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Personal profile

Research interests

Dr. David Waning's research focuses on the emerging importance of bone-muscle crosstalk in aging and disease.

The overarching goal of his research program is to discover and characterize molecular mechanisms that impair musculoskeletal health in disease and aging. Bone and muscle are tightly coupled during growth and development, and also during aging and disease yet the cellular and molecular mechanisms linking these two tissues are not well understood. The Waning lab is developing novel therapeutic approaches that improve musculoskeletal health in pre-clinical models of cancer and chemotherapy-induced sequelae, osteoporosis and aging.

The major aims of Dr. Waning's research are to identify and characterize signal mediators of bone-muscle crosstalk that affect musculoskeletal health. He is especially interested in identifying targets of oxidative stress that affect bone and muscle function; understanding muscle weakness in cachexia; cachexia and the relative contribution of muscle wasting and contractile dysfunction; and bone-muscle crosstalk in rare bone diseases.

Teaching and educational interests

Dr. David Waning is the director of the Cellular and Integrative Physiology Core Option in the Biomedical Sciences Graduate Program at Penn State College of Medicine.

Education/Academic qualification

PhD, Northwestern University

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Bone and Bones Medicine & Life Sciences
Muscle Weakness Medicine & Life Sciences
Bone Neoplasms Medicine & Life Sciences
Muscles Medicine & Life Sciences
Neoplasm Metastasis Medicine & Life Sciences
Skeletal Muscle Medicine & Life Sciences
Parainfluenza Virus 5 Medicine & Life Sciences
Breast Neoplasms Medicine & Life Sciences

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Projects 2016 2019

Ryanodine Receptor Calcium Release Channel
Muscle Weakness
Drug Therapy
Muscles
Oxidative Stress

Research Output 2002 2019

  • 613 Citations
  • 12 h-Index
  • 17 Article
  • 4 Review article
  • 2 Short survey

A “Connexin” Responsible for the Fatal Attraction of Cancer to Bone

Waning, D., Guise, T. A. & Mohammad, K. S., Jan 8 2019, In : Cell Metabolism. 29, 1, p. 6-8 3 p.

Research output: Contribution to journalShort survey

Bone Neoplasms
Connexins
Bone and Bones
Neoplasm Metastasis
Neoplasms
1 Citation (Scopus)

Chronic treatment with multi-kinase inhibitors causes differential toxicities on skeletal and cardiac muscles

Huot, J. R., Essex, A. L., Gutierrez, M., Barreto, R., Wang, M., Waning, D. L., Plotkin, L. I. & Bonetto, A., Apr 2019, In : Cancers. 11, 4, 571.

Research output: Contribution to journalArticle

Open Access
Myocardium
Skeletal Muscle
Phosphotransferases
Muscles
Cachexia

Zoledronic Acid Improves Muscle Function in Healthy Mice Treated with Chemotherapy

Hain, B. A., Jude, B., Xu, H., Smuin, D. M., Fox, E. J., Elfar, J. C. & Waning, D. L., Jan 1 2019, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

zoledronic acid
Carboplatin
Muscle Weakness
Bone and Bones
Drug Therapy
11 Citations (Scopus)

Aromatase inhibitor-induced bone loss increases the progression of estrogen receptor-negative breast cancer in bone and exacerbates muscle weakness in vivo

Wright, L. E., Harhash, A. A., Kozlow, W. M., Waning, D. L., Regan, J. N., She, Y., John, S. K., Murthy, S., Niewolna, M., Marks, A. R., Mohammad, K. S. & Guise, T. A., Jan 1 2017, In : Oncotarget. 8, 5, p. 8406-8419 14 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Aromatase Inhibitors
Muscle Weakness
Estrogen Receptors
Breast Neoplasms
12 Citations (Scopus)

Bone-induced expression of integrin b3 enables targeted nanotherapy of breast cancer metastases

Ross, M. H., Esser, A. K., Fox, G. C., Schmieder, A. H., Yang, X., Hu, G., Pan, D., Su, X., Xu, Y., Novack, D. V., Walsh, T., Colditz, G. A., Lukaszewicz, G. H., Cordell, E., Novack, J., Fitzpatrick, J. A. J., Waning, D. L., Mohammad, K. S., Guise, T. A., Lanza, G. M. & 1 others, Weilbaecher, K. N., Nov 15 2017, In : Cancer Research. 77, 22, p. 6299-6312 14 p.

Research output: Contribution to journalArticle

docetaxel
Integrins
Breast Neoplasms
Neoplasm Metastasis
Bone and Bones