Projects per year
Personal profile
Research interests
Dr. David Claxton has longstanding interests in leukemia biology and therapeutics. Leukemia molecular genetics and diagnostics are ongoing interests. Acute myeloid leukemia and related disorders are his principal foci. Leukemia therapeutics are particular interests, including drug development and clinical studies, blood and marrow transplantation, and clinical supportive care. He has a laboratory which has banked many samples of human leukemias and lymphomas. These are viably cryopreserved, used in studies and available to collaborators.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Tissue Repository and Animal Models Core
Claxton, D. & Claxton, D. D. F.
5/1/20 → 5/31/23
Project: Research project
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Animal Modeling and Clinical Resources Core
Claxton, D. & Kester, M.
9/10/13 → 8/31/18
Project: Research project
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CORE BINDING FACTOR IN LEUKEMOGENESIS--INV(16) AND T(8;21)
10/1/95 → 9/30/01
Project: Research project
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THE THERAPY OF AML
Andreeff, M. W., Benedict, W. F., Berry, D. A., Champlin, R. E., Claxton, D., Croce, C. M., Deisseroth, A. B., Estey, E., Kornblau, S. M., Kornblau, S., Liang, J. C., Nagarajan, L., Plunkett, W. K., Reading, C., Reed, J. C., Siciliano, M. J., Thall, P. F., Thomas, M. J., Andreeff, M. W. & Andreeff, M.
6/1/92 → 8/31/15
Project: Research project
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Acute Myeloid Leukemia Stem Cells: Origin, Characteristics, and Clinical Implications
Long, N. A., Golla, U., Sharma, A. & Claxton, D. F., Apr 2022, In: Stem Cell Reviews and Reports. 18, 4, p. 1211-1226 16 p.Research output: Contribution to journal › Review article › peer-review
3 Scopus citations -
Alterations in sphingolipid composition and mitochondrial bioenergetics represent synergistic therapeutic vulnerabilities linked to multidrug resistance in leukemia
Fisher-Wellman, K. H., Hagen, J. T., Kassai, M., Kao, L. P., Nelson, M. A. M., McLaughlin, K. L., Coalson, H. S., Fox, T. E., Tan, S. F., Feith, D. J., Kester, M., Loughran, T. P., Claxton, D. F. & Cabot, M. C., Jan 2022, In: FASEB Journal. 36, 1, e22094.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
A novel clinically relevant graft-versus-leukemia model in humanized mice
Jia, B., Zhao, C., Bayerl, M., Shike, H., Claxton, D. F., Ehmann, W. C., Mineishi, S., Schell, T. D., Zheng, P., Zhang, Y., Shultz, L. D., Prabhu, K. S., Paulson, R. F. & Zheng, H., Feb 2022, In: Journal of Leukocyte Biology. 111, 2, p. 427-437 11 p.Research output: Contribution to journal › Article › peer-review
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Beware clonal haematopoiesis following chronic lymphocytic leukaemia treatment
Claxton, D. F., Jul 2022, In: British Journal of Haematology. 198, 1, p. 9-10 2 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Ceramide nanoliposomes augment the efficacy of venetoclax and cytarabine in models of acute myeloid leukemia
Khokhlatchev, A. V., Sharma, A., Deering, T. G., Shaw, J. J. P., Costa-Pinheiro, P., Golla, U., Annageldiyev, C., Cabot, M. C., Conaway, M. R., Tan, S. F., Ung, J., Feith, D. J., Loughran, T. P., Claxton, D. F., Fox, T. E. & Kester, M., Oct 2022, In: FASEB Journal. 36, 10, e22514.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Prizes
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Outstanding Collaborative Research Team
Adair, James Hansell (Recipient), Amin, Shantu (Recipient), Claxton, David (Recipient), Desai, Dhimant (Recipient), Hengst, Jeremy (Recipient), Liao, Jiangang "Jason" (Recipient), Paulson, Robert (Recipient), Sharma, Arun (Recipient), Stanley, Bruce (Recipient), Wang, Hong-Gang (Recipient), Yun, Jong (Recipient) & Zhu, Junjia (Recipient), 2015
Prize