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Article
2020

High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma

Kim, G. B., Aragon-Sanabria, V., Randolph, L., Jiang, H., Reynolds, J. A., Webb, B. S., Madhankumar, A., Lian, X., Connor, J. R., Yang, J. & Dong, C., Sep 2020, In : Bioactive Materials. 5, 3, p. 624-635 12 p.

Research output: Contribution to journalArticle

Open Access
2019

Development of osteopromotive poly (octamethylene citrate glycerophosphate) for enhanced bone regeneration

He, Y., Li, Q., Ma, C., Xie, D., Li, L., Zhao, Y., Shan, D., Chomos, S. K., Dong, C., Tierney, J. W., Sun, L., Lu, D., Gui, L. & Yang, J., Jul 15 2019, In : Acta Biomaterialia. 93, p. 180-191 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Integration of biochemical and biomechanical signals regulating endothelial barrier function

Sanabria, V. A. & Dong, C., Jan 1 2018, In : MCB Molecular and Cellular Biomechanics. 15, 1, p. 1-19 19 p.

Research output: Contribution to journalArticle

2 Scopus citations

The critical chemical and mechanical regulation of folic acid on neural engineering

Kim, G. B., Chen, Y., Kang, W., Guo, J., Payne, R., Li, H., Wei, Q., Baker, J., Dong, C., Zhang, S., Wong, P. K., Rizk, E. B., Yan, J. & Yang, J., Sep 2018, In : Biomaterials. 178, p. 504-516 13 p.

Research output: Contribution to journalArticle

8 Scopus citations
2017

Immune Cell-Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting and Drug Delivery

Xie, Z., Su, Y., Kim, G. B., Selvi, E., Ma, C., Aragon-Sanabria, V., Hsieh, J. T., Dong, C. & Yang, J., Mar 14 2017, In : Small. 13, 10, 1603121.

Research output: Contribution to journalArticle

22 Scopus citations

VE-Cadherin Disassembly and Cell Contractility in the Endothelium are Necessary for Barrier Disruption Induced by Tumor Cells

Aragon-Sanabria, V., Pohler, S. E., Eswar, V. J., Bierowski, M., Gomez, E. W. & Dong, C., Apr 10 2017, In : Scientific reports. 7, 45835.

Research output: Contribution to journalArticle

18 Scopus citations
2016

CD82 suppresses CD44 alternative splicing-dependent melanoma metastasis by mediating U2AF2 ubiquitination and degradation

Zhang, P., Feng, S., Liu, G., Wang, H., Fu, A., Zhu, H., Ren, Q., Wang, B., Xu, X., Bai, H. & Dong, C., Sep 22 2016, In : Oncogene. 35, 38, p. 5056-5069 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mutant B-Raf(V600E) promotes melanoma paracellular transmigration by inducing thrombin-mediated endothelial junction breakdown

Zhang, P., Feng, S., Liu, G., Wang, H., Zhu, H., Ren, Q., Bai, H., Fu, C. & Dong, C., Jan 29 2016, In : Journal of Biological Chemistry. 291, 5, p. 2087-2106 20 p.

Research output: Contribution to journalArticle

7 Scopus citations
2015

3D numerical study of tumor blood perfusion and oxygen transport during vascular normalization

Wu, J., Cai, Y., Fu, Y., Tan, Z., Sun, R., Xu, S., Ding, Z. & Dong, C., Jan 1 2015, In : Applied Mathematics and Mechanics (English Edition). 36, 2, p. 153-162 10 p.

Research output: Contribution to journalArticle

A Drosera-bioinspired hydrogel for catching and killing cancer cells

Li, S., Chen, N., Gaddes, E. R., Zhang, X., Dong, C. & Wang, Y., Sep 23 2015, In : Scientific reports. 5, 14297.

Research output: Contribution to journalArticle

17 Scopus citations

Aptamer-Based Polyvalent Ligands for Regulated Cell Attachment on the Hydrogel Surface

Gaddes, E. R., Gydush, G., Li, S., Chen, N., Dong, C. & Wang, Y., Apr 13 2015, In : Biomacromolecules. 16, 4, p. 1382-1389 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

C6-ceramide nanoliposome suppresses tumor metastasis by eliciting PI3K and PKCζ tumor-suppressive activities and regulating integrin affinity modulation

Zhang, P., Fu, C., Hu, Y., Dong, C., Song, Y. & Song, E., 2015, In : Scientific reports. 5, 9275.

Research output: Contribution to journalArticle

14 Scopus citations

Cyclovirobuxine D inhibits cell proliferation and induces mitochondria-mediated apoptosis in human gastric cancer cells

Wu, J., Tan, Z., Chen, J. & Dong, C., Nov 19 2015, In : Molecules. 20, 11, p. 20659-20668 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Effects of ghost red blood cells on tumor cell adhesion in shear flow

Fu, Y., Wu, J., Sun, R., Ding, Z. R. & Dong, C., Apr 1 2015, In : Yiyong Shengwu Lixue/Journal of Medical Biomechanics. 30, 2, p. 99-103 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Investigation of cell aggregation on the substrate of a parallel-plate flow chamber

Bai, F., Dong, C., Cao, C. & Sun, R., Jan 1 2015, In : Cellular and Molecular Biology. 61, 2, p. 86-93 8 p.

Research output: Contribution to journalArticle

Localized modeling of biochemical and flow interactions during cancer cell adhesion

Behr, J., Gaskin, B., Fu, C., Dong, C. & Kunz, R., Sep 14 2015, In : PloS one. 10, 9, e0136926.

Research output: Contribution to journalArticle

6 Scopus citations

Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells

Haakenson, J. K., Khokhlatchev, A. V., Choi, Y. J., Linton, S. S., Zhang, P., Zaki, P. M., Fu, C., Cooper, T. K., Manni, A., Zhu, J., Fox, T. E., Dong, C. & Kester, M., Mar 27 2015, In : Journal of Biological Chemistry. 290, 13, p. 8632-8643 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Perspectives: Interplay Between Melanoma Regulated Fibrin and Receptor Mediated Adhesion Under Shear Flow

Ozdemir, T., Gaddes, E., Wang, Y. & Dong, C., Jan 1 2015, In : Cellular and Molecular Bioengineering. 8, 1, p. 86-95 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

RacGAP1-driven focal adhesion formation promotes melanoma transendothelial migration through mediating adherens junction disassembly

Zhang, P., Bai, H., Fu, C., Chen, F., Zeng, P., Wu, C., Ye, Q., Dong, C., Song, Y. & Song, E., Mar 27 2015, In : Biochemical and Biophysical Research Communications. 459, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Regulation of fibrin-mediated tumor cell adhesion to the endothelium using anti-thrombin aptamer

Gaddes, E. R., Lee, D., Gydush, G., Wang, Y. & Dong, C., Dec 1 2015, In : Experimental Cell Research. 339, 2, p. 417-426 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

The effect of concentration ratio on tumor cell adhesion in shear flow

Fu, Y., Wang, Y., Bai, F., Wu, J., Sun, R., Ding, Z. R. & Dong, C., Oct 1 2015, In : Yiyong Shengwu Lixue/Journal of Medical Biomechanics. 30, 5, p. 392-396 5 p.

Research output: Contribution to journalArticle

1 Scopus citations
2014

Actinomyosin contraction, phosphorylation of VE-cadherin, and actin remodeling enable melanoma-induced endothelial cell-cell junction disassembly

Weidert, E., Pohler, S. E., Gomez, E. W. & Dong, C., Sep 16 2014, In : PloS one. 9, 9, e108092.

Research output: Contribution to journalArticle

9 Scopus citations

A noninvasive approach to determine viscoelastic properties of an individual adherent cell under fluid flow

Qiu, J., Baik, A. D., Lu, X. L., Hillman, E. M. C., Zhuang, Z., Dong, C. & Guo, X. E., Apr 11 2014, In : Journal of Biomechanics. 47, 6, p. 1537-1541 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

CD82/KAI expression prevents IL-8-mediated endothelial gap formation in late-stage melanomas

Khanna, P., Chung, C. Y., Neves, R. I., Robertson, G. P. & Dong, C., May 29 2014, In : Oncogene. 33, 22, p. 2898-2908 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Melanoma upregulates ICAM-1 expression on endothelial cells through engagement of tumor CD44 with endothelial E-selectin and activation of a PKCα-p38-SP-1 pathway

Zhang, P., Goodrich, C., Fu, C. & Dong, C., Nov 1 2014, In : FASEB Journal. 28, 11, p. 4591-4609 19 p.

Research output: Contribution to journalArticle

29 Scopus citations

Nuclear Stiffening Inhibits Migration of Invasive Melanoma Cells

Ribeiro, A. J. S., Khanna, P., Sukumar, A., Dong, C. & Dahl, K. N., Jan 1 2014, In : Cellular and Molecular Bioengineering. 7, 4, p. 544-551 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
2013

Simultaneous tracking of 3D actin and microtubule strains in individual MLO-Y4 osteocytes under oscillatory flow

Baik, A. D., Qiu, J., Hillman, E. M. C., Dong, C. & Guo, X. E., Feb 11 2013, In : Biochemical and Biophysical Research Communications. 431, 4, p. 718-723 6 p.

Research output: Contribution to journalArticle

8 Scopus citations
2012

3D numerical study of tumor microenvironmental flow in response to vascular-disrupting treatments

Wu, J., Cai, Y., Xu, S., Long, Q., Ding, Z. & Dong, C., Aug 24 2012, In : MCB Molecular and Cellular Biomechanics. 9, 2, p. 95-125 31 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cellular and molecular bioengineering: A tipping point

Brown, G., Butler, P. J., Chang, D. W., Chien, S., Clegg, R. M., Dewey, C. F., Dong, C., Guo, X. E., Helmke, B. P., Hess, H., Jacobs, C. R., Kaunas, R. R., Kumar, S., Lu, H. H., Mathur, A. B., Mow, V. C., Schmid-Schonbein, G. W., Skoracki, R., Wang, N., Wang, Y. & 1 others, Zhu, C., Sep 1 2012, In : Cellular and Molecular Bioengineering. 5, 3, p. 239-253 15 p.

Research output: Contribution to journalArticle

Fibrin serves as a divalent ligand that regulates neutrophil-mediated melanoma cells adhesion to endothelium under shear conditions

Ozdemir, T., Zhang, P., Fu, C. & Dong, C., Apr 15 2012, In : American Journal of Physiology - Cell Physiology. 302, 8, p. C1189-C1201

Research output: Contribution to journalArticle

14 Scopus citations

Study of local hydrodynamic environment in cell-substrate adhesion using side-view μPIV technology

Fu, Y., Kunz, R., Wu, J. & Dong, C., Feb 17 2012, In : PloS one. 7, 2, e30721.

Research output: Contribution to journalArticle

9 Scopus citations

Theoretical analysis of novel quasi-3D microscopy of cell deformation

Qiu, J., Baik, A. D., Lu, X. L., Hillman, E. M. C., Zhuang, Z., Dong, C. & Guo, X. E., Jun 1 2012, In : Cellular and Molecular Bioengineering. 5, 2, p. 165-172 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
2011

Determining β 2-integrin and intercellular adhesion molecule 1 binding kinetics in tumor cell adhesion to leukocytes and endothelial cells by a gas-driven micropipette assay

Fu, C., Tong, C., Wang, M., Gao, Y., Zhang, Y., Lü, S., Liang, S., Dong, C. & Long, M., Oct 7 2011, In : Journal of Biological Chemistry. 286, 40, p. 34777-34787 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Modeling of cell aggregation dynamics governed by receptor-ligand binding under shear flow

Fu, C., Tong, C., Dong, C. & Long, M., Sep 1 2011, In : Cellular and Molecular Bioengineering. 4, 3, p. 427-441 15 p.

Research output: Contribution to journalArticle

7 Scopus citations

Model simulations reveal vcam-1 augment PAK activation rates to amplify p38 MAPK and VE-cadherin phosphorylation

Khanna, P., Weidert, E., Vital-Lopez, F., Armaou, A., Maranas, C. D. & Dong, C., Dec 1 2011, In : Cellular and Molecular Bioengineering. 4, 4, p. 656-669 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Sequential binding of αvβ3and ICAM-1 determines fibrin-mediated melanoma capture and stable adhesion to CD11b/CD18 on neutrophils

Zhang, P., Ozdemir, T., Chung, C. Y., Robertson, G. P. & Dong, C., Jan 1 2011, In : Journal of Immunology. 186, 1, p. 242-254 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Site-specific sonoporation of human melanoma cells at the cellular level using high lateral-resolution ultrasonic micro-transducer arrays

Thein, M., Cheng, A., Khanna, P., Zhang, C., Park, E. J., Ahmed, D., Goodrich, C. J., Asphahani, F., Wu, F., Smith, N. B., Dong, C., Jiang, X., Zhang, M. & Xu, J., Sep 15 2011, In : Biosensors and Bioelectronics. 27, 1, p. 25-33 9 p.

Research output: Contribution to journalArticle

6 Scopus citations
2010

Application of population dynamics to study heterotypic cell aggregations in the near-wall region of a shear flow

Ma, Y., Wang, J., Liang, S., Dong, C. & Du, Q., Mar 1 2010, In : Cellular and Molecular Bioengineering. 3, 1, p. 3-19 17 p.

Research output: Contribution to journalArticle

7 Scopus citations

P38 MAP kinase is necessary for melanoma-mediated regulation of VE-cadherin disassembly

Khanna, P., Yunkunis, T., Muddana, H. S., Peng, H. H., August, A. & Dong, C., May 1 2010, In : American Journal of Physiology - Cell Physiology. 298, 5, p. C1140-C1150

Research output: Contribution to journalArticle

25 Scopus citations

Quasi-3D cytoskeletal dynamics of osteocytes under fluid flow

Baik, A. D., Lu, X. L., Qiu, J., Huo, B., Hillman, E. M. C., Dong, C. & Guo, X. E., Nov 3 2010, In : Biophysical journal. 99, 9, p. 2812-2820 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development

Huh, S. J., Liang, S., Sharma, A., Dong, C. & Robertson, G. P., Jul 15 2010, In : Cancer Research. 70, 14, p. 6071-6082 12 p.

Research output: Contribution to journalArticle

176 Scopus citations

Tumor cell extravasation mediated by leukocyte adhesion is shear rate dependent on IL-8 signaling

Liang, S., Hoskins, M. & Dong, C., 2010, In : MCB Molecular and Cellular Biomechanics. 7, 2, p. 77-91 15 p.

Research output: Contribution to journalArticle

14 Scopus citations
2009

Biomechanics: Cell research and applications for the next decade

Discher, D., Dong, C., Fredberg, J. J., Guilak, F., Ingber, D., Janmey, P., Kamm, R. D., Schmid-Schönbein, G. W. & Weinbaum, S., May 1 2009, In : Annals of Biomedical Engineering. 37, 5, p. 847-859 13 p.

Research output: Contribution to journalArticle

145 Scopus citations

Coupled flow-structure-biochemistry simulations of dynamic systems of blood cells using an adaptive surface tracking method

Hoskins, M. H., Kunz, R. F., Bistline, J. E. & Dong, C., Jul 1 2009, In : Journal of Fluids and Structures. 25, 5, p. 936-953 18 p.

Research output: Contribution to journalArticle

11 Scopus citations

Gene expression regulated by IL-4/ Stat6 signaling pathway in breast cancer cells with different Stat6 activation phenotypes

Li, B. H., Yang, X. Z., Li, P. D., Yuan, Q., Liu, X. H., Gerhard, G. S., Cheng, D., Chorney, M. J. & Zhang, W. J., Feb 1 2009, In : Chinese Journal of Cancer Prevention and Treatment. 16, 3, p. 161-163 3 p.

Research output: Contribution to journalArticle

Immunoediting of leukocyte functions within the tumor microenvironment promotes cancer metastasis development

Dong, C. & Robertson, G. P., Sep 21 2009, In : Biorheology. 46, 4, p. 265-279 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

Single-layer planar on-chip flow cytometer using microfluidic drifting based three-dimensional (3D) hydrodynamic focusing

Mao, X., Lin, S. C. S., Dong, C. & Huang, T. J., Jan 1 2009, In : Lab on a Chip. 9, 11, p. 1583-1589 7 p.

Research output: Contribution to journalArticle

168 Scopus citations

Systemic analysis of tumor cell-induced endothelial calcium signaling and junction disassembly

Peng, H. H. & Dong, C., Sep 1 2009, In : Cellular and Molecular Bioengineering. 2, 3, p. 375-385 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
2008

Hydrodynamic shear rate regulates melanoma-leukocyte aggregation, melanoma adhesion to the endothelium, and subsequent extravasation

Liang, S., Slattery, M. J., Wagner, D., Simon, S. I. & Dong, C., Apr 1 2008, In : Annals of Biomedical Engineering. 36, 4, p. 661-671 11 p.

Research output: Contribution to journalArticle

63 Scopus citations

IL-4-induced Stat6 activities affect apoptosis and gene expression in breast cancer cells

Zhang, W. J., Li, B. H., Yang, X. Z., Li, P. D., Yuan, Q., Liu, X. H., Xu, S. B., Zhang, Y., Yuan, J., Gerhard, G. S., Masker, K. K., Dong, C., Koltun, W. A. & Chorney, M. J., Apr 1 2008, In : Cytokine. 42, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

40 Scopus citations