Charles Lang, MS, PhD

    • 12461 Citations
    • 62 h-Index
    1980 …2022
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    Research Output 1980 2019

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    Article
    2019
    TOR Serine-Threonine Kinases
    Autophagy
    Muscle
    Skeletal Muscle
    Ethanol

    Resistin directly inhibits bacterial killing in neutrophils

    Miller, L., Singbartl, K., Chroneos, Z., Ruiz-Velasco, V., Lang, C. & Bonavia, A., May 30 2019, In : Intensive Care Medicine Experimental. 7, 30

    Research output: Contribution to journalArticle

    Open Access
    2018
    1 Citation (Scopus)

    Acute alcohol prevents the refeeding-induced decrease in autophagy but does not alter the increased protein synthetic response in heart

    Mekheal, M., Steiner, J. L. & Lang, C., Dec 1 2018, In : Alcohol. 73, p. 79-88 10 p.

    Research output: Contribution to journalArticle

    Autophagy
    Ethanol
    alcohol
    Alcohols
    redistribution
    1 Citation (Scopus)

    Combination of hindlimb suspension and immobilization by casting exaggerates sarcopenia by stimulating autophagy but does not worsen osteopenia

    Speacht, T. L., Krause, A. R., Steiner, J. L., Lang, C. & Donahue, H. J., May 1 2018, In : Bone. 110, p. 29-37 9 p.

    Research output: Contribution to journalArticle

    Sarcopenia
    Hindlimb Suspension
    Metabolic Bone Diseases
    Autophagy
    Muscles
    1 Citation (Scopus)

    Effects of phytonutrients alone or in combination with monensin on productivity in lactating dairy cows

    Oh, J., Harper, M., Lang, C., Wall, E. H. & Hristov, A. N., Aug 1 2018, In : Journal of dairy science. 101, 8, p. 7190-7198 9 p.

    Research output: Contribution to journalArticle

    Monensin
    Capsicum
    monensin
    Phytochemicals
    Eugenol
    Muscle Proteins
    Sex Characteristics
    Alcohols
    Proteins
    Estrus
    1 Citation (Scopus)

    Temporally distinct regulation of pathways contributing to cardiac proteostasis during the acute and recovery phases of sepsis

    Crowell, K. T., Moreno, S., Steiner, J. L., Coleman, C., Soybel, D. & Lang, C., Jan 1 2018, In : Shock. 50, 6, p. 616-626 11 p.

    Research output: Contribution to journalArticle

    Inflammasomes
    Sepsis
    Proteasome Endopeptidase Complex
    Proteins
    Apoptosis
    2017
    6 Citations (Scopus)

    FoxO1-AMPK-ULK1 Regulates Ethanol-Induced Autophagy in Muscle by Enhanced ATG14 Association with the BECN1-PIK3C3 Complex

    Hong-Brown, L. Q., Brown, C. R., Navaratnarajah, M. & Lang, C. H., May 1 2017, In : Alcoholism: Clinical and Experimental Research. 41, 5, p. 895-910 16 p.

    Research output: Contribution to journalArticle

    AMP-Activated Protein Kinases
    Autophagy
    Muscle
    Ethanol
    Phosphorylation
    1 Citation (Scopus)

    Immune and metabolic responses in early and late sepsis during mild dietary zinc restriction

    Crowell, K. T., Phillips, B. E., Kelleher, S. L., Soybel, D. I. & Lang, C. H., Apr 1 2017, In : Journal of Surgical Research. 210, p. 47-58 12 p.

    Research output: Contribution to journalArticle

    Zinc
    Sepsis
    Liver
    Punctures
    Interferon-gamma
    3 Citations (Scopus)
    White Adipose Tissue
    Autophagy
    Proteasome Endopeptidase Complex
    Sepsis
    Apoptosis
    5 Citations (Scopus)

    RESTORATIVE MECHANISMS REGULATING PROTEIN BALANCE in SKELETAL MUSCLE during RECOVERY from SEPSIS

    Crowell, K. T., Soybel, D. I. & Lang, C. H., Apr 1 2017, In : Shock. 47, 4, p. 463-473 11 p.

    Research output: Contribution to journalArticle

    Sepsis
    Phosphorylation
    Proteins
    Muscle Proteins
    Autophagy
    6 Citations (Scopus)

    Simulated space radiation sensitizes bone but not muscle to the catabolic effects of mechanical unloading

    Krause, A. R., Speacht, T. L., Zhang, Y., Lang, C. & Donahue, H. J., Aug 1 2017, In : PloS one. 12, 8, e0182403.

    Research output: Contribution to journalArticle

    Unloading
    limbs (animal)
    Muscle
    Bone
    bones
    2016
    10 Citations (Scopus)

    Acute alcohol-induced decrease in muscle protein synthesis in female mice is REDD-1 and mTOR-independent

    Steiner, J. L., Kimball, S. R. & Lang, C. H., May 1 2016, In : Alcohol and Alcoholism. 51, 3, p. 242-250 9 p.

    Research output: Contribution to journalArticle

    Muscle Proteins
    Alcohols
    Proteins
    Proteasome Endopeptidase Complex
    Ubiquitin
    11 Citations (Scopus)
    White Adipose Tissue
    Autophagy
    Alcohol Drinking
    Adipose Tissue
    Chemical activation
    3 Citations (Scopus)
    Rumen
    proteasome endopeptidase complex
    Proteasome Endopeptidase Complex
    Sirolimus
    ubiquitin
    1 Citation (Scopus)

    Marginal dietary zinc deprivation augments sepsis-induced alterations in skeletal muscle TNF-α but not protein synthesis

    Crowell, K. T., Kelleher, S. L., Soybel, D. I. & Lang, C. H., Nov 1 2016, In : Physiological Reports. 4, 21, e13017.

    Research output: Contribution to journalArticle

    Zinc
    Sepsis
    Skeletal Muscle
    Muscle Proteins
    Proteins
    2015
    13 Citations (Scopus)

    Adamts1 mediates ethanol-induced alterations in collagen and elastin via a FoxO1-sestrin3-AMPK signaling cascade in myocytes

    Hong-Brown, L. Q., Brown, C. R., Navaratnarajah, M. & Lang, C. H., Jan 1 2015, In : Journal of cellular biochemistry. 116, 1, p. 91-101 11 p.

    Research output: Contribution to journalArticle

    AMP-Activated Protein Kinases
    Elastin
    Muscle Cells
    Ethanol
    Collagen
    8 Citations (Scopus)

    Alcohol Differentially Alters Extracellular Matrix and Adhesion Molecule Expression in Skeletal Muscle and Heart

    Steiner, J. L., Pruznak, A. M., Navaratnarajah, M. & Lang, C. H., Aug 1 2015, In : Alcoholism: Clinical and Experimental Research. 39, 8, p. 1330-1340 11 p.

    Research output: Contribution to journalArticle

    Extracellular Matrix
    Muscle
    Skeletal Muscle
    Adhesion
    Alcohols
    13 Citations (Scopus)
    Alcoholic Intoxication
    Signal transduction
    Muscle Proteins
    Sirolimus
    Muscle Contraction
    13 Citations (Scopus)
    DNA Damage
    Sepsis
    Skeletal Muscle
    Genes
    Autophagy
    25 Citations (Scopus)

    Impact of alcohol on glycemic control and insulin action

    Steiner, J. L., Crowell, K. T. & Lang, C. H., Jan 1 2015, In : Biomolecules. 5, 4, p. 2223-2246 24 p., A05.

    Research output: Contribution to journalArticle

    Alcohols
    Insulin
    Tissue
    Medical problems
    Metabolism
    13 Citations (Scopus)

    Moderate alcohol consumption does not impair overloadinduced muscle hypertrophy and protein synthesis

    Steiner, J. L., Gordon, B. S. & Lang, C. H., Jan 1 2015, In : Physiological reports. 3, 3, e12333.

    Research output: Contribution to journalArticle

    Muscle Proteins
    Alcohol Drinking
    Hypertrophy
    Skeletal Muscle
    Muscles
    2 Citations (Scopus)
    Sympathetic Ganglia
    G-Protein-Coupled Receptors
    abdomen
    Abdomen
    Neurons
    31 Citations (Scopus)

    Nutrient-induced stimulation of protein synthesis in mouse skeletal muscle is limited by the mTORC1 repressor REDD1

    Gordon, B. S., Williamson, D. L., Lang, C. H., Jefferson, L. S. & Kimball, S. R., Jan 1 2015, In : Journal of Nutrition. 145, 4, p. 708-713 6 p.

    Research output: Contribution to journalArticle

    DNA Damage
    Skeletal Muscle
    Food
    Proteins
    mechanistic target of rapamycin complex 1
    12 Citations (Scopus)

    Sepsis attenuates the anabolic response to skeletal muscle contraction

    Steiner, J. L. & Lang, C. H., Apr 16 2015, In : Shock. 43, 4, p. 344-351 8 p.

    Research output: Contribution to journalArticle

    Muscle Contraction
    Sepsis
    Skeletal Muscle
    Phosphorylation
    Punctures
    2014
    21 Citations (Scopus)
    Muscle Proteins
    Sirolimus
    Muscle Contraction
    Skeletal Muscle
    Alcohols
    22 Citations (Scopus)
    Inbred F344 Rats
    Alcohol Drinking
    Alcohols
    Proteins
    Phosphorylation
    13 Citations (Scopus)

    Chronic alcohol ingestion in rats alters lung metabolism, promotes lipid accumulation, and impairs alveolar macrophage functions

    Romero, F., Shah, D., Duong, M., Stafstrom, W., Hoek, J. B., Kallen, C. B., Lang, C. H. & Summer, R., Dec 1 2014, In : American journal of respiratory cell and molecular biology. 51, 6, p. 840-849 10 p.

    Research output: Contribution to journalArticle

    Alveolar Macrophages
    Lipid Metabolism
    Rats
    Eating
    Alcohols
    10 Citations (Scopus)

    Disruption of genes encoding eIF4E binding proteins-1 and -2 does not alter basal or sepsis-induced changes in skeletal muscle protein synthesis in male or female mice

    Steiner, J. L., Pruznak, A. M., Deiter, G., Navaratnarajah, M., Kutzler, L., Kimball, S. R. & Lang, C. H., Jun 19 2014, In : PloS one. 9, 6, e99582.

    Research output: Contribution to journalArticle

    Phosphorylation
    Gene encoding
    Muscle Proteins
    muscle protein
    gene targeting
    12 Citations (Scopus)

    Glucocorticoids attenuate the central sympathoexcitatory actions of insulin

    Steiner, J. L., Bardgett, M. E., Wolfgang, L., Lang, C. H. & Stocker, S. D., Nov 15 2014, In : Journal of Neurophysiology. 112, 10, p. 2597-2604 8 p.

    Research output: Contribution to journalArticle

    Glucocorticoids
    Insulin
    Dexamethasone
    Arcuate Nucleus of Hypothalamus
    Eating
    42 Citations (Scopus)

    Interdependence of muscle atrophy and bone loss induced by mechanical unloading

    Lloyd, S. A., Lang, C. H., Zhang, Y., Paul, E. M., Laufenberg, L. J., Lewis, G. S. & Donahue, H. J., Jan 1 2014, In : Journal of Bone and Mineral Research. 29, 5, p. 1118-1130 13 p.

    Research output: Contribution to journalArticle

    Hindlimb Suspension
    Muscular Atrophy
    Bone and Bones
    Femur
    Tibia
    22 Citations (Scopus)

    Reduced REDD1 expression contributes to activation of mTORC1 following electrically induced muscle contraction

    Gordon, B. S., Steiner, J. L., Lang, C. H., Jefferson, L. S. & Kimball, S. R., Oct 15 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 307, 8, p. E703-E711

    Research output: Contribution to journalArticle

    Muscle Contraction
    DNA Damage
    Proteins
    Sciatic Nerve
    Electric Stimulation
    19 Citations (Scopus)

    Sepsis-induced changes in amino acid transporters and leucine signaling via mTOR in skeletal muscle

    Laufenberg, L. J., Pruznak, A. M., Navaratnarajah, M. & Lang, C. H., Jan 1 2014, In : Amino Acids. 46, 12, p. 2787-2798 12 p.

    Research output: Contribution to journalArticle

    Amino Acid Transport Systems
    Leucine
    Muscle
    Sepsis
    Skeletal Muscle
    14 Citations (Scopus)

    Strain-Dependent Differences for Suppression of Insulin-Stimulated Glucose Uptake in Skeletal and Cardiac Muscle by Ethanol

    Lang, C. H., Derdak, Z. & Wands, J. R., Jan 1 2014, In : Alcoholism: Clinical and Experimental Research. 38, 4, p. 897-910 14 p.

    Research output: Contribution to journalArticle

    Muscle
    Rats
    Myocardium
    Skeletal Muscle
    Ethanol
    2013
    5 Citations (Scopus)

    Activation of AMPK/TSC2/PLD by alcohol regulates mTORC1 and mTORC2 assembly in C2C12 myocytes

    Hong-Brown, L. Q., Brown, C. R., Navaratnarajah, M. & Lang, C. H., Nov 1 2013, In : Alcoholism: Clinical and Experimental Research. 37, 11, p. 1849-1861 13 p.

    Research output: Contribution to journalArticle

    Phospholipase D
    Phosphatidic Acids
    AMP-Activated Protein Kinases
    Muscle Cells
    Chemical activation
    23 Citations (Scopus)
    Alcohols
    Proteins
    Raptors
    AMP-Activated Protein Kinases
    Proteasome Endopeptidase Complex
    19 Citations (Scopus)

    Chronic α-hydroxyisocaproic acid treatment improves muscle recovery after immobilization-induced atrophy

    Lang, C. H., Pruznak, A., Navaratnarajah, M., Rankine, K. A., Deiter, G., Magne, H., Offord, E. A. & Breuillé, D., Aug 1 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 305, 3

    Research output: Contribution to journalArticle

    Immobilization
    Atrophy
    Leucine
    Proteasome Endopeptidase Complex
    Muscles
    7 Citations (Scopus)

    Direct central nervous system effect of alcohol alters synthesis and degradation of skeletal muscle protein

    Pruznak, A. M., Nystrom, J. & Lang, C. H., Mar 1 2013, In : Alcohol and Alcoholism. 48, 2, p. 138-145 8 p.

    Research output: Contribution to journalArticle

    Muscle Proteins
    Neurology
    Skeletal Muscle
    Central Nervous System
    Alcohols
    31 Citations (Scopus)

    Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway

    Crossland, H., Kazi, A., Lang, C., Timmons, J. A., Pierre, P., Wilkinson, D. J., Smith, K., Szewczyk, N. J. & Atherton, P. J., Jul 15 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 305, 2

    Research output: Contribution to journalArticle

    Focal Adhesion Protein-Tyrosine Kinases
    Tuberous Sclerosis
    Insulin-Like Growth Factor I
    Muscle Cells
    Skeletal Muscle
    44 Citations (Scopus)

    Leucine and Protein Metabolism in Obese Zucker Rats

    She, P., Olson, K. C., Kadota, Y., Inukai, A., Shimomura, Y., Hoppel, C. L., Adams, S. H., Kawamata, Y., Matsumoto, H., Sakai, R., Lang, C. H. & Lynch, C. J., Mar 20 2013, In : PLoS One. 8, 3, e59443.

    Research output: Contribution to journalArticle

    Zucker Rats
    Branched Chain Amino Acids
    branched chain amino acids
    protein metabolism
    Metabolism
    4 Citations (Scopus)
    Nociception
    Stellate Ganglion
    Neurons
    Sepsis
    Punctures
    8 Citations (Scopus)
    Aurintricarboxylic Acid
    Muscle Proteins
    Endotoxins
    Sepsis
    Inflammation
    2012
    28 Citations (Scopus)

    Atypical antipsychotics rapidly and inappropriately switch peripheral fuel utilization to lipids, impairing metabolic flexibility in rodents

    Albaugh, V. L., Vary, T. C., Ilkayeva, O., Wenner, B. R., Maresca, K. P., Joyal, J. L., Breazeale, S., Elich, T. D., Lang, C. H. & Lynch, C. J., Jan 1 2012, In : Schizophrenia Bulletin. 38, 1, p. 153-166 14 p.

    Research output: Contribution to journalArticle

    Nonesterified Fatty Acids
    Antipsychotic Agents
    olanzapine
    Rodentia
    Lipids
    8 Citations (Scopus)

    Comparison of the agar block and Lieber-DeCarli diets to study chronic alcohol consumption in an aging model of Fischer 344 female rats

    Sharda, D. R., Miller-Lee, J. L., Kanski, G. M., Hunter, J. C., Lang, C. H., Kennett, M. J. & Korzick, D. H., Jan 1 2012, In : Journal of Pharmacological and Toxicological Methods. 66, 3, p. 257-263 7 p.

    Research output: Contribution to journalArticle

    Nutrition
    Alcohol Drinking
    Agar
    Rats
    Ethanol
    46 Citations (Scopus)

    Delayed recovery of skeletal muscle mass following hindlimb immobilization in mTOR heterozygous mice

    Lang, S. M., Kazi, A., Hong, L. & Lang, C., Jun 22 2012, In : PloS one. 7, 6, e38910.

    Research output: Contribution to journalArticle

    Hindlimb Suspension
    Muscle
    skeletal muscle
    Skeletal Muscle
    Recovery
    23 Citations (Scopus)

    Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine

    Hong, L., Randell Brown, C., Kazi, A., Navaratnarajah, M. & Lang, C., May 15 2012, In : American Journal of Physiology - Cell Physiology. 302, 10

    Research output: Contribution to journalArticle

    AMP-Activated Protein Kinases
    GTP Phosphohydrolases
    Leucine
    Alcohols
    Raptors
    2011
    63 Citations (Scopus)

    Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease

    Derdak, Z., Lang, C. H., Villegas, K. A., Tong, M., Mark, N. M., De La Monte, S. M. & Wands, J. R., Jan 1 2011, In : Journal of Hepatology. 54, 1, p. 164-172 9 p.

    Research output: Contribution to journalArticle

    Alcoholic Liver Diseases
    Insulin Resistance
    Apoptosis
    Liver
    Ethanol
    16 Citations (Scopus)

    Alcohol-induced modulation of rictor and mTORC2 activity in C2C12 myoblasts

    Hong-Brown, L. Q., Brown, C. R., Navaratnarajah, M., Huber, D. S. & Lang, C. H., Aug 1 2011, In : Alcoholism: Clinical and Experimental Research. 35, 8, p. 1445-1453 9 p.

    Research output: Contribution to journalArticle

    Myoblasts
    Alcohols
    Modulation
    Phosphorylation
    Proteins
    37 Citations (Scopus)

    Deptor knockdown enhances mTOR Activity and protein synthesis in myocytes and ameliorates disuse muscle atrophy.

    Kazi, A. A., Hong-Brown, L., Lang, S. M. & Lang, C. H., Sep 2011, In : Molecular Medicine. 17, 9-10, p. 925-936 12 p.

    Research output: Contribution to journalArticle

    TOR Serine-Threonine Kinases
    Atrophic Muscular Disorders
    Muscular Atrophy
    Muscle Cells
    Proteins
    6 Citations (Scopus)

    Ethyl pyruvate preserves IGF-I sensitivity toward mTOR substrates and protein synthesis in C2C12 myotubes

    Frost, R. A., Pereyra, E. & Lang, C. H., Jan 1 2011, In : Endocrinology. 152, 1, p. 151-163 13 p.

    Research output: Contribution to journalArticle

    TOR Serine-Threonine Kinases
    Skeletal Muscle Fibers
    Sirolimus
    Insulin-Like Growth Factor I
    Interferons