If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

Dr. David Claxton has longstanding interests in leukemia biology and therapeutics. Leukemia molecular genetics and diagnostics are ongoing interests. Acute myeloid leukemia and related disorders are his principal foci. Leukemia therapeutics are particular interests, including drug development and clinical studies, blood and marrow transplantation, and clinical supportive care. He has a laboratory which has banked many samples of human leukemias and lymphomas. These are viably cryopreserved, used in studies and available to collaborators.

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 10 Similar Profiles
Acute Myeloid Leukemia Medicine & Life Sciences
Leukemia Medicine & Life Sciences
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Medicine & Life Sciences
Bone Marrow Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Hematologic Neoplasms Medicine & Life Sciences
Stem Cells Medicine & Life Sciences
Neoplasms Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 1989 2018

Targeted Sphingolipid Metabolism for Treatment of AML

Claxton, D., Wang, H., Wang, H., Amin, S., Liao, J. (., Fox, T., Loughran, T. P., Loughran, T. P., Kester, M., Kester, M. & Cabot, M. C.

National Institutes of Health

9/10/138/31/18

Project: Research projectResearch Program Projects

Acute Myeloid Leukemia
Acid Ceramidase
Sphingolipids
Ceramides
Tamoxifen

THERAPY OF AML

Claxton, D., Deisseroth, A., Siciliano, M., Benedict, W., Reading, C., Liang, J., Plunkett, W., Thall, P., Thomas, M., Reed, J., Andreeff, M., Berry, D., Kornblau, S., Croce, C., Estey, E., Champlin, R. E., Nagarajan, L. & Deisseroth, A.

National Institutes of Health

6/1/928/31/15

Project: Research projectResearch Program Projects

Core Binding Factors
Genes
Transcription Factors
Leukemia
Genetically Modified Animals

THERAPY OF CML

Claxton, D., Kurzrock, R., Ming-Sheng, L., Reading, C., Emerson, S., Liang, J., Feinberg, A., Deisseroth, A., Siciliano, M., Kantarjian, H., Talpaz, M., Andreeff, M., Kornblau, S., Thall, P., Issa, J., Estrov, Z., Arlinghaus, R. B., Deininger, M., Cortes, J., Shpall, E., Champlin, R., Belmont, J., Reisner, Y., Austin, D. & Issa, K.

National Institutes of Health

12/1/896/30/16

Project: Research projectResearch Program Projects

Dendritic Cells
Immunity
Lymphocytes
Cytogenetics
Therapeutics

Research Output 1989 2018

A phase II study of vascular endothelial growth factor trap (Aflibercept, NSC 724770) in patients with myelodysplastic syndrome: a California Cancer Consortium Study

Kirschbaum, M. H., Frankel, P., Synold, T. W., Zain, J., Claxton, D., Tuscano, J., Newman, E. M., Gandara, D. R. & Lara, P. N., Feb 1 2018, In : British Journal of Haematology. 180, 3, p. 445-448 4 p.

Research output: Contribution to journalLetter

Recombinant Fusion Proteins
Vascular Endothelial Growth Factor Receptor
Myelodysplastic Syndromes
Vascular Endothelial Growth Factor A
Clinical Trials
Leukemia
Bone Marrow
T-Lymphocytes
1 Citations

Characteristics of early acute respiratory distress syndrome in newly diagnosed acute myeloid leukemia

Van de Louw, A., Desai, R. J., Zhu, J. & Claxton, D. F., Feb 13 2018, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-8 8 p.

Research output: Contribution to journalArticle

Adult Respiratory Distress Syndrome
Acute Myeloid Leukemia
Multivariate Analysis
Mortality
Leukocyte Count
1 Citations
Busulfan
Whole-Body Irradiation
Acute Myeloid Leukemia
Cyclophosphamide
Stem Cells
1 Citations

Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies

Prabhu, V. V., Talekar, M. K., Lulla, A. R., Kline, C. L. B., Zhou, L., Hall, J., Van den Heuvel, A. P. J., Dicker, D. T., Babar, J., Grupp, S. A., Garnett, M. J., McDermott, U., Benes, C. H., Pu, J. J., Claxton, D. F., Khan, N., Oster, W., Allen, J. E. & El-Deiry, W. S., Feb 16 2018, In : Cell Cycle. 17, 4, p. 468-478 11 p.

Research output: Contribution to journalArticle

Hematologic Neoplasms
Multiple Myeloma
Lymphoma
Leukemia
Burkitt Lymphoma