Christopher Niyibizi, MSc, PhD &ndash; Research Output

Article

A 92 kDa Gelatinase (MMP-9) cleavage site in native Type V collagen

Niyibizi, C., Chan, R., Wu, J. J. & Eyre, D., Jul 15 1994, In : Biochemical and Biophysical Research Communications. 202, 1, p. 328-333 6 p.

Research output: Contribution to journal › Article

Collagen Type V

Matrix Metalloproteinase 9

Matrix Metalloproteinases

Gelatinases

Molecules

92 Citations (Scopus)

Adenoviral-mediated transfer of TGF-β1 but not IGF-1 induces chondrogenic differentiation of human mesenchymal stem cells in pellet cultures

Kawamura, K., Chu, C. R., Sobajima, S., Robbins, P. D., Fu, F. H., Izzo, N. J. & Niyibizi, C., Aug 1 2005, In : Experimental Hematology. 33, 8, p. 865-872 8 p.

Research output: Contribution to journal › Article

Transforming Growth Factors

Somatomedins

Mesenchymal Stromal Cells

Intercellular Signaling Peptides and Proteins

Gene Expression

Adult stem cells and skeletal repair and regeneration

Niyibizi, C., Li, F., Wang, X. & Liao, X., Dec 1 2006, In : MCB Molecular and Cellular Biomechanics. 3, 4, 1 p.

Research output: Contribution to journal › Article

Adult Stem Cells

Mesenchymal Stromal Cells

Regeneration

Bone and Bones

Bone Matrix

37 Citations (Scopus)

Antisense oligonucleotides reduce synthesis of procollagen α1 (V) chain in human patellar tendon fibroblasts: Potential application in healing ligaments and tendons

Shimomura, T., Jia, F., Niyibizi, C. & Woo, S. L. Y., Nov 3 2003, In : Connective Tissue Research. 44, 3-4, p. 167-172 6 p.

Research output: Contribution to journal › Article

Collagen Type V

Procollagen

Patellar Ligament

Antisense Oligonucleotides

Ligaments

78 Citations (Scopus)

Biochemical analysis of collagens at the ligament-bone interface reveals presence of cartilage-specific collagens

Sagarriga Visconti, C., Kavalkovich, K., Wu, J. J. & Niyibizi, C., Apr 1 1996, In : Archives of Biochemistry and Biophysics. 328, 1, p. 135-142 8 p.

Research output: Contribution to journal › Article

Collagen Type II

Ligaments

Cartilage

Bone

Collagen Type IX

36 Citations (Scopus)

Bone marrow stromal cells contribute to bone formation following infusion into femoral cavities of a mouse model of osteogenesis imperfecta

Li, F., Wang, X. & Niyibizi, C., Sep 1 2010, In : Bone. 47, 3, p. 546-555 10 p.

Research output: Contribution to journal › Article

Osteogenesis Imperfecta

Thigh

Mesenchymal Stromal Cells

Osteogenesis

Femur

35 Citations (Scopus)

Bone type v collagen: Chain composition and location of a trypsin cleavage site

Niyibizi, C. & Eyre, D. R., Jan 1 1989, In : Connective Tissue Research. 20, 1-4, p. 247-250 4 p.

Research output: Contribution to journal › Article

Collagen Type V

Trypsin

Bone

Collagen

Bone and Bones

4 Citations (Scopus)

Breakout session 4: Gene therapy for genetic diseases of bone

Lian, J. B. & Niyibizi, C., Jan 1 2000, In : Clinical orthopaedics and related research. 379 SUPPL., p. S159-S163

Research output: Contribution to journal › Article

Osteogenesis Imperfecta

Gene Transfer Techniques

Bone Neoplasms

Inborn Genetic Diseases

Bone Diseases

9 Citations (Scopus)

Breast and abdominal adipose multipotent mesenchymal stromal cells and stage-specific embryonic antigen 4 expression

Maddox, J. R., Ludlow, K. D., Li, F. & Niyibizi, C., Jun 1 2012, In : Cells Tissues Organs. 196, 2, p. 107-116 10 p.

Research output: Contribution to journal › Article

Mesenchymal Stromal Cells

Breast

Abdominal Fat

stage-specific embryonic antigen-4

Adipose Tissue

50 Citations (Scopus)

Cartilage tissue engineering for laryngotracheal reconstruction: Comparison of chondrocytes from three anatomic locations in the rabbit

Henderson, J. H., Welter, J. F., Mansour, J. M., Niyibizi, C., Caplan, A. I. & Dennis, J. E., Apr 1 2007, In : Tissue Engineering. 13, 4, p. 843-853 11 p.

Research output: Contribution to journal › Article

Cartilage

Tissue engineering

Testing

Tissue

Collagen

30 Citations (Scopus)

Cells derived from murine induced pluripotent stem cells (iPSC) by treatment with members of TGF-beta family give rise to osteoblasts differentiation and form bone in vivo

Li, F. & Niyibizi, C., Dec 15 2012, In : BMC Cell Biology. 13, 35.

Research output: Contribution to journal › Article

Induced Pluripotent Stem Cells

Osteoblasts

Transforming Growth Factor beta

Bone and Bones

Bone Morphogenetic Protein 2

42 Citations (Scopus)

Collagens in an adult bovine medial collateral ligament: Immunofluorescence localization by confocal microscopy reveals that type XIV collagen predominates at the ligament-bone junction

Niyibizi, C., Visconti, C. S., Kavalkovich, K. & Woo, S. L. Y., Jan 1 1995, In : Matrix Biology. 14, 9, p. 743-751 9 p.

Research output: Contribution to journal › Article

Collateral Ligaments

Ligaments

Confocal Microscopy

Fluorescent Antibody Technique

Collagen

69 Citations (Scopus)

Cytokine-induced tendinitis: A preliminary study in rabbits

Stone, D., Green, C., Rao, U., Aizawa, H., Yamaji, T., Niyibizi, C., Carlin, G. & Woo, S. L. Y., Dec 1 1999, In : Journal of Orthopaedic Research. 17, 2, p. 168-177 10 p.

Research output: Contribution to journal › Article

Tendinopathy

Tendons

Collagenases

Patellar Ligament

Cytokines

63 Citations (Scopus)

Derivation of murine induced pluripotent stem cells (iPS) and assessment of their differentiation toward osteogenic lineage

Li, F., Bronson, S. & Niyibizi, C., Mar 1 2010, In : Journal of Cellular Biochemistry. 109, 4, p. 643-652 10 p.

Research output: Contribution to journal › Article

Induced Pluripotent Stem Cells

Stem cells

Embryoid Bodies

Transforming Growth Factor beta

Embryonic Stem Cells

17 Citations (Scopus)

Differentiating multipotent mesenchymal stromal cells generate factors that exert paracrine activities on exogenous MSCs: Implications for paracrine activities in bone regeneration

Li, F., Whyte, N. & Niyibizi, C., Oct 5 2012, In : Biochemical and Biophysical Research Communications. 426, 4, p. 475-479 5 p.

Research output: Contribution to journal › Article

Bone Regeneration

Mesenchymal Stromal Cells

Bone

Tissue

Alkaline Phosphatase

18 Citations (Scopus)

Distribution of murine adipose-derived mesenchymal stem cells in vivo following transplantation in developing mice

Liao, X., Li, F., Wang, X., Yanoso, J. & Niyibizi, C., Apr 1 2008, In : Stem Cells and Development. 17, 2, p. 303-314 12 p.

Research output: Contribution to journal › Article

Mesenchymal Stromal Cells

Transplantation

Bone and Bones

Transforming Growth Factors

Tissue Transplantation

43 Citations (Scopus)

Distribution of single-cell expanded marrow derived progenitors in a developing mouse model of osteogenesis imperfecta following systemic transplantation

Li, F., Wang, X. & Niyibizi, C., Dec 1 2007, In : STEM CELLS. 25, 12, p. 3183-3193 11 p.

Research output: Contribution to journal › Article

Osteogenesis Imperfecta

Transplantation

Bone Marrow

Bone and Bones

Cell Transplantation

6 Citations (Scopus)

Downregulation of human type III collagen gene expression by antisense oligodeoxynucleotide

Jia, F., Shimomura, T., Niyibizi, C. & Woo, S. L. Y., Sep 1 2005, In : Tissue Engineering. 11, 9-10, p. 1429-1435 7 p.

Research output: Contribution to journal › Article

Collagen

Gene expression

Tendons

Fibroblasts

Ligaments

170 Citations (Scopus)

Effect of growth factors on matrix synthesis by ligament fibroblasts

Marui, T., Niyibizi, C., Georgescu, H. I., Cao, M., Kavalkovich, K. W., Levine, R. E. & Woo, S. L. Y., Jan 1 1997, In : Journal of Orthopaedic Research. 15, 1, p. 18-23 6 p.

Research output: Contribution to journal › Article

Ligaments

Intercellular Signaling Peptides and Proteins

Fibroblasts

Anterior Cruciate Ligament

Collagen

51 Citations (Scopus)

Effect of rhBMP-2 on the osteogenic potential of bone marrow stromal cells from an osteogenesis imperfecta mouse

Balk, M. L., Bray, J., Day, C., Epperly, M., Greenberger, J., Evans, C. H. & Niyibizi, C., Jul 1 1997, In : Bone. 21, 1, p. 7-15 9 p.

Research output: Contribution to journal › Article

Osteogenesis Imperfecta

Stromal Cells

Mesenchymal Stromal Cells

Alkaline Phosphatase

Osteocalcin

4 Citations (Scopus)

Engraftability of Murine Bone Marrow-Derived Multipotent Mesenchymal Stem Cell Subpopulations in the Tissues of Developing Mice following Systemic Transplantation

Li, F. & Niyibizi, C., Dec 1 2015, In : Cells Tissues Organs. 201, 1, p. 14-25 12 p.

Research output: Contribution to journal › Article

Multipotent Stem Cells

Mesenchymal Stromal Cells

Transplantation

Bone Marrow

Cardiovascular System

111 Citations (Scopus)

Ex vivo gene therapy to produce bone using different cell types

Musgrave, D. S., Bosch, P., Lee, J. Y., Pelinkovic, D., Ghivizzani, S. C., Whalen, J., Niyibizi, C. & Huard, J., Jan 1 2000, In : Clinical orthopaedics and related research. 378, p. 290-305 16 p.

Research output: Contribution to journal › Article

Genetic Therapy

Bone Morphogenetic Protein 2

Mesenchymal Stromal Cells

Bone and Bones

Muscle Cells

9 Citations (Scopus)

Feasibility of percutaneous gene transfer to an atrophic nonunion in a rabbit

Lattermann, C., Baltzer, A. W., Zelle, B. A., Whalen, J. D., Niyibizi, C., Robbins, P. D., Evans, C. H. & Gruen, G. S., Aug 2004, In : Clinical orthopaedics and related research. 425, p. 237-243 7 p.

Research output: Contribution to journal › Article

Rabbits

Genes

Transgenes

Genetic Therapy

Intercellular Signaling Peptides and Proteins

GAG-augmented polysaccharide hydrogel: A novel biocompatible and biodegradable material to support chondrogenesis

Sechriest, V. F., Miao, Y. J., Niyibizi, C., Westerhausen-Larson, A., Matthew, H. W., Evans, C. H., Fu, F. H. & Suh, J. K., Mar 15 2000, In : Journal of Biomedical Materials Research. 49, 4, p. 534-541 8 p.

Research output: Contribution to journal › Article

Hydrogel

Chitosan

Biocompatible Materials

Polysaccharides

Glycosaminoglycans

235 Citations (Scopus)

GAG-augmented polysaccharide hydrogel: A novel biocompatible and biodegradable material to support chondrogenesis

Sechriest, V. F., Miao, Y. J., Niyibizi, C., Westerhausen-Larson, A., Matthew, H. W., Evans, C. H., Fu, F. H. & Suh, J. K., Mar 15 2000, In : Journal of Biomedical Materials Research. 49, 4, p. 534-541 8 p.

Research output: Contribution to journal › Article

Hydrogel

Chitosan

Biocompatible Materials

Polysaccharides

Glycosaminoglycans

59 Citations (Scopus)

Gene therapy for meniscal injury: Enhanced synthesis of proteoglycan and collagen by meniscal cells transduced with a TGFβ₁ gene

Goto, H., Shuler, F. D., Niyibizi, C., Fu, F. H., Robbins, P. D. & Evans, C. H., Jan 1 2000, In : Osteoarthritis and Cartilage. 8, 4, p. 266-271 6 p.

Research output: Contribution to journal › Article

Gene therapy

Proteoglycans

Collagen

Genetic Therapy

Genes

154 Citations (Scopus)

Genetic enhancement of matrix synthesis by articular chondrocytes: Comparison of different growth factor genes in the presence and absence of interleukin-1

Smith, P., Shuler, F. D., Georgescu, H. I., Ghivizzani, S. C., Johnstone, B., Niyibizi, C., Robbins, P. D. & Evans, C. H., May 1 2000, In : Arthritis and Rheumatism. 43, 5, p. 1156-1164 9 p.

Research output: Contribution to journal › Article

Genetic Enhancement

Chondrocytes

Interleukin-1

Intercellular Signaling Peptides and Proteins

Joints

20 Citations (Scopus)

Gene transfer to the tendon-bone insertion site

Lattermann, C., Zelle, B. A., Whalen, J. D., Baltzer, A. W. A., Robbins, P. D., Niyibizi, C., Evans, C. H. & Fu, F. H., Sep 1 2004, In : Knee Surgery, Sports Traumatology, Arthroscopy. 12, 5, p. 510-515 6 p.

Research output: Contribution to journal › Article

Tendon Transfer

Tendons

Bone and Bones

Genes

Immersion

1 Citation (Scopus)

Human Placental α1(V) α2(V) α3(V) and [α1(V)]₂, α2(V) Collagen Heterotrimers

VAN DER REST, MICHEL., Niyibizi, C. & FIETZEK, PETER. P., Jan 1 1985, In : Annals of the New York Academy of Sciences. 460, 1, p. 517-519 3 p.

Research output: Contribution to journal › Article

Collagen

83 Citations (Scopus)

Human placenta type V collagens. Evidence for the existence of an α1(V)α2(V)α3(V) collagen molecule

Niyibizi, C., Fietzek, P. P. & Van der Rest, M., Dec 1 1984, In : Journal of Biological Chemistry. 259, 22, p. 14170-14174 5 p.

Research output: Contribution to journal › Article

Collagen Type V

Placenta

Collagen

Ammonium Sulfate

Chromatography

69 Citations (Scopus)

Identification and immunolocalization of type X collagen at the ligament-bone interface

Niyibizi, C., Sagarriga Visconti, C., Gibson, G. & Kavalkovich, K., May 15 1996, In : Biochemical and Biophysical Research Communications. 222, 2, p. 584-589 6 p.

Research output: Contribution to journal › Article

Collagen Type X

Ligaments

Bone

Fibrocartilage

Bone and Bones

83 Citations (Scopus)

Identification of the cartilage α 1(XI) chain in type V collagen from bovine bone

Niyibizi, C. & Eyre, D. R., Jan 2 1989, In : FEBS Letters. 242, 2, p. 314-318 5 p.

Research output: Contribution to journal › Article

Collagen Type V

Cartilage

Bone

Bone and Bones

Peptides

63 Citations (Scopus)

Identification of types II, IX and X collagens at the insertion site of the bovine Achilles tendon

Fukuta, S., Oyama, M., Kavalkovich, K., Fu, F. H. & Niyibizi, C., Jan 1 1998, In : Matrix Biology. 17, 1, p. 65-73 9 p.

Research output: Contribution to journal › Article

Collagen Type IX

Collagen Type X

Achilles Tendon

Collagen Type II

Calcaneus

12 Citations (Scopus)

Incorporation of type I collagen molecules that contain a mutant α2(I) chain (Gly580 → Asp) into bone matrix in a lethal case of osteogenesis imperfecta

Niyibizi, C., Bonadio, J., Byers, P. H. & Eyre, D. R., Nov 15 1992, In : Journal of Biological Chemistry. 267, 32, p. 23108-23112 5 p.

Research output: Contribution to journal › Article

Osteogenesis Imperfecta

Bone Matrix

Viperidae

Collagen Type I

Bone

93 Citations (Scopus)

Increased matrix synthesis following adenoviral transfer of a transforming growth factor β₁ gene into articular chondrocytes

Shuler, F. D., Georgescu, H. I., Niyibizi, C., Studer, R. K., Mi, Z., Johnstone, B., Robbins, P. D. & Evans, C. H., Jan 1 2000, In : Journal of Orthopaedic Research. 18, 4, p. 585-592 8 p.

Research output: Contribution to journal › Article

Transforming Growth Factors

Chondrocytes

Joints

Collagen

Genes

12 Citations (Scopus)

Interaction of TGF-beta1 and rhBMP-2 on human bone marrow stromal cells cultured in collagen gel matrix.

Kim, M. K. & Niyibizi, C., Jan 1 2001, In : Yonsei Medical Journal. 42, 3, p. 338-344 7 p.

Research output: Contribution to journal › Article

Transforming Growth Factor beta1

Mesenchymal Stromal Cells

Collagen

Gels

Osteoblasts

35 Citations (Scopus)

Intermittent sub-ambient interstitial hydrostatic pressure as a potential mechanical stimulator for chondrocyte metabolism

Suh, J. K., Baek, G. H., Arøen, A., Malin, C. M., Niyibizi, C., Evans, C. H. & Westerhausen-Larson, A., Jan 1 1999, In : Osteoarthritis and Cartilage. 7, 1, p. 71-80 10 p.

Research output: Contribution to journal › Article

Hydrostatic Pressure

Hydrostatic pressure

Chondrocytes

Metabolism

Pressure

16 Citations (Scopus)

In vivo expression of human growth hormone by genetically modified murine bone marrow stromal cells and its effect on the cells in vitro

Suzuki, K., Oyama, M., Faulcon, L., Robbins, P. D. & Niyibizi, C., Jan 1 2000, In : Cell Transplantation. 9, 3, p. 319-327 9 p.

Research output: Contribution to journal › Article

Human Growth Hormone

Hormones

Mesenchymal Stromal Cells

Bone

Femur

Isolation of mesenchymal stem cells from bone marrow with distinct differentiation and engraftment in developing mice

Li, F., Wang, X., Liao, X. & Niyibizi, C., Dec 1 2006, In : MCB Molecular and Cellular Biomechanics. 3, 4, p. 167-168 2 p.

Research output: Contribution to journal › Article

Mesenchymal Stromal Cells

Bone Marrow

Bone and Bones

24 Citations (Scopus)

Low oxygen tension during incubation periods of chondrocyte expansion is sufficient to enhance postexpansion chondrogenesis

Henderson, J. H., Ginley, N. M., Caplan, A. I., Niyibizi, C. & Dennis, J. E., May 1 2010, In : Tissue Engineering - Part A. 16, 5, p. 1585-1593 9 p.

Research output: Contribution to journal › Article

Chondrogenesis

Chondrocytes

Glycosaminoglycans

Oxygen

Cartilage

39 Citations (Scopus)

Medial collateral knee ligament healing. Combined medial collateral and anterior cruciate ligament injuries studied in rabbits

Woo, S. L. Y., Niyibizi, C., Matyas, J., Kavalkovich, K., Weaver-Green, C. & Fox, R. J., Jan 1 1997, In : Acta Orthopaedica Scandinavica. 68, 2, p. 142-148 7 p.

Research output: Contribution to journal › Article

Knee Medial Collateral Ligament

Collateral Ligaments

Rabbits

Ligaments

Collagen

31 Citations (Scopus)

Medial collateral ligament healing one year after a concurrent medial collateral ligament and anterior cruciate ligament injury: An interdisciplinary study in rabbits

Yamaji, T., Levine, R. E., Woo, S. L. Y., Niyibizi, C., Kavalkovich, K. W. & Weaver- Green, C. M., Mar 1 1996, In : Journal of Orthopaedic Research. 14, 2, p. 223-227 5 p.

Research output: Contribution to journal › Article

Interdisciplinary Studies

Collateral Ligaments

Anterior Cruciate Ligament

Rabbits

Knee

43 Citations (Scopus)

Multipotent mesenchymal stem cells from human subacromial bursa: Potential for cell based tendon tissue engineering

Song, N., Armstrong, A., Li, F., Ouyang, H. & Niyibizi, C., Jan 1 2014, In : Tissue Engineering - Part A. 20, 1-2, p. 239-249 11 p.

Research output: Contribution to journal › Article

Multipotent Stem Cells

Tendons

Bioelectric potentials

Tissue Engineering

Stem cells

125 Citations (Scopus)

Muscle derived, cell based ex vivo gene therapy for treatment of full thickness articular cartilage defects

Adachi, N., Sato, K., Usas, A., Fu, F. H., Ochi, M., Han, C. W., Niyibizi, C. & Huard, J., Sep 1 2002, In : Journal of Rheumatology. 29, 9, p. 1920-1930 11 p.

Research output: Contribution to journal › Article

Articular Cartilage

Genetic Therapy

Muscle Cells

Chondrocytes

Collagen

147 Citations (Scopus)

Nitric oxide inhibits the synthesis of type-II collagen without altering Col2A1 mRNA abundance: Prolyl hydroxylase as a possible target

Cao, M., Westerhausen-Larson, A., Niyibizi, C., Kavalkovich, K., Georgescu, H. I., Rizzo, C. F., Hebda, P. A., Stefanovic-Racic, M. & Evans, C. H., May 15 1997, In : Biochemical Journal. 324, 1, p. 305-310 6 p.

Research output: Contribution to journal › Article

Prolyl Hydroxylases

Collagen Type II

Interleukin-1

Nitric Oxide

Collagen