• 495 Citations
  • 10 h-Index
19992023
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Personal profile

Research interests

The laboratory of Dr. Daniel Morgan focuses on understanding the mechanisms responsible for the different roles of cannabinoid signaling in human health and disease. One of the lab's main areas of interest is to better understand the mechanisms responsible for tolerance to cannabinoids such as delta-9-tetrahydrocannabinol (∆9-THC) in pathological models of pain including agonist-specific differences in the mechanisms responsible for cannabinoid tolerance. Previous studies have shown that receptor desensitization is involved in the development of tolerance for GPCR-directed agonists in vivo. The laboratory’s work utilizes a novel “knock-in” mouse line that expresses a desensitization-resistant form of the cannabinoid receptor 1 (CB1) to investigate tolerance for ∆9-THC and two synthetic cannabinoid agonists, WIN 55,212-2 and CP55,950. Results from the lab show that tolerance to WIN 55,212-2 is mediated exclusively through this classical mechanism of desensitization, whereas tolerance to ∆9-THC is only partially attenuated when this mechanism is disrupted. Interestingly, data strongly suggests that tolerance to ∆9-THC, but not the other two synthetic agonists, is partially mediated through a c-Jun N-terminal kinase (JNK) signaling pathway. The laboratory is currently engaged in work to better understand the molecular mechanisms responsible for this novel form of JNK-mediated ∆9-THC tolerance. The laboratory is also engaged in a second major project to understand the role of CB1 internalization and trafficking in cannabinoid tolerance and dependence. This project involves using a second “knock-in” mouse that expresses an internalization-deficient form of CB1 to study tolerance and physical dependence for ∆9-THC, WIN 55,212-2 and CP55,950.

Education/Academic qualification

Postdoctoral Training, Indiana Unviersity

20072010

Senior Fellow, University of Washington School of Medicine

20042007

PhD, Rutgers University

19972004

BA, Grinnell College

19931997

External positions

Session Chair and Program Committee, International Cannabinoid Research Society

2018

Program Committee, Winter Conference on Brain Research

20172019

Neuropharmacology Executive Committee, American Society for Pharmacology and Experimental Therapeutics

20162019

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Projects 2013 2023

Mechanisms of cannabinoid tolerance

Morgan, D. & Guindon, J.

National Institutes of Health

9/1/187/31/23

Project: Research projectResearch Project

Dronabinol
Cannabinoids
JNK Mitogen-Activated Protein Kinases
Neuralgia
Cannabinoid Receptor Agonists

Desensitization and downregulation of CB1 during cannabinoid tolerance

Morgan, D.

National Institutes of Health

2/1/151/31/18

Project: Research projectResearch Scientist Development Award - Research & Training

Cannabinoid Receptors
Dronabinol
Cannabinoids
rimonabant
Down-Regulation

Characterization of a novel JNK-mediated mechanism of cannabinoid tolerance

Morgan, D.

National Institutes of Health

7/15/136/30/16

Project: Research projectExploratory/Developmental Grants

Dronabinol
Cannabinoids
Phosphotransferases
Analgesics
Microarray Analysis

Research Output 1999 2018

  • 495 Citations
  • 10 h-Index
  • 21 Article
  • 1 Editorial
  • 1 Short survey
2 Citations

Alterations in nociception and morphine antinociception in mice fed a high-fat diet

Nealon, C. M., Patel, C., Worley, B. L., Henderson-Redmond, A. N., Morgan, D. & Czyzyk, T. A., Apr 1 2018, In : Brain Research Bulletin. 138, p. 64-72 9 p.

Research output: Contribution to journalArticle

Nociception
High Fat Diet
Morphine
Tail
Induced Hypothermia
1 Citations

Increased ethanol drinking in “humanized” mice expressing the mu opioid receptor A118G polymorphism are mediated through sex-specific mechanisms

Henderson-Redmond, A. N., Lowe, T. E., Tian, X. B. & Morgan, D., Apr 1 2018, In : Brain Research Bulletin. 138, p. 12-19 8 p.

Research output: Contribution to journalArticle

mu Opioid Receptor
Drinking
Ethanol
Hypnotics and Sedatives
Righting Reflex

Sex differences in antinociceptive response to Δ-9-tetrahydrocannabinol and CP 55,940 in the mouse formalin test

Lafleur, R. A., Wilson, R. P., Morgan, D. J. & Henderson-Redmond, A. N., Jan 1 2018, In : NeuroReport. 29, 6, p. 447-452 6 p.

Research output: Contribution to journalArticle

Dronabinol
Pain Measurement
Sex Characteristics
Cannabinoids
Cannabinoid Receptors
1 Citations

A GPR119 signaling system in the murine eye regulates intraocular pressure in a sex-dependent manner

Miller, S., Hu, S. S. J., Leishman, E., Morgan, D., Wager-Miller, J., Mackie, K., Bradshaw, H. B. & Straiker, A., Jun 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 7, p. 2930-2938 9 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Lipids
Trabecular Meshwork
Endocannabinoids
Messenger RNA
1 Citations

Anti-nociceptive interactions between opioids and a cannabinoid receptor 2 agonist in inflammatory pain

Yuill, M. B., Hale, D. E., Guindon, J. & Morgan, D., Sep 1 2017, In : Molecular Pain. 13

Research output: Contribution to journalArticle

Cannabinoid Receptor Agonists
Cannabinoid Receptors
Opioid Analgesics
Morphine
Pain