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Personal profile

Research interests

Computational protein design; enzyme and antibody engineering;  reconstruction, curation and analysis of metabolic networks; computational strain design and synthetic biology; metabolism of photosynthetic organisms; metabolism of obligatory anaerobes; modeling of microbial communities; optimization theory and algorithms. 

Education/Academic qualification

Chemical Engineering, PhD, Princeton Univercity

Fingerprint Dive into the research topics where Costas D. Maranas is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Genome Medicine & Life Sciences
Metabolic Networks and Pathways Medicine & Life Sciences
Genes Engineering & Materials Science
Escherichia coli Engineering & Materials Science
Fluxes Engineering & Materials Science
Metabolism Engineering & Materials Science
Metabolites Engineering & Materials Science
Enzymes Engineering & Materials Science

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Research Output 1992 2020

Metabolic model guided strain design of cyanobacteria

Hendry, J. I., Bandyopadhyay, A., Srinivasan, S., Pakrasi, H. B. & Maranas, C. D., Aug 1 2020, In : Current Opinion in Biotechnology. 64, p. 17-23 7 p.

Research output: Contribution to journalReview article

1-Butanol
Sunlight
Cyanobacteria
Metabolic Networks and Pathways
Carbon Dioxide
4 Citations (Scopus)

A diurnal flux balance model of Synechocystis sp. PCC 6803 metabolism

Sarkar, D., Mueller, T. J., Liu, D., Pakrasi, H. B. & Maranas, C. D., Jan 1 2019, In : PLoS computational biology. 15, 1, e1006692.

Research output: Contribution to journalArticle

Synechocystis sp. PCC 6803
Synechocystis
Metabolism
metabolism
Fluxes
20 Citations (Scopus)

Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0

Heirendt, L., Arreckx, S., Pfau, T., Mendoza, S. N., Richelle, A., Heinken, A., Haraldsdóttir, H. S., Wachowiak, J., Keating, S. M., Vlasov, V., Magnusdóttir, S., Ng, C. Y., Preciat, G., Žagare, A., Chan, S. H. J., Aurich, M. K., Clancy, C. M., Modamio, J., Sauls, J. T., Noronha, A. & 35 others, Bordbar, A., Cousins, B., El Assal, D. C., Valcarcel, L. V., Apaolaza, I., Ghaderi, S., Ahookhosh, M., Ben Guebila, M., Kostromins, A., Sompairac, N., Le, H. M., Ma, D., Sun, Y., Wang, L., Yurkovich, J. T., Oliveira, M. A. P., Vuong, P. T., El Assal, L. P., Kuperstein, I., Zinovyev, A., Hinton, H. S., Bryant, W. A., Aragón Artacho, F. J., Planes, F. J., Stalidzans, E., Maass, A., Vempala, S., Hucka, M., Saunders, M. A., Maranas, C. D., Lewis, N. E., Sauter, T., Palsson, B., Thiele, I. & Fleming, R. M. T., Mar 1 2019, In : Nature Protocols. 14, 3, p. 639-702 64 p.

Research output: Contribution to journalArticle

Biotechnology
Reaction kinetics
Design of experiments
Metabolomics
Systems Biology

Directed Evolution Reveals the Functional Sequence Space of an Adenylation Domain Specificity Code

Throckmorton, K., Vinnik, V., Chowdhury, R., Cook, T., Chevrette, M. G., Maranas, C. D., Pfleger, B. & Thomas, M. G., Sep 20 2019, In : ACS chemical biology. 14, 9, p. 2044-2054 11 p.

Research output: Contribution to journalArticle

Peptide Synthases
Substrates
Enterobactin
Peptides
Genetic Selection
2 Citations (Scopus)

EcoFABs: advancing microbiome science through standardized fabricated ecosystems

Zengler, K., Hofmockel, K., Baliga, N. S., Behie, S. W., Bernstein, H. C., Brown, J. B., Dinneny, J. R., Floge, S. A., Forry, S. P., Hess, M., Jackson, S. A., Jansson, C., Lindemann, S. R., Pett-Ridge, J., Maranas, C. D., Venturelli, O. S., Wallenstein, M. D., Shank, E. A. & Northen, T. R., Jul 1 2019, In : Nature methods. 16, 7, p. 567-571 5 p.

Research output: Contribution to journalComment/debate

Microbiota
Ecosystems
Ecosystem
Health