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Research Output 2010 2019

  • 1286 Citations
  • 18 h-Index
  • 36 Article
  • 2 Letter
  • 1 Chapter
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Article
2019

Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use

CHD Exome+ Consortium, Consortium for Genetics of Smoking Behaviour, Brazel, D. M., Jiang, Y., Hughey, J. M., Turcot, V., Zhan, X., Gong, J., Batini, C., Weissenkampen, J. D., Liu, M. Z., Surendran, P., Young, R., Barnes, D. R., Nielsen, S. F., Rasheed, A., Samuel, M., Zhao, W., Kontto, J., Perola, M. & 32 othersCaslake, M., de Craen, A. J. M., Trompet, S., Uria-Nickelsen, M., Malarstig, A., Reily, D. F., Hoek, M., Vogt, T., Jukema, J. W., Sattar, N., Ford, I., Packard, C. J., Alam, D. S., Majumder, A. A. S., Di Angelantonio, E., Chowdhury, R., Amouyel, P., Arveiler, D., Blankenberg, S., Ferrières, J., Kee, F., Kuulasmaa, K., Müller-Nurasyid, M., Veronesi, G., Virtamo, J., EPIC-CVD Consortium, C., Frossard, P., Nordestgaard, B. G., Saleheen, D., Danesh, J., Butterworth, A. S. & Liu, D., Jun 1 2019, In : Biological Psychiatry. 85, 11, p. 946-955 10 p.

Research output: Contribution to journalArticle

Exome
Behavioral Genetics
Genome-Wide Association Study
Nicotine
Tobacco

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

Understanding Society Scientific Group, EPIC-CVD, GSCAN, Consortium for Genetics of Smoking Behaviour, CHD Exome+ consortium, Erzurumluoglu, A. M., Liu, M., Jackson, V. E., Barnes, D. R., Datta, G., Melbourne, C. A., Young, R., Batini, C., Surendran, P., Jiang, T., Adnan, S. D., Afaq, S., Agrawal, A., Altmaier, E., Antoniou, A. C., Asselbergs, F. W., Baumbach, C., Bierut, L., Bertelsen, S. & 31 othersBoehnke, M., Bots, M. L., Brazel, D. M., Chambers, J. C., Chang-Claude, J., Chen, C., Corley, J., Chou, Y. L., David, S. P., de Boer, R. A., de Leeuw, C. A., Dennis, J. G., Dominiczak, A. F., Dunning, A. M., Easton, D. F., Eaton, C., Elliott, P., Evangelou, E., Faul, J. D., Foroud, T., Goate, A., Gong, J., Grabe, H. J., Haessler, J., Haiman, C., Hallmans, G., Hammerschlag, A. R., Harris, S. E., Hattersley, A., Heath, A. & Liu, D., Jan 1 2019, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Open Access
Genetic Loci
Meta-Analysis
Smoking
Nucleotides
Exome

Methods for the Analysis and Interpretation for Rare Variants Associated with Complex Traits

Weissenkampen, J. D., Jiang, Y., Eckert, S., Jiang, B., Li, B. & Liu, D., Apr 1 2019, In : Current protocols in human genetics. 101, 1, e83.

Research output: Contribution to journalArticle

Exome
Precision Medicine
DNA Sequence Analysis
Sequence Analysis
Meta-Analysis

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

T2D-Genes Consortium, The MAGIC Investigators, CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct & ReproGen Consortium, Mar 1 2019, In : Nature Genetics. 51, 3, p. 452-469 18 p.

Research output: Contribution to journalArticle

Body Fat Distribution
Homeostasis
Lipids
Fats
Genes
2018
1 Citation (Scopus)

Adaptive-weight burden test for associations between quantitative traits and genotype data with complex correlations

Wu, X., Guan, T., Liu, D., Novelo, L. G. L. & Bandyopadhyay, D., Sep 1 2018, In : Annals of Applied Statistics. 12, 3, p. 1558-1582 25 p.

Research output: Contribution to journalArticle

Genotype
Genes
Glucose
Throughput
Statistics
11 Citations (Scopus)

Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program

The Geisinger-Regeneron DiscovEHR Collaboration, The VA Million Veteran Program, Global Lipids Genetics Consortium & Myocardial Infarction Genetics (MIGen) Consortium, Nov 1 2018, In : Nature Genetics. 50, 11, p. 1514-1523 10 p.

Research output: Contribution to journalArticle

Veterans
Lipids
Electronic Health Records
Abdominal Aortic Aneurysm
Hispanic Americans
3 Citations (Scopus)

Proper conditional analysis in the presence of missing data: Application to large scale meta-analysis of tobacco use phenotypes

Jiang, Y., Chen, S., McGuire, D., Chen, F., Liu, M., Iacono, W. G., Hewitt, J. K., Hokanson, J. E., Krauter, K., Laakso, M., Li, K. W., Lutz, S. M., McGue, M., Pandit, A., Zajac, G. J. M., Boehnke, M., Abecasis, G. R., Vrieze, S. I., Zhan, X., Jiang, B. & 1 othersLiu, D., Jul 1 2018, In : PLoS genetics. 14, 7, e1007452.

Research output: Contribution to journalArticle

tobacco use
meta-analysis
Tobacco Use
tobacco
Meta-Analysis
41 Citations (Scopus)

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, K. L., Alfred, T. & 379 othersFeitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Allison, M., Amouyel, P., Asselbergs, F. W., Auer, P. L., Balkau, B., Bang, L. E., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, L. F., Blüher, M., Boehnke, M., Boeing, H., Boerwinkle, E., Böger, C. A., Bork-Jensen, J., Bots, M. L., Bottinger, E. P., Bowden, D. W., Brandslund, I., Breen, G., Brilliant, M. H., Broer, L., Brumat, M., Burt, A. A., Butterworth, A. S., Campbell, P. T., Cappellani, S., Carey, D. J., Catamo, E., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Cocca, M., Cook, J. P., Corley, J., Corominas Galbany, J., Cox, A. J., Crosslin, D. S., Cuellar-Partida, G., D'Eustacchio, A., Danesh, J., Davies, G., Bakker, P. I. W., Groot, M. C. H., Mutsert, R., Deary, I. J., Dedoussis, G., Demerath, E. W., Heijer, M., Hollander, A. I., Ruijter, H. M., Dennis, J. G., Denny, J. C., Angelantonio, E., Drenos, F., Du, M., Dubé, M. P., Dunning, A. M., Easton, D. F., Edwards, T. L., Ellinghaus, D., Ellinor, P. T., Elliott, P., Evangelou, E., Farmaki, A. E., Farooqi, I. S., Faul, J. D., Fauser, S., Feng, S., Ferrannini, E., Ferrieres, J., Florez, J. C., Ford, I., Fornage, M., Franco, O. H., Franke, A., Franks, P. W., Friedrich, N., Frikke-Schmidt, R., Galesloot, T. E., Gan, W., Gandin, I., Gasparini, P., Gibson, J., Giedraitis, V., Gjesing, A. P., Gordon-Larsen, P., Gorski, M., Grabe, H. J., Grant, S. F. A., Grarup, N., Griffiths, H. L., Grove, M. L., Gudnason, V., Gustafsson, S., Haessler, J., Hakonarson, H., Hammerschlag, A. R., Hansen, T., Harris, K. M., Harris, T. B., Hattersley, A. T., Have, C. T., Hayward, C., He, L., Heard-Costa, N. L., Heath, A. C., Heid, I. M., Helgeland, Ø., Hernesniemi, J., Hewitt, A. W., Holmen, O. L., Hovingh, G. K., Howson, J. M. M., Hu, Y., Huang, P. L., Huffman, J. E., Ikram, M. A., Ingelsson, E., Jackson, A. U., Jansson, J. H., Jarvik, G. P., Jensen, G. B., Jia, Y., Johansson, S., Jørgensen, M. E., Jørgensen, T., Jukema, J. W., Kahali, B., Kahn, R. S., Kähönen, M., Kamstrup, P. R., Kanoni, S., Kaprio, J., Karaleftheri, M., Kardia, S. L. R., Karpe, F., Kathiresan, S., Kee, F., Kiemeney, L. A., Kim, E., Kitajima, H., Komulainen, P., Kooner, J. S., Kooperberg, C., Korhonen, T., Kovacs, P., Kuivaniemi, H., Kutalik, Z., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, T. A., Lamparter, D., Lange, E. M., Lange, L. A., Langenberg, C., Larson, E. B., Lee, N. R., Lehtimäki, T., Lewis, C. E., Li, H., Li, J., Li-Gao, R., Lin, H., Lin, K. H., Lin, L. A., Lin, X., Lind, L., Lindström, J., Linneberg, A., Liu, C. T., Liu, D., Liu, Y., Lo, K. S., Lophatananon, A., Lotery, A. J., Loukola, A., Luan, JA., Lubitz, S. A., Lyytikäinen, L. P., Männistö, S., Marenne, G., Mazul, A. L., McCarthy, M. I., McKean-Cowdin, R., Medland, S. E., Meidtner, K., Milani, L., Mistry, V., Mitchell, P., Mohlke, K. L., Moilanen, L., Moitry, M., Montgomery, G. W., Mook-Kanamori, D. O., Moore, C., Mori, T. A., Morris, A. D., Morris, A. P., Müller-Nurasyid, M., Munroe, P. B., Nalls, M. A., Narisu, N., Nelson, C. P., Neville, M., Nielsen, S. F., Nikus, K., Njølstad, P. R., Nordestgaard, B. G., Nyholt, D. R., O'Connel, J. R., O'Donoghue, M. L., Olde Loohuis, L. M., Ophoff, R. A., Owen, K. R., Packard, C. J., Padmanabhan, S., Palmer, C. N. A., Palmer, N. D., Pasterkamp, G., Patel, A. P., Pattie, A., Pedersen, O., Peissig, P. L., Peloso, G. M., Pennell, C. E., Perola, M., Perry, J. A., Perry, J. R. B., Pers, T. H., Person, T. N., Peters, A., Petersen, E. R. B., Peyser, P. A., Pirie, A., Polasek, O., Polderman, T. J., Puolijoki, H., Raitakari, O. T., Rasheed, A., Rauramaa, R., Reilly, D. F., Renström, F., Rheinberger, M., Ridker, P. M., Rioux, J. D., Rivas, M. A., Roberts, D. J., Robertson, N. R., Robino, A., Rolandsson, O., Rudan, I., Ruth, K. S., Saleheen, D., Salomaa, V., Samani, N. J., Sapkota, Y., Sattar, N., Schoen, R. E., Schreiner, P. J., Schulze, M. B., Scott, R. A., Segura-Lepe, M. P., Shah, S. H., Sheu, W. H. H., Sim, X., Slater, A. J., Small, K. S., Smith, A. V., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Stefansson, K., Steinthorsdottir, V., Stirrups, K. E., Strauch, K., Stringham, H. M., Stumvoll, M., Sun, L., Surendran, P., Swift, A. J., Tada, H., Tansey, K. E., Tardif, J. C., Taylor, K. D., Teumer, A., Thompson, D. J., Thorleifsson, G., Thorsteinsdottir, U., Thuesen, B. H., Tönjes, A., Tromp, G., Trompet, S., Tsafantakis, E., Tuomilehto, J., Tybjaerg-Hansen, A., Tyrer, J. P., Uher, R., Uitterlinden, A. G., Uusitupa, M., Laan, S. W., Duijn, C. M., Leeuwen, N., Van Setten, J., Vanhala, M., Varbo, A., Varga, T. V., Varma, R., Velez Edwards, D. R., Vermeulen, S. H., Veronesi, G., Vestergaard, H., Vitart, V., Vogt, T. F., Völker, U., Vuckovic, D., Wagenknecht, L. E., Walker, M., Wallentin, L., Wang, F., Wang, C. A., Wang, S., Wang, Y., Ware, E. B., Wareham, N. J., Warren, H. R., Waterworth, D. M., Wessel, J., White, H. D., Willer, C. J., Wilson, J. G., Witte, D. R., Wood, A. R., Wu, Y., Yaghootkar, H., Yao, J., Yao, P., Yerges-Armstrong, L. M., Young, R., Zeggini, E., Zhan, X., Zhang, W., Zhao, J. H., Zhao, W., Zhou, W., Zondervan, K. T., Rotter, J. I., Pospisilik, J. A., Rivadeneira, F., Borecki, I. B., Deloukas, P., Frayling, T. M., Lettre, G., North, K. E., Lindgren, C. M., Hirschhorn, J. N. & Loos, R. J. F., Jan 1 2018, In : Nature Genetics. 50, 1, p. 26-35 10 p.

Research output: Contribution to journalArticle

Energy Intake
Energy Metabolism
Body Mass Index
Obesity
Genes
2 Citations (Scopus)

Rare loss of function variants in candidate genes and risk of colorectal cancer

NHLBI GO Exome Sequencing Project, Pulmonary Arterial Hypertension (PAH), Severe Asthma Research Program (SARP), Women’s Health Initiative (WHI), Anthropometry Project Team, Blood Count/Hematology Project Team, Blood Pressure Project Team, Data Flow Working Group, Early MI Project Team, ELSI Working Group, Executive Committee, Family Study Project Team, Lipids Project Team, Lung Project Team, Personal Genomics Project Team, Phenotype and Harmonization Working Group, Population Genetics and Statistical Analysis Working Group, Publications and Presentations Working Group, Quantitative Analysis Ad Hoc Task Group, Sequencing and Genotyping Working Group & 15 othersSteering Committee, Stroke Project Team, Structural Variation Working Group, Subclinical/Quantitative Project Team, Acute Lung Injury (ALI), Atherosclerosis Risk in Communities (ARIC), Cardiovascular Health Study (CHS), Chronic Obstructive Pulmonary Disease (COPDGene), Coronary Artery Risk Development in Young Adults (CARDIA), Cystic Fibrosis (CF), Early Pseudomonas Infection Control (EPIC), Framingham Heart Study (FHS), Jackson Heart Study (JHS), Lung Health Study (LHS) & Multi-Ethnic Study of Atherosclerosis (MESA), Oct 1 2018, In : Human genetics. 137, 10, p. 795-806 12 p.

Research output: Contribution to journalArticle

Polyps
Colorectal Neoplasms
Genes
Penetrance
Genetic Testing
31 Citations (Scopus)

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes article

ExomeBP Consortium, MAGIC Consortium & GIANT Consortium, Apr 1 2018, In : Nature Genetics. 50, 4, p. 559-571 13 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Causality
Odds Ratio
Genome
Therapeutics
2017
1 Citation (Scopus)

Analysis of single nucleotide variants of HFE gene and association to survival in the Cancer Genome Atlas GBM data

Lee, S., Zhu, J., Salzberg, A. C., Zhang, B., Liu, D., Muscat, J., Langan, S. T. & Connor, J., Mar 1 2017, In : PloS one. 12, 3, e0174778.

Research output: Contribution to journalArticle

Atlases
Glioblastoma
Nucleotides
Genes
nucleotides
44 Citations (Scopus)

Association of rare and common variation in the lipoprotein lipase gene with coronary artery disease

Khera, A. V., Won, H. H., Peloso, G. M., O'Dushlaine, C., Liu, D., Stitziel, N. O., Natarajan, P., Nomura, A., Emdin, C. A., Gupta, N., Borecki, I. B., Asselta, R., Duga, S., Merlini, P. A., Correa, A., Kessler, T., Wilson, J. G., Bown, M. J., Hall, A. S., Braund, P. S. & 24 othersCarey, D. J., Murray, M. F., Kirchner, H. L., Leader, J. B., Lavage, D. R., Manus, J. N., Hartzel, D. N., Samani, N. J., Schunkert, H., Marrugat, J., Elosua, R., McPherson, R., Farrall, M., Watkin, H., Lander, E. S., Rader, D. J., Danesh, J., Ardissino, D., Gabriel, S., Willer, C., Abecasis, G. R., Saleheen, D., Dewey, F. E. & Kathiresan, S., Mar 7 2017, In : JAMA - Journal of the American Medical Association. 317, 9, p. 937-946 10 p.

Research output: Contribution to journalArticle

Lipoprotein Lipase
Coronary Artery Disease
Genes
Triglycerides
Mutation
5 Citations (Scopus)

Clonal evolution in paired endometrial intraepithelial neoplasia/atypical hyperplasia and endometrioid adenocarcinoma

Russo, M., Broach, J., Sheldon, K., Houser, K. R., Liu, D., Kesterson, J., Phaeton, R., Hossler, C., Hempel, N., Baker, M., Newell, J., Zaino, R. & Warrick, J., Sep 1 2017, In : Human Pathology. 67, p. 69-77 9 p.

Research output: Contribution to journalArticle

Clonal Evolution
Endometrioid Carcinoma
Endometrial Hyperplasia
Hyperplasia
Endometrial Neoplasms
20 Citations (Scopus)

Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease

Lu, X., Peloso, G. M., Liu, D., Wu, Y., Zhang, H., Zhou, W., Li, J., Tang, C. S. M., Dorajoo, R., Li, H., Long, J., Guo, X., Xu, M., Spracklen, C. N., Chen, Y., Liu, X., Zhang, Y., Khor, C. C., Liu, J., Sun, L. & 47 othersWang, L., Gao, Y. T., Hu, Y., Yu, K., Wang, Y., Cheung, C. Y. Y., Wang, F., Huang, J., Fan, Q., Cai, Q., Chen, S., Shi, J., Yang, X., Zhao, W., Sheu, W. H. H., Cherny, S. S., He, M., Feranil, A. B., Adair, L. S., Gordon-Larsen, P., Du, S., Varma, R., Chen, Y. D. I., Shu, X. O., Lam, K. S. L., Wong, T. Y., Ganesh, S. K., Mo, Z., Hveem, K., Fritsche, L. G., Nielsen, J. B., Tse, H. F., Huo, Y., Cheng, C. Y., Chen, Y. E., Zheng, W., Tai, E. S., Gao, W., Lin, X., Huang, W., Abecasis, G., Kathiresan, S., Mohlke, K. L., Wu, T., Sham, P. C., Gu, D. & Willer, C. J., Dec 1 2017, In : Nature Genetics. 49, 12, p. 1722-1730 9 p.

Research output: Contribution to journalArticle

Exome
Meta-Analysis
Coronary Artery Disease
Lipids
Genes
65 Citations (Scopus)

Exome-wide association study of plasma lipids in >300,000 individuals

Liu, D., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X., Mahajan, A., Saleheen, D., Emdin, C., Alam, D., Alves, A. C., Amouyel, P., Angelantonio, E. DI., Arveiler, D., Assimes, T. L., Auer, P. L., Baber, U., Ballantyne, C. M., Bang, L. E., Benn, M., Bis, J. C. & 207 othersBoehnke, M., Boerwinkle, E., Bork-Jensen, J., Bottinger, E. P., Brandslund, I., Brown, M., Busonero, F., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. E., Chen, Y. D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Connell, J. M., Cucca, F., Cupples, L. A., Damrauer, S. M., Davies, G., Deary, I. J., Dedoussis, G., Denny, J. C., Dominiczak, A., Dubé, M. P., Ebeling, T., Eiriksdottir, G., Esko, T., Farmaki, A. E., Feitosa, M. F., Ferrario, M., Ferrieres, J., Ford, I., Fornage, M., Franks, P. W., Frayling, T. M., Frikke-Schmidt, R., Fritsche, L. G., Frossard, P., Fuster, V., Ganesh, S. K., Gao, W., Garcia, M. E., Gieger, C., Giulianini, F., Goodarzi, M. O., Grallert, H., Grarup, N., Groop, L., Grove, M. L., Gudnason, V., Hansen, T., Harris, T. B., Hayward, C., Hirschhorn, J. N., Holmen, O. L., Huffman, J., Huo, Y., Hveem, K., Jabeen, S., Jackson, A. U., Jakobsdottir, J., Jarvelin, M. R., Jensen, G. B., Jørgensen, M. E., Jukema, J. W., Justesen, J. M., Kamstrup, P. R., Kanoni, S., Karpe, F., Kee, F., Khera, A. V., Klarin, D., Koistinen, H. A., Kooner, J. S., Kooperberg, C., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, T., Langenberg, C., Langsted, A., Launer, L. J., Lauritzen, T., MLiewald, D. C., Lin, L. A., Linneberg, A., Loos, R. J. F., Lu, Y., Lu, X., Mägi, R., Malarstig, A., Manichaikul, A., Manning, A. K., Mäntyselkä, P., Marouli, E., Masca, N. G. D., Maschio, A., Meigs, J. B., Melander, O., Metspalu, A., Morris, A. P., Morrison, A. C., Mulas, A., Müller-Nurasyid, M., Munroe, P. B., Neville, M. J., Nielsen, S. F., Nielsen, J. B., Nordestgaard, B. G., Ordovas, J. M., Mehran, R., O'Donnell, C. J., Orho-Melander, M., Molony, C. M., Muntendam, P., Padmanabhan, S., Palmer, C. N. A., Pasko, D., Patel, A. P., Pedersen, O., Perola, M., Peters, A., Pisinger, C., Pistis, G., Polasek, O., Poulter, N., Psaty, B. M., Rader, D. J., Rasheed, A., Rauramaa, R., Reilly, D. F., Reiner, A. P., Renström, F., Rich, S. S., Ridker, P. M., Rioux, J. D., Robertson, N. R., Roden, D. M., Rotter, J. I., Rudan, I., Salomaa, V., Samani, N. J., Sanna, S., Sattar, N., Schmidt, E. M., Scott, R. A., Sever, P., Sevilla, R. S., Shaffer, C. M., Sim, X., Sivapalaratnam, S., Small, K. S., Smith, A. V., Smith, B. H., Somayajula, S., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Stirrups, K. E., Stitziel, N., Strauch, K., Stringham, H. M., Surendran, P., Tada, H., Tall, A. R., Tang, H., Tardif, J. C., Taylor, K. D., Trompet, S., Tsao, P. S., Tuomilehto, J., Tybjaerg-Hansen, A., Zuydam, N. R. V., Varbo, A., Varga, T. V., Virtamo, J., Waldenberger, M., Wang, N., Wareham, N. J., Warren, H. R., Weeke, P. E., Weinstock, J., Wessel, J., Wilson, J. G., Wilson, P. W. F., Xu, M., Yaghootkar, H., Young, R., Zeggini, E., Zhang, H., Zheng, N. S., Zhang, W., Zhang, Y., Zhou, W., Zhou, Y., Zoledziewska, M., Howson, J. M. M., Danesh, J., McCarthy, M. I., Cowan, C. A., Abecasis, G., Deloukas, P., Musunuru, K., Willer, C. J. & Kathiresan, S., Dec 1 2017, In : Nature Genetics. 49, 12, p. 1758-1766 9 p.

Research output: Contribution to journalArticle

Exome
Lipids
Cholesterol
Type 2 Diabetes Mellitus
Coronary Artery Disease
131 Citations (Scopus)

Rare and low-frequency coding variants alter human adult height

MAGIC Investigators, The EPIC-InterAct Consortium, EPIC-CVD Consortium, CHD Exome+ Consortium, ExomeBP Consortium, T2D-Genes Consortium, GoT2D Genes Consortium, Global Lipids Genetics Consortium & ReproGen Consortium, Feb 9 2017, In : Nature. 542, 7640, p. 186-190 5 p.

Research output: Contribution to journalArticle

Alleles
Insulin-Like Growth Factor Binding Protein 4
Pregnancy-Associated Plasma Protein-A
Growth Disorders
Multifactorial Inheritance
8 Citations (Scopus)

Robust and rapid algorithms facilitate large-scale whole genome sequencing downstream analysis in an integrative framework

Li, M., Li, J., Li, M. J., Pan, Z., Hsu, J. S., Liu, D., Zhan, X., Junwen, W., Youqiang, S. & Sham, P. C., May 19 2017, In : Nucleic acids research. 45, 9, e75.

Research output: Contribution to journalArticle

Genotype
Genome
Molecular Sequence Annotation
Quality Control
Alleles
1 Citation (Scopus)

SEQSpark: A Complete Analysis Tool for Large-Scale Rare Variant Association Studies Using Whole-Genome and Exome Sequence Data

Zhang, D., Zhao, L., Li, B., He, Z., Wang, G. T., Liu, D. & Leal, S. M., Jul 6 2017, In : American Journal of Human Genetics. 101, 1, p. 115-122 8 p.

Research output: Contribution to journalArticle

Exome
Genome-Wide Association Study
Genome
High-Throughput Nucleotide Sequencing
Waist-Hip Ratio
2016
12 Citations (Scopus)

Genetic variants in CETP increase risk of intracerebral hemorrhage

on behalf of the Global Lipids Genetics Consortium and International Stroke Genetics Consortium, Nov 1 2016, In : Annals of Neurology. 80, 5, p. 730-740 11 p.

Research output: Contribution to journalArticle

Cholesterol Ester Transfer Proteins
Cerebral Hemorrhage
HDL Cholesterol
Odds Ratio
Genetic Association Studies
28 Citations (Scopus)

Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals

Eicher, J. D., Chami, N., Kacprowski, T., Nomura, A., Chen, M. H., Yanek, L. R., Tajuddin, S. M., Schick, U. M., Slater, A. J., Pankratz, N., Polfus, L., Schurmann, C., Giri, A., Brody, J. A., Lange, L. A., Manichaikul, A., Hill, W. D., Pazoki, R., Elliot, P., Evangelou, E. & 93 othersTzoulaki, I., Gao, H., Vergnaud, A. C., Mathias, R. A., Becker, D. M., Becker, L. C., Burt, A., Crosslin, D. R., Lyytikäinen, L. P., Nikus, K., Hernesniemi, J., Kähönen, M., Raitoharju, E., Mononen, N., Raitakari, O. T., Lehtimäki, T., Cushman, M., Zakai, N. A., Nickerson, D. A., Raffield, L. M., Quarells, R., Willer, C. J., Peloso, G. M., Abecasis, G. R., Liu, D., Deloukas, P., Samani, N. J., Schunkert, H., Erdmann, J., Fornage, M., Richard, M., Tardif, J. C., Rioux, J. D., Dube, M. P., de Denus, S., Lu, Y., Bottinger, E. P., Loos, R. J. F., Smith, A. V., Harris, T. B., Launer, L. J., Gudnason, V., Velez Edwards, D. R., Torstenson, E. S., Liu, Y., Tracy, R. P., Rotter, J. I., Rich, S. S., Highland, H. M., Boerwinkle, E., Li, J., Lange, E., Wilson, J. G., Mihailov, E., Mägi, R., Hirschhorn, J., Metspalu, A., Esko, T., Vacchi-Suzzi, C., Nalls, M. A., Zonderman, A. B., Evans, M. K., Engström, G., Orho-Melander, M., Melander, O., O'Donoghue, M. L., Waterworth, D. M., Wallentin, L., White, H. D., Floyd, J. S., Bartz, T. M., Rice, K. M., Psaty, B. M., Starr, J. M., Liewald, D. C. M., Hayward, C., Deary, I. J., Greinacher, A., Völker, U., Thiele, T., Völzke, H., van Rooij, F. J. A., Uitterlinden, A. G., Franco, O. H., Dehghan, A., Edwards, T. L., Ganesh, S. K., Kathiresan, S., Faraday, N., Auer, P. L., Reiner, A. P., Lettre, G. & Johnson, A. D., Jul 7 2016, In : American Journal of Human Genetics. 99, 1, p. 40-55 16 p.

Research output: Contribution to journalArticle

Mean Platelet Volume
Platelet Count
Meta-Analysis
Blood Platelets
Blood Cells
175 Citations (Scopus)

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

Zanoni, P., Khetarpal, S. A., Larach, D. B., Hancock-Cerutti, W. F., Millar, J. S., Cuchel, M., DerOhannessian, S., Kontush, A., Surendran, P., Saleheen, D., Trompet, S., Wouter Jukema, J., De Craen, A., Deloukas, P., Sattar, N., Ford, I., Packard, C., Majumder, A. A. S., Alam, D. S., Di Angelantonio, E. & 29 othersAbecasis, G., Chowdhury, R., Erdmann, J., Nordestgaard, B. G., Nielsen, S. F., Tybjærg-Hansen, A., Ruth Frikke Schmidt, F. S., Kuulasmaa, K., Liu, D., Perola, M., Blankenberg, S., Salomaa, V., Männistö, S., Amouyel, P., Arveiler, D., Ferrieres, J., Möller-Nurasyid, M., Ferrario, M., Kee, F., Willer, C. J., Samani, N., Schunkert, H., Butterworth, A. S., Howson, J. M. M., Peloso, G. M., Stitziel, N. O., Danesh, J., Kathiresan, S. & Rader, D. J., Mar 11 2016, In : Science. 351, 6278, p. 1166-1171 6 p.

Research output: Contribution to journalArticle

Scavenger Receptors
HDL Lipoproteins
HDL Cholesterol
Coronary Disease
Induced Pluripotent Stem Cells
44 Citations (Scopus)

RVTESTS: An efficient and comprehensive tool for rare variant association analysis using sequence data

Zhan, X., Hu, Y., Li, B., Abecasis, G. R. & Liu, D., May 1 2016, In : Bioinformatics. 32, 9, p. 1423-1426 4 p.

Research output: Contribution to journalArticle

Sequence Analysis
Genes
Gene
Computational Biology
Bioinformatics
2015
10 Citations (Scopus)

Methods for association analysis and meta-analysis of rare variants in families

Feng, S., Pistis, G., Zhang, H., Zawistowski, M., Mulas, A., Zoledziewska, M., Holmen, O. L., Busonero, F., Sanna, S., Hveem, K., Willer, C., Cucca, F., Liu, D. & Abecasis, G. R., May 1 2015, In : Genetic Epidemiology. 39, 4, p. 227-238 12 p.

Research output: Contribution to journalArticle

Exome
Meta-Analysis
Genes
Sample Size
HDL Cholesterol
11 Citations (Scopus)

SEQMINER: An R-Package to Facilitate the Functional Interpretation of Sequence-Based Associations

Zhan, X. & Liu, D., Dec 1 2015, In : Genetic Epidemiology. 39, 8, p. 619-623 5 p.

Research output: Contribution to journalArticle

Databases
Computational Biology
Linkage Disequilibrium
Genetic Association Studies
Documentation
2014
97 Citations (Scopus)

Meta-analysis of gene-level tests for rare variant association

Liu, D., Peloso, G. M., Zhan, X., Holmen, O. L., Zawistowski, M., Feng, S., Nikpay, M., Auer, P. L., Goel, A., Zhang, H., Peters, U., Farrall, M., Orho-Melander, M., Kooperberg, C., Mcpherson, R., Watkins, H., Willer, C. J., Hveem, K., Melander, O., Kathiresan, S. & 1 othersAbecasis, G. R., Jan 1 2014, In : Nature Genetics. 46, 2, p. 200-204 5 p.

Research output: Contribution to journalArticle

Meta-Analysis
Genes
Exome
Genetic Association Studies
Sample Size
41 Citations (Scopus)

RAREMETAL: Fast and powerful meta-analysis for rare variants

Feng, S., Liu, D., Zhan, X., Wing, M. K. & Abecasis, G. R., Apr 2 2014, In : Bioinformatics. 30, 19, p. 2828-2829 2 p.

Research output: Contribution to journalArticle

Sequencing
Meta-Analysis
2013
20 Citations (Scopus)

Identifying rare variants associated with complex traits via sequencing

Li, B., Liu, D. & Leal, S. M., Jan 1 2013, In : Current protocols in human genetics. SUPPL.78, 1.26.

Research output: Contribution to journalArticle

Genome
Genome-Wide Association Study
Technology
Genes
Surveys and Questionnaires
2012
5 Citations (Scopus)
Phenotype
Sampling Studies
Genetic Models
Population Genetics
Sample Size
12 Citations (Scopus)

A unified framework for detecting rare variant quantitative trait associations in pedigree and unrelated individuals via sequence data

Liu, D. & Leal, S. M., May 1 2012, In : Human heredity. 73, 2, p. 105-122 18 p.

Research output: Contribution to journalArticle

Pedigree
Population Genetics
Genetic Association Studies
Sequence Analysis
Costs and Cost Analysis
3 Citations (Scopus)

A Unified Method for Detecting Secondary Trait Associations with Rare Variants: Application to Sequence Data

Liu, D. & Leal, S. M., Nov 1 2012, In : PLoS genetics. 8, 11, e1003075.

Research output: Contribution to journalArticle

Blood Pressure
testing
LDL Lipoproteins
Italy
quantitative traits
21 Citations (Scopus)

Estimating genetic effects and quantifying missing heritability explained by identified rare-variant associations

Liu, D. & Leal, S. M., Oct 5 2012, In : American Journal of Human Genetics. 91, 4, p. 585-596 12 p.

Research output: Contribution to journalArticle

Genetic Association Studies
Population
Genes
Analysis of Variance
Genotype
21 Citations (Scopus)

Genetic association of cyclic AMP signaling genes with bipolar disorder.

McDonald, M. L., MacMullen, C., Liu, D., Leal, S. M. & Davis, R. L., Jan 1 2012, In : Translational Psychiatry. 2

Research output: Contribution to journalArticle

Bipolar Disorder
Cyclic AMP
Genes
Single Nucleotide Polymorphism
Haplotypes
4 Citations (Scopus)

Seqchip: A powerful method to integrate sequence and genotype data for the detection of rare variant associations

Liu, D. & Leal, S. M., Jul 1 2012, In : Bioinformatics. 28, 13, p. 1745-1751 7 p., bts263.

Research output: Contribution to journalArticle

Genotype
Integrate
Type I error
Sequencing
Costs
2010
157 Citations (Scopus)
gene
seeds
Genes
genes
Exome
45 Citations (Scopus)

Replication strategies for rare variant complex trait association studies via next-generation sequencing

Liu, D. & Leal, S. M., Dec 10 2010, In : American Journal of Human Genetics. 87, 6, p. 790-801 12 p.

Research output: Contribution to journalArticle

Chromosome Mapping
Genetic Models
Population Genetics
Population
Nucleotides
122 Citations (Scopus)

VAMP8/endobrevin is overexpressed in hyperreactive human platelets: Suggested role for platelet microRNA

Kondkar, A. A., Bray, M. S., Leal, S. M., Nagalla, S., Liu, D., Jin, Y., Dong, J. F., Ren, Q., Whiteheart, S. W., Shaw, C. & Bray, P. F., Feb 1 2010, In : Journal of Thrombosis and Haemostasis. 8, 2, p. 369-378 10 p.

Research output: Contribution to journalArticle

MicroRNAs
Blood Platelets
Messenger RNA
SNARE Proteins
Validation Studies