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Personal profile

Research interests

Dr. David Claxton has longstanding interests in leukemia biology and therapeutics. Leukemia molecular genetics and diagnostics are ongoing interests. Acute myeloid leukemia and related disorders are his principal foci. Leukemia therapeutics are particular interests, including drug development and clinical studies, blood and marrow transplantation, and clinical supportive care. He has a laboratory which has banked many samples of human leukemias and lymphomas. These are viably cryopreserved, used in studies and available to collaborators.

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Projects 1989 2018

Targeted Sphingolipid Metabolism for Treatment of AML

Claxton, D., Wang, H., Wang, H., Amin, S., Liao, J. (., Fox, T., Loughran, T. P., Loughran, T. P., Kester, M., Kester, M. & Cabot, M. C.

National Institutes of Health


Project: Research project

Acute Myeloid Leukemia
Acid Ceramidase


Claxton, D., Deisseroth, A., Siciliano, M., Benedict, W., Reading, C., Liang, J., Plunkett, W., Thall, P., Thomas, M., Reed, J., Andreeff, M., Berry, D., Kornblau, S., Croce, C., Estey, E., Nagarajan, L., Deisseroth, A. & Champlin, R. E.

National Institutes of Health


Project: Research project

Core Binding Factors
Transcription Factors
Genetically Modified Animals


Claxton, D., Kurzrock, R., Ming-Sheng, L., Reading, C., Emerson, S., Liang, J., Feinberg, A., Deisseroth, A., Siciliano, M., Kantarjian, H., Talpaz, M., Andreeff, M., Kornblau, S., Thall, P., Issa, J., Estrov, Z., Arlinghaus, R. B., Deininger, M., Cortes, J., Shpall, E., Champlin, R., Belmont, J., Reisner, Y., Austin, D. & Issa, K.

National Institutes of Health


Project: Research project

Dendritic Cells

Research Output 1989 2018

A phase II study of vascular endothelial growth factor trap (Aflibercept, NSC 724770) in patients with myelodysplastic syndrome: a California Cancer Consortium Study

Kirschbaum, M. H., Frankel, P., Synold, T. W., Zain, J., Claxton, D., Tuscano, J., Newman, E. M., Gandara, D. R. & Lara, P. N., Feb 1 2018, In : British Journal of Haematology. 180, 3, p. 445-448 4 p.

Research output: Contribution to journalLetter

Recombinant Fusion Proteins
Vascular Endothelial Growth Factor Receptor
Myelodysplastic Syndromes
Vascular Endothelial Growth Factor A
Clinical Trials
1 Citations (Scopus)
Bone Marrow
1 Citations (Scopus)

Characteristics of early acute respiratory distress syndrome in newly diagnosed acute myeloid leukemia

Van De Louw, A., Desai, R. J., Zhu, J. & Claxton, D., Oct 3 2018, In : Leukemia and Lymphoma. 59, 10, p. 2369-2376 8 p.

Research output: Contribution to journalArticle

Adult Respiratory Distress Syndrome
Acute Myeloid Leukemia
Multivariate Analysis
Leukocyte Count
1 Citations (Scopus)
Whole-Body Irradiation
Acute Myeloid Leukemia
Stem Cells

Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity

Kokolus, K. M., Haley, J. S., Koubek, E. J., Gowda, R., Dinavahi, S. S., Sharma, A., Claxton, D., Helm, K., Drabick, J., Robertson, G., Neighbors, J., Hohl, R. & Schell, T., Jan 1 2018, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

Biological Products