosis
Escherichia coli
Enzymes
62 Citations (Scopus)

Characterization of RimO, a new member of the methylthiotransferase subclass of the radical SAM superfamily

Lee, K. H., Saleh, L., Anton, B. P., Madinger, C. L., Benner, J. S., Iwig, D. F., Roberts, R. J., Krebs, C. & Booker, S. J., Oct 27 2009, In : Biochemistry. 48, 42, p. 10162-10174 13 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Escherichia coli
Enzymes
Transfer RNA
Sulfur
79 Citations (Scopus)

Characterization of the Cofactor Composition of Escherichia coli Biotin Synthase

Cosper, M. M., Jameson, G. N. L., Hernández, H. L., Krebs, C., Huynh, B. H. & Johnson, M. K., Feb 24 2004, In : Biochemistry. 43, 7, p. 2007-2021 15 p.

Research output: Contribution to journalArticle

Pyridoxal Phosphate
Escherichia coli
Cysteine Synthase
Chemical analysis
S-Adenosylmethionine
13 Citations (Scopus)

ChlR protein of Synechococcus sp. PCC 7002 is a transcription activator that uses an oxygen-sensitive [4Fe-4S] cluster to control genes involved in pigment biosynthesis

Ludwig, M., Pandelia, M. E., Chew, C. Y., Zhang, B., Golbeck, J. H., Krebs, C. & Bryant, D. A., Jun 13 2014, In : Journal of Biological Chemistry. 289, 24, p. 16624-16639 16 p.

Research output: Contribution to journalArticle

Synechococcus
Biosynthesis
Transcription
Pigments
Operon
4 Citations (Scopus)
Inositol Oxygenase
Dichroism
Inositol
Magnetic Fields
Circular Dichroism
61 Citations (Scopus)

Conversion of 3Fe-4S to 4Fe-4S clusters in native pyruvate formate-lyase activating enzyme: Mössbauer characterization and implications for mechanism

Krebs, C., Henshaw, T. F., Cheek, J., Huynh, B. H. & Broderick, J. B., Dec 20 2000, In : Journal of the American Chemical Society. 122, 50, p. 12497-12506 10 p.

Research output: Contribution to journalArticle

Iron
Enzymes
Sulfur
Dithionite
formate C-acetyltransferase
78 Citations (Scopus)
formic acid
Oxygenases
Aldehydes
Oxidation-Reduction
Nostoc
104 Citations (Scopus)

Coordination of adenosylmethionine to a unique iron site of the [4Fe-4S] of pyruvate formate-lyase activating enzyme: A Mössbauer spectroscopic study

Krebs, C., Broderick, W. E., Henshaw, T. F., Broderick, J. B. & Huynh, B. H., Feb 12 2002, In : Journal of the American Chemical Society. 124, 6, p. 912-913 2 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Iron
Enzymes
Isomers
Catalysis
40 Citations (Scopus)

Cryoreduction of the NO-Adduct of Taurine: α-Ketoglutarate Dioxygenase (TauD) Yields an Elusive {FeNO}8 Species

Ye, S., Price, J. C., Barr, E. W., Green, M. T., Bollinger, Jr., J. M., Krebs, C. & Neese, F., Apr 7 2010, In : Journal of the American Chemical Society. 132, 13, p. 4739-4751 13 p.

Research output: Contribution to journalArticle

Dioxygenases
Taurine
Reaction intermediates
Enzymes
Ground state
10 Citations (Scopus)
Inositol Oxygenase
Electron Spin Resonance Spectroscopy
Inositol
Spectrum Analysis
Demonstrations
86 Citations (Scopus)
formic acid
Alkanes
Carbon Monoxide
Aldehydes
Carbon monoxide
119 Citations (Scopus)

Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme

Zhang, Y., Zhu, X., Torelli, A. T., Lee, M., Dzikovski, B., Koralewski, R. M., Wang, E., Freed, J., Krebs, C., Ealick, S. E. & Lin, H., Jun 17 2010, In : Nature. 465, 7300, p. 891-896 6 p.

Research output: Contribution to journalArticle

Sulfur
Methionine
Pyrococcus horikoshii
Iron
Enzymes
4 Citations (Scopus)

Direct Measurement of the Radical Translocation Distance in the Class i Ribonucleotide Reductase from Chlamydia trachomatis

Livada, J., Martinie, R. J., Dassama, L. M. K., Krebs, C., Bollinger, Jr., J. M. & Silakov, A., Oct 29 2015, In : Journal of Physical Chemistry B. 119, 43, p. 13777-13784 8 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Electron resonance
Deoxyribonucleotides
diphosphates
Ribonucleotides
55 Citations (Scopus)

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase

Matthews, M. L., Chang, W. C., Layne, A. P., Miles, L. A., Krebs, C. & Bollinger, Jr., J. M., Jan 1 2014, In : Nature Chemical Biology. 10, 3, p. 209-215 7 p.

Research output: Contribution to journalArticle

Anions
Carbon
Iron
Decarboxylation
Halogens
154 Citations (Scopus)

Direct spectroscopic and kinetic evidence for the involvement of a peroxodiferric intermediate during the ferroxidase reaction in fast ferritin mineralization

Pereira, A. S., Small, W., Krebs, C., Tavares, P., Edmondson, D. E., Theil, E. C. & Huynh, B. H., Jul 14 1998, In : Biochemistry. 37, 28, p. 9871-9876 6 p.

Research output: Contribution to journalArticle

Ceruloplasmin
Ferritins
Kinetics
Apoferritins
methane monooxygenase
220 Citations (Scopus)

Direct spectroscopic detection of a C-H-cleaving high-spin Fe(IV) complex in a prolyl-4-hydroxylase

Hoffart, L. M., Barr, E. W., Guyer, R. B., Bollinger, Jr., J. M. & Krebs, C., Oct 3 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 40, p. 14738-14743 6 p.

Research output: Contribution to journalArticle

Prolyl Hydroxylases
Dioxygenases
Taurine
Hydroxylation
Enzymes
128 Citations (Scopus)

Direct spectroscopic evidence for a high-spin Fe(IV) intermediate in tyrosine hydroxylase

Eser, B. E., Barr, E. W., Frantom, P. A., Saleh, L., Bollinger, Jr., J. M., Krebs, C. & Fitzpatrick, P. F., Sep 19 2007, In : Journal of the American Chemical Society. 129, 37, p. 11334-11335 2 p.

Research output: Contribution to journalArticle

Hydroxylation
Tyrosine 3-Monooxygenase
Aromatic Amino Acids
Dihydroxyphenylalanine
Mixed Function Oxygenases
42 Citations (Scopus)

Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers

Fuller, F. D., Gul, S., Chatterjee, R., Sethe Burgie, E., Young, I. D., Lebrette, H., Srinivas, V., Brewster, A. S., Michels-Clark, T., Clinger, J. A., Andi, B., Ibrahim, M., Pastor, E., De Lichtenberg, C., Hussein, R., Pollock, C. J., Zhang, M., Stan, C. A., Kroll, T., Fransson, T. & 36 others, Weninger, C., Kubin, M., Aller, P., Lassalle, L., Bräuer, P., Miller, M. D., Amin, M., Koroidov, S., Roessler, C. G., Allaire, M., Sierra, R. G., Docker, P. T., Glownia, J. M., Nelson, S., Koglin, J. E., Zhu, D., Chollet, M., Song, S., Lemke, H., Liang, M., Sokaras, D., Alonso-Mori, R., Zouni, A., Messinger, J., Bergmann, U., Boal, A. K., Bollinger, Jr., J. M., Krebs, C., Högbom, M., Phillips, G. N., Vierstra, R. D., Sauter, N. K., Orville, A. M., Kern, J., Yachandra, V. K. & Yano, J., Feb 27 2017, In : Nature methods. 14, 4, p. 443-449 7 p.

Research output: Contribution to journalArticle

Belt drives
Phytochrome
X ray lasers
Ribonucleotide Reductases
Crystallography
12 Citations (Scopus)
Nostoc
Acyl Carrier Protein
Oxygenases
Aldehydes
Oxidoreductases
55 Citations (Scopus)

Electronic structure analysis of the oxygen-activation mechanism by Fe II- and α-ketoglutarate (αKG)-dependent dioxygenases

Ye, S., Riplinger, C., Hansen, A., Krebs, C., Bollinger, J. M. & Neese, F., May 21 2012, In : Chemistry - A European Journal. 18, 21, p. 6555-6567 13 p.

Research output: Contribution to journalArticle

Dioxygenases
Electronic structure
Chemical activation
Oxygen
Superoxides
29 Citations (Scopus)

Electronic Structure of the Ferryl Intermediate in the α-Ketoglutarate Dependent Non-Heme Iron Halogenase SyrB2: Contributions to H Atom Abstraction Reactivity

Srnec, M., Wong, S. D., Matthews, M. L., Krebs, C., Bollinger, Jr., J. M. & Solomon, E. I., May 4 2016, In : Journal of the American Chemical Society. 138, 15, p. 5110-5122 13 p.

Research output: Contribution to journalArticle

Anisotropy
Molecular orbitals
Electronic structure
Spectrum Analysis
Iron
103 Citations (Scopus)

Elucidation of the Fe(iv)=O intermediate in the catalytic cycle of the halogenase SyrB2

Wong, S. D., Srnec, M., Matthews, M. L., Liu, L. V., Kwak, Y., Park, K., Bell, C. B., Alp, E. E., Zhao, J., Yoda, Y., Kitao, S., Seto, M., Krebs, C., Bollinger, Jr., J. M. & Solomon, E. I., Jul 26 2013, In : Nature. 499, 7458, p. 320-323 4 p.

Research output: Contribution to journalArticle

Halogenation
Enzymes
Hydroxylation
Spectrum Analysis
Pseudomonas syringae
97 Citations (Scopus)

Escherichia coli lipoyl synthase binds two distinct [4Fe-4S] clusters per polypeptide

Cicchillo, R. M., Lee, K. H., Baleanu-Gogonea, C., Nesbitt, N. M., Krebs, C. & Booker, S. J., Sep 21 2004, In : Biochemistry. 43, 37, p. 11770-11781 12 p.

Research output: Contribution to journalArticle

Escherichia coli
Sulfides
Peptides
S-Adenosylmethionine
Iron
30 Citations (Scopus)

Escherichia coli L-serine deaminase requires a [4Fe-4S] cluster in catalysis

Cicchillo, R. M., Baker, M. A., Schnitzer, E. J., Newman, E. B., Krebs, C. & Booker, S. J., Jul 30 2004, In : Journal of Biological Chemistry. 279, 31, p. 32418-32425 8 p.

Research output: Contribution to journalArticle

L-Serine Dehydratase
Catalysis
Serine
Escherichia coli
Iron
30 Citations (Scopus)

Escherichia coli quinolinate synthetase does indeed harbor a [4Fe-4S] cluster

Cicchillo, R. M., Tu, L., Stromberg, J. A., Hoffart, L. M., Krebs, C. & Booker, S. J., May 25 2005, In : Journal of the American Chemical Society. 127, 20, p. 7310-7311 2 p.

Research output: Contribution to journalArticle

Quinolinic Acid
Ports and harbors
Escherichia coli
Acids
Dihydroxyacetone Phosphate
29 Citations (Scopus)

Evidence for a catalytically and kinetically competent enzyme-substrate cross-linked intermediate in catalysis by lipoyl synthase

Lanz, N. D., Pandelia, M. E., Kakar, E. S., Lee, K. H., Krebs, C. & Booker, S. J., Jul 22 2014, In : Biochemistry. 53, 28, p. 4557-4572 16 p.

Research output: Contribution to journalArticle

Catalysis
Sulfur
Methionine
Atoms
Substrates
9 Citations (Scopus)

Evidence for a Di-μ-oxo diamond core in the Mn(IV)/Fe(IV) activation intermediate of ribonucleotide reductase from chlamydia trachomatis

Martinie, R. J., Blaesi, E. J., Krebs, C., Bollinger, Jr., J. M., Silakov, A. & Pollock, C. J., Feb 8 2017, In : Journal of the American Chemical Society. 139, 5, p. 1950-1957 8 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Diamond
Chlamydia trachomatis
Electron Spin Resonance Spectroscopy
X ray absorption