Research output per year
Research output per year
Personal profile
Research interests
Dr. David Claxton has longstanding interests in leukemia biology and therapeutics. Leukemia molecular genetics and diagnostics are ongoing interests. Acute myeloid leukemia and related disorders are his principal foci. Leukemia therapeutics are particular interests, including drug development and clinical studies, blood and marrow transplantation, and clinical supportive care. He has a laboratory which has banked many samples of human leukemias and lymphomas. These are viably cryopreserved, used in studies and available to collaborators.
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A novel clinically relevant graft-versus-leukemia model in humanized mice
Jia, B., Zhao, C., Bayerl, M., Shike, H., Claxton, D. F., Ehmann, W. C., Mineishi, S., Schell, T. D., Zheng, P., Zhang, Y., Shultz, L. D., Prabhu, K. S., Paulson, R. F. & Zheng, H., 2021, (Accepted/In press) In: Journal of Leukocyte Biology.Research output: Contribution to journal › Article › peer-review
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A phase I clinical trial of avelumab in combination with decitabine as first line treatment of unfit patients with acute myeloid leukemia
Zheng, H., Mineishi, S., Claxton, D., Zhu, J., Zhao, C., Jia, B., Ehmann, W. C., Rybka, W. B., Naik, S., Songdej, N., Drabick, J. J. & Hohl, R. J., Feb 1 2021, In: American Journal of Hematology. 96, 2, p. E46-E50Research output: Contribution to journal › Letter › peer-review
Open Access1 Scopus citations -
Comparison of CALGB 10403 (Alliance) and COG AALL0232 toxicity results in young adults with acute lymphoblastic leukemia
Advani, A. S., Larsen, E., Laumann, K., Luger, S. M., Liedtke, M., Devidas, M., Chen, Z., Yin, J., Foster, M. C., Claxton, D., Coffan, K., Tallman, M. S., Appelbaum, F. R., Erba, H., Stone, R. M., Hunger, S. P., McNeer, J. L., Loh, M. L., Raetz, E., Winick, N. & 3 others, , Jan 26 2021, In: Blood Advances. 5, 2, p. 504-512 9 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Dj4 targets the rho-associated protein kinase pathway and attenuates disease progression in preclinical murine models of acute myeloid leukemia
Golla, U., Ehudin, M. A., Annageldiyev, C., Zeng, Z., Bastihalli Tukaramrao, D., Tarren, A., Date, A. A., Elcheva, I., Berg, A., Amin, S., Loughran, T. P., Kester, M., Desai, D., Dovat, S., Claxton, D. & Sharma, A., Oct 1 2021, In: Cancers. 13, 19, 4889.Research output: Contribution to journal › Article › peer-review
Open Access -
HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia
Zhu, G., Luo, H., Feng, Y., Guryanova, O. A., Xu, J., Chen, S., Lai, Q., Sharma, A., Xu, B., Zhao, Z., Feng, R., Ni, H., Claxton, D., Guo, Y., Mesa, R. A., Qiu, Y., Yang, F. C., Li, W., Nimer, S. D., Huang, S. & 1 others, , Dec 2021, In: Nature communications. 12, 1, 1956.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations
Prizes
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Outstanding Collaborative Research Team
Adair, James Hansell (Recipient), Amin, Shantu (Recipient), Claxton, David (Recipient), Desai, Dhimant (Recipient), Hengst, Jeremy (Recipient), Liao, Jiangang "Jason" (Recipient), Paulson, Robert (Recipient), Sharma, Arun (Recipient), Stanley, Bruce (Recipient), Wang, Hong-Gang (Recipient), Yun, Jong (Recipient) & Zhu, Junjia (Recipient), 2015
Prize