Projects per year
Personal profile
Research interests
Dr. David Claxton has longstanding interests in leukemia biology and therapeutics. Leukemia molecular genetics and diagnostics are ongoing interests. Acute myeloid leukemia and related disorders are his principal foci. Leukemia therapeutics are particular interests, including drug development and clinical studies, blood and marrow transplantation, and clinical supportive care. He has a laboratory which has banked many samples of human leukemias and lymphomas. These are viably cryopreserved, used in studies and available to collaborators.
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Acute Myeloid Leukemia
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Bone Marrow
Medicine & Life Sciences
Therapeutics
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Hematologic Neoplasms
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Neoplasms
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Stem Cells
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 1989 2018
- 3 Finished
Targeted Sphingolipid Metabolism for Treatment of AML
Claxton, D., Wang, H., Wang, H., Amin, S., Liao, J. (., Fox, T., Loughran, T. P., Loughran, T. P., Kester, M., Kester, M. & Cabot, M. C.
9/10/13 → 8/31/18
Project: Research project
Acute Myeloid Leukemia
Acid Ceramidase
Sphingolipids
Ceramides
Tamoxifen
THERAPY OF AML
Claxton, D., Deisseroth, A., Siciliano, M., Benedict, W., Reading, C., Liang, J., Plunkett, W., Thall, P., Thomas, M., Reed, J., Andreeff, M., Berry, D., Kornblau, S., Croce, C., Estey, E., Nagarajan, L., Deisseroth, A. & Champlin, R. E.
6/1/92 → 8/31/15
Project: Research project
Core Binding Factors
Genes
Transcription Factors
Leukemia
Genetically Modified Animals
THERAPY OF CML
Claxton, D., Kurzrock, R., Ming-Sheng, L., Reading, C., Emerson, S., Liang, J., Feinberg, A., Deisseroth, A., Siciliano, M., Kantarjian, H., Talpaz, M., Andreeff, M., Kornblau, S., Thall, P., Issa, J., Estrov, Z., Arlinghaus, R. B., Deininger, M., Cortes, J., Shpall, E., Champlin, R., Belmont, J., Reisner, Y., Austin, D. & Issa, K.
12/1/89 → 6/30/16
Project: Research project
Dendritic Cells
Immunity
Lymphocytes
Cytogenetics
Therapeutics
Research Output 1989 2018
A phase II study of vascular endothelial growth factor trap (Aflibercept, NSC 724770) in patients with myelodysplastic syndrome: a California Cancer Consortium Study
Kirschbaum, M. H., Frankel, P., Synold, T. W., Zain, J., Claxton, D., Tuscano, J., Newman, E. M., Gandara, D. R. & Lara, P. N., Feb 1 2018, In : British Journal of Haematology. 180, 3, p. 445-448 4 p.Research output: Contribution to journal › Letter
Recombinant Fusion Proteins
Vascular Endothelial Growth Factor Receptor
Myelodysplastic Syndromes
Vascular Endothelial Growth Factor A
Clinical Trials
1
Citations
(Scopus)
Bone marrow CD8 T cells express high frequency of PD-1 and exhibit reduced anti-leukemia response in newly diagnosed AML patients
Jia, B., Wang, L., Claxton, D., Ehmann, W. C., Rybka, W., Mineishi, S., Rizvi, S., Shike, H., Bayerl, M., Schell, T., Hohl, R. & Zheng, H., Mar 1 2018, In : Blood Cancer Journal. 8, 3, 34.Research output: Contribution to journal › Letter
Leukemia
Bone Marrow
T-Lymphocytes
1
Citations
(Scopus)
Characteristics of early acute respiratory distress syndrome in newly diagnosed acute myeloid leukemia
Van De Louw, A., Desai, R. J., Zhu, J. & Claxton, D., Oct 3 2018, In : Leukemia and Lymphoma. 59, 10, p. 2369-2376 8 p.Research output: Contribution to journal › Article
Adult Respiratory Distress Syndrome
Acute Myeloid Leukemia
Multivariate Analysis
Mortality
Leukocyte Count
1
Citations
(Scopus)
Clofarabine followed by haploidentical stem cell transplant using fludarabine, busulfan, and total-body irradiation with post-transplant cyclophosphamide in non-remission AML
Rakszawski, K., Miki, K., Claxton, D., Wagner, H., Shike, H., Mineishi, S. & Naik, S., Sep 1 2018, In : International Journal of Hematology. 108, 3, p. 348-350 3 p.Research output: Contribution to journal › Article
Busulfan
Whole-Body Irradiation
Acute Myeloid Leukemia
Cyclophosphamide
Stem Cells
Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity
Kokolus, K. M., Haley, J. S., Koubek, E. J., Gowda, R., Dinavahi, S. S., Sharma, A., Claxton, D., Helm, K., Drabick, J., Robertson, G., Neighbors, J., Hohl, R. & Schell, T., Jan 1 2018, (Accepted/In press) In : OncoImmunology.Research output: Contribution to journal › Article
Biological Products
Immunity
Melanoma
Immunotherapy
Neoplasms