Projects per year
Personal profile
Research interests
For more than two decades, Dr. Charles Palmer has worked on ways to support neonatal ventilation noninvasively by developing technologies that can act directly on the very compliant chest wall of premature infants. He and his engineering colleagues have used this technology and developed a method for adhering a soft silicone device to the chest wall. This device can be pneumatically activated to move the chest wall and thereby maintain lung volume, provide negative distending pressure, and potentially provide external high frequency oscillatory ventilation by direct engagement of the chest and abdominal walls. Clinical testing is underway.
Dr. Palmer’s early research focused on the prevention of hypoxic-ischemic brain injury in the rodent model. He was one of the first to show that perinatal-ischemic brain injury evolved during recovery and could be reduced by interventions initiated after reperfusion. Dr. Palmer’s National Institutes of Health (NIH)-funded research focused on the contribution of free radicals, iron, neutrophils, and nitric oxide to evolving brain injury, as well as neuroprotective mechanisms of hypothermia.
Concurrently with his interest in perinatal brain injury, Dr. Palmer has maintained an avid interest in developing technologies that can improve the care of newborns. He holds 11 patents in various fields of invention. Dr. Palmer has participated in studies that explore the role of skin conductance and autonomic regulation. He and his colleagues observed that heart rate variability can predict the risk of developing necrotizing enterocolitis. This research led to a patent on a predictive algorithm, which measures vagal tone that is low in patients at greatest risk of developing necrotizing enterocolitis. Recently, Dr. Palmer’s team showed that vagal tone can be improved by paying attention to the electrical environment, and, more specifically, by connecting the infant to electrical ground.
Education/Academic qualification
Neonatology, Fellowship, Penn State Health Milton S. Hershey Medical Center
… → 1990
MBChB, University of Cape Town Faculty of Medicine
… → 1974
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Network
Projects
- 2 Finished
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PERINATAL HYPOXIC ISCHEMIC BRAIN DAMAGE
vannucci, R. & Palmer, C.
Eunice Kennedy Shriver National Institute of Child Health and Human Development
9/6/94 → 12/31/04
Project: Research project
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PREVENTION OF PERINATAL HYPOXIC-ISCHEMIC BRAIN DAMAGE
National Institute of Neurological Disorders and Stroke
4/1/92 → 3/31/97
Project: Research project
Research output
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Vagaltone and proinflammatory cytokines predict feeding intolerance and necrotizing enterocolitis risk
Meister, A. L., Gardner, F. C., Browning, K. N., Travagli, R. A., Palmer, C. & Doheny, K. K., Dec 1 2021, In: Advances in Neonatal Care. 21, 6, p. 452-461 10 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Meningitis, urinary tract, and bloodstream infections in very low birth weight infants enrolled in a heart rate characteristics monitoring trial
Weitkamp, J. H., Aschner, J. L., Carlo, W. A., Bancalari, E., Perez, J. A., Navarrete, C. T., Schelonka, R. L., Whit Walker, M., Porcelli, P., O’Shea, T. M., Palmer, C., Grossarth, S., Lake, D. E. & Fairchild, K. D., Jun 1 2020, In: Pediatric Research. 87, 7, p. 1226-1230 5 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Electrical grounding improves vagal tone in preterm infants
Passi, R., Doheny, K. K., Gordin, Y., Hinssen, H. & Palmer, C., Aug 1 2017, In: Neonatology. 112, 2, p. 187-192 6 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Hyperglycaemia in infants with hypoxic-ischaemic encephalopathy is associated with improved outcomes after therapeutic hypothermia: A post hoc analysis of the CoolCap Study
for the CoolCap Study Group, Jul 1 2017, In: Archives of Disease in Childhood: Fetal and Neonatal Edition. 102, 4, p. F299-F306Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Diminished vagal tone is a predictive biomarker of necrotizing enterocolitis-risk in preterm infants
Doheny, K. K., Palmer, C., Browning, K. N., Jairath, P., Liao, D., He, F. & Travagli, R. A., Jun 2014, In: Neurogastroenterology and Motility. 26, 6, p. 832-840 9 p.Research output: Contribution to journal › Article › peer-review
40 Scopus citations