Research Output per year
Personal profile
Research interests
Dr. Chandrika Gowda is a board-certified hematologist/oncologist who has strong commitment to research in childhood cancer, including leukemia and neuroblastoma. Her major research project is to study Role of Ikaros tumor suppressor and pro-oncogenic casein Kinase II(CK2) in leukemogenesis and drug resistance. Dr.Gowda's current work is focused on targeting CK2 for treatment of hematological malignancies.
Her most notable work, published in Blood in 2015, established the novel approach of using specific CK2 inhibitors for treatment of high-risk B cell lineage leukemia using PDX models. She has presented her work at various national and international scientific forums and gained national recognition as an outstanding young investigator.
Dr. Gowda's research is currently supported by several extramural grants. She has also authored several chapters and review articles related to leukemia, CK2 and Ikaros. Her other projects are focused on designing novel therapeutic strategies for treatment of high risk neuroblastoma, which is the most common abdominal solid tumor in young children, with poor prognosis.
Education/Academic qualification
Pediatric Hematology/Oncology, Clinical Fellowship, Penn State Health Milton S. Hershey Medical Center
2010 → 2013
Pediatrics, Residency, Monmouth Medical Center
2007 → 2010
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Casein Kinase II
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Transcription
Chemical Compounds
Network
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Research Output 2013 2019
Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity
Ding, Y., Zhang, B., Payne, J. L., Song, C., Ge, Z., Gowda, C., Iyer, S., Dhanyamraju, P. K., Dorsam, G., Reeves, M. E., Desai, D., Huang, S., Payne, K. J., Yue, F. & Dovat, S., Jan 1 2019, In : Leukemia.Research output: Contribution to journal › Article
Open Access
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
T-Lymphocytes
Epigenomics
Chromatin
Cell Differentiation
11
Citations
(Scopus)
Casein Kinase II (CK2), Glycogen Synthase Kinase-3 (GSK-3) and Ikaros mediated regulation of leukemia
Gowda, C., Soliman, M., Kapadia, M., Ding, Y., Payne, K. & Dovat, S., Aug 1 2017, In : Advances in Biological Regulation. 65, p. 16-25 10 p.Research output: Contribution to journal › Review article
Phosphatidylinositol 3-Kinase
Glycogen Synthase Kinase 3
Casein Kinase II
Leukemia
Phosphorylation
7
Citations
(Scopus)
Casein kinase II (CK2) as a therapeutic target for hematological malignancies
Gowda, C., Sachdev, M., Muthusami, S., Kapadia, M., Petrovic-Dovat, L., Hartman, M., Ding, Y., Song, C., Payne, J. L., Tan, B. & Dovat, S., Jan 1 2017, In : Current Pharmaceutical Design. 23, 1, p. 95-107 13 p.Research output: Contribution to journal › Review article
Casein Kinase II
Hematologic Neoplasms
Leukemia
Neoplasms
Therapeutics
15
Citations
(Scopus)
Regulation of cellular proliferation in acute lymphoblastic leukemia by Casein Kinase II (CK2) and Ikaros
Gowda, C., Song, C., Kapadia, M., Payne, J. L., Hu, T., Ding, Y. & Dovat, S., Jan 1 2017, In : Advances in Biological Regulation. 63, p. 71-80 10 p.Research output: Contribution to journal › Review article
Casein Kinase II
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Cell Proliferation
Ikaros Transcription Factor
14
Citations
(Scopus)
Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia
Song, C., Pan, X., Ge, Z., Gowda, C., Ding, Y., Li, H., Li, Z., Yochum, G., Muschen, M., Li, Q., Payne, K. J. & Dovat, S., Jun 1 2016, In : Leukemia. 30, 6, p. 1436-1440 5 p.Research output: Contribution to journal › Letter