David Degraff, PhD

Assistant Professor, Department of Pathology and Laboratory Medicine
Division of Experimental Pathology
Assistant Professor, Department of Surgery
Penn State Cancer Institute
Cancer Institute, Experimental Therapeutics

642 Citations
16 h-Index

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Projects 2013 2017

1 Finished

Mechanisms of Urothelial Metaplasia and Tumorigenesis

Degraff, D.

National Institutes of Health

8/1/13 → 7/31/17

Project: Research project

Metaplasia

Urinary Bladder Neoplasms

Carcinogenesis

Peroxisome Proliferator-Activated Receptors

Urinary Bladder

Research Output 2007 2019

642 Citations
16 h-Index
29 Article
9 Review article
4 Editorial
1 Chapter

1 Citation (Scopus)

Characterization of histone deacetylase expression within in vitro and in vivo bladder cancer model systems

Buckwalter, J. M., Chan, W., Shuman, L., Wildermuth, T., Ellis-Mohl, J., Walter, V., Warrick, J. I., Wu, X. R., Kaag, M., Raman, J. D. & Degraff, D. J., May 2 2019, In : International journal of molecular sciences. 20, 10, 2599.

Research output: Contribution to journal › Article

Open Access

Histone Deacetylases

bladder

Polymerase chain reaction

Urinary Bladder Neoplasms

cancer

13 Citations (Scopus)

Intratumoral Heterogeneity of Bladder Cancer by Molecular Subtypes and Histologic Variants [Figure presented]

Warrick, J., Sjödahl, G., Kaag, M. G., Raman, J., Merrill, S., Shuman, L., Chen, G., Walter, V. & Degraff, D., Jan 1 2019, In : European Urology. 75, 1, p. 18-22 5 p.

Research output: Contribution to journal › Article

Urinary Bladder Neoplasms

Neoplasms

Histology

Selection Bias

Carcinoma

1 Citation (Scopus)

Maintenance of the bladder cancer precursor urothelial hyperplasia requires FOXA1 and persistent expression of oncogenic HRAS

Yee, C. H., Zheng, Z., Shuman, L., Yamashita, H., Warrick, J., Wu, X. R., Raman, J. & Degraff, D., Dec 1 2019, In : Scientific reports. 9, 1, 270.

Research output: Contribution to journal › Article

Oncogenes

Urinary Bladder Neoplasms

Hyperplasia

Maintenance

Neoplasms

Mitotic activity in noninvasive papillary urothelial carcinoma: its value in predicting tumor recurrence and comparison with the contemporary 2-tier grading system

Zaleski, M., Gogoj, A., Walter, V., Raman, J., Kaag, M. G., Merrill, S., Drabick, J., Joshi, M., Holder, S., Degraff, D. & Warrick, J., Feb 1 2019, In : Human Pathology. 84, p. 275-282 8 p.

Research output: Contribution to journal › Article

Papillary Carcinoma

Recurrence

Neoplasms

Proportional Hazards Models

Neoplasm Grading

Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

Buj, R., Chen, C. W., Dahl, E. S., Leon, K. E., Kuskovsky, R., Maglakelidze, N., Navaratnarajah, M., Zhang, G., Doan, M. T., Jiang, H., Zaleski, M., Kutzler, L., Lacko, H., Lu, Y., Mills, G. B., Gowda, R., Robertson, G., Warrick, J., Herlyn, M., Imamura, Y. & 4 others, Kimball, S., Degraff, D., Snyder, N. W. & Aird, K., Aug 20 2019, In : Cell Reports. 28, 8, p. 1971-1980.e8

Research output: Contribution to journal › Article

Open Access

Nucleotides

Metabolism

Carcinogenesis

Up-Regulation

Neoplasms