• 14583 Citations
  • 56 h-Index
1976 …2020
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Research Output 1976 2019

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Article
2019
Mitochondrial Degradation
Retinal Ganglion Cells
Glaucoma
Cell Death
Neuroglia
2018
2 Citations (Scopus)

Generation of Photoreceptor Precursors from Mouse Embryonic Stem Cells

Lu, A. Q. & Barnstable, C., Apr 1 2018, In : Stem Cell Reviews and Reports. 14, 2, p. 247-261 15 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Organoids
Gene Expression
Activins
Intrinsic Factor

Perineuronal nets labeled by monoclonal antibody VC1.1 ensheath interneurons expressing parvalbumin and calbindin in the rat amygdala

McDonald, A. J., Hamilton, P. G. & Barnstable, C., Apr 1 2018, In : Brain Structure and Function. 223, 3, p. 1133-1148 16 p.

Research output: Contribution to journalArticle

Calbindins
Parvalbumins
Interneurons
Amygdala
Monoclonal Antibodies

The 3-phosphoinositide-dependent protein kinase 1 inhibits rod photoreceptor development

Xing, T., Hass, D. T., Zhang, S. S. & Barnstable, C., Oct 10 2018, In : Frontiers in Cell and Developmental Biology. 6, OCT, 134.

Research output: Contribution to journalArticle

3-Phosphoinositide-Dependent Protein Kinases
Retinal Rod Photoreceptor Cells
Phosphatidylinositols
Protein Kinases
Retina
2017
2 Citations (Scopus)

Activin Signals through SMAD2/3 to Increase Photoreceptor Precursor Yield during Embryonic Stem Cell Differentiation

Lu, A. Q., Popova, E. & Barnstable, C., Sep 12 2017, In : Stem Cell Reports. 9, 3, p. 838-852 15 p.

Research output: Contribution to journalArticle

Activins
Embryonic Stem Cells
Stem cells
Cell Differentiation
Stem Cells
7 Citations (Scopus)

Histone deacetylase 1 is essential for rod photoreceptor differentiation by regulating acetylation at histone H3 lysine 9 and histone H4 lysine 12 in the mouse retina

Ferreira, R. C., Popova, E. Y., James, J., Briones, M. R. S., Zhang, S. S. & Barnstable, C. J., Feb 10 2017, In : Journal of Biological Chemistry. 292, 6, p. 2422-2440 19 p.

Research output: Contribution to journalArticle

Histone Deacetylase 1
Retinal Rod Photoreceptor Cells
Acetylation
Histones
Lysine
4 Citations (Scopus)

Identification and prediction of alternative transcription start sites that generate rod photoreceptor-specific transcripts from ubiquitously expressed genes

Popova, E., Salzberg, A. C., Yang, C., Zhang, S. S. M. & Barnstable, C., Jun 1 2017, In : PLoS One. 12, 6, e0179230.

Research output: Contribution to journalArticle

rods (retina)
Retinal Rod Photoreceptor Cells
Transcription Initiation Site
transcription (genetics)
Genes
2016
6 Citations (Scopus)

High pressure-induced mtDNA alterations in retinal ganglion cells and subsequent apoptosis

Zhang, S. H., Gao, F. J., Sun, Z. M., Xu, P., Chen, J. Y., Sun, X. H., Wu, J. H., Wang, H., Joachim, S. C. & Barnstable, C., Nov 24 2016, In : Frontiers in Cellular Neuroscience. 10, NOV2016, 254.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Mitochondrial DNA
Apoptosis
Pressure
Hydrostatic Pressure
13 Citations (Scopus)

LSD1-Mediated Demethylation of H3K4me2 Is Required for the Transition from Late Progenitor to Differentiated Mouse Rod Photoreceptor

Popova, E., Pinzon-Guzman, C., Salzberg, A. C., Zhang, S. S. M. & Barnstable, C., Sep 1 2016, In : Molecular Neurobiology. 53, 7, p. 4563-4581 19 p.

Research output: Contribution to journalArticle

Retinal Rod Photoreceptor Cells
Gene Expression
Transcription Factors
Histone Demethylases
Genes
8 Citations (Scopus)

Mitochondrial Uncoupling Protein 2 (UCP2) Regulates Retinal Ganglion Cell Number and Survival

Barnstable, C., Reddy, R., Li, H. & Horvath, T. L., Apr 1 2016, In : Journal of Molecular Neuroscience. 58, 4, p. 461-469 9 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Cell Survival
Cell Count
Retina
Intraocular Injections
2015
11 Citations (Scopus)

Therapeutic Retrobulbar Inhibition of STAT3 Protects Ischemic Retina Ganglion Cells

Wong, M., Li, Y., Li, S., Zhang, S., Li, W., Zhang, P., Chen, C., Barnstable, C., Zhang, S. S., Zhang, C. & Huang, P., Dec 1 2015, In : Molecular Neurobiology. 52, 3, p. 1364-1377 14 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Optic Nerve
Ganglia
Astrocytes
Retina
2014
4 Citations (Scopus)

Cell type-specific epigenetic signatures accompany late stages of mouse retina development

Popova, E., Barnstable, C. & Zhang, S. S. M., Jan 1 2014, In : Advances in Experimental Medicine and Biology. 801, p. 3-8 6 p.

Research output: Contribution to journalArticle

Epigenomics
Retina
Genes
Retinal Rod Photoreceptor Cells
Genome
8 Citations (Scopus)

Regulation of Rod Photoreceptor Differentiation by STAT3 Is Controlled by a Tyrosine Phosphatase

Pinzon-Guzman, C., Xing, T., Zhang, S. S. M. & Barnstable, C., Jan 1 2014, In : Journal of Molecular Neuroscience. 55, 1, p. 152-159 8 p.

Research output: Contribution to journalArticle

Retinal Rod Photoreceptor Cells
Insulin-Like Growth Factor I
Phosphoric Monoester Hydrolases
Tyrosine
Retina
19 Citations (Scopus)

Stat3 mediates LIF-induced protection of astrocytes against toxic ROS by upregulating the UPC2 mRNA pool

Lapp, D. W., Zhang, S. S. & Barnstable, C., Feb 1 2014, In : GLIA. 62, 2, p. 159-170 12 p.

Research output: Contribution to journalArticle

Leukemia Inhibitory Factor
Poisons
Astrocytes
Reactive Oxygen Species
Messenger RNA
9 Citations (Scopus)

Tetrandrine protects mouse retinal ganglion cells from ischemic injury

Li, W., Yang, C., Lu, J., Huang, P., Barnstable, C. J., Zhang, C. & Zhang, S. S., Mar 21 2014, In : Drug Design, Development and Therapy. 8, p. 327-339 13 p.

Research output: Contribution to journalArticle

tetrandrine
Retinal Ganglion Cells
Wounds and Injuries
Ischemia
Staurosporine
2013
6 Citations (Scopus)

CD4 positive T helper cells contribute to retinal ganglion cell death in mouse model of ischemia reperfusion injury

Huang, P., Huo, Y., Lou, L. X., Li, H., Barnstable, C., Zhang, C. & Zhang, S. S., Oct 1 2013, In : Experimental Eye Research. 115, p. 131-139 9 p.

Research output: Contribution to journalArticle

SCID Mice
Retinal Ganglion Cells
Helper-Inducer T-Lymphocytes
Reperfusion Injury
Cell Death
29 Citations (Scopus)
Retinal Rod Photoreceptor Cells
Heterochromatin
Structural integrity
Histones
Retina
2012
69 Citations (Scopus)

Pigment epithelium-derived factor (PEDF) peptide eye drops reduce inflammation, cell death and vascular leakage in diabetic retinopathy in Ins2(Akita) mice.

Liu, Y., Leo, L. F., McGregor, C., Grivitishvili, A., Barnstable, C. & Tombran-Tink, J., Jan 1 2012, In : Unknown Journal. 18, p. 1387-1401 15 p.

Research output: Contribution to journalArticle

Ophthalmic Solutions
Diabetic Retinopathy
Occludin
Blood Vessels
Retina
33 Citations (Scopus)

Stage and Gene Specific Signatures Defined by Histones H3K4me2 and H3K27me3 Accompany Mammalian Retina Maturation In Vivo

Popova, E., Xu, X., DeWan, A. T., Salzberg, A. C., Berg, A., Hoh, J., Zhang, S. S. & Barnstable, C., Oct 9 2012, In : PloS one. 7, 10, e46867.

Research output: Contribution to journalArticle

retina
histones
Histones
Retina
Genes
2011
2 Citations (Scopus)

Purified mouse retinal ganglion cell culture

Huang, P., Zhang, C., Wang, W., Zhang, S. M. & Barnstable, C., Feb 1 2011, In : Chinese Journal of Ophthalmology. 47, 2, p. 129-133 5 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Cell Culture Techniques
Suspensions
Dendrites
Thy-1 Antigens
15 Citations (Scopus)

Specific protein kinase C isoforms are required for rod photoreceptor differentiation

Pinzon-Guzman, C., Zhang, S. S. M. & Barnstable, C., Dec 14 2011, In : Journal of Neuroscience. 31, 50, p. 18606-18617 12 p.

Research output: Contribution to journalArticle

Retinal Rod Photoreceptor Cells
Protein Kinase C
Protein Isoforms
Retina
Proliferating Cell Nuclear Antigen
2010
1 Citation (Scopus)

MAPK signaling during Müller glial cell development in retina explant cultures

Zhang, S. S. M., Li, H., Huang, P., Lou, L. X., Fu, X. Y. & Barnstable, C., Dec 1 2010, In : Journal of Ocular Biology, Diseases, and Informatics. 3, 4, p. 129-133 5 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinases
Neuroglia
Retina
Ciliary Neurotrophic Factor
Cell Proliferation
2009
69 Citations (Scopus)
Autocrine Communication
Retinal Pigments
Retinal Pigment Epithelium
Interleukin-8
Endotoxins
15 Citations (Scopus)
Vertebrate Photoreceptor Cells
Neurogenesis
Nerve Growth Factors
Neuroglia
Retina
2008
47 Citations (Scopus)

Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors

Leung, K. W., Liu, M., Xu, M., Seiler, M. J., Barnstable, C. & Tombran-Tink, J., Mar 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 3, p. 1221-1231 11 p.

Research output: Contribution to journalArticle

Nerve Growth Factors
Zinc
Neuroglia
Ciliary Neurotrophic Factor
Eye Diseases
33 Citations (Scopus)

STAT3 activation protects retinal ganglion cell layer neurons in response to stress

Zhang, C., Li, H., Liu, M. G., Kawasaki, A., Fu, X. Y., Barnstable, C. & Shao-Min Zhang, S., Jun 1 2008, In : Experimental Eye Research. 86, 6, p. 991-997 7 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Adenoviridae
Ganglia
Ischemia
Reperfusion
2006
31 Citations (Scopus)

A biphasic pattern of gene expression during mouse retina development

Zhang, S. S. M., Xu, X., Liu, M. G., Zhao, H., Soares, M. B., Barnstable, C. & Fu, X. Y., Oct 17 2006, In : BMC Developmental Biology. 6, 48.

Research output: Contribution to journalArticle

Retina
Gene Expression
Genes
RNA
Retinal Rod Photoreceptor Cells
72 Citations (Scopus)

A PEDF N-terminal peptide protects the retina from ischemic injury when delivered in PLGA nanospheres

Li, H., Tran, V. V., Hu, Y., Mark Saltzman, W., Barnstable, C. J. & Tombran-Tink, J., Oct 1 2006, In : Experimental Eye Research. 83, 4, p. 824-833 10 p.

Research output: Contribution to journalArticle

Nanospheres
Retina
Retinal Ganglion Cells
Peptides
Wounds and Injuries
13 Citations (Scopus)

Developmental abnormalities in the Nuc1 rat retina: A spontaneous mutation that affects neuronal and vascular remodeling and retinal function

Gehlbach, P., Hose, S., Lei, B., Zhang, C., Cano, M., Arora, M., Neal, R., Barnstable, C., Goldberg, M. F., Zigler, J. S. & Sinha, D., Jan 9 2006, In : Neuroscience. 137, 2, p. 447-461 15 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Retina
Retinal Detachment
Retinal Cone Photoreceptor Cells
Ependymoglial Cells
634 Citations (Scopus)

HTRA1 promoter polymorphism in wet age-related macular degeneration

DeWan, A., Liu, M., Hartman, S., Zhang, S. S. M., Liu, D. T. L., Zhao, C., Tam, P. O. S., Chan, W. M., Lam, D. S. C., Snyder, M., Barnstable, C., Pang, C. P. & Hoh, J., Nov 10 2006, In : Science. 314, 5801, p. 989-992 4 p.

Research output: Contribution to journalArticle

Macular Degeneration
Genotype
Complement Factor H
Chromosome Mapping
Serine Proteases
13 Citations (Scopus)

Molecular phylogeny of the antiangiogenic and neurotrophic serpin, pigment epithelium derived factor in vertebrates

Xu, X., Zhang, S. S. M., Barnstable, C. & Tombran-Tink, J., Oct 4 2006, In : BMC genomics. 7, 248.

Research output: Contribution to journalArticle

Serpins
Phylogeny
Vertebrates
Genes
Biological Phenomena
62 Citations (Scopus)
Endothelial cells
p38 Mitogen-Activated Protein Kinases
Caspases
Endothelial Cells
Apoptosis
2005
3037 Citations (Scopus)

Complement factor H polymorphism in age-related macular degeneration

Klein, R. J., Zeiss, C., Chew, E. Y., Tsai, J. Y., Sackler, R. S., Haynes, C., Henning, A. K., SanGiovanni, J. P., Mane, S. M., Mayne, S. T., Bracken, M. B., Ferris, F. L., Ott, J., Barnstable, C. & Hoh, J., Apr 15 2005, In : Science. 308, 5720, p. 385-389 5 p.

Research output: Contribution to journalArticle

Complement Factor H
Macular Degeneration
Genes
Alleles
Chromosomes, Human, Pair 1
12 Citations (Scopus)

Comprehensive in silico functional specification of mouse retina transcripts

Zhang, S. S. M., Xu, X., Li, J., Liu, M. G., Zhao, H., Soares, M. B., Barnstable, C. J. & Fu, X. Y., Mar 18 2005, In : BMC genomics. 6, 40.

Research output: Contribution to journalArticle

Computer Simulation
Retina
Expressed Sequence Tags
Central Nervous System
Organ Specificity
39 Citations (Scopus)

Expression of angiogenesis factors in human umbilical vein endothelial cells and their regulation by PEDF

Aparicio, S., Sawant, S., Lara, N., Barnstable, C. J. & Tombran-Tink, J., Jan 14 2005, In : Biochemical and Biophysical Research Communications. 326, 2, p. 387-394 8 p.

Research output: Contribution to journalArticle

Angiogenesis Inducing Agents
Endothelial cells
Human Umbilical Vein Endothelial Cells
Thrombospondin 1
Vascular Endothelial Growth Factor A
14 Citations (Scopus)

Molecular mechanisms of neuroprotection in the eye

Barnstable, C. & Tombran-Tink, J., Dec 1 2005, In : Advances in experimental medicine and biology. 572, p. 291-295 5 p.

Research output: Contribution to journalArticle

Eye Proteins
Neurodegenerative diseases
Serpins
Retinal Rod Photoreceptor Cells
Nerve Degeneration
34 Citations (Scopus)

PEDF and the serpins: Phylogeny, sequence conservation, and functional domains

Tombran-Tink, J., Aparicio, S., Xu, X., Tink, A. R., Lara, N., Sawant, S., Barnstable, C. J. & Zhang, S. S. M., Aug 1 2005, In : Journal of Structural Biology. 151, 2, p. 130-150 21 p.

Research output: Contribution to journalArticle

Serpins
Phylogeny
pigment epithelium-derived factor
Nuclear Localization Signals
Peptides
8 Citations (Scopus)
Weightlessness
Newborn Animals
Rod Cell Outer Segment
Space Flight
Retinal Degeneration
4 Citations (Scopus)
Newborn Animals
Weightlessness
Space Flight
Sprague Dawley Rats
Retina
54 Citations (Scopus)

STAT3 activation in response to growth factors or cytokines participates in retina precursor proliferation

Zhang, S. S. M., Liu, M. G., Kano, A., Zhang, C., Fu, X. Y. & Barnstable, C., Jul 1 2005, In : Experimental Eye Research. 81, 1, p. 103-115 13 p.

Research output: Contribution to journalArticle

Retina
Intercellular Signaling Peptides and Proteins
Ciliary Neurotrophic Factor
Cytokines
Leukemia Inhibitory Factor
148 Citations (Scopus)

Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease

Andrews, Z. B., Horvath, B., Barnstable, C., Elseworth, J., Yang, L., Beal, M. F., Roth, R. H., Matthews, R. T. & Horvath, T. L., Jan 5 2005, In : Journal of Neuroscience. 25, 1, p. 184-191 8 p.

Research output: Contribution to journalArticle

Substantia Nigra
Parkinson Disease
Dopamine
Cell Survival
Reactive Oxygen Species
2004
36 Citations (Scopus)

Modulation of synaptic function by cGMP and cGMP-gated cation channels

Barnstable, C., Wei, J. Y. & Han, M. H., Nov 1 2004, In : Neurochemistry International. 45, 6, p. 875-884 10 p.

Research output: Contribution to journalArticle

Cyclic Nucleotide-Gated Cation Channels
Cations
Excitatory Postsynaptic Potentials
Synapses
Olfactory Receptor Neurons
130 Citations (Scopus)
Vascular Endothelial Growth Factor Receptor
Bone Remodeling
Osteoblasts
Osteoclasts
Pigments
53 Citations (Scopus)

Regulation of factors controlling angiogenesis in liver development: A role for PEDF in the formation and maintenance of normal vasculature

Sawant, S., Aparicio, S., Tink, A. R., Lara, N., Barnstable, C. & Tombran-Tink, J., Dec 10 2004, In : Biochemical and Biophysical Research Communications. 325, 2, p. 408-413 6 p.

Research output: Contribution to journalArticle

Angiogenesis Inducing Agents
Liver
Vascular Endothelial Growth Factor A
Maintenance
Blood Vessels
42 Citations (Scopus)

Retinoic acid and dexamethasone regulate the expression of PEDF in retinal and endothelial cells

Tombran-Tink, J., Lara, N., Apricio, S. E., Potluri, P., Gee, S., Ma, J. X., Chader, G. & Barnstable, C., May 1 2004, In : Experimental Eye Research. 78, 5, p. 945-955 11 p.

Research output: Contribution to journalArticle

Tretinoin
Dexamethasone
Endothelial Cells
Retinoic Acid Receptors
Luciferases
49 Citations (Scopus)

STAT3-mediated signaling in the determination of rod photoreceptor cell fate in mouse retina

Zhang, S. S. M., Wei, J., Qin, H., Zhang, L., Xie, B., Hui, P., Deisseroth, A., Barnstable, C. & Fu, X. Y., Jul 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 7, p. 2407-2412 6 p.

Research output: Contribution to journalArticle

Retinal Rod Photoreceptor Cells
Mitogen-Activated Protein Kinases
Ciliary Neurotrophic Factor
Retina
Leukemia Inhibitory Factor
2003
81 Citations (Scopus)

Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease

Horvath, T. L., Diano, S., Leranth, C., Garcia-Segura, L. M., Cowley, M. A., Shanabrough, M., Elsworth, J. D., Sotonyi, P., Roth, R. H., Dietrich, E. H., Matthews, R. T., Barnstable, C. & Redmond, D. E., Jul 1 2003, In : Endocrinology. 144, 7, p. 2757-2760 4 p.

Research output: Contribution to journalArticle

Ubiquinone
Substantia Nigra
Primates
Parkinson Disease
Dopamine
12 Citations (Scopus)

Developmental and tissue expression patterns of mouse Mpp4 gene

Li, M., Zhang, S. S. M. & Barnstable, C., Jul 25 2003, In : Biochemical and Biophysical Research Communications. 307, 2, p. 229-235 7 p.

Research output: Contribution to journalArticle

Membrane Proteins
Genes
Tissue
Presynaptic Terminals
Membranes
38 Citations (Scopus)

Expression and activation of STAT proteins during mouse retina development

Zhang, S. S. M., Wei, J. Y., Li, C., Barnstable, C. & Fu, X. Y., Apr 1 2003, In : Experimental Eye Research. 76, 4, p. 421-431 11 p.

Research output: Contribution to journalArticle

Retina
Retinal Pigment Epithelium
Proteins
Ganglia
STAT Transcription Factors
5 Citations (Scopus)

Mitochondrial uncoupling proteins: Regulators of retinal cell death

Barnstable, C., Li, M., Reddy, R. & Horvath, T. L., Dec 1 2003, In : Advances in Experimental Medicine and Biology. 533, p. 269-275 7 p.

Research output: Contribution to journalArticle

Mitochondrial Proteins
Neuroprotective Agents
Cell death
Ion Channels
Brain