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Research Output 1998 2019

2019
2 Citations (Scopus)

Closing the therapeutic loop

Campbell, K. S., Yengo, C., Lee, L. C., Kotter, J., Sorrell, V. L., Guglin, M. & Wenk, J. F., Mar 15 2019, In : Archives of Biochemistry and Biophysics. 663, p. 129-131 3 p.

Research output: Contribution to journalReview article

Therapeutics

Converter domain mutations in myosin alter structural kinetics and motor function

Gunther, L. K., Rohde, J. A., Tang, W., Walton, S. D., Unrath, W. C., Trivedi, D. V., Muretta, J. M., Thomas, D. D. & Yengo, C., Jan 1 2019, In : Journal of Biological Chemistry. 294, 5, p. 1554-1567 14 p.

Research output: Contribution to journalArticle

Myosins
Mutation
Kinetics
Adenosine Triphosphatases
Conformations
2 Citations (Scopus)

Structure of the MORN4/Myo3a Tail Complex Reveals MORN Repeats as Protein Binding Modules

Li, J., Liu, H., Raval, M. H., Wan, J., Yengo, C. M., Liu, W. & Zhang, M., Sep 3 2019, In : Structure. 27, 9, p. 1366-1374.e3

Research output: Contribution to journalArticle

Protein Binding
Tail
Tandem Repeat Sequences
Proteins
Ankyrins
2018

Characterization of a novel MYO3A missense mutation associated with a dominant form of late onset hearing loss

Dantas, V. G. L., Raval, M. H., Ballesteros, A., Cui, R., Gunther, L. K., Yamamoto, G. L., Alves, L. U., Bueno, A. S., Lezirovitz, K., Pirana, S., Mendes, B. C. A., Yengo, C., Kachar, B. & Mingroni-Netto, R. C., Dec 1 2018, In : Scientific reports. 8, 1, 8706.

Research output: Contribution to journalArticle

Stereocilia
Missense Mutation
Hearing Loss
Actins
Myosins

Getting site-specific with actomyosin inhibitors

Gunther, L. K. & Yengo, C., Jan 1 2018, In : Journal of Biological Chemistry. 293, 31, p. 12299-12300 2 p.

Research output: Contribution to journalArticle

Actomyosin
Myosins
Actins
High-Throughput Screening Assays
Molecules

Inter-filament co-operativity is crucial for regulating muscle contraction

Tang, W. & Yengo, C., Jan 1 2018, In : Journal of Physiology. 596, 1, p. 17-18 2 p.

Research output: Contribution to journalArticle

Fluorescence Polarization
Myosins
Muscle Contraction
Actins
Myocardium
2017
1 Citation (Scopus)

Corrigendum: Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like

Ebrahim, S., Avenarius, M. R., Grati, M., Krey, J. F., Windsor, A. M., Sousa, A. D., Ballesteros, A., Cui, R., Millis, B. A., Salles, F. T., Baird, M. A., Davidson, M. W., Jones, S. M., Choi, D., Dong, L., Raval, M. H., Yengo, C., Barr-Gillespie, P. G. & Kachar, B., Aug 14 2017, In : Nature communications. 8, 1 p.

Research output: Contribution to journalComment/debate

Myosin Type III
Stereocilia
myosins
stairways
spacing
6 Citations (Scopus)

Modulating beta-cardiac myosin function at the molecular and tissue levels

Tang, W., Blair, C. A., Walton, S. D., Málnási-Csizmadia, A., Campbell, K. S. & Yengo, C. M., Jan 1 2017, In : Frontiers in Physiology. 7, JAN, 659.

Research output: Contribution to journalArticle

Ventricular Myosins
Myosins
Mutation
Hypertrophic Cardiomyopathy
Cardiomyopathies
17 Citations (Scopus)

Omecamtiv mecarbil enhances the duty ratio of human β-cardiac myosin resulting in increased calcium sensitivity and slowed force development in cardiac muscle

Swenson, A. M., Tang, X. W., Blair, C. A., Fetrow, C. M., Unrath, W. C., Previs, M. J., Campbell, K. S. & Yengo, C. M., Mar 3 2017, In : Journal of Biological Chemistry. 292, 9, p. 3768-3778 11 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Myosins
Muscle
Actins
Myocardium
2016
17 Citations (Scopus)

Biological nanomotors with a revolution, linear, or rotation motion mechanism

Guo, P., Noji, H., Yengo, C. M., Zhao, Z. & Graingei, I., Mar 2016, In : Microbiology and Molecular Biology Reviews. 80, 1, p. 161-186 26 p.

Research output: Contribution to journalReview article

DNA
Entropy
Bacterial Chromosomes
Dyneins
Kinesin
2 Citations (Scopus)

Impact of the motor and tail domains of class III myosins on regulating the formation and elongation of actin protrusions

Raval, M. H., Quintero, O. A., Weck, M. L., Unrath, W. C., Gallagher, J. W., Cui, R., Kachar, B., Tyska, M. J. & Yengo, C. M., Oct 21 2016, In : Journal of Biological Chemistry. 291, 43, p. 27781-27792 12 p.

Research output: Contribution to journalArticle

Myosin Type III
Tail
Actins
Elongation
Pseudopodia
7 Citations (Scopus)

MYO3A Causes Human Dominant Deafness and Interacts with Protocadherin 15-CD2 Isoform

Grati, M., Yan, D., Raval, M. H., Walsh, T., Ma, Q., Chakchouk, I., Kannan-Sundhari, A., Mittal, R., Masmoudi, S., Blanton, S. H., Tekin, M., King, M. C., Yengo, C. M. & Liu, X. Z., May 1 2016, In : Human mutation. 37, 5, p. 481-487 7 p.

Research output: Contribution to journalArticle

Stereocilia
Deafness
Protein Isoforms
Molecular Motor Proteins
Hearing Loss
9 Citations (Scopus)

Myosin III-mediated cross-linking and stimulation of actin bundling activity of Espin

Liu, H., Li, J., Raval, M. H., Yao, N., Deng, X., Lu, Q., Nie, S., Feng, W., Wan, J., Yengo, C. M., Liu, W. & Zhang, M., Jan 19 2016, In : eLife. 5, JANUARY2016, e12856.

Research output: Contribution to journalArticle

Myosin Type III
Actins
Stereocilia
Ankyrin Repeat
Audition
7 Citations (Scopus)
Single-Cell Analysis
Pulmonary Surfactant-Associated Protein A
Alveolar Macrophages
Actin Cytoskeleton
varespladib methyl
17 Citations (Scopus)

Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like

Ebrahim, S., Avenarius, M. R., Grati, M., Krey, J. F., Windsor, A. M., Sousa, A. D., Ballesteros, A., Cui, R., Millis, B. A., Salles, F. T., Baird, M. A., Davidson, M. W., Jones, S. M., Choi, D., Dong, L., Raval, M. H., Yengo, C., Barr-Gillespie, P. G. & Kachar, B., Mar 1 2016, In : Nature communications. 7, 10833.

Research output: Contribution to journalArticle

Myosin Type III
Stereocilia
myosins
cargo
stairways
2015
21 Citations (Scopus)

Direct measurements of the coordination of lever arm swing and the catalytic cycle in myosin V

Trivedia, D. V., Murettab, J. M., Swensona, A. M., Davisc, J. P., Thomasb, D. D. & Yengo, C., Nov 24 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 47, p. 14593-14598 6 p.

Research output: Contribution to journalArticle

Myosin Type V
Stroke
Myosins
Hydrolysis
Adenosine Triphosphate
8 Citations (Scopus)

Invertebrate and vertebrate class III myosins interact with MORN repeat-containing adaptor proteins

Mecklenburg, K. L., Freed, S. A., Raval, M., Quintero, O. A., Yengo, C. & O'Tousa, J. E., Mar 30 2015, In : PloS one. 10, 3, e0122502.

Research output: Contribution to journalArticle

Myosin Type III
Invertebrates
myosin
Vertebrates
Tail
2014
12 Citations (Scopus)

Magnesium modulates actin binding and ADP release in myosin motors

Swenson, A. M., Trivedi, D. V., Rauscher, A. A., Wang, Y., Takagi, Y., Palmer, B. M., Málnási-Csizmadia, A., Debold, E. P. & Yengo, C. M., Jan 1 2014, In : Journal of Biological Chemistry. 289, 34, p. 23977-23991 15 p.

Research output: Contribution to journalArticle

Myosin Type V
Myosins
Myosin Type II
Adenosine Diphosphate
Magnesium
2013
9 Citations (Scopus)

Biochemical and bioinformatic analysis of the myosin-XIX motor domain

Adikes, R. C., Unrath, W. C., Yengo, C. M. & Quintero, O. A., May 1 2013, In : Cytoskeleton. 70, 5, p. 281-295 15 p.

Research output: Contribution to journalArticle

Myosins
Computational Biology
Mitochondrial Dynamics
Mitochondria
Actins
11 Citations (Scopus)

Magnesium impacts myosin v motor activity by altering key conformational changes in the mechanochemical cycle

Trivedi, D. V., Muretta, J. M., Swenson, A. M., Thomas, D. D. & Yengo, C. M., Jul 9 2013, In : Biochemistry. 52, 27, p. 4710-4722 13 p.

Research output: Contribution to journalArticle

Myosins
Magnesium
Motor Activity
Actomyosin
Myosin Type V
13 Citations (Scopus)

Myosin 3A kinase activity is regulated by phosphorylation of the kinase domain activation loop

Quintero, O. A., Unrath, W. C., Stevens, S. M., Manor, U., Kachar, B. & Yengo, C., Dec 27 2013, In : Journal of Biological Chemistry. 288, 52, p. 37126-37137 12 p.

Research output: Contribution to journalArticle

Myosin-Light-Chain Kinase
Phosphorylation
Myosins
Phosphotransferases
Chemical activation
2012
1 Citation (Scopus)

Basics of the cytoskeleton: Myosins

Quintero, O. A., Moore, J. E. & Yengo, C., Dec 1 2012, Cytoskeleton and Human Disease. Humana Press Inc., Vol. 9781617797880. p. 73-100 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Myosins
Cytoskeleton
Actin Cytoskeleton
Actins
Adenosine Triphosphate
10 Citations (Scopus)

Exercise training post-MI favorably modifies heart extracellular matrix in the rat

Yengo, C., Zimmerman, S. D., McCormick, R. J. & Paul Thomas, D., Jun 1 2012, In : Medicine and Science in Sports and Exercise. 44, 6, p. 1005-1012 8 p.

Research output: Contribution to journalArticle

Extracellular Matrix
Myocardial Infarction
Exercise
Collagen
Heart Ventricles
36 Citations (Scopus)

Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions

Merritt, R. C., Manor, U., Salles, F. T., Grati, MH., Dose, A. C., Unrath, W. C., Quintero, O. A., Yengo, C. & Kachar, B., Feb 21 2012, In : Current Biology. 22, 4, p. 320-325 6 p.

Research output: Contribution to journalArticle

Myosins
myosin
actin
Actins
pseudopodia
1 Citation (Scopus)

Myosin X dimerization and its impact on cellular functions

Quintero, O. A. & Yengo, C., Oct 23 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 43, p. 17313-17314 2 p.

Research output: Contribution to journalComment/debate

Dimerization
Myosins
18 Citations (Scopus)

Switch II mutants reveal coupling between the nucleotide- and actin-binding regions in myosin v

Trivedi, D. V., David, C., Jacobs, D. J. & Yengo, C., Jun 6 2012, In : Biophysical journal. 102, 11, p. 2545-2555 11 p.

Research output: Contribution to journalArticle

Myosins
Actins
Nucleotides
Myosin Type V
Adenosine Triphosphate
20 Citations (Scopus)

Temperature dependent measurements reveal similarities between muscle and non-muscle myosin motility

Yengo, C., Takagi, Y. & Sellers, J. R., Aug 29 2012, In : Journal of Muscle Research and Cell Motility. 33, 6, p. 385-394 10 p.

Research output: Contribution to journalArticle

Myosin Subfragments
Muscle
Assays
Muscles
Temperature
2011
19 Citations (Scopus)
Alveolar Macrophages
Proteome
Knockout Mice
Actins
Proteins
19 Citations (Scopus)

Kinetics and thermodynamics of the rate-limiting conformational change in the actomyosin V mechanochemical cycle

Jacobs, D. J., Trivedi, D., David, C. & Yengo, C., Apr 15 2011, In : Journal of Molecular Biology. 407, 5, p. 716-730 15 p.

Research output: Contribution to journalArticle

Actomyosin
Thermodynamics
Myosin Type V
Nucleotides
Myosins
4 Citations (Scopus)

Nonmuscle myosin II regulates migration but not contraction in rat hepatic stellate cells

Moore, C. C., Lakner, A. M., Yengo, C. & Schrum, L. W., Dec 1 2011, In : World Journal of Hepatology. 3, 7, p. 184-197 14 p.

Research output: Contribution to journalArticle

Myosin Type II
Hepatic Stellate Cells
Small Interfering RNA
Bile Ducts
Protein Isoforms
2010
27 Citations (Scopus)
Fluorescence Resonance Energy Transfer
Fluorescence Polarization
High-Throughput Screening Assays
Proteins
Fluorescence Spectrometry
30 Citations (Scopus)

Intermolecular autophosphorylation regulates myosin IIIa activity and localization in parallel actin bundles

Quintero, O. A., Moore, J. E., Unrath, W. C., Manor, U., Salles, F. T., Grati, MH., Kachar, B. & Yengo, C. M., Nov 12 2010, In : Journal of Biological Chemistry. 285, 46, p. 35770-35782 13 p.

Research output: Contribution to journalArticle

Myosins
Actins
Phosphotransferases
Phosphorylation
Adenosine Triphosphatases
2009
17 Citations (Scopus)

Kinetic and thermodynamic characterization of dihydrotestosterone-induced conformational perturbations in androgen receptor ligand-binding domain

Jasuja, R., Ulloor, J., Yengo, C., Choong, K., Istomin, A. Y., Livesay, D. R., Jacobs, D. J., Swerdloff, R. S., Mikšovská, J., Larsen, R. W. & Bhasin, S., Aug 1 2009, In : Molecular Endocrinology. 23, 8, p. 1231-1241 11 p.

Research output: Contribution to journalArticle

Dihydrotestosterone
Androgen Receptors
Thermodynamics
Ligands
Pressure
90 Citations (Scopus)

Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments

Salles, F. T., Merritt, R. C., Manor, U., Dougherty, G. W., Sousa, A. D., Moore, J. E., Yengo, C., Dosé, A. C. & Kachar, B., Mar 16 2009, In : Nature Cell Biology. 11, 4, p. 443-450 8 p.

Research output: Contribution to journalArticle

Stereocilia
Myosins
Actin Cytoskeleton
Actins
Pseudopodia
61 Citations (Scopus)

Sensorimotor function as a predictor of chronic ankle instability

Sefton, J. E. M., Hicks-Little, C. A., Hubbard, T. J., Clemens, M. G., Yengo, C., Koceja, D. M. & Cordova, M. L., Jun 1 2009, In : Clinical Biomechanics. 24, 5, p. 451-458 8 p.

Research output: Contribution to journalArticle

Ankle
Motor Neurons
Kinesthesis
Ankle Injuries
Rehabilitation
2008
26 Citations (Scopus)

Characterization of the pre-force-generation state in the actomyosin cross-bridge cycle

Sun, M., Rose, M. B., Ananthanarayanan, S. K., Jacobs, D. J. & Yengo, C., Jun 24 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 25, p. 8631-8636 6 p.

Research output: Contribution to journalArticle

Actomyosin
Actins
Nucleotides
Adenosine Diphosphate
Fluorescence Resonance Energy Transfer
9 Citations (Scopus)

Human deafness mutation E385D disrupts the mechanochemical coupling and subcellular targeting of myosin-1a

Yengo, C., Ananthanarayanan, S. K., Brosey, C. A., Mao, S. & Tyska, M. J., Jan 15 2008, In : Biophysical journal. 94, 2

Research output: Contribution to journalArticle

Deafness
Myosins
Mutation
Actins
Microvilli
32 Citations (Scopus)

Segmental Spinal Reflex Adaptations Associated With Chronic Ankle Instability

Sefton, J. E. M., Hicks-Little, C. A., Hubbard, T. J., Clemens, M. G., Yengo, C., Koceja, D. M. & Cordova, M. L., Oct 1 2008, In : Archives of Physical Medicine and Rehabilitation. 89, 10, p. 1991-1995 5 p.

Research output: Contribution to journalArticle

Ankle
Reflex
varespladib methyl
Healthy Volunteers
Motor Neurons
22 Citations (Scopus)

The kinase domain alters the kinetic properties of the myosin IIIA motor

Dosé, A. C., Ananthanarayanan, S., Moore, J. E., Corsa, A. C., Burnside, B. & Yengo, C., Feb 26 2008, In : Biochemistry. 47, 8, p. 2485-2496 12 p.

Research output: Contribution to journalArticle

Myosins
Phosphotransferases
Actins
Kinetics
Inner Auditory Hair Cells
2007

Development of polymeric micro/nanostructures for gene delivery

Alyounes, D., Yengo, C., Doran, T., Lu, Q. & Gonsalves, K., Dec 1 2007, Materials Research Society Symposium Proceedings - Engineered Nanoscale Materials for the Diagnosis and Treatment of Disease. p. 41-48 8 p. (Materials Research Society Symposium Proceedings; vol. 1019).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Poloxamer
UCON 50-HB-5100
genes
affinity
Nanostructures
33 Citations (Scopus)

Kinetic mechanism of human myosin IIIA

Dosé, A. C., Ananthanarayanan, S., Moore, J. E., Burnside, B. & Yengo, C. M., Jan 5 2007, In : Journal of Biological Chemistry. 282, 1, p. 216-231 16 p.

Research output: Contribution to journalArticle

Myosins
Actins
Kinetics
Myosin Type III
Actomyosin
39 Citations (Scopus)

T-cell signaling pathways inhibited by the tick saliva immunosuppressor, Salp15

Juncadella, I. J., Garg, R., Ananthnarayanan, S. K., Yengo, C. & Anguita, J., Apr 1 2007, In : FEMS Immunology and Medical Microbiology. 49, 3, p. 433-438 6 p.

Research output: Contribution to journalArticle

Ticks
Saliva
Salivary Proteins and Peptides
T-Lymphocytes
Immunosuppressive Agents
2006
76 Citations (Scopus)

Cutting edge: CD4 is the receptor for the tick saliva immunosuppressor, Salp15

Garg, R., Juncadella, I. J., Ramamoorthi, N., Ashish, Ananthanarayanan, S. K., Thomas, V., Rincón, M., Krueger, J. K., Fikrig, E., Yengo, C. & Anguita, J., Nov 15 2006, In : Journal of Immunology. 177, 10, p. 6579-6583 5 p.

Research output: Contribution to journalArticle

CD4 Antigens
Ticks
Saliva
T-Lymphocytes
Ligation
24 Citations (Scopus)

Dynamics of the upper 50-kDa domain of myosin V examined with fluorescence resonance energy transfer

Sun, M., Oakes, J. L., Ananthanarayanan, S. K., Hawley, K. H., Tsien, R. Y., Adams, S. R. & Yengo, C., Mar 3 2006, In : Journal of Biological Chemistry. 281, 9, p. 5711-5717 7 p.

Research output: Contribution to journalArticle

Myosin Type V
Fluorescence Resonance Energy Transfer
Energy Transfer
Actins
Energy transfer
2005
36 Citations (Scopus)

Mutation of smooth muscle myosin causes epithelial invasion and cystic expansion of the zebrafish intestine

Wallace, K. N., Dolan, A. C., Seiler, C., Smith, E. M., Yusuff, S., Chaille-Arnold, L., Judson, B., Sierk, R., Yengo, C., Sweeney, H. L. & Pack, M., May 1 2005, In : Developmental Cell. 8, 5, p. 717-726 10 p.

Research output: Contribution to journalArticle

Smooth Muscle Myosins
Zebrafish
Intestines
Genes
Cells
157 Citations (Scopus)

The structure of the myosin VI motor reveals the mechanism of directionality reversal

Ménétrey, J., Bahloul, A., Wells, A. L., Yengo, C., Morris, C. A., Sweeney, H. L. & Houdusse, A., Jun 9 2005, In : Nature. 435, 7043, p. 779-785 7 p.

Research output: Contribution to journalArticle

Calmodulin
Myosins
Nucleotides
Kinesin
Actin Cytoskeleton
2004
56 Citations (Scopus)

Functional Role of Loop 2 in Myosin V

Yengo, C. & Sweeney, H. L., Mar 9 2004, In : Biochemistry. 43, 9, p. 2605-2612 8 p.

Research output: Contribution to journalArticle

Myosin Type V
Actins
Myosin Type II
Adenosine Triphosphatases
Phosphates
53 Citations (Scopus)

Kinetic mechanism of blebbistatin inhibition of nonmuscle myosin IIB

Ramamurthy, B., Yengo, C., Straight, A. F., Mitchison, T. J. & Sweeney, H. L., Nov 23 2004, In : Biochemistry. 43, 46, p. 14832-14839 8 p.

Research output: Contribution to journalArticle

Nonmuscle Myosin Type IIB
Myosin Subfragments
Kinetics
Myosins
pioglitazone
2003
230 Citations (Scopus)

A structural state of the myosin V motor without bound nucleotide

Coureux, P. D., Wells, A. L., Ménétrey, J., Yengo, C., Morris, C. A., Sweeney, H. L. & Houdusse, A., Sep 25 2003, In : Nature. 425, 6956, p. 419-423 5 p.

Research output: Contribution to journalArticle

Myosin Type V
Myosins
Nucleotides
Actins
Binding Sites
15 Citations (Scopus)

Does the S2 Rod of Myosin II Uncoil upon Two-Headed Binding to Actin? A Leucine-Zippered HMM Study

Chakrabarty, T., Yengo, C., Baldacchino, C., Chen, L. Q., Sweeney, H. L. & Selvin, P. R., Nov 11 2003, In : Biochemistry. 42, 44, p. 12886-12892 7 p.

Research output: Contribution to journalArticle

Myosin Type II
Myosin Subfragments
Leucine
Actins
Myosins