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Personal profile

Research interests

Presently, the central research goals of Dr. Craig Meyers' laboratory are to study the differentiation-dependent life cycle of human papillomavirus (HPV) and HPV-associated oncogenesis. Studies in the Meyers lab follow five general research themes:

  • Investigation of the molecular biology and genetics of HPV morphogenesis and structure in native virus replicated under natural physiological differentiation conditions of the host tissue. The majority of the laboratories studying HPV morphogenesis and structure utilize synthetic particles such as virus-like particles (VLPs) or pseudoviral particles (PsV). The Meyers lab's studies have shown that the morphogenesis, maturation, and structure of native HPV differs in many significant characteristic from VLPs or PsV particles. 
  • Developing an understanding of ethnic differences in HPV types and variants using a whole-genome analysis, including infection prevalence and carcinogenicity. 
  • Investigating the epigenetic mechanisms of HPV-associated oral disease. This will be done by measuring genome-wide epigenetic changes occurring at different stages of the HPV16 life cycle, carcinogenic progression, and in response to ART treatment. Determining the interaction of highly active anti-retroviral drugs on oral tissues, HPV and HPV’s infection of oral tissue. 
  • Comparative analysis of HPV infection, life cycle and oncogenesis at different anatomical sites, including the cervix, foreskin, tonsil and anal canal. 
  • In addition to HPV, Dr. Meyers is also interested in studying the life cycle of other epitheliotropic infectious agents, such as the Herpes virus family, in three-dimensional human epithelial tissue.

Teaching and educational interests

Dr. Craig Meyers is the program director for an NIH funded T32 training grant. This long-standing Training Program supports graduate students and postdoctoral scholars as they acquire the knowledge and skills to investigate viruses and cancer.

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Projects 1994 2022

Mouth Neoplasms
Epigenomics
Acquired Immunodeficiency Syndrome
MicroRNAs
Mouth Diseases

VIRUSES AND CANCER

Meyers, C., Isom, H. C., Courtney, R. & Lukacher, A.

National Institutes of Health

5/6/947/31/22

Project: Research project

Allergy and Immunology
Virology
Viruses
Neoplasms
Retroviridae
Genome
Life Cycle Stages
Viruses
Population
Genes
Human Herpesvirus 8
Epithelium
Kaposi's Sarcoma
Primates
Infection
Life Cycle Stages
Growth
Infection
Epithelium
Oral Health

Research Output 1989 2019

  • 4168 Citations
  • 33 h-Index
  • 105 Article
  • 5 Review article
  • 3 Chapter
  • 2 Letter
1 Citation (Scopus)

Genome-Wide Profiling of Cervical RNA-Binding Proteins Identifies Human Papillomavirus Regulation of RNASEH2A Expression by Viral E7 and E2F1

Xu, J., Liu, H., Yang, Y., Wang, X., Liu, P., Li, Y., Meyers, C., Banerjee, N. S., Wang, H. K., Cam, M., Lu, W., Chow, L. T., Xie, X., Zhu, J. & Zheng, Z. M., Jan 29 2019, In : mBio. 10, 1

Research output: Contribution to journalArticle

RNA-Binding Proteins
Genome
Uterine Cervical Neoplasms
p16 Genes
DNA Replication
2 Citations (Scopus)

Effect of productive human papillomavirus 16 infection on global gene expression in cervical epithelium

Kang, S. D., Chatterjee, S., Alam, S., Salzberg, A. C., Milici, J., Van Der Burg, S. H. & Meyers, C., Oct 1 2018, In : Journal of virology. 92, 20, e01261.

Research output: Contribution to journalArticle

Human papillomavirus 16
Papillomavirus Infections
epithelium
Epithelium
Gene Expression
1 Citation (Scopus)

Microarray analysis of human keratinocytes from different anatomic sites reveals site-specific immune signaling and responses to human papillomavirus type 16 transfection

Israr, M., Rosenthal, D., Frejo-Navarro, L., Devoti, J., Meyers, C. & Bonagura, V. R., May 16 2018, In : Molecular Medicine. 24, 1, 23.

Research output: Contribution to journalArticle

Human papillomavirus 16
Microarray Analysis
Keratinocytes
Transfection
Innate Immunity

Production and characterization of a novel HPV anti-L2 monoclonal antibody panel

Bywaters, S. M., Brendle, S. A., Biryukov, J., Wang, J. W., Walston, J., Milici, J., Roden, R. B., Meyers, C. & Christensen, N., Nov 1 2018, In : Virology. 524, p. 106-113 8 p.

Research output: Contribution to journalArticle

Epitopes
Monoclonal Antibodies
Capsid Proteins
Capsid
Research Personnel
2 Citations (Scopus)

Superinfection exclusion between two highrisk human papillomavirus types during a coinfection

Biryukov, J. & Meyers, C., Apr 1 2018, In : Journal of Virology. 92, 8, e01993-17.

Research output: Contribution to journalArticle

Superinfection
Papillomaviridae
Coinfection
mixed infection
Life Cycle Stages