• 10508 Citations
  • 60 h-Index
19952020

Research output per year

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Research Output

Article

A 2.8 Å Fe-Fe separation in the Fe2III/IV intermediate, X, from Escherichia coli ribonucleotide reductase

Dassama, L. M. K., Silakov, A., Krest, C. M., Calixto, J. C., Krebs, C., Bollinger, J. M. & Green, M. T., Nov 13 2013, In : Journal of the American Chemical Society. 135, 45, p. 16758-16761 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

Ability of Tetrahydrobiopterin Analogues to Support Catalysis by Inducible Nitric Oxide Synthase: Formation of a Pterin Radical is Required for Enzyme Activity

Hurshman, A. R., Krebs, C., Edmondson, D. E. & Marletta, M. A., Nov 18 2003, In : Biochemistry. 42, 45, p. 13287-13303 17 p.

Research output: Contribution to journalArticle

49 Scopus citations

A catalytic di-heme bis-Fe(IV) intermediate, alternative to an Fe(IV)=0 porphyrin radical

Li, X., Fu, R., Lee, S., Krebs, C., Davidson, V. L. & Liu, A., Jun 24 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 25, p. 8597-8600 4 p.

Research output: Contribution to journalArticle

72 Scopus citations

A consensus mechanism for radical SAM-dependent dehydrogenation? BtrN contains two [4Fe-4S] clusters

Grove, T. L., Ahlum, J. H., Sharma, P., Krebs, C. & Booker, S. J., May 11 2010, In : Biochemistry. 49, 18, p. 3783-3785 3 p.

Research output: Contribution to journalArticle

52 Scopus citations

A coupled dinuclear iron cluster that is perturbed by substrate binding in myo-inositol oxygenase

Xing, G., Hoffart, L. M., Diao, Y., Prabhu, K. S., Arner, R. J., Reddy, C. C., Krebs, C. & Bollinger, Jr., J. M., May 2 2006, In : Biochemistry. 45, 17, p. 5393-5401 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Active site threonine facilitates proton transfer during dioxygen activation at the diiron center of toluene/o-xylene monooxygenase hydroxylase

Song, W. J., McCormick, M. S., Behan, R. K., Sazinsky, M. H., Jiang, W., Lin, J., Krebs, C. & Lippard, S. J., Oct 6 2010, In : Journal of the American Chemical Society. 132, 39, p. 13582-13585 4 p.

Research output: Contribution to journalArticle

23 Scopus citations

A long-lived, substrate-hydroxylating peroxodiiron(III/III) intermediate in the amine oxygenase, AurF, from Streptomyces thioluteus

Korboukh, V. K., Li, N., Barr, E. W., Bollinger, J. M. & Krebs, C., Oct 13 2009, In : Journal of the American Chemical Society. 131, 38, p. 13608-13609 2 p.

Research output: Contribution to journalArticle

51 Scopus citations

A manganese(IV)/iron(III) cofactor in Chlamydia trachomatis ribonucleotide reductase

Jiang, W., Yun, D., Saleh, L., Barr, E. W., Xing, G., Hoffart, L. M., Maslak, M. A., Krebs, C. & Bollinger, J. M., May 25 2007, In : Science. 316, 5828, p. 1188-1191 4 p.

Research output: Contribution to journalArticle

143 Scopus citations

A manganese(IV)/iron(IV) intermediate in assembly of the manganese(IV)/iron(III) cofactor of Chlamydia trachomatis ribonucleotide reductase

Jiang, W., Hoffart, L. M., Krebs, C. & Bollinger, Jr., J. M., Jul 31 2007, In : Biochemistry. 46, 30, p. 8709-8716 8 p.

Research output: Contribution to journalArticle

60 Scopus citations

Analysis of RNA Methylation by Phylogenetically Diverse Cfr Radical S-Adenosylmethionine Enzymes Reveals an Iron-Binding Accessory Domain in a Clostridial Enzyme

Gumkowski, J. D., Martinie, R. J., Corrigan, P. S., Pan, J., Bauerle, M. R., Almarei, M., Booker, S. J., Silakov, A., Krebs, C. & Boal, A. K., Jun 27 2019, In : Biochemistry. 58, 29, p. 3169-3184 16 p.

Research output: Contribution to journalArticle

A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases

Rajakovich, L. J., Pandelia, M. E., Mitchell, A. J., Chang, W. C., Zhang, B., Boal, A. K., Krebs, C. & Bollinger, J. M., Mar 26 2019, In : Biochemistry. 58, 12, p. 1627-1647 21 p.

Research output: Contribution to journalArticle

2 Scopus citations

A paramagnetic copper(III) complex containing an octahedral Cu(III)S6 coordination polyhedron

Krebs, C., Glaser, T., Bill, E., Weyhermüller, T., Meyer-Klaucke, W. & Wieghardt, K., Feb 1 1999, In : Angewandte Chemie - International Edition. 38, 3, p. 359-361 3 p.

Research output: Contribution to journalArticle

40 Scopus citations

A radically different mechanism for S-adenosylmethionine-dependent methyltransferases

Grove, T. L., Benner, J. S., Radle, M. I., Ahlum, J. H., Landgraf, B. J., Krebs, C. & Booker, S. J., Apr 29 2011, In : Science. 332, 6029, p. 604-607 4 p.

Research output: Contribution to journalArticle

145 Scopus citations

A Role for Iron in an Ancient Carbonic Anhydrase

Tripp, B. C., Bell, C. B., Cruz, F., Krebs, C. & Ferry, J. G., Feb 20 2004, In : Journal of Biological Chemistry. 279, 8, p. 6683-6687 5 p.

Research output: Contribution to journalArticle

112 Scopus citations

Aromatic C-F Hydroxylation by Nonheme Iron(IV)-Oxo Complexes: Structural, Spectroscopic, and Mechanistic Investigations

Sahu, S., Zhang, B., Pollock, C. J., Dürr, M., Davies, C. G., Confer, A. M., Ivanović-Burmazović, I., Siegler, M. A., Jameson, G. N. L., Krebs, C. & Goldberg, D. P., Oct 5 2016, In : Journal of the American Chemical Society. 138, 39, p. 12791-12802 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

A triangular iron(III) complex potentially relevant to iron(III)-binding sites in ferreascidin

Bill, E., Krebs, C., Winter, M., Gerdan, M., Trautwein, A. X., Flörke, U., Haupt, H. J. & Chaudhuri, P., Jan 1 1997, In : Chemistry - A European Journal. 3, 2, p. 193-201 9 p.

Research output: Contribution to journalArticle

48 Scopus citations

AurF from Streptomyces thioluteus and a possible new family of manganese/iron oxygenases

Krebs, C., Matthews, M. L., Jiang, W. & Bollinger, Jr., J. M., Sep 18 2007, In : Biochemistry. 46, 37, p. 10413-10418 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Biochemical and spectroscopic characterization of overexpressed fuscoredoxin from Escherichia coli

Pereira, A. S., Tavares, P., Krebs, C., Huynh, B. H., Rusnak, F., Moura, I. & Moura, J. J. G., Jun 24 1999, In : Biochemical and Biophysical Research Communications. 260, 1, p. 209-215 7 p.

Research output: Contribution to journalArticle

8 Scopus citations
27 Scopus citations

Branched activation- and catalysis-specific pathways for electron relay to the manganese/iron cofactor in ribonucleotide reductase from Chlamydia trachomatis

Jiang, W., Saleh, L., Barr, E. W., Xie, J., Gardner, M. M., Krebs, C. & Bollinger, Jr., J. M., Aug 19 2008, In : Biochemistry. 47, 33, p. 8477-8484 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

CD and MCD of CytC3 and taurine dioxygenase: Role of the facial triad in α-KG-dependent oxygenases

Neidig, M. L., Brown, C. D., Light, K. M., Fujimori, D. G., Nolan, E. M., Price, J. C., Barr, E. W., Bollinger, J. M., Krebs, C., Walsh, C. T. & Solomon, E. I., Nov 21 2007, In : Journal of the American Chemical Society. 129, 46, p. 14224-14231 8 p.

Research output: Contribution to journalArticle

67 Scopus citations
45 Scopus citations

Characterization of Lipoyl Synthase from Mycobacterium tuberculosis

Lanz, N. D., Lee, K. H., Horstmann, A. K., Pandelia, M. E., Cicchillo, R. M., Krebs, C. & Booker, S. J., Mar 8 2016, In : Biochemistry. 55, 9, p. 1372-1383 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Characterization of quinolinate synthases from Escherichia coli, Mycobacterium tuberculosis, and Pyrococcus horikoshii indicates that [4Fe-4S] clusters are common cofactors throughout this class of enzymes

Saunders, A. H., Griffiths, A. E., Lee, K. H., Cicchillo, R. M., Tu, L., Stromberg, J. A., Krebs, C. & Booker, S. J., Oct 14 2008, In : Biochemistry. 47, 41, p. 10999-11012 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

Characterization of RimO, a new member of the methylthiotransferase subclass of the radical SAM superfamily

Lee, K. H., Saleh, L., Anton, B. P., Madinger, C. L., Benner, J. S., Iwig, D. F., Roberts, R. J., Krebs, C. & Booker, S. J., Oct 27 2009, In : Biochemistry. 48, 42, p. 10162-10174 13 p.

Research output: Contribution to journalArticle

64 Scopus citations

Characterization of the Cofactor Composition of Escherichia coli Biotin Synthase

Cosper, M. M., Jameson, G. N. L., Hernández, H. L., Krebs, C., Huynh, B. H. & Johnson, M. K., Feb 24 2004, In : Biochemistry. 43, 7, p. 2007-2021 15 p.

Research output: Contribution to journalArticle

80 Scopus citations

ChlR protein of Synechococcus sp. PCC 7002 is a transcription activator that uses an oxygen-sensitive [4Fe-4S] cluster to control genes involved in pigment biosynthesis

Ludwig, M., Pandelia, M. E., Chew, C. Y., Zhang, B., Golbeck, J. H., Krebs, C. & Bryant, D. A., Jun 13 2014, In : Journal of Biological Chemistry. 289, 24, p. 16624-16639 16 p.

Research output: Contribution to journalArticle

15 Scopus citations
4 Scopus citations

Conversion of 3Fe-4S to 4Fe-4S clusters in native pyruvate formate-lyase activating enzyme: Mössbauer characterization and implications for mechanism

Krebs, C., Henshaw, T. F., Cheek, J., Huynh, B. H. & Broderick, J. B., Dec 20 2000, In : Journal of the American Chemical Society. 122, 50, p. 12497-12506 10 p.

Research output: Contribution to journalArticle

65 Scopus citations
85 Scopus citations

Coordination of adenosylmethionine to a unique iron site of the [4Fe-4S] of pyruvate formate-lyase activating enzyme: A Mössbauer spectroscopic study

Krebs, C., Broderick, W. E., Henshaw, T. F., Broderick, J. B. & Huynh, B. H., Feb 12 2002, In : Journal of the American Chemical Society. 124, 6, p. 912-913 2 p.

Research output: Contribution to journalArticle

107 Scopus citations

Cryoreduction of the NO-Adduct of Taurine: α-Ketoglutarate Dioxygenase (TauD) Yields an Elusive {FeNO}8 Species

Ye, S., Price, J. C., Barr, E. W., Green, M. T., Bollinger, J. M., Krebs, C. & Neese, F., Apr 7 2010, In : Journal of the American Chemical Society. 132, 13, p. 4739-4751 13 p.

Research output: Contribution to journalArticle

41 Scopus citations

Demonstration by 2H ENDOR spectroscopy that myo-inositol binds via an alkoxide bridge to the mixed-valent diiron center of myo-inositol oxygenase

Kim, S. H., Xing, G., Bollinger, J. M., Krebs, C. & Hoffman, B. M., Aug 16 2006, In : Journal of the American Chemical Society. 128, 32, p. 10374-10375 2 p.

Research output: Contribution to journalArticle

10 Scopus citations
89 Scopus citations

Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme

Zhang, Y., Zhu, X., Torelli, A. T., Lee, M., Dzikovski, B., Koralewski, R. M., Wang, E., Freed, J., Krebs, C., Ealick, S. E. & Lin, H., Jun 17 2010, In : Nature. 465, 7300, p. 891-896 6 p.

Research output: Contribution to journalArticle

123 Scopus citations

Direct Measurement of the Radical Translocation Distance in the Class i Ribonucleotide Reductase from Chlamydia trachomatis

Livada, J., Martinie, R. J., Dassama, L. M. K., Krebs, C., Bollinger, J. M. & Silakov, A., Oct 29 2015, In : Journal of Physical Chemistry B. 119, 43, p. 13777-13784 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase

Matthews, M. L., Chang, W. C., Layne, A. P., Miles, L. A., Krebs, C. & Bollinger, J. M., Mar 2014, In : Nature Chemical Biology. 10, 3, p. 209-215 7 p.

Research output: Contribution to journalArticle

62 Scopus citations

Direct spectroscopic and kinetic evidence for the involvement of a peroxodiferric intermediate during the ferroxidase reaction in fast ferritin mineralization

Pereira, A. S., Small, W., Krebs, C., Tavares, P., Edmondson, D. E., Theil, E. C. & Huynh, B. H., Jul 14 1998, In : Biochemistry. 37, 28, p. 9871-9876 6 p.

Research output: Contribution to journalArticle

155 Scopus citations

Direct spectroscopic detection of a C-H-cleaving high-spin Fe(IV) complex in a prolyl-4-hydroxylase

Hoffart, L. M., Barr, E. W., Guyer, R. B., Bollinger, J. M. & Krebs, C., Oct 3 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 40, p. 14738-14743 6 p.

Research output: Contribution to journalArticle

235 Scopus citations

Direct spectroscopic evidence for a high-spin Fe(IV) intermediate in tyrosine hydroxylase

Eser, B. E., Barr, E. W., Frantom, P. A., Saleh, L., Bollinger, Jr., J. M., Krebs, C. & Fitzpatrick, P. F., Sep 19 2007, In : Journal of the American Chemical Society. 129, 37, p. 11334-11335 2 p.

Research output: Contribution to journalArticle

132 Scopus citations

Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers

Fuller, F. D., Gul, S., Chatterjee, R., Sethe Burgie, E., Young, I. D., Lebrette, H., Srinivas, V., Brewster, A. S., Michels-Clark, T., Clinger, J. A., Andi, B., Ibrahim, M., Pastor, E., De Lichtenberg, C., Hussein, R., Pollock, C. J., Zhang, M., Stan, C. A., Kroll, T., Fransson, T. & 36 others, Weninger, C., Kubin, M., Aller, P., Lassalle, L., Bräuer, P., Miller, M. D., Amin, M., Koroidov, S., Roessler, C. G., Allaire, M., Sierra, R. G., Docker, P. T., Glownia, J. M., Nelson, S., Koglin, J. E., Zhu, D., Chollet, M., Song, S., Lemke, H., Liang, M., Sokaras, D., Alonso-Mori, R., Zouni, A., Messinger, J., Bergmann, U., Boal, A. K., Martin Bollinger, J., Krebs, C., Högbom, M., Phillips, G. N., Vierstra, R. D., Sauter, N. K., Orville, A. M., Kern, J., Yachandra, V. K. & Yano, J., Feb 27 2017, In : Nature methods. 14, 4, p. 443-449 7 p.

Research output: Contribution to journalArticle

56 Scopus citations
15 Scopus citations

Electronic structure analysis of the oxygen-activation mechanism by Fe II- and α-ketoglutarate (αKG)-dependent dioxygenases

Ye, S., Riplinger, C., Hansen, A., Krebs, C., Bollinger, J. M. & Neese, F., May 21 2012, In : Chemistry - A European Journal. 18, 21, p. 6555-6567 13 p.

Research output: Contribution to journalArticle

60 Scopus citations

Electronic Structure of the Ferryl Intermediate in the α-Ketoglutarate Dependent Non-Heme Iron Halogenase SyrB2: Contributions to H Atom Abstraction Reactivity

Srnec, M., Wong, S. D., Matthews, M. L., Krebs, C., Bollinger, J. M. & Solomon, E. I., May 4 2016, In : Journal of the American Chemical Society. 138, 15, p. 5110-5122 13 p.

Research output: Contribution to journalArticle

32 Scopus citations

Elucidation of the Fe(iv)=O intermediate in the catalytic cycle of the halogenase SyrB2

Wong, S. D., Srnec, M., Matthews, M. L., Liu, L. V., Kwak, Y., Park, K., Bell, C. B., Alp, E. E., Zhao, J., Yoda, Y., Kitao, S., Seto, M., Krebs, C., Bollinger, J. M. & Solomon, E. I., Jul 26 2013, In : Nature. 499, 7458, p. 320-323 4 p.

Research output: Contribution to journalArticle

115 Scopus citations

Escherichia coli lipoyl synthase binds two distinct [4Fe-4S] clusters per polypeptide

Cicchillo, R. M., Lee, K. H., Baleanu-Gogonea, C., Nesbitt, N. M., Krebs, C. & Booker, S. J., Sep 21 2004, In : Biochemistry. 43, 37, p. 11770-11781 12 p.

Research output: Contribution to journalArticle

101 Scopus citations

Escherichia coli L-serine deaminase requires a [4Fe-4S] cluster in catalysis

Cicchillo, R. M., Baker, M. A., Schnitzer, E. J., Newman, E. B., Krebs, C. & Booker, S. J., Jul 30 2004, In : Journal of Biological Chemistry. 279, 31, p. 32418-32425 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Escherichia coli quinolinate synthetase does indeed harbor a [4Fe-4S] cluster

Cicchillo, R. M., Tu, L., Stromberg, J. A., Hoffart, L. M., Krebs, C. & Booker, S. J., May 25 2005, In : Journal of the American Chemical Society. 127, 20, p. 7310-7311 2 p.

Research output: Contribution to journalArticle

32 Scopus citations

Evidence for a catalytically and kinetically competent enzyme-substrate cross-linked intermediate in catalysis by lipoyl synthase

Lanz, N. D., Pandelia, M. E., Kakar, E. S., Lee, K. H., Krebs, C. & Booker, S. J., Jul 22 2014, In : Biochemistry. 53, 28, p. 4557-4572 16 p.

Research output: Contribution to journalArticle

32 Scopus citations

Evidence for a Di-μ-oxo diamond core in the Mn(IV)/Fe(IV) activation intermediate of ribonucleotide reductase from chlamydia trachomatis

Martinie, R. J., Blaesi, E. J., Krebs, C., Bollinger, Jr., J. M., Silakov, A. & Pollock, C. J., Feb 8 2017, In : Journal of the American Chemical Society. 139, 5, p. 1950-1957 8 p.

Research output: Contribution to journalArticle

13 Scopus citations