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David Claxton, MD

 https://orcid.org/0000-0001-9209-2405
    • 7799 Citations
    • 37 h-Index
    1989 …2018
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    Research interests

    Dr. David Claxton has longstanding interests in leukemia biology and therapeutics. Leukemia molecular genetics and diagnostics are ongoing interests. Acute myeloid leukemia and related disorders are his principal foci. Leukemia therapeutics are particular interests, including drug development and clinical studies, blood and marrow transplantation, and clinical supportive care. He has a laboratory which has banked many samples of human leukemias and lymphomas. These are viably cryopreserved, used in studies and available to collaborators.

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    Projects 1989 2018

    Targeted Sphingolipid Metabolism for Treatment of AML

    Claxton, D., Wang, H., Wang, H., Amin, S., Liao, J. (., Fox, T., Loughran, T. P., Loughran, T. P., Kester, M., Kester, M. & Cabot, M. C.

    National Institutes of Health

    9/10/13 → 8/31/18

    Project: Research project › Research Program Projects

    Acute Myeloid Leukemia
    Acid Ceramidase
    Sphingolipids
    Ceramides
    Tamoxifen

    THERAPY OF AML

    Claxton, D., Deisseroth, A., Siciliano, M., Benedict, W., Reading, C., Liang, J., Plunkett, W., Thall, P., Thomas, M., Reed, J., Andreeff, M., Berry, D., Kornblau, S., Croce, C., Estey, E., Champlin, R. E., Nagarajan, L. & Deisseroth, A.

    National Institutes of Health

    6/1/92 → 8/31/15

    Project: Research project › Research Program Projects

    Core Binding Factors
    Genes
    Transcription Factors
    Leukemia
    Genetically Modified Animals

    THERAPY OF CML

    Claxton, D., Kurzrock, R., Ming-Sheng, L., Reading, C., Emerson, S., Liang, J., Feinberg, A., Deisseroth, A., Siciliano, M., Kantarjian, H., Talpaz, M., Andreeff, M., Kornblau, S., Thall, P., Issa, J., Estrov, Z., Arlinghaus, R. B., Deininger, M., Cortes, J., Shpall, E., Champlin, R., Belmont, J., Reisner, Y., Austin, D. & Issa, K.

    National Institutes of Health

    12/1/89 → 6/30/16

    Project: Research project › Research Program Projects

    Dendritic Cells
    Immunity
    Lymphocytes
    Cytogenetics
    Therapeutics

    Research Output 1989 2018

    A phase II study of vascular endothelial growth factor trap (Aflibercept, NSC 724770) in patients with myelodysplastic syndrome: a California Cancer Consortium Study

    Kirschbaum, M. H., Frankel, P., Synold, T. W., Zain, J., Claxton, D., Tuscano, J., Newman, E. M., Gandara, D. R. & Lara, P. N., Feb 1 2018, In : British Journal of Haematology. 180, 3, p. 445-448 4 p.

    Research output: Contribution to journal › Letter

    Recombinant Fusion Proteins
    Vascular Endothelial Growth Factor Receptor
    Myelodysplastic Syndromes
    Vascular Endothelial Growth Factor A
    Clinical Trials

    Bone marrow CD8 T cells express high frequency of PD-1 and exhibit reduced anti-leukemia response in newly diagnosed AML patients

    Jia, B., Wang, L., Claxton, D. F., Ehmann, W. C., Rybka, W. B., Mineishi, S., Rizvi, S., Shike, H., Bayerl, M., Schell, T. D., Hohl, R. J. & Zheng, H., Mar 1 2018, In : Blood Cancer Journal. 8, 3, 34

    Research output: Contribution to journal › Letter

    Leukemia
    Bone Marrow
    T-Lymphocytes
    1 Citations

    Characteristics of early acute respiratory distress syndrome in newly diagnosed acute myeloid leukemia

    Van de Louw, A., Desai, R. J., Zhu, J. & Claxton, D. F., Feb 13 2018, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-8 8 p.

    Research output: Contribution to journal › Article

    Adult Respiratory Distress Syndrome
    Acute Myeloid Leukemia
    Multivariate Analysis
    Mortality
    Leukocyte Count
    1 Citations

    Clofarabine followed by haploidentical stem cell transplant using fludarabine, busulfan, and total-body irradiation with post-transplant cyclophosphamide in non-remission AML

    Rakszawski, K., Miki, K., Claxton, D., Wagner, H., Shike, H., Mineishi, S. & Naik, S., Sep 1 2018, In : International journal of hematology. 108, 3, p. 348-350 3 p.

    Research output: Contribution to journal › Article

    Busulfan
    Whole-Body Irradiation
    Acute Myeloid Leukemia
    Cyclophosphamide
    Stem Cells
    1 Citations

    Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies

    Prabhu, V. V., Talekar, M. K., Lulla, A. R., Kline, C. L. B., Zhou, L., Hall, J., Van den Heuvel, A. P. J., Dicker, D. T., Babar, J., Grupp, S. A., Garnett, M. J., McDermott, U., Benes, C. H., Pu, J. J., Claxton, D. F., Khan, N., Oster, W., Allen, J. E. & El-Deiry, W. S., Feb 16 2018, In : Cell Cycle. 17, 4, p. 468-478 11 p.

    Research output: Contribution to journal › Article

    Hematologic Neoplasms
    Multiple Myeloma
    Lymphoma
    Leukemia
    Burkitt Lymphoma