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1979 …2019
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Research Output 1979 2019

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Article
2019
1 Citation (Scopus)

Association between inflammatory cytokine levels and anemia during Plasmodium falciparum and Plasmodium vivax infections in Mangaluru: A Southwestern Coastal Region of India

Punnath, K., Dayanand, K. K., Chandrashekhar, V. N., Achur, R. N., Kakkilaya, S. B., Ghosh, S. K., Kumari, S. N. & Gowda, C., Jul 1 2019, In : Tropical Parasitology. 9, 2, p. 98-107 10 p.

Research output: Contribution to journalArticle

Plasmodium vivax
Plasmodium falciparum
Malaria
Anemia
India

Malarial anemia among pregnant women in the south-western coastal city of Mangaluru in India

Chandrashekar, V. N., Punnath, K., Dayanand, K. K., Achur, R. N., Kakkilaya, S. B., Jayadev, P., Kumari, S. N. & Gowda, C., Jan 1 2019, In : Informatics in Medicine Unlocked. 15, 100159.

Research output: Contribution to journalArticle

Open Access
Malaria
Anemia
Pregnant Women
India
Pregnancy

Malaria severity in Mangaluru city in the southwestern coastal region of India

Dayanand, K. K., Kishore, P., Chandrashekar, V., Achur, R. N., Ghosh, S. K., Kakkilaya, S. B., Kumari, S. N., Tiwari, S., Boloor, A., Devi, R. & Gowda, C., Jan 1 2019, In : American Journal of Tropical Medicine and Hygiene. 100, 2, p. 275-279 5 p.

Research output: Contribution to journalArticle

Malaria
India
Plasmodium falciparum
Plasmodium vivax
Vivax Malaria
2018
4 Citations (Scopus)
Interleukin-4
Dendritic Cells
Malaria
Interleukin-12
Proteins
3 Citations (Scopus)

Drug resistance genes: Pvcrt-o and pvmdr-1 polymorphism in patients from malaria endemic South Western Coastal Region of India

Joy, S., Mukhi, B., Ghosh, S. K., Achur, R. N., Gowda, D. C. & Surolia, N., Jan 19 2018, In : Malaria journal. 17, 1, 40.

Research output: Contribution to journalArticle

Plasmodium vivax
Drug Resistance
Malaria
India
Chloroquine
1 Citation (Scopus)

Presence of novel triple mutations in the pvdhfr from Plasmodium vivax in Mangaluru city area in the southwestern coastal region of India

Joy, S., Ghosh, S. K., Achur, R. N., Gowda, C. & Surolia, N., Apr 16 2018, In : Malaria journal. 17, 1, 167.

Research output: Contribution to journalArticle

Plasmodium vivax
Tetrahydrofolate Dehydrogenase
India
Mutation
Plasmodium falciparum
2017
3 Citations (Scopus)

CD36 receptor regulates malaria-induced immune responses primarily at early blood stage infection contributing to parasitemia control and resistance to mortality

Thylur, R. P., Wu, X., Gowda, N. M., Punnath, K., Neelgund, S. E., Febbraio, M. & Gowda, C., Jun 2 2017, In : Journal of Biological Chemistry. 292, 22, p. 9394-9408 15 p.

Research output: Contribution to journalArticle

Parasitemia
Malaria
Blood
Mortality
Cytokines
7 Citations (Scopus)

Malaria prevalence in Mangaluru city area in the southwestern coastal region of India

Dayanand, K. K., Punnath, K., Chandrashekar, V., Achur, R. N., Kakkilaya, S. B., Ghosh, S. K., Kumari, S. & Gowda, C., Dec 19 2017, In : Malaria journal. 16, 1, 492.

Research output: Contribution to journalArticle

Malaria
India
Infection
Incidence
Demography
2 Citations (Scopus)
Parasite Load
T-cells
Malaria
Molecules
Malaria control
2016
1 Citation (Scopus)

Case report: Malaria transmission under an unusual circumstance causing death in two siblings

Dayanand, K. K., Punnath, K., Chandrashekar, V. N., Kakkilaya, S. B., Ghosh, S. K., Tiwari, S. N., Achur, R. N., Kadambi, S. S. & Gowda, C., Jul 1 2016, In : American Journal of Tropical Medicine and Hygiene. 95, 1, p. 155-157 3 p.

Research output: Contribution to journalArticle

Malaria
Siblings
India
Cerebral Malaria
Fatal Outcome
7 Citations (Scopus)

Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model

Yao, X., Wu, J., Lin, M., Sun, W., He, X., Gowda, C., Bolland, S., Long, C. A., Wang, R. & Su, X. Z., Oct 2016, In : PLoS pathogens. 12, 10, e1005930.

Research output: Contribution to journalArticle

Interferon Type I
Malaria
Rodentia
Parasites
Erythrocytes
17 Citations (Scopus)

Inflammatory cytokine and humoral responses to plasmodium falciparum glycosylphosphatidylinositols correlates with malaria immunity and pathogenesis

Mbengue, B., Niang, B., Sylla Niang, M., Varela, M. L., Fall, B., Fall, M. M., Ndiaye Diallo, R., Diatta, B., Gowda, C., Dieye, A. & Perraut, R., Jan 1 2016, In : Immunity Inflammation and Disease. 4, 1, p. 24-34 11 p.

Research output: Contribution to journalArticle

Open Access
Glycosylphosphatidylinositols
Plasmodium falciparum
Malaria
Immunity
Cytokines
2015
11 Citations (Scopus)

A non-cytotoxic N-dehydroabietylamine derivative with potent antimalarial activity

Sadashiva, M. P., Gowda, R., Wu, X., Inamdar, G. S., Kuzu, O. F., Rangappa, K. S., Robertson, G. & Gowda, C., Aug 1 2015, In : Experimental Parasitology. 155, p. 68-73 6 p.

Research output: Contribution to journalArticle

Antimalarials
Inhibitory Concentration 50
Parasites
Diterpenes
Malaria
3 Citations (Scopus)

Synthesis, antimalarial activity, and target binding of dibenzazepine-tethered isoxazolines

Vinay Kumar, K. S., Lingaraju, G. S., Bommegowda, Y. K., Vinayaka, A. C., Bhat, P., Pradeepa Kumara, C. S., Rangappa, K. S., Gowda, C. & Sadashiva, M. P., Jan 1 2015, In : RSC Advances. 5, 110, p. 90408-90421 14 p.

Research output: Contribution to journalArticle

Antimalarials
Chloroquine
Dibenzazepines
Pharmaceutical Preparations
Enzymes
2014
20 Citations (Scopus)

Facile synthesis of antimalarial 1,2-disubstituted 4-quinolones from 1,3-bisaryl-monothio-1,3-diketones

Vinayaka, A. C., Sadashiva, M. P., Wu, X., Biryukov, S. S., Stoute, J., Rangappa, K. S. & Gowda, C., Nov 14 2014, In : Organic and Biomolecular Chemistry. 12, 42, p. 8555-8561 7 p.

Research output: Contribution to journalArticle

4-Quinolones
Antimalarials
Plasmodium falciparum
synthesis
Inhibitory Concentration 50
8 Citations (Scopus)

Targeted disruption of a ring-infected erythrocyte surface antigen (RESA)-like export protein gene in Plasmodium falciparum confers stable chondroitin 4-sulfate cytoadherence capacity

Goel, S., Muthusamy, A., Miao, J., Cui, L., Salanti, A., Winzeler, E. A. & Gowda, C., Dec 5 2014, In : Journal of Biological Chemistry. 289, 49, p. 34408-34421 14 p.

Research output: Contribution to journalArticle

Chondroitin Sulfates
Plasmodium falciparum
Surface Antigens
Erythrocytes
Parasites
2013
4 Citations (Scopus)

An alternative protocol for Plasmodium falciparum culture synchronization and a new method for synchrony confirmation

Childs, R. A., Miao, J., Gowda, C. & Cui, L., Nov 6 2013, In : Malaria journal. 12, 1, 386.

Research output: Contribution to journalArticle

Plasmodium falciparum
Parasites
Schizonts
Centrifugation
Plasmodium
15 Citations (Scopus)

CD36 Contributes to Malaria Parasite-Induced Pro-Inflammatory Cytokine Production and NK and T Cell Activation by Dendritic Cells

Gowda, N. M., Wu, X., Kumar, S., Febbraio, M. & Gowda, C., Oct 28 2013, In : PloS one. 8, 10, e77604.

Research output: Contribution to journalArticle

T-cells
natural killer cells
dendritic cells
Natural Killer Cells
malaria

Subdural haematoma in Plasmodium falciparum and Plasmodium vivax mixed infection presenting multiple clinical complications

Devaraju, P. B., Padukone, S., Veerabhadraiah, S. R., Ramachandrappa, V. S., Panji, N., Chandrappagowda, P. B., Rudrappa, M. B., Gowda, C. & Achur, R. N., Dec 1 2013, In : Journal of Medical Microbiology. 62, PART 12, p. 1902-1904 3 p.

Research output: Contribution to journalArticle

Plasmodium vivax
Subdural Hematoma
Plasmodium falciparum
Coinfection
Schizonts
2012
12 Citations (Scopus)

CD36 modulates proinflammatory cytokine responses to Plasmodium falciparum glycosylphosphatidylinositols and merozoites by dendritic cells

Kumar, S., Gowda, N. M., Wu, X., Gowda, R. N. & Gowda, C., Jul 1 2012, In : Parasite Immunology. 34, 7, p. 372-382 11 p.

Research output: Contribution to journalArticle

Merozoites
Glycosylphosphatidylinositols
Plasmodium falciparum
Dendritic Cells
Toll-Like Receptor 2
3 Citations (Scopus)

Iκb-ζ plays an important role in the ERK-dependent dysregulation of malaria parasite GPI-induced IL-12 expression

Zhu, J., Weinberg, R., Wu, X., Gowda, N. M., Muta, T. & Gowda, C., Jan 1 2012, In : IUBMB Life. 64, 2, p. 187-193 7 p.

Research output: Contribution to journalArticle

Glycosylphosphatidylinositols
Extracellular Signal-Regulated MAP Kinases
Interleukin-12
Malaria
Parasites
48 Citations (Scopus)

Plasmodium falciparum histones induce endothelial proinflammatory response and barrier dysfunction

Gillrie, M. R., Lee, K., Gowda, C., Davis, S. P., Monestier, M., Cui, L., Hien, T. T., Day, N. P. J. & Ho, M., Jan 1 2012, In : American Journal of Pathology. 180, 3, p. 1028-1039 12 p.

Research output: Contribution to journalArticle

Plasmodium falciparum
Histones
Parasites
Nucleosomes
Falciparum Malaria
9 Citations (Scopus)

Targeting Toll-like receptors by chloroquine protects mice from experimental cerebral malaria

Zhu, X., Pan, Y., Li, Y., Jiang, Y., Shang, H., Gowda, C., Cui, L. & Cao, Y., Aug 1 2012, In : International Immunopharmacology. 13, 4, p. 392-397 6 p.

Research output: Contribution to journalArticle

Cerebral Malaria
Toll-Like Receptors
Chloroquine
Dendritic Cells
Plasmodium berghei
52 Citations (Scopus)

TLR9 and MyD88 are crucial for the development of protective immunity to malaria

Gowda, N. M., Wu, X. & Gowda, C., May 15 2012, In : Journal of Immunology. 188, 10, p. 5073-5085 13 p.

Research output: Contribution to journalArticle

Malaria
Immunity
Anti-Inflammatory Agents
Cytokines
Cellular Immunity
2011
6 Citations (Scopus)

Plasmodium falciparum: Differential merozoite dose requirements for maximal production of various inflammatory cytokines

Wu, X., Gowda, N. M. & Gowda, C., Jan 1 2011, In : Experimental Parasitology. 127, 1, p. 202-207 6 p.

Research output: Contribution to journalArticle

Merozoites
Plasmodium falciparum
Cytokines
Ligands
Interleukin-12
36 Citations (Scopus)
Toll-Like Receptor 2
Glycosylphosphatidylinositols
Plasmodium falciparum
Fatty Acids
Macrophages
34 Citations (Scopus)
nucleosomes
Nucleosomes
Plasmodium falciparum
histones
Histones
2010
18 Citations (Scopus)

Dual stage synthesis and crucial role of cytoadherence-linked asexual gene 9 in the surface expression of malaria parasite var proteins

Goel, S., Valiyaveettil, M., Achur, R. N., Goyal, A., Mattei, D., Salanti, A., Trenholme, K. R., Gardiner, D. L. & Gowda, C., Sep 21 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 38, p. 16643-16648 6 p.

Research output: Contribution to journalArticle

Malaria
Parasites
Erythrocytes
Genes
Proteins
9 Citations (Scopus)

Neutralization of malaria glycosylphosphatidylinositol in vitro by serum IgG from malaria-exposed individuals

De Souza, J. B., Runglall, M., Corran, P. H., Okell, L. C., Kumar, S., Gowda, C., Couper, K. N. & Riley, E. M., Sep 1 2010, In : Infection and Immunity. 78, 9, p. 3920-3929 10 p.

Research output: Contribution to journalArticle

Glycosylphosphatidylinositols
Malaria
Immunoglobulin G
Serum
Plasmodium falciparum
96 Citations (Scopus)

Protein-DNA complex is the exclusive malaria parasite component that activates dendritic cells and triggers innate immune responses

Wu, X., Gowda, N. M., Kumar, S. & Gowda, C., Apr 15 2010, In : Journal of Immunology. 184, 8, p. 4338-4348 11 p.

Research output: Contribution to journalArticle

Innate Immunity
Dendritic Cells
Malaria
Parasites
DNA
18 Citations (Scopus)

Subdomain 3 of Plasmodium falciparum VAR2CSA DBL3x is identified as a minimal chondroitin sulfate A-binding region

Singh, K., Gitti, R. K., Diouf, A., Zhou, H., Gowda, C., Miura, K., Ostazeski, S. A., Fairhurst, R. M., Garboczi, D. N. & Long, C. A., Aug 6 2010, In : Journal of Biological Chemistry. 285, 32, p. 24855-24862 8 p.

Research output: Contribution to journalArticle

Chondroitin Sulfates
Plasmodium falciparum
Malaria
Pregnancy
Mali
2009
47 Citations (Scopus)

C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: Potential implications for placental malaria

Conroy, A., Serghides, L., Finney, C., Owino, S. O., Kumar, S., Gowda, C., Liles, W. C., Moore, J. M. & Kain, K. C., Mar 24 2009, In : PloS one. 4, 3, e4953.

Research output: Contribution to journalArticle

Anaphylatoxin C5a Receptor
malaria
Malaria
Chemical activation
Angiogenesis Inducing Agents
63 Citations (Scopus)

CD36 and TLR interactions in inflammation and phagocytosis: Implications for malaria

Erdman, L. K., Cosio, G., Helmers, A. J., Gowda, C., Grinstein, S. & Kain, K. C., Nov 15 2009, In : Journal of Immunology. 183, 10, p. 6452-6459 8 p.

Research output: Contribution to journalArticle

Phagocytosis
Malaria
Erythrocytes
Inflammation
Macrophages
28 Citations (Scopus)

MAPK-activated protein kinase 2 differentially regulates plasmodium falciparum glycosylphosphatidylinositol-inducedproduction of tumor necrosis Factor-α and interleukin-12 in macrophages

Zhu, J., Wu, X., Goel, S., Gowda, N. M., Kumar, S., Gowda, K., Mishra, G., Weinberg, R., Li, G., Gaestel, M., Muta, T. & Gowda, C., Jun 5 2009, In : Journal of Biological Chemistry. 284, 23, p. 15756-15761 6 p.

Research output: Contribution to journalArticle

Glycosylphosphatidylinositols
Macrophages
Plasmodium falciparum
Interleukin-12
Protein Kinases
3 Citations (Scopus)
Chondroitin
Chondroitin Sulfates
Proteoglycans
Plasmodium falciparum
Chondroitin Sulfate Proteoglycans
51 Citations (Scopus)

Rosiglitazone modulates the innate immune response to plasmodium falciparum infection and improves outcome in experimental cerebral malaria

Serghides, L., Patel, S. N., Ayi, K., Lu, Z., Gowda, C., Liles, W. C. & Kain, K. C., May 15 2009, In : Journal of Infectious Diseases. 199, 10, p. 1536-1545 10 p.

Research output: Contribution to journalArticle

rosiglitazone
Cerebral Malaria
Plasmodium falciparum
Innate Immunity
Malaria
10 Citations (Scopus)
Cerebral Malaria
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Toll-Like Receptors
Macrophages
Cytokines
2008
1 Citation (Scopus)

Binding affinity of Plasmodium falciparum-infected erythrocytes from infected placentas and laboratory selected strains to chondroitin 4-sulfate

Achur, R. N., Muthusamy, A., Madhunapantula, S. R. V. & Gowda, C., May 1 2008, In : Molecular and biochemical parasitology. 159, 1, p. 79-84 6 p.

Research output: Contribution to journalArticle

Chondroitin Sulfates
Plasmodium falciparum
Placenta
Parasites
Erythrocytes
76 Citations (Scopus)

C5 deficiency and C5a or C5aR blockade protects against cerebral malaria

Patel, S. N., Berghout, J., Lovegrove, F. E., Ayi, K., Conroy, A., Serghides, L., Min-Oo, G., Gowda, C., Sarma, J. V., Rittirsch, D., Ward, P. A., Liles, W. C., Gros, P. & Kain, K. C., May 12 2008, In : Journal of Experimental Medicine. 205, 5, p. 1133-1143 11 p.

Research output: Contribution to journalArticle

Anaphylatoxin C5a Receptor
Cerebral Malaria
Plasmodium berghei
Alleles
Glycosylphosphatidylinositols
6 Citations (Scopus)

Effect of GPI anchor moiety on the immunogenicity of DNA plasmids encoding the 19-kDa C-terminal portion of Plasmodium falciparum MSP-1

Li, G., Basagoudanavar, S. H. & Gowda, C., Jun 1 2008, In : Parasite Immunology. 30, 6-7, p. 315-322 8 p.

Research output: Contribution to journalArticle

Merozoite Surface Protein 1
Glycosylphosphatidylinositols
Plasmodium falciparum
Plasmids
DNA
23 Citations (Scopus)

Structural interactions in chondroitin 4-sulfate mediated adherence of Plasmodium falciparum infected erythrocytes in human placenta during pregnancy-associated malaria

Achur, R. N., Kakizaki, I., Goel, S., Kojima, K., Madhunapantula, S. V., Goyal, A., Ohta, M., Kumar, S., Takagaki, K. & Gowda, C., Nov 25 2008, In : Biochemistry. 47, 47, p. 12635-12643 9 p.

Research output: Contribution to journalArticle

Chondroitin Sulfates
Plasmodium falciparum
Placenta
Malaria
Blood
71 Citations (Scopus)

Structure of the DBL3x domain of pregnancy-associated malaria protein VAR2CSA complexed with chondroitin sulfate A

Singh, K., Gittis, A. G., Nguyen, P., Gowda, C., Miller, L. H. & Garboczi, D. N., Sep 1 2008, In : Nature Structural and Molecular Biology. 15, 9, p. 932-938 7 p.

Research output: Contribution to journalArticle

Chondroitin Sulfates
Malaria
Pregnancy
Proteins
Binding Sites
2007
40 Citations (Scopus)

Chondroitin sulfate proteoglycan but not hyaluronic acid is the receptor for the adherence of Plasmodium falciparum-infected erythrocytes in human placenta, and infected red blood cell adherence up-regulates the receptor expression

Muthusamy, A., Achur, R. N., Valiyaveettil, M., Botti, J. J., Taylor, D. W., Leke, R. F. & Gowda, C., Jan 1 2007, In : American Journal of Pathology. 170, 6, p. 1989-2000 12 p.

Research output: Contribution to journalArticle

Chondroitin Sulfate Proteoglycans
Hyaluronic Acid
Plasmodium falciparum
Placenta
Up-Regulation
10 Citations (Scopus)
Plasmodium falciparum
Cell Cycle
Chondroitin Sulfates
Cell Count
Erythrocytes
55 Citations (Scopus)

Disruption of CD36 impairs cytokine response to Plasmodium falciparum glycosylphosphatidylinositol and confers susceptibility to severe and fatal malaria in vivo

Patel, S. N., Lu, Z., Ayi, K., Serghides, L., Gowda, C. & Kain, K. C., Mar 15 2007, In : Journal of Immunology. 178, 6, p. 3954-3961 8 p.

Research output: Contribution to journalArticle

Glycosylphosphatidylinositols
Plasmodium falciparum
Malaria
Cytokines
Macrophages
7 Citations (Scopus)

Plasmodium falciparum GPI mannosyltransferase-III has novel signature sequence and is functional

Basagoudanavar, S. H., Feng, X., Gowda, K., Muthusamy, A. & Gowda, C., Dec 28 2007, In : Biochemical and Biophysical Research Communications. 364, 4, p. 748-754 7 p.

Research output: Contribution to journalArticle

Mannosyltransferases
Glycosylphosphatidylinositols
Plasmodium falciparum
Parasites
Biosynthesis
48 Citations (Scopus)

Src-family kinase-dependent disruption of endothelial barrier function by Plasmodium falciparum merozoite proteins

Gillrie, M. R., Krishnegowda, G., Lee, K., Buret, A. G., Robbins, S. M., Looareesuwan, S., Gowda, D. C. & Ho, M., Nov 1 2007, In : Blood. 110, 9, p. 3426-3435 10 p.

Research output: Contribution to journalArticle

Merozoites
src-Family Kinases
Plasmodium falciparum
Claudin-5
Falciparum Malaria
23 Citations (Scopus)

Structural basis for the adherence of Plasmodium falciparum-infected erythrocytes to chondroitin 4-sulfate and design of novel photoactivable reagents for the identification of parasite adhesive proteins

Gowda, A. S. P., Madhunapantula, S. R. V., Achur, R. N., Valiyaveettil, M., Bhavanandan, V. P. & Gowda, C., Jan 12 2007, In : Journal of Biological Chemistry. 282, 2, p. 916-928 13 p.

Research output: Contribution to journalArticle

Chondroitin Sulfates
Plasmodium falciparum
Adhesives
Parasites
Erythrocytes
3 Citations (Scopus)

The effect of substitution of the N-acetyl groups of N-acetylgalactosamine residues in chondroitin sulfate on its degradation by chondroitinase ABC

Madhunapantula, S. V., Achur, R. N., Bhavanandan, V. P. & Gowda, C., Nov 1 2007, In : Glycoconjugate Journal. 24, 8, p. 465-473 9 p.

Research output: Contribution to journalArticle

Chondroitin ABC Lyase
Acetylgalactosamine
Chondroitin Sulfates
Substitution reactions
Degradation
2006
42 Citations (Scopus)

Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model

Lu, Z., Serghides, L., Patel, S. N., Degousee, N., Rubin, B. B., Krishnegowda, G., Gowda, D. C., Karin, M. & Kain, K. C., Nov 1 2006, In : Journal of Immunology. 177, 9, p. 6344-6352 9 p.

Research output: Contribution to journalArticle

Cerebral Malaria
Glycosylphosphatidylinositols
Plasmodium falciparum
Cytokines
Macrophages