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Personal profile

Research interests

Dr. Chandrika Gowda is a board-certified hematologist/oncologist who has strong commitment to research in childhood cancer, including leukemia and neuroblastoma. Her major research project is to study Role of Ikaros tumor suppressor and pro-oncogenic casein Kinase II(CK2) in leukemogenesis and drug resistance. Dr.Gowda's current work is focused on targeting CK2 for treatment of hematological malignancies.

Her most notable work, published in Blood in 2015, established the novel approach of using specific CK2 inhibitors for treatment of high-risk B cell lineage leukemia using PDX models. She has presented her work at various national and international scientific forums and gained national recognition as an outstanding young investigator.

Dr. Gowda's research is currently supported by several extramural grants. She has also authored several chapters and review articles related to leukemia, CK2 and Ikaros. Her other projects are focused on designing novel therapeutic strategies for treatment of high risk neuroblastoma, which is the most common abdominal solid tumor in young children, with poor prognosis.

Education/Academic qualification

Pediatric Hematology/Oncology, Clinical Fellowship, Penn State Health Milton S. Hershey Medical Center

20102013

Pediatrics, Residency, Monmouth Medical Center

20072010

Fingerprint Dive into the research topics where Chandrika Gowda is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 24 Similar Profiles
Casein Kinase II Medicine & Life Sciences
Leukemia Medicine & Life Sciences
Precursor Cell Lymphoblastic Leukemia-Lymphoma Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Genes Chemical Compounds
Cell Proliferation Medicine & Life Sciences
Phosphatidylinositol 3-Kinase Medicine & Life Sciences
Epigenomics Medicine & Life Sciences

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Research Output 2013 2019

  • 144 Citations
  • 7 h-Index
  • 4 Article
  • 4 Review article
  • 1 Chapter
  • 1 Letter

Cellular signaling and epigenetic regulation of gene expression in leukemia

Gowda, C., Song, C., Ding, Y., Iyer, S., Dhanyamraju, P., McGrath, M., Bamme, Y., Soliman, M., Kane, S., Payne, J. L. & Dovat, S., Jan 1 2019, (Accepted/In press) In : Advances in Biological Regulation. 100665.

Research output: Contribution to journalReview article

Open Access
Gene Expression Regulation
Epigenomics
Leukemia
Ikaros Transcription Factor
Gene Expression
1 Citation (Scopus)

Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity

Ding, Y., Zhang, B., Payne, J. L., Song, C., Ge, Z., Gowda, C., Iyer, S., Dhanyamraju, P. K., Dorsam, G., Reeves, M. E., Desai, D., Huang, S., Payne, K. J., Yue, F. & Dovat, S., Jan 1 2019, In : Leukemia.

Research output: Contribution to journalArticle

Open Access
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
T-Lymphocytes
Epigenomics
Chromatin
Cell Differentiation
13 Citations (Scopus)

Casein Kinase II (CK2), Glycogen Synthase Kinase-3 (GSK-3) and Ikaros mediated regulation of leukemia

Gowda, C., Soliman, M., Kapadia, M., Ding, Y., Payne, K. & Dovat, S., Aug 1 2017, In : Advances in Biological Regulation. 65, p. 16-25 10 p.

Research output: Contribution to journalReview article

Phosphatidylinositol 3-Kinase
Glycogen Synthase Kinase 3
Casein Kinase II
Leukemia
Phosphorylation
8 Citations (Scopus)

Casein kinase II (CK2) as a therapeutic target for hematological malignancies

Gowda, C., Sachdev, M., Muthusami, S., Kapadia, M., Petrovic-Dovat, L., Hartman, M., Ding, Y., Song, C., Payne, J. L., Tan, B. & Dovat, S., Jan 1 2017, In : Current Pharmaceutical Design. 23, 1, p. 95-107 13 p.

Research output: Contribution to journalReview article

Casein Kinase II
Hematologic Neoplasms
Leukemia
Neoplasms
Therapeutics
16 Citations (Scopus)

Regulation of cellular proliferation in acute lymphoblastic leukemia by Casein Kinase II (CK2) and Ikaros

Gowda, C., Song, C., Kapadia, M., Payne, J. L., Hu, T., Ding, Y. & Dovat, S., Jan 1 2017, In : Advances in Biological Regulation. 63, p. 71-80 10 p.

Research output: Contribution to journalReview article

Casein Kinase II
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Cell Proliferation
Ikaros Transcription Factor