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Personal profile

Research interests

Dr. Dajiang Liu's lab is a small research group at Penn State College of Medicine that works on statistical genetics, complex trait genetics and functional genomics. The lab actively develops novel methods and applies them to interesting datasets. It also generates datasets using high-throughput genotyping and sequencing.

The lab's statistical genetics research focuses on method development for analyzing large scale sequence-based association studies. The Liu lab developed the widely-used software package RAREMETAL and RVTESTS for association analysis and meta-analysis and is actively conducting research in this area to develop more efficient and powerful methods for studying the genetic basis for complex traits. 

Dr. Liu's lab develops computational methods to interpret the GWAS findings using integrative approaches and is also developing methods to study the functional genomics for X chromosome inactivation. 

The lab studies a few complex traits in great detail, including lipids and cardiovascular disease, smoking drinking addiction as well as lupus. Many of the applied projects offered interesting problems and motivated the lab's methodology research. 

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Research Output

  • 2275 Citations
  • 21 h-Index
  • 38 Article
  • 2 Letter
  • 1 Chapter
  • 1 Comment/debate

Association analysis and meta-analysis of multiallelic variants for large-scale sequence data

Jiang, Y., Chen, S., Wang, X., Liu, M., Iacono, W. G., Hewitt, J. K., Hokanson, J. E., Krauter, K., Laakso, M., Li, K. W., Lutz, S. M., McGue, M., Pandit, A., Zajac, G. J. M., Boehnke, M., Abecasis, G. R., Vrieze, S. I., Jiang, B., Zhan, X. & Liu, D. J., May 2020, In : Genes. 11, 5, 585.

Research output: Contribution to journalArticle

Open Access
  • Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

    23andMe Research Team, HUNT All-In Psychiatry, Liu, M., Jiang, Y., Wedow, R., Li, Y., Brazel, D. M., Chen, F., Datta, G., Davila-Velderrain, J., McGuire, D., Tian, C., Zhan, X., Agee, M., Alipanahi, B., Auton, A., Bell, R. K., Bryc, K., Elson, S. L., Fontanillas, P. & 32 others, Furlotte, N. A., Hinds, D. A., Hromatka, B. S., Huber, K. E., Kleinman, A., Litterman, N. K., McIntyre, M. H., Mountain, J. L., Northover, C. A. M., Sathirapongsasuti, J. F., Sazonova, O. V., Shelton, J. F., Shringarpure, S., Tian, C., Tung, J. Y., Vacic, V., Wilson, C. H., Pitts, S. J., Mitchell, A., Skogholt, A. H., Winsvold, B. S., Sivertsen, B., Stordal, E., Morken, G., Kallestad, H., Heuch, I., Zwart, J. A., Fjukstad, K. K., Pedersen, L. M., Gabrielsen, M. E., Johnsen, M. B. & Liu, D., Feb 1 2019, In : Nature Genetics. 51, 2, p. 237-244 8 p.

    Research output: Contribution to journalLetter

  • 82 Scopus citations

    Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use

    CHD Exome+ Consortium, Consortium for Genetics of Smoking Behaviour, Brazel, D. M., Jiang, Y., Hughey, J. M., Turcot, V., Zhan, X., Gong, J., Batini, C., Weissenkampen, J. D., Liu, M. Z., Surendran, P., Young, R., Barnes, D. R., Nielsen, S. F., Rasheed, A., Samuel, M., Zhao, W., Kontto, J., Perola, M. & 32 others, Caslake, M., de Craen, A. J. M., Trompet, S., Uria-Nickelsen, M., Malarstig, A., Reily, D. F., Hoek, M., Vogt, T., Jukema, J. W., Sattar, N., Ford, I., Packard, C. J., Alam, D. S., Majumder, A. A. S., Di Angelantonio, E., Chowdhury, R., Amouyel, P., Arveiler, D., Blankenberg, S., Ferrières, J., Kee, F., Kuulasmaa, K., Müller-Nurasyid, M., Veronesi, G., Virtamo, J., EPIC-CVD Consortium, C., Frossard, P., Nordestgaard, B. G., Saleheen, D., Danesh, J., Butterworth, A. S. & Liu, D., Jun 1 2019, In : Biological Psychiatry. 85, 11, p. 946-955 10 p.

    Research output: Contribution to journalArticle

  • 9 Scopus citations

    Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

    Understanding Society Scientific Group, EPIC-CVD, GSCAN, Consortium for Genetics of Smoking Behaviour, CHD Exome+ consortium, Erzurumluoglu, A. M., Liu, M., Jackson, V. E., Barnes, D. R., Datta, G., Melbourne, C. A., Young, R., Batini, C., Surendran, P., Jiang, T., Adnan, S. D., Afaq, S., Agrawal, A., Altmaier, E., Antoniou, A. C., Asselbergs, F. W., Baumbach, C., Bierut, L., Bertelsen, S. & 31 others, Boehnke, M., Bots, M. L., Brazel, D. M., Chambers, J. C., Chang-Claude, J., Chen, C., Corley, J., Chou, Y. L., David, S. P., de Boer, R. A., de Leeuw, C. A., Dennis, J. G., Dominiczak, A. F., Dunning, A. M., Easton, D. F., Eaton, C., Elliott, P., Evangelou, E., Faul, J. D., Foroud, T., Goate, A., Gong, J., Grabe, H. J., Haessler, J., Haiman, C., Hallmans, G., Hammerschlag, A. R., Harris, S. E., Hattersley, A., Heath, A. & Liu, D., Jan 1 2019, (Accepted/In press) In : Molecular Psychiatry.

    Research output: Contribution to journalArticle

    Open Access
  • 7 Scopus citations

    Methods for the Analysis and Interpretation for Rare Variants Associated with Complex Traits

    Weissenkampen, J. D., Jiang, Y., Eckert, S., Jiang, B., Li, B. & Liu, D. J., Apr 2019, In : Current protocols in human genetics. 101, 1, e83.

    Research output: Contribution to journalArticle

  • 5 Scopus citations