Projects per year
Personal profile
Research interests
Dr. David Claxton has longstanding interests in leukemia biology and therapeutics. Leukemia molecular genetics and diagnostics are ongoing interests. Acute myeloid leukemia and related disorders are his principal foci. Leukemia therapeutics are particular interests, including drug development and clinical studies, blood and marrow transplantation, and clinical supportive care. He has a laboratory which has banked many samples of human leukemias and lymphomas. These are viably cryopreserved, used in studies and available to collaborators.
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Projects
- 3 Finished
Targeted Sphingolipid Metabolism for Treatment of AML
Claxton, D., Kester, M., Loughran, T. P., Wang, H. G., Kester, M., Loughran, T. P., Kester, M., Wang, H. G., CABOT, M., Kester, M., Fox, T., LIAO, J., Loughran, T. P., AMIN, S., Kester, M. & Kester, M.
9/10/13 → 8/31/14
Project: Research project
THERAPY OF CML
Claxton, D., Kornblau, S., Arlinghaus, R. B., Reisner, Y., Austin, D., Champlin, R., Kantarjian, H., Champlin, R., Feinberg, A. & Deisseroth, A.
9/30/98 → 1/31/99
Project: Research project
THERAPY OF AML
Claxton, D., Benedict, W., Liang, J., Plunkett, W., Reed, J., Andreeff, M., Kornblau, S., Estey, E., Andreeff, M. & Champlin, R.
9/30/96 → 3/31/97
Project: Research project
Research Output
Ceramide analogue SACLAC modulates sphingolipid levels and MCL-1 splicing to induce apoptosis in acute myeloid leukemia
Pearson, J. M., Tan, S. F., Sharma, A., Annageldiyev, C., Fox, T. E., Abad, J. L., Fabrias, G., Desai, D., Amin, S., Wang, H. G., Cabot, M. C., Claxton, D. F., Kester, M., Feith, D. J. & Loughran, T. P., Jan 1 2020, In : Molecular Cancer Research. 18, 3, p. 352-363 12 p.Research output: Contribution to journal › Article
Multi-dimensional analysis identifies an immune signature predicting response to decitabine treatment in elderly patients with AML
Zhao, C., Jia, B., Wang, M., Schell, T. D., Claxton, D. F., Ehmann, W. C., Rybka, W. B., Mineishi, S., Naik, S., Songdej, N., Sivik, J. M., Hohl, R. J., Zeng, H. & Zheng, H., Mar 1 2020, In : British Journal of Haematology. 188, 5, p. 674-684 11 p.Research output: Contribution to journal › Article
Open Access
The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia
Annageldiyev, C., Gowda, K., Patel, T., Bhattacharya, P., Tan, S. F., Iyer, S., Desai, D., Dovat, S., Feith, D. J., Loughran, T. P., Amin, S., Claxton, D. & Sharma, A., Mar 1 2020, In : Haematologica. 105, 3, p. 687-696 10 p.Research output: Contribution to journal › Article
Open Access
1
Scopus
citations
Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation
Tan, S. F., Dunton, W., Liu, X., Fox, T. E., Morad, S. A. F., Desai, D., Doi, K., Conaway, M. R., Amin, S., Claxton, D. F., Wang, H. G., Kester, M., Cabot, M. C., Feith, D. J. & Loughran, T. P., Jan 1 2019, In : Journal of Lipid Research. 60, 6, p. 1078-1086 9 p.Research output: Contribution to journal › Article
2
Scopus
citations
Animal mouse models of acute myeloid leukemia
Patel, T. N., Madhunapantula, S. R. V., Annageldiyev, C., Claxton, D. & Sharma, A., 2019, Animal Models in Cancer Drug Discovery. Azmi, A. & Mohammad, R. M. (eds.). Academic Press, p. 419-438Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)