• 520 Citations
  • 10 h-Index
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Personal profile

Research interests

The laboratory of Dr. Daniel Morgan focuses on understanding the mechanisms responsible for the different roles of cannabinoid signaling in human health and disease. One of the lab's main areas of interest is to better understand the mechanisms responsible for tolerance to cannabinoids such as delta-9-tetrahydrocannabinol (∆9-THC) in pathological models of pain including agonist-specific differences in the mechanisms responsible for cannabinoid tolerance. Previous studies have shown that receptor desensitization is involved in the development of tolerance for GPCR-directed agonists in vivo. The laboratory’s work utilizes a novel “knock-in” mouse line that expresses a desensitization-resistant form of the cannabinoid receptor 1 (CB1) to investigate tolerance for ∆9-THC and two synthetic cannabinoid agonists, WIN 55,212-2 and CP55,950. Results from the lab show that tolerance to WIN 55,212-2 is mediated exclusively through this classical mechanism of desensitization, whereas tolerance to ∆9-THC is only partially attenuated when this mechanism is disrupted. Interestingly, data strongly suggests that tolerance to ∆9-THC, but not the other two synthetic agonists, is partially mediated through a c-Jun N-terminal kinase (JNK) signaling pathway. The laboratory is currently engaged in work to better understand the molecular mechanisms responsible for this novel form of JNK-mediated ∆9-THC tolerance. The laboratory is also engaged in a second major project to understand the role of CB1 internalization and trafficking in cannabinoid tolerance and dependence. This project involves using a second “knock-in” mouse that expresses an internalization-deficient form of CB1 to study tolerance and physical dependence for ∆9-THC, WIN 55,212-2 and CP55,950.

Education/Academic qualification

Postdoctoral Training, Indiana Unviersity


Senior Fellow, University of Washington School of Medicine


PhD, Rutgers University


BA, Grinnell College


External positions

Session Chair and Program Committee, International Cannabinoid Research Society


Program Committee, Winter Conference on Brain Research


Neuropharmacology Executive Committee, American Society for Pharmacology and Experimental Therapeutics


Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Cannabinoid Receptors Medicine & Life Sciences
Dronabinol Medicine & Life Sciences
Morphine Medicine & Life Sciences
Endocannabinoids Medicine & Life Sciences
Cannabinoids Medicine & Life Sciences
mu Opioid Receptor Medicine & Life Sciences
Proprotein Convertase 1 Medicine & Life Sciences
JNK Mitogen-Activated Protein Kinases Medicine & Life Sciences

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Projects 2013 2023

Mechanisms of cannabinoid tolerance

Morgan, D. & Guindon, J.

National Institutes of Health


Project: Research project

JNK Mitogen-Activated Protein Kinases
Cannabinoid Receptor Agonists
Cannabinoid Receptors
Microarray Analysis

Research Output 1999 2019

  • 520 Citations
  • 10 h-Index
  • 22 Article
  • 1 Editorial
  • 1 Short survey

Tolerance to WIN55,212-2 is delayed in desensitization-resistant S426A/S430A mice

Nealon, C. M., Henderson-Redmond, A. N., Hale, D. E. & Morgan, D., Apr 1 2019, In : Neuropharmacology. 148, p. 151-159 9 p.

Research output: Contribution to journalArticle

Cannabinoid Receptors
Cannabinoid Receptor Agonists
G-Protein-Coupled Receptor Kinase 1
3 Citations (Scopus)

Alterations in nociception and morphine antinociception in mice fed a high-fat diet

Nealon, C. M., Patel, C., Worley, B. L., Henderson-Redmond, A. N., Morgan, D. & Czyzyk, T. A., Apr 1 2018, In : Brain Research Bulletin. 138, p. 64-72 9 p.

Research output: Contribution to journalArticle

High Fat Diet
Induced Hypothermia
1 Citation (Scopus)

Increased ethanol drinking in “humanized” mice expressing the mu opioid receptor A118G polymorphism are mediated through sex-specific mechanisms

Henderson-Redmond, A. N., Lowe, T. E., Tian, X. B. & Morgan, D., Apr 1 2018, In : Brain Research Bulletin. 138, p. 12-19 8 p.

Research output: Contribution to journalArticle

mu Opioid Receptor
Hypnotics and Sedatives
Righting Reflex
2 Citations (Scopus)

Sex differences in antinociceptive response to Δ-9-tetrahydrocannabinol and CP 55,940 in the mouse formalin test

Lafleur, R. A., Wilson, R., Morgan, D. & Henderson-Redmond, A. N., Jan 1 2018, In : NeuroReport. 29, 6, p. 447-452 6 p.

Research output: Contribution to journalArticle

Pain Measurement
Sex Characteristics
Cannabinoid Receptors
3 Citations (Scopus)

A GPR119 signaling system in the murine eye regulates intraocular pressure in a sex-dependent manner

Miller, S., Hu, S. S. J., Leishman, E., Morgan, D., Wager-Miller, J., Mackie, K., Bradshaw, H. B. & Straiker, A., Jun 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 7, p. 2930-2938 9 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Trabecular Meshwork
Messenger RNA