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Personal profile

Research interests

Dr. David Claxton has longstanding interests in leukemia biology and therapeutics. Leukemia molecular genetics and diagnostics are ongoing interests. Acute myeloid leukemia and related disorders are his principal foci. Leukemia therapeutics are particular interests, including drug development and clinical studies, blood and marrow transplantation, and clinical supportive care. He has a laboratory which has banked many samples of human leukemias and lymphomas. These are viably cryopreserved, used in studies and available to collaborators.

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Acute Myeloid Leukemia Medicine & Life Sciences
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Hematologic Neoplasms Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Stem Cells Medicine & Life Sciences

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Projects 1989 2018

Targeted Sphingolipid Metabolism for Treatment of AML

Claxton, D., Wang, H., Wang, H., Amin, S., Liao, J. (., Fox, T., Loughran, T. P., Loughran, T. P., Kester, M., Kester, M. & Cabot, M. C.

National Institutes of Health

9/10/138/31/18

Project: Research project

Acute Myeloid Leukemia
Acid Ceramidase
Sphingolipids
Ceramides
Tamoxifen

THERAPY OF AML

Claxton, D., Deisseroth, A., Siciliano, M., Benedict, W., Reading, C., Liang, J., Plunkett, W., Thall, P., Thomas, M., Reed, J., Andreeff, M., Berry, D., Kornblau, S., Croce, C., Estey, E., Nagarajan, L., Deisseroth, A. & Champlin, R. E.

National Institutes of Health

6/1/928/31/15

Project: Research project

Core Binding Factors
Genes
Transcription Factors
Leukemia
Genetically Modified Animals

THERAPY OF CML

Claxton, D., Kurzrock, R., Ming-Sheng, L., Reading, C., Emerson, S., Liang, J., Feinberg, A., Deisseroth, A., Siciliano, M., Kantarjian, H., Talpaz, M., Andreeff, M., Kornblau, S., Thall, P., Issa, J., Estrov, Z., Arlinghaus, R. B., Deininger, M., Cortes, J., Shpall, E., Champlin, R., Belmont, J., Reisner, Y., Austin, D. & Issa, K.

National Institutes of Health

12/1/896/30/16

Project: Research project

Dendritic Cells
Immunity
Lymphocytes
Cytogenetics
Therapeutics

Research Output 1989 2018

A phase II study of vascular endothelial growth factor trap (Aflibercept, NSC 724770) in patients with myelodysplastic syndrome: a California Cancer Consortium Study

Kirschbaum, M. H., Frankel, P., Synold, T. W., Zain, J., Claxton, D., Tuscano, J., Newman, E. M., Gandara, D. R. & Lara, P. N., Feb 1 2018, In : British Journal of Haematology. 180, 3, p. 445-448 4 p.

Research output: Contribution to journalLetter

Recombinant Fusion Proteins
Vascular Endothelial Growth Factor Receptor
Myelodysplastic Syndromes
Vascular Endothelial Growth Factor A
Clinical Trials
1 Citations (Scopus)
Leukemia
Bone Marrow
T-Lymphocytes
1 Citations (Scopus)

Characteristics of early acute respiratory distress syndrome in newly diagnosed acute myeloid leukemia

Van De Louw, A., Desai, R. J., Zhu, J. & Claxton, D., Oct 3 2018, In : Leukemia and Lymphoma. 59, 10, p. 2369-2376 8 p.

Research output: Contribution to journalArticle

Adult Respiratory Distress Syndrome
Acute Myeloid Leukemia
Multivariate Analysis
Mortality
Leukocyte Count
1 Citations (Scopus)
Busulfan
Whole-Body Irradiation
Acute Myeloid Leukemia
Cyclophosphamide
Stem Cells

Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity

Kokolus, K. M., Haley, J. S., Koubek, E. J., Gowda, R., Dinavahi, S. S., Sharma, A., Claxton, D., Helm, K., Drabick, J., Robertson, G., Neighbors, J., Hohl, R. & Schell, T., Jan 1 2018, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

Biological Products
Immunity
Melanoma
Immunotherapy
Neoplasms