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Research Output 2007 2019

  • 642 Citations
  • 16 h-Index
  • 29 Article
  • 9 Review article
  • 4 Editorial
  • 1 Chapter
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Article
Article
40 Citations (Scopus)

Activation of NF-kappa B Signaling Promotes Growth of Prostate Cancer Cells in Bone

Jin, R., Sterling, J. A., Edwards, J. R., Degraff, D., Lee, C., Park, S. I. & Matusik, R. J., Apr 5 2013, In : PLoS One. 8, 4, e60983.

Research output: Contribution to journalArticle

NF-kappa B
prostatic neoplasms
Prostatic Neoplasms
Bone
Chemical activation
8 Citations (Scopus)

Altered Expression of the Transcription Factor Forkhead Box A1 (FOXA1) Is Associated With Poor Prognosis in Urothelial Carcinoma of the Upper Urinary Tract

Raman, J., Warrick, J., Caruso, C., Yang, Z., Shuman, L., Bruggeman, R. D., Shariat, S., Karam, J. A., Wood, C., Weizer, A. Z., Remzi, M., Haitel, A., Bensalah, K., Rioux-Leclerq, N., Bolenz, C., Roscigno, M., Krabbe, L. M., Kapur, P., Lotan, Y., Margulis, V. & 1 others, Degraff, D., Aug 1 2016, In : Urology. 94, p. 314.e1-314.e7

Research output: Contribution to journalArticle

Forkhead Transcription Factors
Urinary Tract
Carcinoma
Carcinoma in Situ
Confidence Intervals
3 Citations (Scopus)

Androgen mediated translational and postranslational regulation of IGFBP-2 in androgen-sensitive LNCAP human prostate cancer cells

Degraff, D., Aguiar, A. A., Chen, Q., Adams, L. K., Williams, B. J. & Sikes, R. A., 2010, In : American Journal of Translational Research. 2, 2, p. 200-208 9 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 2
Androgens
Prostatic Neoplasms
Cells
Messenger RNA
12 Citations (Scopus)

Characterization of cis elements of the probasin promoter necessary for prostate-specific gene expression

Zhang, J. F., Gao, N., Degraff, D., Yu, X., Sun, Q., Case, T. C., Kasper, S. & Matusik, R. J., Jun 15 2010, In : Prostate. 70, 9, p. 934-951 18 p.

Research output: Contribution to journalArticle

Prostate
Gene Expression
Transgenic Mice
Genetically Modified Animals
Transcription Factors
1 Citation (Scopus)

Characterization of histone deacetylase expression within in vitro and in vivo bladder cancer model systems

Buckwalter, J. M., Chan, W., Shuman, L., Wildermuth, T., Ellis-Mohl, J., Walter, V., Warrick, J. I., Wu, X. R., Kaag, M., Raman, J. D. & Degraff, D. J., May 2 2019, In : International journal of molecular sciences. 20, 10, 2599.

Research output: Contribution to journalArticle

Open Access
Histone Deacetylases
bladder
Polymerase chain reaction
Urinary Bladder Neoplasms
cancer
3 Citations (Scopus)

Clinical significance of prominent retraction clefts in invasive urothelial carcinoma

Shah, T. S., Kaag, M. G., Raman, J., Chan, W., Tran, T., Kunchala, S., Shuman, L., Degraff, D., Chen, G. & Warrick, J., Mar 1 2017, In : Human Pathology. 61, p. 90-96 7 p.

Research output: Contribution to journalArticle

Carcinoma
Lymph Nodes
Neoplasm Metastasis
Cystectomy
Neoplasms
15 Citations (Scopus)

Deficiency in metabolic regulators PPARγ and PTEN cooperates to drive keratinizing squamous metaplasia in novel models of human tissue regeneration

Strand, D. W., Degraff, D., Jiang, M., Sameni, M., Franco, O. E., Love, H. D., Hayward, W. J., Lin-Tsai, O., Wang, A. Y., Cates, J. M. M., Sloane, B. F., Matusik, R. J. & Hayward, S. W., Feb 1 2013, In : American Journal of Pathology. 182, 2, p. 449-459 11 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Metaplasia
Regeneration
Prostate
Epithelial Cells
9 Citations (Scopus)

Enhancer of zeste homolog 2 (EZH2) expression in bladder cancer

Warrick, J., Raman, J., Kaag, M. G., Bruggeman, T., Cates, J., Clark, P. & Degraff, D., Jun 1 2016, In : Urologic Oncology: Seminars and Original Investigations. 34, 6, p. 258.e1-258.e6

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Carcinoma in Situ
Urothelium
Carcinoma
ROC Curve
24 Citations (Scopus)

FOXA1, GATA3 and PPARIγ Cooperate to drive luminal subtype in bladder cancer: A molecular analysis of established human cell lines

Warrick, J., Walter, V., Yamashita, H., Chung, E., Shuman, L., Amponsa, V. O., Zheng, Z., Chan, W., Whitcomb, T., Yue, F., Iyyanki, T., Imamura, Y., Kaag, M. G., Guo, W., Raman, J., Park, J. S. & Degraff, D., Dec 7 2016, In : Scientific reports. 6, 38531.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Cell Line
Basal Cell Neoplasms
Encyclopedias
Neoplasms
6 Citations (Scopus)

FOXA1 and CK14 as markers of luminal and basal subtypes in histologic variants of bladder cancer and their associated conventional urothelial carcinoma

Warrick, J., Kaag, M. G., Raman, J., Chan, W., Tran, T., Kunchala, S., Shuman, L., Degraff, D. & Chen, G., Sep 1 2017, In : Virchows Archiv. 471, 3, p. 337-345 9 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Carcinoma
Squamous Cell Carcinoma
Histology
Cystectomy
22 Citations (Scopus)

FOXA1 deletion in luminal epithelium causes prostatic hyperplasia and alteration of differentiated phenotype

Degraff, D., Grabowska, M. M., Case, T. C., Yu, X., Herrick, M. K., Hayward, W. J., Strand, D. W., Cates, J. M., Hayward, S. W., Gao, N., Walter, M. A., Buttyan, R., Yi, Y., Kaestner, K. H. & Matusik, R. J., Jan 1 2014, In : Laboratory Investigation. 94, 7, p. 726-739 14 p.

Research output: Contribution to journalArticle

Prostatic Hyperplasia
Prostate
Epithelium
Phenotype
Castration
16 Citations (Scopus)

Hormonal regulation of IGFBP-2 proteolysis is attenuated with progression to androgen insensitivity in the LNCaP progression model

Degraff, D., Malik, M., Chen, Q., Miyako, K., Rejto, L., Aguiar, A. A., Bancroft, D. R. E., Cohen, P. & Sikes, R. A., Oct 1 2007, In : Journal of Cellular Physiology. 213, 1, p. 261-268 8 p.

Research output: Contribution to journalArticle

Proteolysis
Insulin-Like Growth Factor Binding Protein 2
Androgens
Cells
Prostatic Neoplasms
13 Citations (Scopus)

Intratumoral Heterogeneity of Bladder Cancer by Molecular Subtypes and Histologic Variants [Figure presented]

Warrick, J., Sjödahl, G., Kaag, M. G., Raman, J., Merrill, S., Shuman, L., Chen, G., Walter, V. & Degraff, D., Jan 1 2019, In : European Urology. 75, 1, p. 18-22 5 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Neoplasms
Histology
Selection Bias
Carcinoma
33 Citations (Scopus)

Loss of FOXA1 drives sexually dimorphic changes in urothelial differentiation and is an independent predictor of poor prognosis in bladder cancer

Reddy, O. L., Cates, J. M., Gellert, L. L., Crist, H., Yang, Z., Yamashita, H., Taylor, J. A., Smith, J. A., Chang, S. S., Cookson, M. S., You, C., Barocas, D. A., Grabowska, M. M., Ye, F., Wu, X. R., Yi, Y., Matusik, R. J., Kaestner, K. H., Clark, P. E. & Degraff, D., May 1 2015, In : American Journal of Pathology. 185, 5, p. 1385-1395 11 p., 1980.

Research output: Contribution to journalArticle

Keratin-14
Urinary Bladder Neoplasms
Urothelium
Knockout Mice
Urinary Bladder
17 Citations (Scopus)

Loss of Sh3gl2/endophilin A1 is a common event in urothelial carcinoma that promotes malignant behavior

Majumdar, S., Gong, E. M., Di Vizio, D., Dreyfuss, J., Degraff, D., Hager, M. H., Park, P. J., Bellmunt, J., Matusik, R. J., Rosenberg, J. E. & Adam, R. M., Jan 1 2013, In : Neoplasia (United States). 15, 7, p. 749-760 12 p.

Research output: Contribution to journalArticle

Carcinoma
Epidermal Growth Factor Receptor
Informatics
Neoplasms
Cell Line
46 Citations (Scopus)

Loss of the urothelial differentiation marker FOXA1 is associated with high grade, late stage bladder cancer and increased tumor proliferation

Degraff, D., Clark, P. E., Cates, J. M., Yamashita, H., Robinson, V. L., Yu, X., Smolkin, M. E., Chang, S. S., Cookson, M. S., Herrick, M. K., Shariat, S. F., Steinberg, G. D., Frierson, H. F., Wu, X. R., Theodorescu, D. & Matusik, R. J., May 10 2012, In : PloS one. 7, 5, e36669.

Research output: Contribution to journalArticle

Differentiation Antigens
Urinary Bladder Neoplasms
Muscle
Tumors
Cells
26 Citations (Scopus)

Macrophage migratory inhibitory factor promotes bladder cancer progression via increasing proliferation and angiogenesis

Choudhary, S., Hegde, P., Pruitt, J. R., Sielecki, T. M., Choudhary, D., Scarpato, K., DeGraff, D. J., Pilbeam, C. C. & Taylor, J. A., Dec 1 2013, In : Carcinogenesis. 34, 12, p. 2891-2899 9 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Extracellular Signal-Regulated MAP Kinases
Macrophages
Tumor Burden
Thymidine
1 Citation (Scopus)

Maintenance of the bladder cancer precursor urothelial hyperplasia requires FOXA1 and persistent expression of oncogenic HRAS

Yee, C. H., Zheng, Z., Shuman, L., Yamashita, H., Warrick, J., Wu, X. R., Raman, J. & Degraff, D., Dec 1 2019, In : Scientific reports. 9, 1, 270.

Research output: Contribution to journalArticle

Oncogenes
Urinary Bladder Neoplasms
Hyperplasia
Maintenance
Neoplasms
Papillary Carcinoma
Recurrence
Neoplasms
Proportional Hazards Models
Neoplasm Grading
7 Citations (Scopus)

NFIB regulates transcriptional networks that control the development of prostatic hyperplasia

Grabowska, M. M., Kelly, S. M., Reese, A. L., Cates, J. M., Case, T. C., Zhang, J., Degraff, D., Strand, D. W., Miller, N. L., Clark, P. E., Hayward, S. W., Gronostajski, R. M., Anderson, P. D. & Matusik, R. J., Mar 1 2016, In : Endocrinology. 157, 3, p. 1094-1109 16 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Androgen Receptors
Prostatic Hyperplasia
NFI Transcription Factors
Prostate
32 Citations (Scopus)

NFI transcription factors interact with FOXA1 to regulate prostate-specific gene expression

Grabowska, M. M., Elliott, A. D., Degraff, D., Anderson, P. D., Anumanthan, G., Yamashita, H., Sun, Q., Friedman, D. B., Hachey, D. L., Yu, X., Sheehan, J. H., Ahn, J. M., Raj, G. V., Piston, D. W., Gronostajski, R. M. & Matusik, R. J., Jan 1 2014, In : Molecular Endocrinology. 28, 6, p. 949-964 16 p.

Research output: Contribution to journalArticle

NFI Transcription Factors
Androgen Receptors
Prostate
Transcription Factors
Gene Expression
1 Citation (Scopus)

Proceedings of the 3rd annual albert institute for bladder cancer research symposium

Flaig, T. W., Kamat, A. M., Hansel, D., Ingersoll, M. A., Barton Grossman, H., Mendelsohn, C., Degraff, D., Liao, J. C. & Taylor, J. A., Jan 1 2017, In : Bladder Cancer. 3, 3, p. 211-223 13 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Research
Carcinoma
Therapeutics
Benchmarking
20 Citations (Scopus)

SOX2 expression in the developing, adult, as well as, diseased prostate

Yu, X., Cates, J. M., Morrissey, C., You, C., Grabowska, M. M., Zhang, J., Degraff, D., Strand, D. W., Franco, O. E., Lin-Tsai, O., Hayward, S. W. & Matusik, R. J., Dec 13 2014, In : Prostate Cancer and Prostatic Diseases. 17, 4, p. 301-309 9 p.

Research output: Contribution to journalArticle

Prostate
Prostatic Neoplasms
Neuroendocrine Tumors
Synaptophysin
Castration
20 Citations (Scopus)

SPARCL1 suppresses metastasis in prostate cancer

Xiang, Y., Qiu, Q., Jiang, M., Jin, R., Lehmann, B. D., Strand, D. W., Jovanovic, B., Degraff, D., Zheng, Y., Yousif, D. A., Simmons, C. Q., Case, T. C., Yi, J., Cates, J. M., Virostko, J., He, X., Jin, X., Hayward, S. W., Matusik, R. J., George, A. L. & 1 others, Yi, Y., Jan 1 2013, In : Molecular Oncology. 7, 6, p. 1019-1030 12 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Neoplasm Metastasis
Heterografts
Cell Movement
Neoplasms
3 Citations (Scopus)

Squamous Dysplasia of the Urinary Bladder

Warrick, J., Kaag, M. G., Raman, J., Chan, W., Tran, T., Kunchala, S., Degraff, D. & Chen, G., Jan 1 2015, In : International Journal of Surgical Pathology. 24, 4, p. 306-314 9 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Cystectomy
Urinary Bladder
Carcinoma
Squamous Cell Carcinoma

Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

Buj, R., Chen, C. W., Dahl, E. S., Leon, K. E., Kuskovsky, R., Maglakelidze, N., Navaratnarajah, M., Zhang, G., Doan, M. T., Jiang, H., Zaleski, M., Kutzler, L., Lacko, H., Lu, Y., Mills, G. B., Gowda, R., Robertson, G., Warrick, J., Herlyn, M., Imamura, Y. & 4 others, Kimball, S., Degraff, D., Snyder, N. W. & Aird, K., Aug 20 2019, In : Cell Reports. 28, 8, p. 1971-1980.e8

Research output: Contribution to journalArticle

Open Access
Nucleotides
Metabolism
Carcinogenesis
Up-Regulation
Neoplasms
4 Citations (Scopus)

The developmental expression profile of PAX2 in the murine prostate

Chen, Q., Degraff, D. & Sikes, R. A., May 1 2010, In : Prostate. 70, 6, p. 654-665 12 p.

Research output: Contribution to journalArticle

Prostate
Western Blotting
Metribolone
Polymerase Chain Reaction
Organogenesis
15 Citations (Scopus)

Upstream stimulatory factor 2, a novel FoxA1-interacting protein, is involved in prostate-specific gene expression

Sun, Q., Yu, X., Degraff, D. & Matusik, R. J., Dec 1 2009, In : Molecular Endocrinology. 23, 12, p. 2038-2047 10 p.

Research output: Contribution to journalArticle

Upstream Stimulatory Factors
Prostate
Gene Expression
Proteins
Transcription Factors
82 Citations (Scopus)

Wnt/Β-Catenin activation promotes prostate tumor progression in a mouse model

Yu, X., Wang, Y., Degraff, D., Wills, M. L. & Matusik, R. J., Apr 21 2011, In : Oncogene. 30, 16, p. 1868-1879 12 p.

Research output: Contribution to journalArticle

Catenins
Prostate
Prostatic Intraepithelial Neoplasia
Neoplasms
Adenocarcinoma