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20102020

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  • 2020

    Association analysis and meta-analysis of multiallelic variants for large-scale sequence data

    Jiang, Y., Chen, S., Wang, X., Liu, M., Iacono, W. G., Hewitt, J. K., Hokanson, J. E., Krauter, K., Laakso, M., Li, K. W., Lutz, S. M., McGue, M., Pandit, A., Zajac, G. J. M., Boehnke, M., Abecasis, G. R., Vrieze, S. I., Jiang, B., Zhan, X. & Liu, D. J., May 2020, In: Genes. 11, 5, 585.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Genetic correlation, pleiotropy, and causal associations between substance use and psychiatric disorder

    Jang, S. K., Saunders, G., Liu, M., Jiang, Y., Liu, D. J. & Vrieze, S., 2020, (Accepted/In press) In: Psychological medicine.

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations
  • Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

    Understanding Society Scientific Group, EPIC-CVD, GSCAN, Consortium for Genetics of Smoking Behaviour, CHD Exome+ consortium, Erzurumluoglu, A. M., Liu, M., Jackson, V. E., Barnes, D. R., Datta, G., Melbourne, C. A., Young, R., Batini, C., Surendran, P., Jiang, T., Adnan, S. D., Afaq, S., Agrawal, A., Altmaier, E., Antoniou, A. C., Asselbergs, F. W., Baumbach, C., Bierut, L., Bertelsen, S. & 31 others, Boehnke, M., Bots, M. L., Brazel, D. M., Chambers, J. C., Chang-Claude, J., Chen, C., Corley, J., Chou, Y. L., David, S. P., de Boer, R. A., de Leeuw, C. A., Dennis, J. G., Dominiczak, A. F., Dunning, A. M., Easton, D. F., Eaton, C., Elliott, P., Evangelou, E., Faul, J. D., Foroud, T., Goate, A., Gong, J., Grabe, H. J., Haessler, J., Haiman, C., Hallmans, G., Hammerschlag, A. R., Harris, S. E., Hattersley, A., Heath, A. & Liu, D., Oct 1 2020, In: Molecular Psychiatry. 25, 10, p. 2392-2409 18 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    13 Scopus citations
  • Prioritizing genetic variants in GWAS with lasso using permutation-assisted tuning

    Yang, S., Wen, J., Eckert, S. T., Wang, Y., Liu, D. J., Wu, R., Li, R. & Zhan, X., Mar 31 2020, In: Bioinformatics. 36, 12, p. 3811-3817 7 p.

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations
  • 2019

    Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use

    CHD Exome+ Consortium, Consortium for Genetics of Smoking Behaviour, Brazel, D. M., Jiang, Y., Hughey, J. M., Turcot, V., Zhan, X., Gong, J., Batini, C., Weissenkampen, J. D., Liu, M. Z., Surendran, P., Young, R., Barnes, D. R., Nielsen, S. F., Rasheed, A., Samuel, M., Zhao, W., Kontto, J., Perola, M. & 32 others, Caslake, M., de Craen, A. J. M., Trompet, S., Uria-Nickelsen, M., Malarstig, A., Reily, D. F., Hoek, M., Vogt, T., Jukema, J. W., Sattar, N., Ford, I., Packard, C. J., Alam, D. S., Majumder, A. A. S., Di Angelantonio, E., Chowdhury, R., Amouyel, P., Arveiler, D., Blankenberg, S., Ferrières, J., Kee, F., Kuulasmaa, K., Müller-Nurasyid, M., Veronesi, G., Virtamo, J., EPIC-CVD Consortium, C., Frossard, P., Nordestgaard, B. G., Saleheen, D., Danesh, J., Butterworth, A. S. & Liu, D., Jun 1 2019, In: Biological Psychiatry. 85, 11, p. 946-955 10 p.

    Research output: Contribution to journalArticlepeer-review

    11 Scopus citations
  • Methods for the Analysis and Interpretation for Rare Variants Associated with Complex Traits

    Weissenkampen, J. D., Jiang, Y., Eckert, S., Jiang, B., Li, B. & Liu, D. J., Apr 2019, In: Current protocols in human genetics. 101, 1, e83.

    Research output: Contribution to journalArticlepeer-review

    6 Scopus citations
  • Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

    T2D-Genes Consortium, The MAGIC Investigators, CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct & ReproGen Consortium, Mar 1 2019, In: Nature Genetics. 51, 3, p. 452-469 18 p.

    Research output: Contribution to journalArticlepeer-review

    21 Scopus citations
  • 2018

    Adaptive-weight burden test for associations between quantitative traits and genotype data with complex correlations

    Wu, X., Guan, T., Liu, D. J., Novelo, L. G. L. & Bandyopadhyay, D., Sep 2018, In: Annals of Applied Statistics. 12, 3, p. 1558-1582 25 p.

    Research output: Contribution to journalArticlepeer-review

    3 Scopus citations
  • Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program

    The Geisinger-Regeneron DiscovEHR Collaboration, The VA Million Veteran Program, Global Lipids Genetics Consortium & Myocardial Infarction Genetics (MIGen) Consortium, Nov 1 2018, In: Nature Genetics. 50, 11, p. 1514-1523 10 p.

    Research output: Contribution to journalArticlepeer-review

    111 Scopus citations
  • Proper conditional analysis in the presence of missing data: Application to large scale meta-analysis of tobacco use phenotypes

    Jiang, Y., Chen, S., McGuire, D., Chen, F., Liu, M., Iacono, W. G., Hewitt, J. K., Hokanson, J. E., Krauter, K., Laakso, M., Li, K. W., Lutz, S. M., McGue, M., Pandit, A., Zajac, G. J. M., Boehnke, M., Abecasis, G. R., Vrieze, S. I., Zhan, X., Jiang, B. & 1 others, Liu, D. J., Jul 2018, In: PLoS genetics. 14, 7, e1007452.

    Research output: Contribution to journalArticlepeer-review

    6 Scopus citations
  • Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

    Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, K. L., Alfred, T. & 379 others, Feitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Allison, M., Amouyel, P., Asselbergs, F. W., Auer, P. L., Balkau, B., Bang, L. E., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, L. F., Blüher, M., Boehnke, M., Boeing, H., Boerwinkle, E., Böger, C. A., Bork-Jensen, J., Bots, M. L., Bottinger, E. P., Bowden, D. W., Brandslund, I., Breen, G., Brilliant, M. H., Broer, L., Brumat, M., Burt, A. A., Butterworth, A. S., Campbell, P. T., Cappellani, S., Carey, D. J., Catamo, E., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Cocca, M., Cook, J. P., Corley, J., Corominas Galbany, J., Cox, A. J., Crosslin, D. S., Cuellar-Partida, G., D'Eustacchio, A., Danesh, J., Davies, G., Bakker, P. I. W., Groot, M. C. H., Mutsert, R., Deary, I. J., Dedoussis, G., Demerath, E. W., Heijer, M., Hollander, A. I., Ruijter, H. M., Dennis, J. G., Denny, J. C., Angelantonio, E., Drenos, F., Du, M., Dubé, M. P., Dunning, A. M., Easton, D. F., Edwards, T. L., Ellinghaus, D., Ellinor, P. T., Elliott, P., Evangelou, E., Farmaki, A. E., Farooqi, I. S., Faul, J. D., Fauser, S., Feng, S., Ferrannini, E., Ferrieres, J., Florez, J. C., Ford, I., Fornage, M., Franco, O. H., Franke, A., Franks, P. W., Friedrich, N., Frikke-Schmidt, R., Galesloot, T. E., Gan, W., Gandin, I., Gasparini, P., Gibson, J., Giedraitis, V., Gjesing, A. P., Gordon-Larsen, P., Gorski, M., Grabe, H. J., Grant, S. F. A., Grarup, N., Griffiths, H. L., Grove, M. L., Gudnason, V., Gustafsson, S., Haessler, J., Hakonarson, H., Hammerschlag, A. R., Hansen, T., Harris, K. M., Harris, T. B., Hattersley, A. T., Have, C. T., Hayward, C., He, L., Heard-Costa, N. L., Heath, A. C., Heid, I. M., Helgeland, Ø., Hernesniemi, J., Hewitt, A. W., Holmen, O. L., Hovingh, G. K., Howson, J. M. M., Hu, Y., Huang, P. L., Huffman, J. E., Ikram, M. A., Ingelsson, E., Jackson, A. U., Jansson, J. H., Jarvik, G. P., Jensen, G. B., Jia, Y., Johansson, S., Jørgensen, M. E., Jørgensen, T., Jukema, J. W., Kahali, B., Kahn, R. S., Kähönen, M., Kamstrup, P. R., Kanoni, S., Kaprio, J., Karaleftheri, M., Kardia, S. L. R., Karpe, F., Kathiresan, S., Kee, F., Kiemeney, L. A., Kim, E., Kitajima, H., Komulainen, P., Kooner, J. S., Kooperberg, C., Korhonen, T., Kovacs, P., Kuivaniemi, H., Kutalik, Z., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, T. A., Lamparter, D., Lange, E. M., Lange, L. A., Langenberg, C., Larson, E. B., Lee, N. R., Lehtimäki, T., Lewis, C. E., Li, H., Li, J., Li-Gao, R., Lin, H., Lin, K. H., Lin, L. A., Lin, X., Lind, L., Lindström, J., Linneberg, A., Liu, C. T., Liu, D. J., Liu, Y., Lo, K. S., Lophatananon, A., Lotery, A. J., Loukola, A., Luan, JA., Lubitz, S. A., Lyytikäinen, L. P., Männistö, S., Marenne, G., Mazul, A. L., McCarthy, M. I., McKean-Cowdin, R., Medland, S. E., Meidtner, K., Milani, L., Mistry, V., Mitchell, P., Mohlke, K. L., Moilanen, L., Moitry, M., Montgomery, G. W., Mook-Kanamori, D. O., Moore, C., Mori, T. A., Morris, A. D., Morris, A. P., Müller-Nurasyid, M., Munroe, P. B., Nalls, M. A., Narisu, N., Nelson, C. P., Neville, M., Nielsen, S. F., Nikus, K., Njølstad, P. R., Nordestgaard, B. G., Nyholt, D. R., O'Connel, J. R., O'Donoghue, M. L., Olde Loohuis, L. M., Ophoff, R. A., Owen, K. R., Packard, C. J., Padmanabhan, S., Palmer, C. N. A., Palmer, N. D., Pasterkamp, G., Patel, A. P., Pattie, A., Pedersen, O., Peissig, P. L., Peloso, G. M., Pennell, C. E., Perola, M., Perry, J. A., Perry, J. R. B., Pers, T. H., Person, T. N., Peters, A., Petersen, E. R. B., Peyser, P. A., Pirie, A., Polasek, O., Polderman, T. J., Puolijoki, H., Raitakari, O. T., Rasheed, A., Rauramaa, R., Reilly, D. F., Renström, F., Rheinberger, M., Ridker, P. M., Rioux, J. D., Rivas, M. A., Roberts, D. J., Robertson, N. R., Robino, A., Rolandsson, O., Rudan, I., Ruth, K. S., Saleheen, D., Salomaa, V., Samani, N. J., Sapkota, Y., Sattar, N., Schoen, R. E., Schreiner, P. J., Schulze, M. B., Scott, R. A., Segura-Lepe, M. P., Shah, S. H., Sheu, W. H. H., Sim, X., Slater, A. J., Small, K. S., Smith, A. V., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Stefansson, K., Steinthorsdottir, V., Stirrups, K. E., Strauch, K., Stringham, H. M., Stumvoll, M., Sun, L., Surendran, P., Swift, A. J., Tada, H., Tansey, K. E., Tardif, J. C., Taylor, K. D., Teumer, A., Thompson, D. J., Thorleifsson, G., Thorsteinsdottir, U., Thuesen, B. H., Tönjes, A., Tromp, G., Trompet, S., Tsafantakis, E., Tuomilehto, J., Tybjaerg-Hansen, A., Tyrer, J. P., Uher, R., Uitterlinden, A. G., Uusitupa, M., Laan, S. W., Duijn, C. M., Leeuwen, N., Van Setten, J., Vanhala, M., Varbo, A., Varga, T. V., Varma, R., Velez Edwards, D. R., Vermeulen, S. H., Veronesi, G., Vestergaard, H., Vitart, V., Vogt, T. F., Völker, U., Vuckovic, D., Wagenknecht, L. E., Walker, M., Wallentin, L., Wang, F., Wang, C. A., Wang, S., Wang, Y., Ware, E. B., Wareham, N. J., Warren, H. R., Waterworth, D. M., Wessel, J., White, H. D., Willer, C. J., Wilson, J. G., Witte, D. R., Wood, A. R., Wu, Y., Yaghootkar, H., Yao, J., Yao, P., Yerges-Armstrong, L. M., Young, R., Zeggini, E., Zhan, X., Zhang, W., Zhao, J. H., Zhao, W., Zhou, W., Zondervan, K. T., Rotter, J. I., Pospisilik, J. A., Rivadeneira, F., Borecki, I. B., Deloukas, P., Frayling, T. M., Lettre, G., North, K. E., Lindgren, C. M., Hirschhorn, J. N. & Loos, R. J. F., Jan 1 2018, In: Nature Genetics. 50, 1, p. 26-35 10 p.

    Research output: Contribution to journalArticlepeer-review

    113 Scopus citations
  • Rare loss of function variants in candidate genes and risk of colorectal cancer

    NHLBI GO Exome Sequencing Project, Pulmonary Arterial Hypertension (PAH), Severe Asthma Research Program (SARP), Women’s Health Initiative (WHI), Anthropometry Project Team, Blood Count/Hematology Project Team, Blood Pressure Project Team, Data Flow Working Group, Early MI Project Team, ELSI Working Group, Executive Committee, Family Study Project Team, Lipids Project Team, Lung Project Team, Personal Genomics Project Team, Phenotype and Harmonization Working Group, Population Genetics and Statistical Analysis Working Group, Publications and Presentations Working Group, Quantitative Analysis Ad Hoc Task Group, Sequencing and Genotyping Working Group & 15 others, Steering Committee, Stroke Project Team, Structural Variation Working Group, Subclinical/Quantitative Project Team, Acute Lung Injury (ALI), Atherosclerosis Risk in Communities (ARIC), Cardiovascular Health Study (CHS), Chronic Obstructive Pulmonary Disease (COPDGene), Coronary Artery Risk Development in Young Adults (CARDIA), Cystic Fibrosis (CF), Early Pseudomonas Infection Control (EPIC), Framingham Heart Study (FHS), Jackson Heart Study (JHS), Lung Health Study (LHS) & Multi-Ethnic Study of Atherosclerosis (MESA), Oct 1 2018, In: Human genetics. 137, 10, p. 795-806 12 p.

    Research output: Contribution to journalArticlepeer-review

    5 Scopus citations
  • Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes article

    ExomeBP Consortium, MAGIC Consortium & GIANT Consortium, Apr 1 2018, In: Nature Genetics. 50, 4, p. 559-571 13 p.

    Research output: Contribution to journalArticlepeer-review

    109 Scopus citations
  • 2017

    Analysis of single nucleotide variants of HFE gene and association to survival in the Cancer Genome Atlas GBM data

    Lee, S. Y., Zhu, J., Salzberg, A. C., Zhang, B., Liu, D. J., Muscat, J. E., Langan, S. T. & Connor, J. R., Mar 2017, In: PloS one. 12, 3, e0174778.

    Research output: Contribution to journalArticlepeer-review

    3 Scopus citations
  • Association of rare and common variation in the lipoprotein lipase gene with coronary artery disease

    Khera, A. V., Won, H. H., Peloso, G. M., O'Dushlaine, C., Liu, D., Stitziel, N. O., Natarajan, P., Nomura, A., Emdin, C. A., Gupta, N., Borecki, I. B., Asselta, R., Duga, S., Merlini, P. A., Correa, A., Kessler, T., Wilson, J. G., Bown, M. J., Hall, A. S., Braund, P. S. & 24 others, Carey, D. J., Murray, M. F., Kirchner, H. L., Leader, J. B., Lavage, D. R., Manus, J. N., Hartzel, D. N., Samani, N. J., Schunkert, H., Marrugat, J., Elosua, R., McPherson, R., Farrall, M., Watkin, H., Lander, E. S., Rader, D. J., Danesh, J., Ardissino, D., Gabriel, S., Willer, C., Abecasis, G. R., Saleheen, D., Dewey, F. E. & Kathiresan, S., Mar 7 2017, In: JAMA - Journal of the American Medical Association. 317, 9, p. 937-946 10 p.

    Research output: Contribution to journalArticlepeer-review

    73 Scopus citations
  • Clonal evolution in paired endometrial intraepithelial neoplasia/atypical hyperplasia and endometrioid adenocarcinoma

    Russo, M., Broach, J., Sheldon, K., Houser, K. R., Liu, D. J., Kesterson, J., Phaeton, R., Hossler, C., Hempel, N., Baker, M., Newell, J. M., Zaino, R. & Warrick, J. I., Sep 2017, In: Human Pathology. 67, p. 69-77 9 p.

    Research output: Contribution to journalArticlepeer-review

    15 Scopus citations
  • Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease

    Lu, X., Peloso, G. M., Liu, D. J., Wu, Y., Zhang, H., Zhou, W., Li, J., Tang, C. S. M., Dorajoo, R., Li, H., Long, J., Guo, X., Xu, M., Spracklen, C. N., Chen, Y., Liu, X., Zhang, Y., Khor, C. C., Liu, J., Sun, L. & 47 others, Wang, L., Gao, Y. T., Hu, Y., Yu, K., Wang, Y., Cheung, C. Y. Y., Wang, F., Huang, J., Fan, Q., Cai, Q., Chen, S., Shi, J., Yang, X., Zhao, W., Sheu, W. H. H., Cherny, S. S., He, M., Feranil, A. B., Adair, L. S., Gordon-Larsen, P., Du, S., Varma, R., Chen, Y. D. I., Shu, X. O., Lam, K. S. L., Wong, T. Y., Ganesh, S. K., Mo, Z., Hveem, K., Fritsche, L. G., Nielsen, J. B., Tse, H. F., Huo, Y., Cheng, C. Y., Chen, Y. E., Zheng, W., Tai, E. S., Gao, W., Lin, X., Huang, W., Abecasis, G., Kathiresan, S., Mohlke, K. L., Wu, T., Sham, P. C., Gu, D. & Willer, C. J., Dec 1 2017, In: Nature Genetics. 49, 12, p. 1722-1730 9 p.

    Research output: Contribution to journalArticlepeer-review

    46 Scopus citations
  • Exome-wide association study of plasma lipids in >300,000 individuals

    Liu, D. J., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X., Mahajan, A., Saleheen, D., Emdin, C., Alam, D., Alves, A. C., Amouyel, P., Angelantonio, E. DI., Arveiler, D., Assimes, T. L., Auer, P. L., Baber, U., Ballantyne, C. M., Bang, L. E., Benn, M., Bis, J. C. & 207 others, Boehnke, M., Boerwinkle, E., Bork-Jensen, J., Bottinger, E. P., Brandslund, I., Brown, M., Busonero, F., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. E., Chen, Y. D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Connell, J. M., Cucca, F., Cupples, L. A., Damrauer, S. M., Davies, G., Deary, I. J., Dedoussis, G., Denny, J. C., Dominiczak, A., Dubé, M. P., Ebeling, T., Eiriksdottir, G., Esko, T., Farmaki, A. E., Feitosa, M. F., Ferrario, M., Ferrieres, J., Ford, I., Fornage, M., Franks, P. W., Frayling, T. M., Frikke-Schmidt, R., Fritsche, L. G., Frossard, P., Fuster, V., Ganesh, S. K., Gao, W., Garcia, M. E., Gieger, C., Giulianini, F., Goodarzi, M. O., Grallert, H., Grarup, N., Groop, L., Grove, M. L., Gudnason, V., Hansen, T., Harris, T. B., Hayward, C., Hirschhorn, J. N., Holmen, O. L., Huffman, J., Huo, Y., Hveem, K., Jabeen, S., Jackson, A. U., Jakobsdottir, J., Jarvelin, M. R., Jensen, G. B., Jørgensen, M. E., Jukema, J. W., Justesen, J. M., Kamstrup, P. R., Kanoni, S., Karpe, F., Kee, F., Khera, A. V., Klarin, D., Koistinen, H. A., Kooner, J. S., Kooperberg, C., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, T., Langenberg, C., Langsted, A., Launer, L. J., Lauritzen, T., MLiewald, D. C., Lin, L. A., Linneberg, A., Loos, R. J. F., Lu, Y., Lu, X., Mägi, R., Malarstig, A., Manichaikul, A., Manning, A. K., Mäntyselkä, P., Marouli, E., Masca, N. G. D., Maschio, A., Meigs, J. B., Melander, O., Metspalu, A., Morris, A. P., Morrison, A. C., Mulas, A., Müller-Nurasyid, M., Munroe, P. B., Neville, M. J., Nielsen, S. F., Nielsen, J. B., Nordestgaard, B. G., Ordovas, J. M., Mehran, R., O'Donnell, C. J., Orho-Melander, M., Molony, C. M., Muntendam, P., Padmanabhan, S., Palmer, C. N. A., Pasko, D., Patel, A. P., Pedersen, O., Perola, M., Peters, A., Pisinger, C., Pistis, G., Polasek, O., Poulter, N., Psaty, B. M., Rader, D. J., Rasheed, A., Rauramaa, R., Reilly, D. F., Reiner, A. P., Renström, F., Rich, S. S., Ridker, P. M., Rioux, J. D., Robertson, N. R., Roden, D. M., Rotter, J. I., Rudan, I., Salomaa, V., Samani, N. J., Sanna, S., Sattar, N., Schmidt, E. M., Scott, R. A., Sever, P., Sevilla, R. S., Shaffer, C. M., Sim, X., Sivapalaratnam, S., Small, K. S., Smith, A. V., Smith, B. H., Somayajula, S., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Stirrups, K. E., Stitziel, N., Strauch, K., Stringham, H. M., Surendran, P., Tada, H., Tall, A. R., Tang, H., Tardif, J. C., Taylor, K. D., Trompet, S., Tsao, P. S., Tuomilehto, J., Tybjaerg-Hansen, A., Zuydam, N. R. V., Varbo, A., Varga, T. V., Virtamo, J., Waldenberger, M., Wang, N., Wareham, N. J., Warren, H. R., Weeke, P. E., Weinstock, J., Wessel, J., Wilson, J. G., Wilson, P. W. F., Xu, M., Yaghootkar, H., Young, R., Zeggini, E., Zhang, H., Zheng, N. S., Zhang, W., Zhang, Y., Zhou, W., Zhou, Y., Zoledziewska, M., Howson, J. M. M., Danesh, J., McCarthy, M. I., Cowan, C. A., Abecasis, G., Deloukas, P., Musunuru, K., Willer, C. J. & Kathiresan, S., Dec 1 2017, In: Nature Genetics. 49, 12, p. 1758-1766 9 p.

    Research output: Contribution to journalArticlepeer-review

    178 Scopus citations
  • Rare and low-frequency coding variants alter human adult height

    MAGIC Investigators, The EPIC-InterAct Consortium, EPIC-CVD Consortium, CHD Exome+ Consortium, ExomeBP Consortium, T2D-Genes Consortium, GoT2D Genes Consortium, Global Lipids Genetics Consortium & ReproGen Consortium, Feb 9 2017, In: Nature. 542, 7640, p. 186-190 5 p.

    Research output: Contribution to journalArticlepeer-review

    248 Scopus citations
  • Robust and rapid algorithms facilitate large-scale whole genome sequencing downstream analysis in an integrative framework

    Li, M., Li, J., Li, M. J., Pan, Z., Hsu, J. S., Liu, D. J., Zhan, X., Junwen, W., Youqiang, S. & Sham, P. C., May 19 2017, In: Nucleic acids research. 45, 9, e75.

    Research output: Contribution to journalArticlepeer-review

    15 Scopus citations
  • SEQSpark: A Complete Analysis Tool for Large-Scale Rare Variant Association Studies Using Whole-Genome and Exome Sequence Data

    Zhang, D., Zhao, L., Li, B., He, Z., Wang, G. T., Liu, D. J. & Leal, S. M., Jul 6 2017, In: American Journal of Human Genetics. 101, 1, p. 115-122 8 p.

    Research output: Contribution to journalArticlepeer-review

    5 Scopus citations
  • 2016

    Genetic variants in CETP increase risk of intracerebral hemorrhage

    on behalf of the Global Lipids Genetics Consortium and International Stroke Genetics Consortium, Nov 1 2016, In: Annals of Neurology. 80, 5, p. 730-740 11 p.

    Research output: Contribution to journalArticlepeer-review

    18 Scopus citations
  • Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals

    Eicher, J. D., Chami, N., Kacprowski, T., Nomura, A., Chen, M. H., Yanek, L. R., Tajuddin, S. M., Schick, U. M., Slater, A. J., Pankratz, N., Polfus, L., Schurmann, C., Giri, A., Brody, J. A., Lange, L. A., Manichaikul, A., Hill, W. D., Pazoki, R., Elliot, P., Evangelou, E. & 93 others, Tzoulaki, I., Gao, H., Vergnaud, A. C., Mathias, R. A., Becker, D. M., Becker, L. C., Burt, A., Crosslin, D. R., Lyytikäinen, L. P., Nikus, K., Hernesniemi, J., Kähönen, M., Raitoharju, E., Mononen, N., Raitakari, O. T., Lehtimäki, T., Cushman, M., Zakai, N. A., Nickerson, D. A., Raffield, L. M., Quarells, R., Willer, C. J., Peloso, G. M., Abecasis, G. R., Liu, D. J., Deloukas, P., Samani, N. J., Schunkert, H., Erdmann, J., Fornage, M., Richard, M., Tardif, J. C., Rioux, J. D., Dube, M. P., de Denus, S., Lu, Y., Bottinger, E. P., Loos, R. J. F., Smith, A. V., Harris, T. B., Launer, L. J., Gudnason, V., Velez Edwards, D. R., Torstenson, E. S., Liu, Y., Tracy, R. P., Rotter, J. I., Rich, S. S., Highland, H. M., Boerwinkle, E., Li, J., Lange, E., Wilson, J. G., Mihailov, E., Mägi, R., Hirschhorn, J., Metspalu, A., Esko, T., Vacchi-Suzzi, C., Nalls, M. A., Zonderman, A. B., Evans, M. K., Engström, G., Orho-Melander, M., Melander, O., O'Donoghue, M. L., Waterworth, D. M., Wallentin, L., White, H. D., Floyd, J. S., Bartz, T. M., Rice, K. M., Psaty, B. M., Starr, J. M., Liewald, D. C. M., Hayward, C., Deary, I. J., Greinacher, A., Völker, U., Thiele, T., Völzke, H., van Rooij, F. J. A., Uitterlinden, A. G., Franco, O. H., Dehghan, A., Edwards, T. L., Ganesh, S. K., Kathiresan, S., Faraday, N., Auer, P. L., Reiner, A. P., Lettre, G. & Johnson, A. D., Jul 7 2016, In: American Journal of Human Genetics. 99, 1, p. 40-55 16 p.

    Research output: Contribution to journalArticlepeer-review

    41 Scopus citations
  • Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

    Zanoni, P., Khetarpal, S. A., Larach, D. B., Hancock-Cerutti, W. F., Millar, J. S., Cuchel, M., DerOhannessian, S., Kontush, A., Surendran, P., Saleheen, D., Trompet, S., Wouter Jukema, J., De Craen, A., Deloukas, P., Sattar, N., Ford, I., Packard, C., Majumder, A. A. S., Alam, D. S., Di Angelantonio, E. & 29 others, Abecasis, G., Chowdhury, R., Erdmann, J., Nordestgaard, B. G., Nielsen, S. F., Tybjærg-Hansen, A., Ruth Frikke Schmidt, F. S., Kuulasmaa, K., Liu, D. J., Perola, M., Blankenberg, S., Salomaa, V., Männistö, S., Amouyel, P., Arveiler, D., Ferrieres, J., Möller-Nurasyid, M., Ferrario, M., Kee, F., Willer, C. J., Samani, N., Schunkert, H., Butterworth, A. S., Howson, J. M. M., Peloso, G. M., Stitziel, N. O., Danesh, J., Kathiresan, S. & Rader, D. J., Mar 11 2016, In: Science. 351, 6278, p. 1166-1171 6 p.

    Research output: Contribution to journalArticlepeer-review

    248 Scopus citations
  • RVTESTS: An efficient and comprehensive tool for rare variant association analysis using sequence data

    Zhan, X., Hu, Y., Li, B., Abecasis, G. R. & Liu, D. J., May 1 2016, In: Bioinformatics. 32, 9, p. 1423-1426 4 p.

    Research output: Contribution to journalArticlepeer-review

    109 Scopus citations
  • 2015

    Methods for association analysis and meta-analysis of rare variants in families

    Feng, S., Pistis, G., Zhang, H., Zawistowski, M., Mulas, A., Zoledziewska, M., Holmen, O. L., Busonero, F., Sanna, S., Hveem, K., Willer, C., Cucca, F., Liu, D. J. & Abecasis, G. R., May 1 2015, In: Genetic Epidemiology. 39, 4, p. 227-238 12 p.

    Research output: Contribution to journalArticlepeer-review

    10 Scopus citations
  • SEQMINER: An R-Package to Facilitate the Functional Interpretation of Sequence-Based Associations

    Zhan, X. & Liu, D. J., Dec 1 2015, In: Genetic Epidemiology. 39, 8, p. 619-623 5 p.

    Research output: Contribution to journalArticlepeer-review

    17 Scopus citations
  • 2014

    Meta-analysis of gene-level tests for rare variant association

    Liu, D. J., Peloso, G. M., Zhan, X., Holmen, O. L., Zawistowski, M., Feng, S., Nikpay, M., Auer, P. L., Goel, A., Zhang, H., Peters, U., Farrall, M., Orho-Melander, M., Kooperberg, C., Mcpherson, R., Watkins, H., Willer, C. J., Hveem, K., Melander, O., Kathiresan, S. & 1 others, Abecasis, G. R., Feb 2014, In: Nature Genetics. 46, 2, p. 200-204 5 p.

    Research output: Contribution to journalArticlepeer-review

    113 Scopus citations
  • RAREMETAL: Fast and powerful meta-analysis for rare variants

    Feng, S., Liu, D., Zhan, X., Wing, M. K. & Abecasis, G. R., Apr 2 2014, In: Bioinformatics. 30, 19, p. 2828-2829 2 p.

    Research output: Contribution to journalArticlepeer-review

    55 Scopus citations
  • Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol

    The NHLBI Grand Opportunity Exome Sequencing Project, Feb 6 2014, In: American Journal of Human Genetics. 94, 2, p. 233-245 13 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    148 Scopus citations
  • 2013

    Identifying rare variants associated with complex traits via sequencing

    Li, B., Liu, D. J. & Leal, S. M., 2013, In: Current protocols in human genetics. SUPPL.78, 1.26.

    Research output: Contribution to journalArticlepeer-review

    22 Scopus citations
  • 2012
    7 Scopus citations
  • A unified framework for detecting rare variant quantitative trait associations in pedigree and unrelated individuals via sequence data

    Liu, D. J. & Leal, S. M., May 2012, In: Human heredity. 73, 2, p. 105-122 18 p.

    Research output: Contribution to journalArticlepeer-review

    12 Scopus citations
  • A Unified Method for Detecting Secondary Trait Associations with Rare Variants: Application to Sequence Data

    Liu, D. J. & Leal, S. M., Nov 2012, In: PLoS genetics. 8, 11, e1003075.

    Research output: Contribution to journalArticlepeer-review

    6 Scopus citations
  • Estimating genetic effects and quantifying missing heritability explained by identified rare-variant associations

    Liu, D. J. & Leal, S. M., Oct 5 2012, In: American Journal of Human Genetics. 91, 4, p. 585-596 12 p.

    Research output: Contribution to journalArticlepeer-review

    23 Scopus citations
  • Genetic association of cyclic AMP signaling genes with bipolar disorder.

    McDonald, M. L., MacMullen, C., Liu, D. J., Leal, S. M. & Davis, R. L., 2012, In: Translational psychiatry. 2, p. e169

    Research output: Contribution to journalArticlepeer-review

    26 Scopus citations
  • Seqchip: A powerful method to integrate sequence and genotype data for the detection of rare variant associations

    Liu, D. J. & Leal, S. M., Jul 2012, In: Bioinformatics. 28, 13, p. 1745-1751 7 p., bts263.

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations
  • 2010
    174 Scopus citations
  • Replication strategies for rare variant complex trait association studies via next-generation sequencing

    Liu, D. J. & Leal, S. M., Dec 10 2010, In: American Journal of Human Genetics. 87, 6, p. 790-801 12 p.

    Research output: Contribution to journalArticlepeer-review

    47 Scopus citations
  • VAMP8/endobrevin is overexpressed in hyperreactive human platelets: Suggested role for platelet microRNA

    Kondkar, A. A., Bray, M. S., Leal, S. M., Nagalla, S., Liu, D. J., Jin, Y., Dong, J. F., Ren, Q., Whiteheart, S. W., Shaw, C. & Bray, P. F., Feb 2010, In: Journal of Thrombosis and Haemostasis. 8, 2, p. 369-378 10 p.

    Research output: Contribution to journalArticlepeer-review

    145 Scopus citations