Projects per year
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Research interests
Dr. Dajiang Liu's lab is a small research group at Penn State College of Medicine that works on statistical genetics, complex trait genetics and functional genomics. The lab actively develops novel methods and applies them to interesting datasets. It also generates datasets using high-throughput genotyping and sequencing.
The lab's statistical genetics research focuses on method development for analyzing large scale sequence-based association studies. The Liu lab developed the widely-used software package RAREMETAL and RVTESTS for association analysis and meta-analysis and is actively conducting research in this area to develop more efficient and powerful methods for studying the genetic basis for complex traits.
Dr. Liu's lab develops computational methods to interpret the GWAS findings using integrative approaches and is also developing methods to study the functional genomics for X chromosome inactivation.
The lab studies a few complex traits in great detail, including lipids and cardiovascular disease, smoking drinking addiction as well as lupus. Many of the applied projects offered interesting problems and motivated the lab's methodology research.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Projects
- 3 Finished
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Methods to maximize the utility of common fund functional genomic data in multi-ethnic genetic studies
9/22/21 → 9/21/22
Project: Research project
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Tools for integrative genomics and disease association study for the X chromosome
National Institute of General Medical Sciences
8/1/18 → 6/30/22
Project: Research project
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Method to Enhance the Rare Variant Genetic Architecture Analysis in Meta-Analyses
National Human Genome Research Institute
5/16/16 → 4/30/21
Project: Research project
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Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus
Khunsriraksakul, C., Li, Q., Markus, H., Patrick, M. T., Sauteraud, R., McGuire, D., Wang, X., Wang, C., Wang, L., Chen, S., Shenoy, G., Li, B., Zhong, X., Olsen, N. J., Carrel, L., Tsoi, L. C., Jiang, B. & Liu, D. J., Dec 2023, In: Nature communications. 14, 1, 668.Research output: Contribution to journal › Article › peer-review
Open Access -
Analysis of KIR gene variants in The Cancer Genome Atlas and UK Biobank using KIRCLE
Gao, G. F., Liu, D., Zhan, X. & Li, B., Dec 2022, In: BMC Biology. 20, 1, 191.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Association of Spinal Cord Stimulator Implantation with Persistent Opioid Use in Patients with Postlaminectomy Syndrome
Vu, T. N., Khunsriraksakul, C., Vorobeychik, Y., Liu, A., Sauteraud, R., Shenoy, G., Liu, D. J. & Cohen, S. P., 2022, (Accepted/In press) In: JAMA network open. e2145876.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Construction and Application of Polygenic Risk Scores in Autoimmune Diseases
Khunsriraksakul, C., Markus, H., Olsen, N. J., Carrel, L., Jiang, B. & Liu, D. J., Jun 27 2022, In: Frontiers in immunology. 13, 889296.Research output: Contribution to journal › Review article › peer-review
Open Access -
Genetic correlation, pleiotropy, and causal associations between substance use and psychiatric disorder
Jang, S. K., Saunders, G., Liu, M. Z., Jiang, Y., Liu, D. J. & Vrieze, S., Apr 7 2022, In: Psychological medicine. 52, 5, p. 968-978 11 p.Research output: Contribution to journal › Article › peer-review
23 Scopus citations