• 2964 Citations
  • 24 h-Index
19992019

Research output per year

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Research Output

  • 2964 Citations
  • 24 h-Index
  • 47 Article
  • 3 Review article
  • 2 Chapter
  • 2 Conference contribution
2019

Abstracts of Presentations at the Association of Clinical Scientists 139th Meeting Hershey, PA, May 15-18, 2019

Donaldson, K., Buchanich, J. M., Grigson, P. S., Deneke, E., Vrana, K. E., Sacks, D. B., Kuehn, G. J., Cardamone, D., Pesce, A., Smiley, S., Nickley, J., Krock, K., Thomas, R., Wilkerson, M. L., Farag, H. A., Challa, S. R., Tice, A. M., Wolk, D. M., Prichard, J., Grant, M. L. & 102 others, Regmi, S., Kerbacher, B., Quinton, L. E., Tice, A. M., Olson, J., Haynes, A., Yu, E., McCully, K. S., Assi, J., Wong, M., Zarrin-Khameh, N., Nifong, T. P., Hawker, C. D., Carlton, G. T., Rivera, J. M., Foulis, P. R., Zuraw, A., Morlote, D., Peker, D., Reddy, V., Harada, S., Crutchfield, C., Zander, D., Barbhuiya, M. A., Pederson, E. C., Straub, M. L., Scott, S. C., Neibauer, T. L., Salter, W. F., Creer, M. H., Zhu, Y., Bornhorst, J. A., Theobald, J. P., Algeciras-Schimnich, A., Cao, L., Knox, J., Hardy, R., Texas, H. J., McGuire, M. F., Hunter, R. L., Brown, R. E., Hicks, J., Cai, Z., Brown, R. E., Ali, Y., Cheng, K. C., Katz, S. R., Ding, Y., Vanselow, D. J., Yakovlev, M. A., Lin, A. Y., Clark, D. P., Vargas, P., Xin, X., Copper, J. E., Canfield, V. A., Ang, K. C., Wang, Y., Xiao, X., De Carlo, F., van Rossum, D. B., La Rivière, P. J., Newell, J., Hossler, C., Roche, M., Warrick, J., Phaeton, R., Kesterson, J., Myers, C., Barrios, R., Mintz, P., Robyak, K., Hamilton, C., McGhee, P., Pederson, C., Straub, M., Scott, S., Neibauer, T., Salter, W., Robyak, K., Singh, N., Morlote, D., Vnencak-Jones, C., Yemelyanova, A., Harada, S., Shah, M., Moghadamtousi, S. Z., Lan, C., Duose, D., Hu, P., Esquenazi, Y., Luthra, R., Ballester, L. Y., Koenig, A. N., Liu, C. G., Zhang, J., Kalia, A., Al-Habib, A., Van Arsdall, M., Dhingra, S., Patel, K. & Tatevian, N., May 1 2019, In : Annals of clinical and laboratory science. 49, 3, p. 403-416 14 p.

Research output: Contribution to journalArticle

Computational 3d histological phenotyping of whole zebrafish by x-ray histotomography

Ding, Y., Vanselow, D. J., Yakovlev, M. A., Katz, S. R., Lin, A. Y., Clark, D. P., Vargas, P., Xin, X., Copper, J. E., Canfield, V. A., Ang, K. C., Wang, Y., Xiao, X., Carlo, F. D., Rossum, D. B. V., Riviere, P. L. & Cheng, K. C., May 2019, In : eLife. 8, e44898.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2018

Comparative analysis of fixation and embedding techniques for optimized histological preparation of zebrafish

Copper, J. E., Budgeon, L. R., Foutz, C. A., van Rossum, D. B., Vanselow, D. J., Hubley, M. J., Clark, D. P., Mandrell, D. T. & Cheng, K. C., Jun 2018, In : Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology. 208, p. 38-46 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Rigid Embedding of Fixed and Stained, Whole, Millimeter-Scale Specimens for Section-free 3D Histology by Micro-Computed Tomography

Lin, A. Y., Ding, Y., Vanselow, D. J., Katz, S. R., Yakovlev, M. A., Clark, D. P., Mandrell, D., Copper, J. E., van Rossum, D. B. & Cheng, K. C., Oct 17 2018, In : Journal of visualized experiments : JoVE. 140

Research output: Contribution to journalArticle

1 Scopus citations

The S6 gate in regulatory Kv6 subunits restricts heteromeric K+ channel stoichiometry

Pisupati, A., Mickolajczyk, K. J., Horton, W., van Rossum, D. B., Anishkin, A., Chintapalli, S. V., Li, X., Chu-Luo, J., Busey, G., Hancock, W. O. & Jegla, T., Dec 1 2018, In : Journal of General Physiology. 150, 12, p. 1702-1721 20 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome

Caraveo, G., Soste, M., Cappelleti, V., Fanning, S., Van Rossum, D. B., Whitesell, L., Huang, Y., Chung, C. Y., Baru, V., Zaichick, S., Picotti, P. & Lindquist, S., Dec 26 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 52, p. E11313-E11322

Research output: Contribution to journalArticle

7 Scopus citations

Synchrotron microCT imaging of soft tissue in juvenile zebrafish reveals retinotectal projections

Xin, X., Clark, D., Ang, K. C., Van Rossum, D. B., Copper, J., Xiao, X., La Riviere, P. J. & Cheng, K. C., Jan 1 2017, Optical Biopsy XV: Toward Real-Time Spectroscopic Imaging and Diagnosis. Alfano, R. R. & Demos, S. G. (eds.). SPIE, 100601I. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10060).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2016

Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment

Jegla, T., Nguyen, M. M., Feng, C., Goetschius, D. J., Luna, E., van Rossum, D. B., Kamel, B., Pisupati, A., Milner, E. S. & Rolls, M. M., Dec 2016, In : PLoS genetics. 12, 12, e1006457.

Research output: Contribution to journalArticle

12 Scopus citations
10 Scopus citations

Novel molecular interactions of acylcarnitines and fatty acids with myoglobin

Chintapalli, S. V., Jayanthi, S., Mallipeddi, P. L., Gundampati, R., Suresh Kumar, T. K., Van Rossum, D. B., Anishkin, A. & Adams, S. H., Nov 25 2016, In : Journal of Biological Chemistry. 291, 48, p. 25133-25143 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
2015

Bimodal regulation of an Elk subfamily K+ channel by phosphatidylinositol 4,5-bisphosphate

Li, X., Anishkin, A., Liu, H., van Rossum, D. B., Chintapalli, S. V., Sassic, J. K., Gallegos, D., Pivaroff-Ward, K. & Jegla, T., Nov 1 2015, In : Journal of General Physiology. 146, 5, p. 357-374 18 p.

Research output: Contribution to journalArticle

14 Scopus citations

Functional characterization of Cnidarian HCN channels points to an early evolution of Ih

Baker, E. C., Layden, M. J., Van Rossum, D. B., Kamel, B., Medina, M., Simpson, E. & Jegla, T., Nov 10 2015, In : PloS one. 10, 11, e0142730.

Research output: Contribution to journalArticle

5 Scopus citations

Major diversification of voltage-gated K+ channels occurred in ancestral parahoxozoans

Li, X., Liu, H., Luo, J. C., Rhodes, S. A., Trigg, L. M., Van Rossum, D. B., Anishkin, A., Diatta, F. H., Sassic, J. K., Simmons, D. K., Kamel, B., Medina, M., Martindale, M. Q. & Jegla, T., Mar 3 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 9, p. E1010-E1019

Research output: Contribution to journalArticle

14 Scopus citations

Molecular dynamic simulations reveal the structural determinants of fatty acid binding to oxy-myoglobin

Chintapalli, S. V., Bhardwaj, G., Patel, R., Shah, N., Patterson, R. L., Van Rossum, D. B., Anishkin, A. & Adams, S. H., Jun 1 2015, In : PloS one. 10, 6, e0128496.

Research output: Contribution to journalArticle

8 Scopus citations

The BRCA1 tumor suppressor binds to inositol 1,4,5-trisphosphate receptors to stimulate apoptotic calcium release

Hedgepeth, S. C., Garcia, M. I., Wagner, L. E., Rodriguez, A. M., Chintapalli, S. V., Snyder, R. R., Hankins, G. D. V., Henderson, B. R., Brodie, K. M., Yule, D. I., Van Rossum, D. B. & Boehning, D., Mar 13 2015, In : Journal of Biological Chemistry. 290, 11, p. 7304-7313 10 p.

Research output: Contribution to journalArticle

36 Scopus citations
2014

Functional evolution of Erg potassium channel gating reveals an ancient origin for IKr

Martinson, A. S., Van Rossum, D. B., Diatta, F. H., Layden, M. J., Rhodes, S. A., Martindale, M. Q. & Jegla, T., Apr 15 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 15, p. 5712-5717 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour

Lindy, A. S., Parekh, P. K., Zhu, R., Kanju, P., Chintapalli, S. V., Tsvilovskyy, V., Patterson, R. L., Anishkin, A., Van Rossum, D. B. & Liedtke, W. B., Sep 2 2014, In : Nature communications. 5, 4734.

Research output: Contribution to journalArticle

12 Scopus citations
2013

Reevaluation of the evolutionary events within recA/RAD51 phylogeny

Chintapalli, S. V., Bhardwaj, G., Babu, J., Hadjiyianni, L., Hong, Y., Todd, G. K., Boosalis, C. A., Zhang, Z., Zhou, X., Ma, H., Anishkin, A., van Rossum, D. B. & Patterson, R. L., Apr 10 2013, In : BMC genomics. 14, 1, 240.

Research output: Contribution to journalArticle

14 Scopus citations
2012

IP3 receptors

Patterson, R. & Van Rossum, D. B., Mar 22 2012, Ion Channels: From Structure to Function. Oxford University Press

Research output: Chapter in Book/Report/Conference proceedingChapter

Phyrn: A robust method for phylogenetic analysis of highly divergent sequences

Bhardwaj, G., Ko, K. D., Hong, Y., Zhang, Z., Ho, N. L., Chintapalli, S. V., Kline, L. A., Gotlin, M., Hartranft, D. N., Patterson, M. E., Dave, F., Smith, E. J., Holmes, E. C., Patterson, R. L. & van Rossum, D. B., Apr 13 2012, In : PloS one. 7, 4, e34261.

Research output: Contribution to journalArticle

12 Scopus citations
2011

Adaptive-BLAST: A user-defined platform for the study of proteins

Hong, Y., Chintapalli, S. V., Bhardwaj, G., Zhang, Z., Patterson, R. L. & Van Rossum, D. B., Feb 2011, In : Journal of Integrated OMICS. 1, 1, p. 88-101 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Conserved GXXXG-and S/T-like motifs in the transmembrane domains of NS4B protein are required for hepatitis C virus replication

Han, Q., Aligo, J., Manna, D., Belton, K., Chintapalli, S. V., Hong, Y., Patterson, R. L., van Rossum, D. B. & Konan, K. V., Jul 1 2011, In : Journal of virology. 85, 13, p. 6464-6479 16 p.

Research output: Contribution to journalArticle

22 Scopus citations

Exploring phospholipase C-coupled Ca 2+ signalling networks using boolean modelling

Bhardwaj, G., Wells, C. P., Albert, R. Z., Van Rossum, D. B. & Patterson, R. L., May 1 2011, In : IET Systems Biology. 5, 3, p. 174-184 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Predicting protein folds with fold-specific pssm libraries

Hong, Y., Chintapalli, S. V., Ko, K. D., Bhardwaj, G., Zhang, Z., van Rossum, D. & Patterson, R. L., Jun 22 2011, In : PloS one. 6, 6, e20557.

Research output: Contribution to journalArticle

5 Scopus citations
2010

Adaptive GDDA-BLAST: Fast and efficient algorithm for protein sequence embedding

Hong, Y., Kang, J., Lee, D. & van Rossum, D. B., Nov 17 2010, In : PloS one. 5, 10, e13596.

Research output: Contribution to journalArticle

1 Scopus citations

Epac1 mediates protein kinase A-independent mechanism of forskolinactivated intestinal chloride secretion

Hoque, K. M., Woodward, O. M., Van Rossum, D. B., Zachos, N. C., Chen, L., Leung, G. P. H., Guggino, W. B., Guggino, S. E. & Tse, C. M., Jan 1 2010, In : Journal of General Physiology. 135, 1, p. 43-58 16 p.

Research output: Contribution to journalArticle

50 Scopus citations

TRPC channels in pheromone sensing

Kiselyov, K., van Rossum, D. B. & Patterson, R. L., Sep 15 2010, In : Vitamins and Hormones. 83, C, p. 197-213 17 p.

Research output: Contribution to journalArticle

15 Scopus citations
2009

Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition

Mustafa, A. K., Van Rossum, D. B., Patterson, R. L., Maag, D., Ehmsen, J. T., Gazi, S. K., Chakraborty, A., Barrow, R. K., Amzel, L. M. & Snyder, S. H., Feb 24 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 8, p. 2921-2926 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Phospholipase C-γ binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity

Zachos, N. C., van Rossum, D. B., Li, X., Caraveo, G., Sarker, R., Cha, B., Mohan, S., Desiderio, S., Patterson, R. L. & Donowitz, M., Jul 17 2009, In : Journal of Biological Chemistry. 284, 29, p. 19437-19444 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Phylogenetic profiles reveal structural/functional determinants of TRPC3 signal-sensing antennae

Ko, K. D., Bhardwaj, G., Hong, Y., Chang, G. S., Kiselyov, K., van Rossum, D. B. & Patterson, R. L., Mar 2009, In : Communicative and Integrative Biology. 2, 2, p. 133-137 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Phylogenetic profiles reveal structural and functional determinants of lipid-binding

Hong, Y., Chalkia, D., Ko, K. D., Bhardwaj, G., Chang, G. S., van Rossum, D. B. & Patterson, R. L., Mar 1 2009, In : Journal of Proteomics and Bioinformatics. 2, 3, p. 139-149 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

PKC and PLA2: Probing the complexities of the calcium network

van Rossum, D. B. & Patterson, R. L., Jun 2009, In : Cell Calcium. 45, 6, p. 535-545 11 p.

Research output: Contribution to journalReview article

28 Scopus citations

The classification of a protein from its primary sequence using functional and structural-specific PSSMs in quantitative measurement

Ko, K. D., Hong, Y. J., Van Rossum, D. B. & Patterson, R. L., Dec 1 2009, Proceedings - 2009 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2009. 1 p. 5332093

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2008

HSP90 regulates cell survival via inositol hexakisphosphate kinase-2

Chakraborty, A., Koldobskiy, M. A., Sixt, K. M., Juluri, K. R., Mustafa, A. K., Snowman, A. M., Van Rossum, D. B., Patterson, R. L. & Snyder, S. H., Jan 29 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 4, p. 1134-1139 6 p.

Research output: Contribution to journalArticle

75 Scopus citations

Phylogenetic profiles reveal evolutionary relationships within the "twilight zone" of sequence similarity

Gue, S. C., Hong, Y., Kyung, D. K., Bhardwaj, G., Holmes, E. C., Patterson, R. L. & Van Rossum, D. B., Sep 9 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 36, p. 13474-13479 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

TRP_2, a lipid/trafficking domain that mediates diacylglycerol-induced vesicle fusion

Van Rossum, D. B., Oberdick, D., Rbaibi, Y., Bhardwaj, G., Barrow, R. K., Nikolaidis, N., Snyder, S. H., Kiselyov, K. & Patterson, R. L., Dec 5 2008, In : Journal of Biological Chemistry. 283, 49, p. 34384-34392 9 p.

Research output: Contribution to journalArticle

24 Scopus citations
2007

Ancient origin of the new developmental superfamily DANGER

Nikolaidis, N., Chalkia, D., Watkins, D. N., Barrow, R. K., Snyder, S. H., van Rossum, D. B. & Patterson, R. L., Feb 14 2007, In : PloS one. 2, 2, e204.

Research output: Contribution to journalArticle

14 Scopus citations

TRPC channels: Integrators of multiple cellular signals

Soboloff, J., Spassova, M., Hewavitharana, T., He, L. P., Luncsford, P., Xu, W., Venkatachalam, K., Van Rossum, D., Patterson, R. L. & Gill, D. L., Dec 1 2007, Transient Receptor Potential (TRP) Channels. Flockerzi, V. & Nilius, B. (eds.). p. 575-591 17 p. (Handbook of Experimental Pharmacology; vol. 179).

Research output: Chapter in Book/Report/Conference proceedingChapter

37 Scopus citations
2006

Action of TFII-I outside the nucleus as an inhibitor of agonist-induced calcium entry

Caraveo, G., Van Rossum, D. B., Patterson, R. L., Snyder, S. H. & Desiderio, S., Oct 6 2006, In : Science. 314, 5796, p. 122-125 4 p.

Research output: Contribution to journalArticle

64 Scopus citations

DANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate-receptor activity

Van Rossum, D. B., Patterson, R. L., Cheung, K. H., Barrow, R. K., Syrovatkina, V., Gessell, G. S., Burkholder, S. G., Watkins, D. N., Foskett, J. K. & Snyder, S. H., Dec 1 2006, In : Journal of Biological Chemistry. 281, 48, p. 37111-37116 6 p.

Research output: Contribution to journalArticle

30 Scopus citations
2005
101 Scopus citations

Association of small ankyrin 1 with the sarcoplasmic reticulum

Porter, N. C., Resneck, W. G., O'Neill, A., Van Rossum, D. B., Stone, M. R. & Bloch, R. J., Sep 1 2005, In : Molecular Membrane Biology. 22, 5, p. 421-432 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Inositol 1,4,5-trisphosphate receptor/GAPDH complex augments Ca 2+ release via locally derived NADH

Patterson, R. L., Van Rossum, D. B., Kaplin, A. I., Barrow, R. K. & Snyder, S. H., Feb 1 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 5, p. 1357-1359 3 p.

Research output: Contribution to journalArticle

65 Scopus citations

Phospholipase C-γ: Diverse roles in receptor-mediated calcium signaling

Patterson, R. L., Van Rossum, D. B., Nikolaidis, N., Gill, D. & Snyder, S. H., Dec 1 2005, In : Trends in Biochemical Sciences. 30, 12, p. 688-697 10 p.

Research output: Contribution to journalReview article

86 Scopus citations

Phospholipase Cγ1 controls surface expression of TRPC3 through an intermolecular PH domain

Van Rossum, D. B., Patterson, R. L., Sharma, S., Barrow, R. K., Kornberg, M., Gill, D. L. & Snyder, S. H., Mar 3 2005, In : Nature. 434, 7029, p. 99-104 6 p.

Research output: Contribution to journalArticle

159 Scopus citations
2004

Agonist-induced Ca2+ entry determined by inositol 1,4,5-trisphosphate recognition

Van Rossum, D. B., Patterson, R. L., Kiselyov, K., Boehning, D., Barrow, R. K., Gill, D. L. & Snyder, S. H., Feb 22 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 8, p. 2323-2327 5 p.

Research output: Contribution to journalArticle

54 Scopus citations

Calcium entry mediated by SOCs and TRP channels: Variations and enigma

Spassova, M. A., Soboloff, J., He, L. P., Hewavitharana, T., Xu, W., Venkatachalam, K., Van Rossum, D. B., Patterson, R. L. & Gill, D. L., Dec 6 2004, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1742, 1-3, p. 9-20 12 p.

Research output: Contribution to journalArticle

91 Scopus citations

RACK1 binds to inositol 1,4,5-trisphosphate receptors and mediates Ca 2+ release

Patterson, R. L., Van Rossum, D. B., Barrow, R. K. & Snyder, S. H., Feb 22 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 8, p. 2328-2332 5 p.

Research output: Contribution to journalArticle

78 Scopus citations
2003

Obscurin is a ligand for small ankyrin 1 in skeletal muscle

Kontrogianni-Konstantopoulos, A., Jones, E. M., Van Rossum, D. B. & Bloch, R. J., Mar 1 2003, In : Molecular biology of the cell. 14, 3, p. 1138-1148 11 p.

Research output: Contribution to journalArticle

139 Scopus citations
2002

Phospholipase C-γ is required for agonist-induced Ca2+ entry

Patterson, R. L., Van Rossum, D. B., Ford, D. L., Hurt, K. J., Bae, S. S., Suh, P. G., Kurosaki, T., Snyder, S. H. & Gill, D. L., Nov 15 2002, In : Cell. 111, 4, p. 529-541 13 p.

Research output: Contribution to journalArticle

162 Scopus citations