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Research Output 1985 2019

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Article
2019
1 Citation (Scopus)

Development of osteopromotive poly (octamethylene citrate glycerophosphate) for enhanced bone regeneration

He, Y., Li, Q., Ma, C., Xie, D., Li, L., Zhao, Y., Shan, D., Chomos, S. K., Dong, C., Tierney, J. W., Sun, L., Lu, D., Gui, L. & Yang, J., Jul 15 2019, In : Acta Biomaterialia. 93, p. 180-191 12 p.

Research output: Contribution to journalArticle

Glycerophosphates
Bone Regeneration
Citric Acid
Durapatite
Hydroxyapatite
2018
2 Citations (Scopus)

Integration of biochemical and biomechanical signals regulating endothelial barrier function

Sanabria, V. A. & Dong, C., Jan 1 2018, In : MCB Molecular and Cellular Biomechanics. 15, 1, p. 1-19 19 p.

Research output: Contribution to journalArticle

Endothelial Cells
Interleukin-8
Interleukin-1
Vascular Diseases
Vascular Endothelial Growth Factor A
6 Citations (Scopus)

The critical chemical and mechanical regulation of folic acid on neural engineering

Kim, G. B., Chen, Y., Kang, W., Guo, J., Payne, R., Li, H., Wei, Q., Baker, J., Dong, C., Zhang, S., Wong, P. K., Rizk, E., Yan, J. & Yang, J., Sep 1 2018, In : Biomaterials. 178, p. 504-516 13 p.

Research output: Contribution to journalArticle

Folic Acid
Acids
Neurotrophin 3
Defects
Regenerative Medicine
2017
22 Citations (Scopus)

Immune Cell-Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting and Drug Delivery

Xie, Z., Su, Y., Kim, G. B., Selvi, E., Ma, C., Aragon-Sanabria, V., Hsieh, J. T., Dong, C. & Yang, J., Mar 14 2017, In : Small. 13, 10, 1603121.

Research output: Contribution to journalArticle

Drug Delivery Systems
Drug delivery
Nanoparticles
Melanoma
Macrophages
15 Citations (Scopus)

VE-Cadherin Disassembly and Cell Contractility in the Endothelium are Necessary for Barrier Disruption Induced by Tumor Cells

Aragon-Sanabria, V., Pohler, S. E., Eswar, V. J., Bierowski, M., Gomez, E. W. & Dong, C., Apr 10 2017, In : Scientific reports. 7, 45835.

Research output: Contribution to journalArticle

Endothelium
Endothelial Cells
Neoplasms
Adherens Junctions
Cell Movement
2016
6 Citations (Scopus)

CD82 suppresses CD44 alternative splicing-dependent melanoma metastasis by mediating U2AF2 ubiquitination and degradation

Zhang, P., Feng, S., Liu, G., Wang, H., Fu, A., Zhu, H., Ren, Q., Wang, B., Xu, X., Bai, H. & Dong, C., Sep 22 2016, In : Oncogene. 35, 38, p. 5056-5069 14 p.

Research output: Contribution to journalArticle

Ubiquitination
Alternative Splicing
Melanoma
Neoplasm Metastasis
Dysplastic Nevus Syndrome
7 Citations (Scopus)

Mutant B-Raf(V600E) promotes melanoma paracellular transmigration by inducing thrombin-mediated endothelial junction breakdown

Zhang, P., Feng, S., Liu, G., Wang, H., Zhu, H., Ren, Q., Bai, H., Fu, C. & Dong, C., Jan 29 2016, In : Journal of Biological Chemistry. 291, 5, p. 2087-2106 20 p.

Research output: Contribution to journalArticle

Thrombin
Melanoma
Adherens Junctions
Phosphorylation
Ubiquitination
2015

3D numerical study of tumor blood perfusion and oxygen transport during vascular normalization

Wu, J., Cai, Y., Fu, Y., Tan, Z., Sun, R., Xu, S., Ding, Z. & Dong, C., Jan 1 2015, In : Applied Mathematics and Mechanics (English Edition). 36, 2, p. 153-162 10 p.

Research output: Contribution to journalArticle

Normalization
Blood
Tumors
Oxygen
Numerical Study
15 Citations (Scopus)

A Drosera-bioinspired hydrogel for catching and killing cancer cells

Li, S., Chen, N., Gaddes, E. R., Zhang, X., Dong, C. & Wang, Y., Sep 23 2015, In : Scientific reports. 5, 14297.

Research output: Contribution to journalArticle

Drosera
Hydrogel
Neoplasms
Doxorubicin
Circulating Neoplastic Cells
15 Citations (Scopus)

Aptamer-Based Polyvalent Ligands for Regulated Cell Attachment on the Hydrogel Surface

Gaddes, E. R., Gydush, G., Li, S., Chen, N., Dong, C. & Wang, Y., Apr 13 2015, In : Biomacromolecules. 16, 4, p. 1382-1389 8 p.

Research output: Contribution to journalArticle

Hydrogel
Hydrogels
Ligands
Biomolecules
Shear stress
11 Citations (Scopus)

C6-ceramide nanoliposome suppresses tumor metastasis by eliciting PI3K and PKCζ tumor-suppressive activities and regulating integrin affinity modulation

Zhang, P., Fu, C., Hu, Y., Dong, C., Song, Y. & Song, E., 2015, In : Scientific reports. 5, 9275.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Integrins
Neoplasm Metastasis
Neoplasms
Melanoma
5 Citations (Scopus)

Cyclovirobuxine D inhibits cell proliferation and induces mitochondria-mediated apoptosis in human gastric cancer cells

Wu, J., Tan, Z., Chen, J. & Dong, C., Nov 19 2015, In : Molecules. 20, 11, p. 20659-20668 10 p.

Research output: Contribution to journalArticle

Mitochondria
mitochondria
Cell proliferation
apoptosis
Stomach Neoplasms
5 Citations (Scopus)

Effects of ghost red blood cells on tumor cell adhesion in shear flow

Fu, Y., Wu, J., Sun, R., Ding, Z. R. & Dong, C., Apr 1 2015, In : Yiyong Shengwu Lixue/Journal of Medical Biomechanics. 30, 2, p. 99-103 5 p.

Research output: Contribution to journalArticle

Cell adhesion
Shear flow
Tumors
Blood
Endothelial cells

Investigation of cell aggregation on the substrate of a parallel-plate flow chamber

Bai, F., Dong, C., Cao, C. & Sun, R., Jan 1 2015, In : Cellular and Molecular Biology. 61, 2, p. 86-93 8 p.

Research output: Contribution to journalArticle

Cell Aggregation
Tumors
Neutrophils
Agglomeration
Endothelial cells
6 Citations (Scopus)

Localized modeling of biochemical and flow interactions during cancer cell adhesion

Behr, J., Gaskin, B., Fu, C., Dong, C. & Kunz, R., Sep 14 2015, In : PloS one. 10, 9, e0136926.

Research output: Contribution to journalArticle

Flow interactions
Cell adhesion
cell adhesion
Cell Adhesion
melanoma
7 Citations (Scopus)

Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells

Haakenson, J. K., Khokhlatchev, A. V., Choi, Y. J., Linton, S. S., Zhang, P., Zaki, P. M., Fu, C., Cooper, T. K., Manni, A., Zhu, J., Fox, T. E., Dong, C. & Kester, M., Mar 27 2015, In : Journal of Biological Chemistry. 290, 13, p. 8632-8643 12 p.

Research output: Contribution to journalArticle

Anoikis
Ceramides
Cells
Carcinoma
Degradation
2 Citations (Scopus)

Perspectives: Interplay Between Melanoma Regulated Fibrin and Receptor Mediated Adhesion Under Shear Flow

Ozdemir, T., Gaddes, E., Wang, Y. & Dong, C., Jan 1 2015, In : Cellular and Molecular Bioengineering. 8, 1, p. 86-95 10 p.

Research output: Contribution to journalArticle

Melanoma
Shear flow
Shear Flow
Adhesion
Receptor
7 Citations (Scopus)

RacGAP1-driven focal adhesion formation promotes melanoma transendothelial migration through mediating adherens junction disassembly

Zhang, P., Bai, H., Fu, C., Chen, F., Zeng, P., Wu, C., Ye, Q., Dong, C., Song, Y. & Song, E., Mar 27 2015, In : Biochemical and Biophysical Research Communications. 459, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Transendothelial and Transepithelial Migration
Adherens Junctions
Focal Adhesions
Melanoma
Adhesion
3 Citations (Scopus)

Regulation of fibrin-mediated tumor cell adhesion to the endothelium using anti-thrombin aptamer

Gaddes, E. R., Lee, D., Gydush, G., Wang, Y. & Dong, C., Dec 1 2015, In : Experimental Cell Research. 339, 2, p. 417-426 10 p.

Research output: Contribution to journalArticle

Fibrin
Cell Adhesion
Endothelium
Thrombin
Fibrinogen
1 Citation (Scopus)

The effect of concentration ratio on tumor cell adhesion in shear flow

Fu, Y., Wang, Y., Bai, F., Wu, J., Sun, R., Ding, Z. R. & Dong, C., Oct 1 2015, In : Yiyong Shengwu Lixue/Journal of Medical Biomechanics. 30, 5, p. 392-396 5 p.

Research output: Contribution to journalArticle

Cell adhesion
Shear flow
Tumors
Shear deformation
Endothelial cells
2014
9 Citations (Scopus)

Actinomyosin contraction, phosphorylation of VE-cadherin, and actin remodeling enable melanoma-induced endothelial cell-cell junction disassembly

Weidert, E., Pohler, S. E., Gomez, E. W. & Dong, C., Sep 16 2014, In : PloS one. 9, 9, e108092.

Research output: Contribution to journalArticle

intercellular junctions
Phosphorylation
Intercellular Junctions
cadherins
Endothelial cells
9 Citations (Scopus)

A noninvasive approach to determine viscoelastic properties of an individual adherent cell under fluid flow

Qiu, J., Baik, A. D., Lu, X. L., Hillman, E. M. C., Zhuang, Z., Dong, C. & Guo, X. E., Apr 11 2014, In : Journal of Biomechanics. 47, 6, p. 1537-1541 5 p.

Research output: Contribution to journalArticle

Flow of fluids
Mechanical properties
Fluid structure interaction
Microscopic examination
Viscosity
18 Citations (Scopus)

CD82/KAI expression prevents IL-8-mediated endothelial gap formation in late-stage melanomas

Khanna, P., Chung, C. Y., Neves, R. I., Robertson, G. P. & Dong, C., May 29 2014, In : Oncogene. 33, 22, p. 2898-2908 11 p.

Research output: Contribution to journalArticle

Interleukin-8
Melanoma
Tetraspanins
Neoplasms
Neoplasm Metastasis
27 Citations (Scopus)

Melanoma upregulates ICAM-1 expression on endothelial cells through engagement of tumor CD44 with endothelial E-selectin and activation of a PKCα-p38-SP-1 pathway

Zhang, P., Goodrich, C., Fu, C. & Dong, C., Nov 1 2014, In : FASEB Journal. 28, 11, p. 4591-4609 19 p.

Research output: Contribution to journalArticle

E-Selectin
Endothelial cells
Intercellular Adhesion Molecule-1
Protein Kinase C
Tumors
20 Citations (Scopus)

Nuclear Stiffening Inhibits Migration of Invasive Melanoma Cells

Ribeiro, A. J. S., Khanna, P., Sukumar, A., Dong, C. & Dahl, K. N., Jan 1 2014, In : Cellular and Molecular Bioengineering. 7, 4, p. 544-551 8 p.

Research output: Contribution to journalArticle

Lamin Type A
Melanoma
Formability
Migration
Cell
2013
7 Citations (Scopus)

Simultaneous tracking of 3D actin and microtubule strains in individual MLO-Y4 osteocytes under oscillatory flow

Baik, A. D., Qiu, J., Hillman, E. M. C., Dong, C. & Guo, X. E., Feb 11 2013, In : Biochemical and Biophysical Research Communications. 431, 4, p. 718-723 6 p.

Research output: Contribution to journalArticle

Osteocytes
Microtubules
Actins
Actin Cytoskeleton
Microscopy
2012
2 Citations (Scopus)

3D numerical study of tumor microenvironmental flow in response to vascular-disrupting treatments

Wu, J., Cai, Y., Xu, S., Long, Q., Ding, Z. & Dong, C., Aug 24 2012, In : MCB Molecular and Cellular Biomechanics. 9, 2, p. 95-125 31 p.

Research output: Contribution to journalArticle

Blood Vessels
Neoplasms
Microvessels
Tumor Microenvironment
Hemodynamics

Cellular and molecular bioengineering: A tipping point

Brown, G., Butler, P. J., Chang, D. W., Chien, S., Clegg, R. M., Dewey, C. F., Dong, C., Guo, X. E., Helmke, B. P., Hess, H., Jacobs, C. R., Kaunas, R. R., Kumar, S., Lu, H. H., Mathur, A. B., Mow, V. C., Schmid-Schonbein, G. W., Skoracki, R., Wang, N., Wang, Y. & 1 others, Zhu, C., Sep 1 2012, In : Cellular and Molecular Bioengineering. 5, 3, p. 239-253 15 p.

Research output: Contribution to journalArticle

Bioengineering
Biomedical Engineering
Biomedical engineering
Expertise
Medicine
14 Citations (Scopus)

Fibrin serves as a divalent ligand that regulates neutrophil-mediated melanoma cells adhesion to endothelium under shear conditions

Ozdemir, T., Zhang, P., Fu, C. & Dong, C., Apr 15 2012, In : American Journal of Physiology - Cell Physiology. 302, 8, p. C1189-C1201

Research output: Contribution to journalArticle

Fibrin
Cell Adhesion
Endothelium
Melanoma
Neutrophils
9 Citations (Scopus)

Study of local hydrodynamic environment in cell-substrate adhesion using side-view μPIV technology

Fu, Y., Kunz, R., Wu, J. & Dong, C., Feb 17 2012, In : PloS one. 7, 2, e30721.

Research output: Contribution to journalArticle

Rheology
Hydrodynamics
Cell Adhesion
Velocity measurement
hydrodynamics
5 Citations (Scopus)

Theoretical analysis of novel quasi-3D microscopy of cell deformation

Qiu, J., Baik, A. D., Lu, X. L., Hillman, E. M. C., Zhuang, Z., Dong, C. & Guo, X. E., Jun 1 2012, In : Cellular and Molecular Bioengineering. 5, 2, p. 165-172 8 p.

Research output: Contribution to journalArticle

Microscopy
Theoretical Analysis
Microscopic examination
Cell
Signal-To-Noise Ratio
2011
24 Citations (Scopus)

Determining β 2-integrin and intercellular adhesion molecule 1 binding kinetics in tumor cell adhesion to leukocytes and endothelial cells by a gas-driven micropipette assay

Fu, C., Tong, C., Wang, M., Gao, Y., Zhang, Y., Lü, S., Liang, S., Dong, C. & Long, M., Oct 7 2011, In : Journal of Biological Chemistry. 286, 40, p. 34777-34787 11 p.

Research output: Contribution to journalArticle

Cell adhesion
Endothelial cells
Intercellular Adhesion Molecule-1
Cell Adhesion
Integrins
7 Citations (Scopus)

Modeling of cell aggregation dynamics governed by receptor-ligand binding under shear flow

Fu, C., Tong, C., Dong, C. & Long, M., Sep 1 2011, In : Cellular and Molecular Bioengineering. 4, 3, p. 427-441 15 p.

Research output: Contribution to journalArticle

Cell Aggregation
Shear flow
Shear Flow
Receptor
Aggregation
4 Citations (Scopus)

Model simulations reveal vcam-1 augment PAK activation rates to amplify p38 MAPK and VE-cadherin phosphorylation

Khanna, P., Weidert, E., Vital-Lopez, F., Armaou, A., Maranas, C. D. & Dong, C., Dec 1 2011, In : Cellular and Molecular Bioengineering. 4, 4, p. 656-669 14 p.

Research output: Contribution to journalArticle

Phosphorylation
Vascular Cell Adhesion Molecule-1
p38 Mitogen-Activated Protein Kinases
Activation
Disassembly
33 Citations (Scopus)

Sequential binding of αvβ3and ICAM-1 determines fibrin-mediated melanoma capture and stable adhesion to CD11b/CD18 on neutrophils

Zhang, P., Ozdemir, T., Chung, C. Y., Robertson, G. P. & Dong, C., Jan 1 2011, In : Journal of Immunology. 186, 1, p. 242-254 13 p.

Research output: Contribution to journalArticle

Intercellular Adhesion Molecule-1
Fibrin
Melanoma
Neutrophils
Cell Adhesion
6 Citations (Scopus)

Site-specific sonoporation of human melanoma cells at the cellular level using high lateral-resolution ultrasonic micro-transducer arrays

Thein, M., Cheng, A., Khanna, P., Zhang, C., Park, E. J., Ahmed, D., Goodrich, C. J., Asphahani, F., Wu, F., Smith, N. B., Dong, C., Jiang, X., Zhang, M. & Xu, J., Sep 15 2011, In : Biosensors and Bioelectronics. 27, 1, p. 25-33 9 p.

Research output: Contribution to journalArticle

Transducers
Ultrasonics
Melanoma
Pressure
Wounds and Injuries
2010
7 Citations (Scopus)

Application of population dynamics to study heterotypic cell aggregations in the near-wall region of a shear flow

Ma, Y., Wang, J., Liang, S., Dong, C. & Du, Q., Mar 1 2010, In : Cellular and Molecular Bioengineering. 3, 1, p. 3-19 17 p.

Research output: Contribution to journalArticle

Cell Aggregation
Population dynamics
Population Dynamics
Shear flow
Shear Flow
25 Citations (Scopus)

P38 MAP kinase is necessary for melanoma-mediated regulation of VE-cadherin disassembly

Khanna, P., Yunkunis, T., Muddana, H. S., Peng, H. H., August, A. & Dong, C., May 1 2010, In : American Journal of Physiology - Cell Physiology. 298, 5, p. C1140-C1150

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Melanoma
Endothelial Cells
Transendothelial and Transepithelial Migration
MAP Kinase Kinase 6
17 Citations (Scopus)

Quasi-3D cytoskeletal dynamics of osteocytes under fluid flow

Baik, A. D., Lu, X. L., Qiu, J., Huo, B., Hillman, E. M. C., Dong, C. & Guo, X. E., Nov 3 2010, In : Biophysical journal. 99, 9, p. 2812-2820 9 p.

Research output: Contribution to journalArticle

Osteocytes
Microtubules
Actins
Microscopy
Hydrodynamics
170 Citations (Scopus)

Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development

Huh, S. J., Liang, S., Sharma, A., Dong, C. & Robertson, G. P., Jul 15 2010, In : Cancer Research. 70, 14, p. 6071-6082 12 p.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Neutrophils
Neoplasm Metastasis
Lung
Melanoma
13 Citations (Scopus)

Tumor cell extravasation mediated by leukocyte adhesion is shear rate dependent on IL-8 signaling

Liang, S., Hoskins, M. & Dong, C., 2010, In : MCB Molecular and Cellular Biomechanics. 7, 2, p. 77-91 15 p.

Research output: Contribution to journalArticle

Interleukin-8
Neutrophils
Leukocytes
Melanoma
Neoplasms
2009
143 Citations (Scopus)

Biomechanics: Cell research and applications for the next decade

Discher, D., Dong, C., Fredberg, J. J., Guilak, F., Ingber, D., Janmey, P., Kamm, R. D., Schmid-Schönbein, G. W. & Weinbaum, S., May 1 2009, In : Annals of Biomedical Engineering. 37, 5, p. 847-859 13 p.

Research output: Contribution to journalArticle

Molecular biology
Biomechanics
Materials properties
Genes
Decision making
11 Citations (Scopus)

Coupled flow-structure-biochemistry simulations of dynamic systems of blood cells using an adaptive surface tracking method

Hoskins, M. H., Kunz, R. F., Bistline, J. E. & Dong, C., Jul 1 2009, In : Journal of Fluids and Structures. 25, 5, p. 936-953 18 p.

Research output: Contribution to journalArticle

Biochemistry
Flow structure
Dynamical systems
Blood
Cells

Gene expression regulated by IL-4/ Stat6 signaling pathway in breast cancer cells with different Stat6 activation phenotypes

Li, B. H., Yang, X. Z., Li, P. D., Yuan, Q., Liu, X. H., Gerhard, G. S., Dong, C., Chorney, M. J. & Zhang, W. J., Feb 1 2009, In : Chinese Journal of Cancer Prevention and Treatment. 16, 3, p. 161-163 3 p.

Research output: Contribution to journalArticle

Interleukin-4
Breast Neoplasms
Phenotype
Gene Expression
Apoptosis
9 Citations (Scopus)

Immunoediting of leukocyte functions within the tumor microenvironment promotes cancer metastasis development

Dong, C. & Robertson, G. P., Sep 21 2009, In : Biorheology. 46, 4, p. 265-279 15 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Leukocytes
Melanoma
Neoplasm Metastasis
Neoplasms
167 Citations (Scopus)

Single-layer planar on-chip flow cytometer using microfluidic drifting based three-dimensional (3D) hydrodynamic focusing

Mao, X., Lin, S. C. S., Dong, C. & Huang, T. J., Jan 1 2009, In : Lab on a Chip. 9, 11, p. 1583-1589 7 p.

Research output: Contribution to journalArticle

Microfluidics
Hydrodynamics
Flow cytometry
Flow Cytometry
Lab-On-A-Chip Devices
8 Citations (Scopus)

Systemic analysis of tumor cell-induced endothelial calcium signaling and junction disassembly

Peng, H. H. & Dong, C., Sep 1 2009, In : Cellular and Molecular Bioengineering. 2, 3, p. 375-385 11 p.

Research output: Contribution to journalArticle

Disassembly
Calcium Signaling
Calcium
Tumors
Tumor
2008
61 Citations (Scopus)

Hydrodynamic shear rate regulates melanoma-leukocyte aggregation, melanoma adhesion to the endothelium, and subsequent extravasation

Liang, S., Slattery, M. J., Wagner, D., Simon, S. I. & Dong, C., Apr 1 2008, In : Annals of Biomedical Engineering. 36, 4, p. 661-671 11 p.

Research output: Contribution to journalArticle

Shear deformation
Tumors
Adhesion
Agglomeration
Hydrodynamics
39 Citations (Scopus)

IL-4-induced Stat6 activities affect apoptosis and gene expression in breast cancer cells

Zhang, W. J., Li, B. H., Yang, X. Z., Li, P. D., Yuan, Q., Liu, X. H., Xu, S. B., Zhang, Y., Yuan, J., Gerhard, G. S., Masker, K. K., Dong, C., Koltun, W. A. & Chorney, M. J., Apr 1 2008, In : Cytokine. 42, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

Gene expression
Interleukin-4
Genes
Cells
Apoptosis
40 Citations (Scopus)
Integrin alpha4beta1
Integrins
Endothelium
Melanoma
Adhesives