• 9984 Citations
  • 57 h-Index
1995 …2023
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1995 2019

2013
30 Citations (Scopus)

Further characterization of Cys-type and Ser-type anaerobic sulfatase maturating enzymes suggests a commonality in the mechanism of catalysis

Grove, T. L., Ahlum, J. H., Qin, R. M., Lanz, N. D., Radle, M. I., Krebs, C. & Booker, S. J., Apr 30 2013, In : Biochemistry. 52, 17, p. 2874-2887 14 p.

Research output: Contribution to journalArticle

Sulfatases
Catalysis
Clostridium
Clostridium perfringens
S-Adenosylmethionine
21 Citations (Scopus)

Geometric and electronic structure of the Mn(IV)Fe(III) cofactor in class Ic ribonucleotide reductase: Correlation to the class ia binuclear non-heme iron enzyme

Kwak, Y., Jiang, W., Dassama, L. M. K., Park, K., Bell, C. B., Liu, L. V., Wong, S. D., Saito, M., Kobayashi, Y., Kitao, S., Seto, M., Yoda, Y., Alp, E. E., Zhao, J., Bollinger, J. M., Krebs, C. & Solomon, E. I., Nov 20 2013, In : Journal of the American Chemical Society. 135, 46, p. 17573-17584 12 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Vibrational spectroscopy
Dichroism
Electronic structure
Spectrum Analysis
14 Citations (Scopus)

Novel approaches for the accumulation of oxygenated intermediates to multi-millimolar concentrations

Krebs, C., Dassama, L. M. K., Matthews, M. L., Jiang, W., Price, J. C., Korboukh, V., Li, N. & Bollinger, Jr., J. M., Jan 1 2013, In : Coordination Chemistry Reviews. 257, 1, p. 234-243 10 p.

Research output: Contribution to journalReview article

chlorite dismutase
Enzymes
Oxygenases
Oxygenation
Molecular oxygen
18 Citations (Scopus)

Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases

Wörsdörfer, B., Lingaraju, M., Yennawar, N. H., Boal, A. K., Krebs, C., Bollinger, J. M. & Pandelia, M. E., Nov 19 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 47, p. 18874-18879 6 p.

Research output: Contribution to journalArticle

Inositol Oxygenase
Organophosphonates
Oxygenases
X Ray Crystallography
Phosphoric Monoester Hydrolases
34 Citations (Scopus)
Cyclization
Biosynthesis
Methionine
Kinetics
Enzymes
20 Citations (Scopus)

Structural basis for assembly of the MnIV/FeIII cofactor in the class ic ribonucleotide reductase from chlamydia trachomatis

Dassama, L. M. K., Krebs, C., Bollinger, Jr., J. M., Rosenzweig, A. C. & Boal, A. K., Sep 17 2013, In : Biochemistry. 52, 37, p. 6424-6436 13 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Chlamydia trachomatis
Apoproteins
Metals
Chemical activation
41 Citations (Scopus)

Substrate-triggered addition of dioxygen to the diferrous cofactor of aldehyde-deformylating oxygenase to form a diferric-peroxide intermediate

Pandelia, M. E., Li, N., Nørgaard, H., Warui, D., Rajakovich, L. J., Chang, W. C., Booker, S. J., Krebs, C. & Bollinger, Jr., J. M., Oct 31 2013, In : Journal of the American Chemical Society. 135, 42, p. 15801-15812 12 p.

Research output: Contribution to journalArticle

formic acid
Oxygenases
Peroxides
Aldehydes
Oxygen
37 Citations (Scopus)

The COMBREX Project: Design, Methodology, and Initial Results

Anton, B. P., Chang, Y. C., Brown, P., Choi, H. P., Faller, L. L., Guleria, J., Hu, Z., Klitgord, N., Levy-Moonshine, A., Maksad, A., Mazumdar, V., McGettrick, M., Osmani, L., Pokrzywa, R., Rachlin, J., Swaminathan, R., Allen, B., Housman, G., Monahan, C., Rochussen, K. & 54 others, Tao, K., Bhagwat, A. S., Brenner, S. E., Columbus, L., de Crécy-Lagard, V., Ferguson, D., Fomenkov, A., Gadda, G., Morgan, R. D., Osterman, A. L., Rodionov, D. A., Rodionova, I. A., Rudd, K. E., Söll, D., Spain, J., Xu, S. Y., Bateman, A., Blumenthal, R. M., Bollinger, J. M., Chang, W. S., Ferrer, M., Friedberg, I., Galperin, M. Y., Gobeill, J., Haft, D., Hunt, J., Karp, P., Klimke, W., Krebs, C., Macelis, D., Madupu, R., Martin, M. J., Miller, J. H., O'Donovan, C., Palsson, B., Ruch, P., Setterdahl, A., Sutton, G., Tate, J., Yakunin, A., Tchigvintsev, D., Plata, G., Hu, J., Greiner, R., Horn, D., Sjölander, K., Salzberg, S. L., Vitkup, D., Letovsky, S., Segrè, D., DeLisi, C., Roberts, R. J., Steffen, M. & Kasif, S., Aug 1 2013, In : PLoS biology. 11, 8, e1001638.

Research output: Contribution to journalArticle

2012
55 Citations (Scopus)

Electronic structure analysis of the oxygen-activation mechanism by Fe II- and α-ketoglutarate (αKG)-dependent dioxygenases

Ye, S., Riplinger, C., Hansen, A., Krebs, C., Bollinger, J. M. & Neese, F., May 21 2012, In : Chemistry - A European Journal. 18, 21, p. 6555-6567 13 p.

Research output: Contribution to journalArticle

Dioxygenases
Electronic structure
Chemical activation
Oxygen
Superoxides
84 Citations (Scopus)

Evidence for only oxygenative cleavage of aldehydes to alk(a/e)nes and formate by cyanobacterial aldehyde decarbonylases

Li, N., Chang, W. C., Warui, D., Booker, S. J., Krebs, C. & Bollinger, Jr., J. M., Oct 9 2012, In : Biochemistry. 51, 40, p. 7908-7916 9 p.

Research output: Contribution to journalArticle

formic acid
Aldehydes
Nostoc
Wetlands
Prochlorococcus
31 Citations (Scopus)
Ribonucleotide Reductases
Chlamydia trachomatis
Manganese
Iron
Ions
5 Citations (Scopus)

Iron-sulfur cluster engineering provides insight into the evolution of substrate specificity among sulfonucleotide reductases

Bhave, D. P., Hong, J. A., Keller, R. L., Krebs, C. & Carroll, K. S., Feb 17 2012, In : ACS chemical biology. 7, 2, p. 306-315 10 p.

Research output: Contribution to journalArticle

Adenosine Phosphosulfate
Substrate Specificity
Sulfur
Oxidoreductases
Iron
19 Citations (Scopus)

O 2-evolving chlorite dismutase as a tool for studying O 2-utilizing enzymes

Dassama, L. M. K., Yosca, T. H., Conner, D. A., Lee, M. H., Blanc, B., Streit, B. R., Green, M. T., DuBois, J. L., Krebs, C. & Bollinger, Jr., J. M., Feb 28 2012, In : Biochemistry. 51, 8, p. 1607-1616 10 p.

Research output: Contribution to journalArticle

chlorite dismutase
Kinetics
Enzymes
Solubility
Gases
4 Citations (Scopus)

Radical-translocation intermediates and hurdling of pathway defects in "super-oxidized" (MnIV/FeIV) Chlamydia trachomatis ribonucleotide reductase

Dassama, L. M. K., Jiang, W., Varano, P. T., Pandelia, M. E., Conner, D. A., Xie, J., Bollinger, Jr., J. M. & Krebs, C., Dec 19 2012, In : Journal of the American Chemical Society. 134, 50, p. 20498-20506 9 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Chlamydia trachomatis
Defects
Enzymes
Proteins
59 Citations (Scopus)

RlmN and AtsB as models for the overproduction and characterization of radical SAM proteins

Lanz, N. D., Grove, T. L., Gogonea, C. B., Lee, K. H., Krebs, C. & Booker, S. J., Jan 1 2012, Methods in Enzymology. Academic Press Inc., p. 125-152 28 p. (Methods in Enzymology; vol. 516).

Research output: Chapter in Book/Report/Conference proceedingChapter

Methionine
Enzymes
Proteins
Iron
Explosions
2011
140 Citations (Scopus)

A radically different mechanism for S-adenosylmethionine-dependent methyltransferases

Grove, T. L., Benner, J. S., Radle, M. I., Ahlum, J. H., Landgraf, B. J., Krebs, C. & Booker, S. J., Apr 29 2011, In : Science. 332, 6029, p. 604-607 4 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Methyltransferases
Methylation
23S Ribosomal RNA
Carbon
43 Citations (Scopus)
S-Adenosylmethionine
Proteins
Iron
Cysteine
Carbon
78 Citations (Scopus)
formic acid
Oxygenases
Aldehydes
Oxidation-Reduction
Nostoc
55 Citations (Scopus)
Alkanes
Biosynthesis
Ferritins
Ribonucleotide Reductases
Iron
86 Citations (Scopus)
formic acid
Alkanes
Carbon Monoxide
Aldehydes
Carbon monoxide

Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme (Nature (2010) 465 (891-896))

Zhang, Y., Zhu, X., Torelli, A. T., Lee, M., Dzikovski, B., Koralewski, R. M., Wang, E., Freed, J., Krebs, C., Ealick, S. E. & Lin, H., May 26 2011, In : Nature. 473, 7348, 1 p.

Research output: Contribution to journalComment/debate

56 Citations (Scopus)

Evidence for a high-Spin Fe(IV) species in the catalytic cycle of a bacterial phenylalanine hydroxylase

Panay, A. J., Lee, M., Krebs, C., Bollinger, Jr., J. M. & Fitzpatrick, P. F., Mar 22 2011, In : Biochemistry. 50, 11, p. 1928-1933 6 p.

Research output: Contribution to journalArticle

Phenylalanine Hydroxylase
Phenylalanine
Tyrosine
Rate constants
Nonheme Iron Proteins
14 Citations (Scopus)

Spectroscopic studies on the [4Fe-4S] cluster in adenosine 5′-phosphosulfate reductase from Mycobacterium tuberculosis

Bhave, D. P., Hong, J. A., Lee, M., Jiang, W., Krebs, C. & Carroll, K. S., Jan 14 2011, In : Journal of Biological Chemistry. 286, 2, p. 1216-1226 11 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Sulfur
Paramagnetic resonance
Iron
Adenosine Phosphosulfate
2010
51 Citations (Scopus)

A consensus mechanism for radical SAM-dependent dehydrogenation? BtrN contains two [4Fe-4S] clusters

Grove, T. L., Ahlum, J. H., Sharma, P., Krebs, C. & Booker, S. J., May 11 2010, In : Biochemistry. 49, 18, p. 3783-3785 3 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Dehydrogenation
Electrons
Oxidation
Enzymes
23 Citations (Scopus)

Active site threonine facilitates proton transfer during dioxygen activation at the diiron center of toluene/o-xylene monooxygenase hydroxylase

Song, W. J., McCormick, M. S., Behan, R. K., Sazinsky, M. H., Jiang, W., Lin, J., Krebs, C. & Lippard, S. J., Oct 6 2010, In : Journal of the American Chemical Society. 132, 39, p. 13582-13585 4 p.

Research output: Contribution to journalArticle

Proton transfer
Threonine
Xylene
Toluene
Protons
40 Citations (Scopus)

Cryoreduction of the NO-Adduct of Taurine: α-Ketoglutarate Dioxygenase (TauD) Yields an Elusive {FeNO}8 Species

Ye, S., Price, J. C., Barr, E. W., Green, M. T., Bollinger, J. M., Krebs, C. & Neese, F., Apr 7 2010, In : Journal of the American Chemical Society. 132, 13, p. 4739-4751 13 p.

Research output: Contribution to journalArticle

Dioxygenases
Taurine
Reaction intermediates
Enzymes
Ground state
119 Citations (Scopus)

Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme

Zhang, Y., Zhu, X., Torelli, A. T., Lee, M., Dzikovski, B., Koralewski, R. M., Wang, E., Freed, J., Krebs, C., Ealick, S. E. & Lin, H., Jun 17 2010, In : Nature. 465, 7300, p. 891-896 6 p.

Research output: Contribution to journalArticle

Sulfur
Methionine
Pyrococcus horikoshii
Iron
Enzymes
46 Citations (Scopus)

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen

Flashman, E., Hoffart, L. M., Hamed, R. B., Bollinger, Jr., J. M., Krebs, C. & Schofield, C. J., Jan 1 2010, In : FEBS Journal. 277, 19, p. 4089-4099 11 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor-Proline Dioxygenases
Prolyl Hydroxylases
Oxygenases
Oxygen
Oxygen sensors
38 Citations (Scopus)
Nitrobenzoates
Streptomyces
Electrons
Oxygenases
para-Aminobenzoates
82 Citations (Scopus)

Substrate activation by iron superoxo intermediates

van der Donk, W. A., Krebs, C. & Bollinger, Jr., J. M., Dec 1 2010, In : Current Opinion in Structural Biology. 20, 6, p. 673-683 11 p.

Research output: Contribution to journalReview article

Iron
Oxygenases
Superoxides
Hydrogen
Oxidoreductases
19 Citations (Scopus)
Ribonucleotide Reductases
Hydroxyurea
Chlamydia trachomatis
Electrons
Proteins
2009
49 Citations (Scopus)

A long-lived, substrate-hydroxylating peroxodiiron(III/III) intermediate in the amine oxygenase, AurF, from Streptomyces thioluteus

Korboukh, V. K., Li, N., Barr, E. W., Bollinger, Jr., J. M. & Krebs, C., Oct 13 2009, In : Journal of the American Chemical Society. 131, 38, p. 13608-13609 2 p.

Research output: Contribution to journalArticle

para-Aminobenzoates
Oxygenases
Streptomyces
Nitrobenzoates
Amines
62 Citations (Scopus)

Characterization of RimO, a new member of the methylthiotransferase subclass of the radical SAM superfamily

Lee, K. H., Saleh, L., Anton, B. P., Madinger, C. L., Benner, J. S., Iwig, D. F., Roberts, R. J., Krebs, C. & Booker, S. J., Oct 27 2009, In : Biochemistry. 48, 42, p. 10162-10174 13 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Escherichia coli
Enzymes
Transfer RNA
Sulfur
10 Citations (Scopus)

Freeze-quench 57Fe-Mössbauer spectroscopy: Trapping reactive intermediates

Krebs, C. & Bollinger, J. M., Nov 1 2009, In : Photosynthesis research. 102, 2, p. 295-304 10 p.

Research output: Contribution to journalReview article

trapping
spectroscopy
Spectrum Analysis
Iron
Spectroscopy
52 Citations (Scopus)

Myo-Inositol oxygenase: A radical new pathway for O2 and C-H activation at a nonheme diiron cluster

Bollinger, Jr., J. M., Diao, Y., Matthews, M. L., Xing, G. & Krebs, C., Mar 24 2009, In : Dalton Transactions. 6, p. 905-914 10 p.

Research output: Contribution to journalArticle

Inositol Oxygenase
Inositol
Chemical activation
Cell signaling
Glucuronic Acid
115 Citations (Scopus)

Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2

Matthews, M. L., Neumann, C. S., Miles, L. A., Grove, T. L., Booker, S. J., Krebs, C., Walsh, C. T. & Bollinger, Jr., J. M., Oct 20 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 42, p. 17723-17728 6 p.

Research output: Contribution to journalArticle

Halogenation
Hydroxylation
Halogens
Mixed Function Oxygenases
Ligands
136 Citations (Scopus)

Substrate-triggered formation and remarkable stability of the C-H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2

Matthews, M. L., Krest, C. M., Barr, E. W., Vaillancourt, F. H., Walsh, C. T., Green, M. T., Krebs, C. & Bollinger, Jr., J. M., May 26 2009, In : Biochemistry. 48, 20, p. 4331-4343 13 p.

Research output: Contribution to journalArticle

Carrier Proteins
Amino Acids
Peptide Synthases
Substrates
Extended X ray absorption fine structure spectroscopy
2008
69 Citations (Scopus)

A catalytic di-heme bis-Fe(IV) intermediate, alternative to an Fe(IV)=0 porphyrin radical

Li, X., Fu, R., Lee, S., Krebs, C., Davidson, V. L. & Liu, A., Jun 24 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 25, p. 8597-8600 4 p.

Research output: Contribution to journalArticle

Porphyrins
Heme
Tryptophan
Protein Precursors
Protein Biosynthesis
26 Citations (Scopus)
Synechococcus
Photosystem I Protein Complex
Cyanobacteria
Sulfur
Iron
40 Citations (Scopus)

Branched activation- and catalysis-specific pathways for electron relay to the manganese/iron cofactor in ribonucleotide reductase from Chlamydia trachomatis

Jiang, W., Saleh, L., Barr, E. W., Xie, J., Gardner, M. M., Krebs, C. & Bollinger, Jr., J. M., Aug 19 2008, In : Biochemistry. 47, 33, p. 8477-8484 8 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Chlamydia trachomatis
Manganese
Catalysis
Iron
17 Citations (Scopus)

Characterization of quinolinate synthases from Escherichia coli, Mycobacterium tuberculosis, and Pyrococcus horikoshii indicates that [4Fe-4S] clusters are common cofactors throughout this class of enzymes

Saunders, A. H., Griffiths, A. E., Lee, K. H., Cicchillo, R. M., Tu, L., Stromberg, J. A., Krebs, C. & Booker, S. J., Oct 14 2008, In : Biochemistry. 47, 41, p. 10999-11012 14 p.

Research output: Contribution to journalArticle

Pyrococcus horikoshii
Quinolinic Acid
Mycobacterium tuberculosis
Escherichia coli
Enzymes
40 Citations (Scopus)

Formation and function of the manganese(iv)/iron(iii) cofactor in chlamydia trachomatis ribonucleotide reductase

Jiang, W., Yun, D., Saleh, L., Martin Bollinger, J. & Krebs, C., Dec 30 2008, In : Biochemistry. 47, 52, p. 13736-13744 9 p.

Research output: Contribution to journalReview article

Ribonucleotide Reductases
Chlamydia trachomatis
Manganese
Iron
Electrons
24 Citations (Scopus)

Importance of the maintenance pathway in the regulation of the activity of Escherichia coli ribonucleotide reductase

Hristova, D., Wu, C. H., Jiang, W., Krebs, C. & Stubbe, J., Apr 1 2008, In : Biochemistry. 47, 13, p. 3989-3999 11 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Escherichia coli
Maintenance
Arabinose
Titration

Intermediates in oxygen activation reactions of diiron enzymes

Krebs, C. & Huynh, B. H., Jan 2 2008, Iron Metabolism: Inorganic Biochemistry and Regulatory Mechanisms. wiley, p. 253-273 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

methane monooxygenase
Ribonucleotide Reductases
Ferritins
Chemical activation
Oxygen
74 Citations (Scopus)

In vitro characterization of AtsB, a radical SAM formylglycine-generating enzyme that contains three [4Fe-4S] clusters

Grove, T. L., Lee, K. H., St. Clair, J., Krebs, C. & Booker, S. J., Jul 15 2008, In : Biochemistry. 47, 28, p. 7523-7538 16 p.

Research output: Contribution to journalArticle

Sulfatases
Sulfides
Peptides
Enzymes
Proteins
28 Citations (Scopus)

Rapid and quantitative activation of Chlamydia trachomatis ribonucleotide reductase by hydrogen peroxide

Jiang, W., Xie, J., Nørgaard, H., Bollinger, Jr., J. M. & Krebs, C., Apr 15 2008, In : Biochemistry. 47, 15, p. 4477-4483 7 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Chlamydia trachomatis
Hydrogen Peroxide
Biochemistry
Chemical activation
99 Citations (Scopus)

Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily

Chatterjee, A., Li, Y., Zhang, Y., Grove, T. L., Lee, M., Krebs, C., Booker, S. J., Begley, T. P. & Ealick, S. E., Jan 1 2008, In : Nature Chemical Biology. 4, 12, p. 758-765 8 p.

Research output: Contribution to journalArticle

Thiamine
Phosphates
Ribonucleotides
pyrimidine
4-amino-5-hydroxymethyl-2-methylpyrimidine
48 Citations (Scopus)
Extended X ray absorption fine structure spectroscopy
Ribonucleotide Reductases
Chlamydia trachomatis
Structural analysis
Density functional theory
47 Citations (Scopus)
Ribonucleotide Reductases
Chlamydia trachomatis
Manganese
Protons
Iron
2007
139 Citations (Scopus)

A manganese(IV)/iron(III) cofactor in Chlamydia trachomatis ribonucleotide reductase

Jiang, W., Yun, D., Saleh, L., Barr, E. W., Xing, G., Hoffart, L. M., Maslak, M. A., Krebs, C. & Bollinger, Jr., J. M., May 25 2007, In : Science. 316, 5828, p. 1188-1191 4 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Chlamydia trachomatis
Manganese
Iron
Cysteine