• 9973 Citations
  • 57 h-Index
1995 …2023
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Research Output 1995 2019

2007
57 Citations (Scopus)

A manganese(IV)/iron(IV) intermediate in assembly of the manganese(IV)/iron(III) cofactor of Chlamydia trachomatis ribonucleotide reductase

Jiang, W., Hoffart, L. M., Krebs, C. & Bollinger, Jr., J. M., Jul 31 2007, In : Biochemistry. 46, 30, p. 8709-8716 8 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Chlamydia trachomatis
Reducing Agents
Pathogens
Manganese
28 Citations (Scopus)

AurF from Streptomyces thioluteus and a possible new family of manganese/iron oxygenases

Krebs, C., Matthews, M. L., Jiang, W. & Bollinger, Jr., J. M., Sep 18 2007, In : Biochemistry. 46, 37, p. 10413-10418 6 p.

Research output: Contribution to journalArticle

Oxygenases
Streptomyces
Manganese
Iron
Chlamydia trachomatis
61 Citations (Scopus)

CD and MCD of CytC3 and taurine dioxygenase: Role of the facial triad in α-KG-dependent oxygenases

Neidig, M. L., Brown, C. D., Light, K. M., Fujimori, D. G., Nolan, E. M., Price, J. C., Barr, E. W., Bollinger, Jr., J. M., Krebs, C., Walsh, C. T. & Solomon, E. I., Nov 21 2007, In : Journal of the American Chemical Society. 129, 46, p. 14224-14231 8 p.

Research output: Contribution to journalArticle

Dioxygenases
Oxygenases
Taurine
Catalytic Domain
Hydroxylation
128 Citations (Scopus)

Direct spectroscopic evidence for a high-spin Fe(IV) intermediate in tyrosine hydroxylase

Eser, B. E., Barr, E. W., Frantom, P. A., Saleh, L., Bollinger, Jr., J. M., Krebs, C. & Fitzpatrick, P. F., Sep 19 2007, In : Journal of the American Chemical Society. 129, 37, p. 11334-11335 2 p.

Research output: Contribution to journalArticle

Hydroxylation
Tyrosine 3-Monooxygenase
Aromatic Amino Acids
Dihydroxyphenylalanine
Mixed Function Oxygenases
104 Citations (Scopus)

Enzymatic C-H activation by metal-superoxo intermediates

Bollinger, Jr., J. M. & Krebs, C., Apr 1 2007, In : Current Opinion in Chemical Biology. 11, 2, p. 151-158 8 p.

Research output: Contribution to journalReview article

Metalloids
Metals
Chemical activation
Arsenals
Oxidation
17 Citations (Scopus)

Further insights into the spectroscopic properties, electronic structure, and kinetics of formation of the heme-peroxo-copper complex [(F 8TPP)FeIII-(O22-)-Cu II(TMPA)]+

Ghiladi, R. A., Chufán, E. E., Del Río, D., Solomon, E. I., Krebs, C., Boi, H. H., Huang, H. W., Moënne-Loccoz, P., Kaderli, S., Honecker, M., Zuberbühler, A. D., Marzilli, L., Cotter, R. J. & Karlin, K. D., May 14 2007, In : Inorganic chemistry. 46, 10, p. 3889-3902 14 p.

Research output: Contribution to journalArticle

Heme
Electronic structure
Copper
peroxides
electronic structure
562 Citations (Scopus)

Non-heme Fe(IV)-oxo intermediates

Krebs, C., Fujimori, D. G., Walsh, C. T. & Bollinger, Jr., J. M., Jul 1 2007, In : Accounts of Chemical Research. 40, 7, p. 484-492 9 p.

Research output: Contribution to journalArticle

Hydroxylation
Halogenation
Substrates
Iron
Oxygenases
25 Citations (Scopus)

Reaction of cytochrome P450 BM3 and peroxynitrite yields nitrosyl complex

Behan, R. K., Hoffart, L. M., Stone, K. L., Krebs, C. & Green, M. T., May 9 2007, In : Journal of the American Chemical Society. 129, 18, p. 5855-5859 5 p.

Research output: Contribution to journalArticle

Peroxynitrous Acid
Cytochrome P-450 Enzyme System
Proteins
Nitration
Density functional theory
127 Citations (Scopus)
Dioxygenases
Taurine
Escherichia coli
Ligands
Density functional theory
90 Citations (Scopus)

Spectroscopic evidence for a high-spin Br-Fe(IV)-OxO intermediate in the α-ketoglutarate-dependent halogenase CytC3 from Streptomyces

Fujimori, D. G., Barr, E. W., Matthews, M. L., Koch, G. M., Yonce, J. R., Walsh, C. T., Bollinger, Jr., J. M., Krebs, C. & Riggs-Gelasco, P. J., Nov 7 2007, In : Journal of the American Chemical Society. 129, 44, p. 13408-13409 2 p.

Research output: Contribution to journalArticle

X-Ray Absorption Spectroscopy
Dioxygenases
Reaction intermediates
X ray absorption spectroscopy
Streptomyces
49 Citations (Scopus)

SufR coordinates two [4Fe-4S]2+,1+ clusters and functions as a transcriptional repressor of the sufBCDS operon and an autoregulator of sufR in cyanobacteria

Shen, G., Balasubramanian, R., Wang, T., Wu, Y., Hoffart, L. M., Krebs, C., Bryant, D. A. & Golbeck, J. H., Nov 2 2007, In : Journal of Biological Chemistry. 282, 44, p. 31909-31919 11 p.

Research output: Contribution to journalArticle

Cyanobacteria
Operon
Binding Sites
Genes
Synechocystis
41 Citations (Scopus)
Ribonucleotide Reductases
Chlamydia trachomatis
Ground state
Proteins
Nucleotides
213 Citations (Scopus)

Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3

Galonić, D. P., Barr, E. W., Walsh, C. T., Bollinger, Jr., J. M. & Krebs, C., Jan 1 2007, In : Nature Chemical Biology. 3, 2, p. 113-116 4 p.

Research output: Contribution to journalArticle

Halogenation
Iron
Halogens
Streptomyces
Enzymes
39 Citations (Scopus)

YfaE, a ferredoxin involved in diferric-tyrosyl radical maintenance in Escherichia coli ribonucleotide reductase

Wu, C. H., Jiang, W., Krebs, C. & Stubbe, J., Oct 16 2007, In : Biochemistry. 46, 41, p. 11577-11588 12 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Ferredoxins
Biosynthetic Pathways
Titration
Escherichia coli
2006
38 Citations (Scopus)

A coupled dinuclear iron cluster that is perturbed by substrate binding in myo-inositol oxygenase

Xing, G., Hoffart, L. M., Diao, Y., Prabhu, K. S., Arner, R. J., Reddy, C. C., Krebs, C. & Bollinger, Jr., J. M., May 2 2006, In : Biochemistry. 45, 17, p. 5393-5401 9 p.

Research output: Contribution to journalArticle

Inositol Oxygenase
Inositol
acyl-(acyl-carrier-protein)desaturase
Iron
methane monooxygenase
10 Citations (Scopus)
Inositol Oxygenase
Electron Spin Resonance Spectroscopy
Inositol
Spectrum Analysis
Demonstrations
220 Citations (Scopus)

Direct spectroscopic detection of a C-H-cleaving high-spin Fe(IV) complex in a prolyl-4-hydroxylase

Hoffart, L. M., Barr, E. W., Guyer, R. B., Bollinger, Jr., J. M. & Krebs, C., Oct 3 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 40, p. 14738-14743 6 p.

Research output: Contribution to journalArticle

Prolyl Hydroxylases
Dioxygenases
Taurine
Hydroxylation
Enzymes
76 Citations (Scopus)

Evidence for basic ferryls in cytochromes P450

Behan, R. K., Hoffart, L. M., Stone, K. L., Krebs, C. & Green, M. T., Sep 6 2006, In : Journal of the American Chemical Society. 128, 35, p. 11471-11474 4 p.

Research output: Contribution to journalArticle

Camphor 5-Monooxygenase
Cytochrome P-450 Enzyme System
Density functional theory
Enzymes
Protonation
86 Citations (Scopus)

Evidence for C-H cleavage by an iron-superoxide complex in the glycol cleavage reaction catalyzed by myo-inositol oxygenase

Xing, G., Diao, Y., Hoffart, L. M., Barr, E. W., Prabhu, K. S., Arner, R. J., Reddy, C. C., Krebs, C. & Bollinger, Jr., J. M., Apr 18 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 16, p. 6130-6135 6 p.

Research output: Contribution to journalArticle

Inositol Oxygenase
Glycols
Inositol
Superoxides
Iron
68 Citations (Scopus)

Evidence for two ferryl species in chloroperoxidase compound II

Stone, K. L., Hoffart, L. M., Behan, R. K., Krebs, C. & Green, M. T., May 10 2006, In : Journal of the American Chemical Society. 128, 18, p. 6147-6153 7 p.

Research output: Contribution to journalArticle

Chloride Peroxidase
Density functional theory
Cryogenics
Absorption spectra
Spectrum Analysis
33 Citations (Scopus)

Identification of FX in the heliobacterial reaction center as a [4Fe-4S] cluster with an S = 3/2 ground spin state

Heinnickel, M., Agalarov, R., Svensen, N., Krebs, C. & Golbeck, J. H., May 30 2006, In : Biochemistry. 45, 21, p. 6756-6764 9 p.

Research output: Contribution to journalArticle

Dithionite
Genetic Recombination
Paramagnetic resonance
Electrons
Azotobacter vinelandii
38 Citations (Scopus)

Oxygen activation by a mixed-valent, diiron(II/III) cluster in the glycol cleavage reaction catalyzed by myo-inositol oxygenase

Xing, G., Barr, E. W., Diao, Y., Hoffart, L. M., Prabhu, K. S., Arner, R. J., Reddy, C. C., Krebs, C. & Bollinger, Jr., J. M., May 2 2006, In : Biochemistry. 45, 17, p. 5402-5412 11 p.

Research output: Contribution to journalArticle

Inositol Oxygenase
Glycols
Inositol
Chemical activation
Oxygen
99 Citations (Scopus)

Stalking intermediates in oxygen activation by iron enzymes: Motivation and method

Bollinger, Jr., J. M. & Krebs, C., Apr 1 2006, In : Journal of Inorganic Biochemistry. 100, 4, p. 586-605 20 p.

Research output: Contribution to journalReview article

Stalking
Enzyme Activation
Motivation
Iron
Chemical activation
2005
30 Citations (Scopus)

Escherichia coli quinolinate synthetase does indeed harbor a [4Fe-4S] cluster

Cicchillo, R. M., Tu, L., Stromberg, J. A., Hoffart, L. M., Krebs, C. & Booker, S. J., May 25 2005, In : Journal of the American Chemical Society. 127, 20, p. 7310-7311 2 p.

Research output: Contribution to journalArticle

Quinolinic Acid
Ports and harbors
Escherichia coli
Acids
Dihydroxyacetone Phosphate
113 Citations (Scopus)

Kinetic dissection of the catalytic mechanism of taurine: α- ketoglutarate dioxygenase (TauD) from Escherichia coli

Price, J. C., Barr, E. W., Hoffart, L. M., Krebs, C. & Bollinger, Jr., J. M., Jun 7 2005, In : Biochemistry. 44, 22, p. 8138-8147 10 p.

Research output: Contribution to journalArticle

Dioxygenases
Dissection
Taurine
Escherichia coli
Kinetics
128 Citations (Scopus)

Mechanism of taurine: α-ketoglutarate dioxygenase (TauD) from Escherichia coli

Bollinger, Jr., J. M., Price, J. C., Hoffart, L. M., Barr, E. W. & Krebs, C., Nov 4 2005, In : European Journal of Inorganic Chemistry. 21, p. 4245-4254 10 p.

Research output: Contribution to journalShort survey

Dioxygenases
Taurine
Escherichia coli
Hydroxylation
Substrates
92 Citations (Scopus)

NifS-mediated assembly of [4Fe-4S] clusters in the N- and C-terminal domains of the NifU Scaffold protein

Smith, A. D., Jameson, G. N. L., Dos Santos, P. C., Agar, J. N., Naik, S., Krebs, C., Frazzon, J., Dean, D. R., Huynh, B. H. & Johnson, M. K., Oct 4 2005, In : Biochemistry. 44, 39, p. 12955-12969 15 p.

Research output: Contribution to journalArticle

Scaffolds
Proteins
Nitrogenase
Protein S
Mutagenesis
98 Citations (Scopus)

Rapid freeze-quench 57Fe Mössbauer spectroscopy: Monitoring changes of an iron-containing active site during a biochemical reaction

Krebs, C., Price, J. C., Baldwin, J., Saleh, L., Green, M. T. & Bollinger, Jr., J. M., Feb 21 2005, In : Inorganic chemistry. 44, 4, p. 742-757 16 p.

Research output: Contribution to journalReview article

Iron
Spectroscopy
iron
Monitoring
spectroscopy
2004
109 Citations (Scopus)

A Role for Iron in an Ancient Carbonic Anhydrase

Tripp, B. C., Bell, C. B., Cruz, F., Krebs, C. & Ferry, J. G., Feb 20 2004, In : Journal of Biological Chemistry. 279, 8, p. 6683-6687 5 p.

Research output: Contribution to journalArticle

Carbonic Anhydrases
Cams
Iron
Enzymes
Methanosarcina
79 Citations (Scopus)

Characterization of the Cofactor Composition of Escherichia coli Biotin Synthase

Cosper, M. M., Jameson, G. N. L., Hernández, H. L., Krebs, C., Huynh, B. H. & Johnson, M. K., Feb 24 2004, In : Biochemistry. 43, 7, p. 2007-2021 15 p.

Research output: Contribution to journalArticle

Pyridoxal Phosphate
Escherichia coli
Cysteine Synthase
Chemical analysis
S-Adenosylmethionine
5 Citations (Scopus)
Dioxygenases
Biochemistry
Escherichia coli
Iron
alpha-ketoglutaric acid
1 Citation (Scopus)

Erratum: A role for iron in an ancient carbonic anhydrase (Journal of Biological Chemistry (2004) 279 (6683-6687)

Tripp, B. C., Bell, C. B., Cruz, F., Krebs, C. & Ferry, J. G., May 14 2004, In : Journal of Biological Chemistry. 279, 20, 1 p.

Research output: Contribution to journalComment/debate

Carbonic Anhydrases
Iron
97 Citations (Scopus)

Escherichia coli lipoyl synthase binds two distinct [4Fe-4S] clusters per polypeptide

Cicchillo, R. M., Lee, K. H., Baleanu-Gogonea, C., Nesbitt, N. M., Krebs, C. & Booker, S. J., Sep 21 2004, In : Biochemistry. 43, 37, p. 11770-11781 12 p.

Research output: Contribution to journalArticle

Escherichia coli
Sulfides
Peptides
S-Adenosylmethionine
Iron
30 Citations (Scopus)

Escherichia coli L-serine deaminase requires a [4Fe-4S] cluster in catalysis

Cicchillo, R. M., Baker, M. A., Schnitzer, E. J., Newman, E. B., Krebs, C. & Booker, S. J., Jul 30 2004, In : Journal of Biological Chemistry. 279, 31, p. 32418-32425 8 p.

Research output: Contribution to journalArticle

L-Serine Dehydratase
Catalysis
Serine
Escherichia coli
Iron
222 Citations (Scopus)

EXAFS spectroscopic evidence for an Fe=O unit in the Fe(IV) intermediate observed during oxygen activation by taurine:α-ketoglutarate dioxygenase

Riggs-Gelasco, P. J., Price, J. C., Guyer, R. B., Brehm, J. H., Barr, E. W., Bollinger, Jr., J. M. & Krebs, C., Jul 7 2004, In : Journal of the American Chemical Society. 126, 26, p. 8108-8109 2 p.

Research output: Contribution to journalArticle

Dioxygenases
Taurine
Iron
X-Ray Absorption Spectroscopy
Chemical activation
31 Citations (Scopus)

Use of a chemical trigger for electron transfer to characterize a precursor to cluster X in assembly of the iron-radical cofactor of Escherichia coli ribonucleotide reductase

Saleh, L., Krebs, C., Ley, B. A., Naik, S., Huynh, B. H. & Bollinger, Jr., J. M., May 25 2004, In : Biochemistry. 43, 20, p. 5953-5964 12 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Escherichia coli
Iron
Skatole
Electrons
2003
48 Citations (Scopus)

Ability of Tetrahydrobiopterin Analogues to Support Catalysis by Inducible Nitric Oxide Synthase: Formation of a Pterin Radical is Required for Enzyme Activity

Hurshman, A. R., Krebs, C., Edmondson, D. E. & Marletta, M. A., Nov 18 2003, In : Biochemistry. 42, 45, p. 13287-13303 17 p.

Research output: Contribution to journalArticle

Pterins
Enzyme activity
Nitric Oxide Synthase Type II
Catalysis
Catalyst supports
280 Citations (Scopus)
Dioxygenases
Hydroxylation
Taurine
Hydrogen
Chemical activation
46 Citations (Scopus)

Ground spin state variation in carboxylate-bridged tetranuclear [Fe2Mn2O2]8+ cores and a comparison with their [Fe4O2]8+ and [Mn4O2]18+ congeners

Chaudhuri, P., Rentschler, E., Birkelbach, F., Krebs, C., Bill, E., Weyhermüller, T. & Flörke, U., Jan 1 2003, In : European Journal of Inorganic Chemistry. 3, p. 541-555 15 p.

Research output: Contribution to journalArticle

Ground state
Acetates
Benzoates
Ions
Ligands
36 Citations (Scopus)

Structural Characterization of the Peroxodiiron(III) Intermediate Generated during Oxygen Activation by the W48A/D84E Variant of Ribonucleotide Reductase Protein R2 from Escherichia coli

Baldwin, J., Krebs, C., Saleh, L., Stelling, M., Huynh, B. H., Bollinger, Jr., J. M. & Riggs-Gelasco, P., Nov 18 2003, In : Biochemistry. 42, 45, p. 13269-13279 11 p.

Research output: Contribution to journalArticle

methane monooxygenase
Ribonucleotide Reductases
Escherichia coli Proteins
Escherichia coli
Chemical activation
456 Citations (Scopus)
Dioxygenases
Taurine
Escherichia coli
Iron
Enzymes
2002
104 Citations (Scopus)

Coordination of adenosylmethionine to a unique iron site of the [4Fe-4S] of pyruvate formate-lyase activating enzyme: A Mössbauer spectroscopic study

Krebs, C., Broderick, W. E., Henshaw, T. F., Broderick, J. B. & Huynh, B. H., Feb 12 2002, In : Journal of the American Chemical Society. 124, 6, p. 912-913 2 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Iron
Enzymes
Isomers
Catalysis
11 Citations (Scopus)

Demonstration of peroxodiferric intermediate in M-ferritin ferroxidase reaction using rapid freeze-quench mössbauer, resonance raman, and XAS spectroscopies

Krebs, C., Edmondson, D. E. & Huynh, B. H., Jan 1 2002, Methods in Enzymology. Academic Press Inc., p. 436-454 19 p. (Methods in Enzymology; vol. 354).

Research output: Chapter in Book/Report/Conference proceedingChapter

Ceruloplasmin
Ferritins
Demonstrations
Spectroscopy
26 Citations (Scopus)

Exchange coupling constant J of peroxodiferric reaction intermediates determined by Mössbauer spectroscopy

Krebs, C., Bollinger, Jr., J. M., Theil, E. C. & Huynh, B. H., Dec 1 2002, In : Journal of Biological Inorganic Chemistry. 7, 7-8, p. 863-869 7 p.

Research output: Contribution to journalArticle

Reaction intermediates
Exchange coupling
Ferritins
Spectrum Analysis
Spectroscopy
26 Citations (Scopus)

Facile electron transfer during formation of cluster X and kinetic competence of X for tyrosyl radical production in protein R2 of ribonucleotide reductase from mouse

Yun, D., Krebs, C., Gupta, G. P., Iwig, D. F., Huynh, B. H. & Bollinger, Jr., J. M., Jan 22 2002, In : Biochemistry. 41, 3, p. 981-990 10 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Mental Competency
Electrons
Oxygen
Escherichia coli
54 Citations (Scopus)

Functional mimic of dioxygen-activating centers in non-heme diiron enzymes: Mechanistic implications of paramagnetic intermediates in the reactions between diiron(II) complexes and dioxygen

Lee, D., Pierce, B., Krebs, C., Hendrich, M. P., Huynh, B. H. & Lippard, S. J., Apr 17 2002, In : Journal of the American Chemical Society. 124, 15, p. 3993-4007 15 p.

Research output: Contribution to journalArticle

Paramagnetic resonance
Enzymes
Oxygen
Benzoates
Biological systems
62 Citations (Scopus)

Stoichiometric production of hydrogen peroxide and parallel formation of ferric multimers through decay of the diferric-peroxo complex, the first detectable intermediate in ferritin mineralization

Jameson, G. N. L., Jin, W., Krebs, C., Perreira, A. S., Tavares, P., Liu, X., Theil, E. C. & Huynh, B. H., Nov 12 2002, In : Biochemistry. 41, 45, p. 13435-13443 9 p.

Research output: Contribution to journalArticle

Ceruloplasmin
Ferritins
Hydrogen Peroxide
Apoferritins
Minerals
2001
73 Citations (Scopus)

Dioxygen reactivity of mononuclear heme and copper components yielding a high-spin heme-peroxo-Cu complex [3]

Ghiladi, R. A., Hatwell, K. R., Karlin, K. D., Huang, H. W., Moënne-Loccoz, P., Krebs, C., Huynh, B. H., Marzilli, L. A., Cotter, R. J., Kaderli, S. & Zuberbühler, A. D., Oct 3 2001, In : Journal of the American Chemical Society. 123, 25, p. 6183-6184 2 p.

Research output: Contribution to journalLetter

Ferric Compounds
Organometallic Compounds
Magnetic resonance spectroscopy
Molecular Conformation
Molecular Models
188 Citations (Scopus)

IscA, an alternate scaffold for Fe-S cluster biosynthesis

Krebs, C., Agar, J. N., Smith, A. D., Frazzon, J., Dean, D. R., Huynh, B. H. & Johnson, M. K., Nov 20 2001, In : Biochemistry. 40, 46, p. 14069-14080 12 p.

Research output: Contribution to journalArticle

Biosynthesis
Scaffolds
Ions
Protein S
Sulfur
67 Citations (Scopus)

Rational reprogramming of the R2 subunit of Escherichia coli ribonucleotide reductase into a self-hydroxylating monooxygenase

Baldwin, J., Voegtli, W. C., Khidekel, N., Mönne-Loccoz, P., Krebs, C., Pereira, A. S., Ley, B. A., Huynh, B. H., Loehr, T. M., Riggs-Gelasco, P. J., Rosenzweig, A. C. & Bollinger, Jr., J. M., Oct 1 2001, In : Journal of the American Chemical Society. 123, 29, p. 7017-7030 14 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
methane monooxygenase
Mixed Function Oxygenases
Hydroxylation
Escherichia coli