Projects per year
Personal profile
Research interests
Dr. Deb Kelly's research focuses on innovative approaches to study biological systems, ranging from human viruses to cancer. Central to her work is high-resolution imaging, primarily cryo-Electron Microscopy (EM). Invasive breast cancer threatens the lives of women everywhere and there is no precise treatment for the disease. Her team has developed a tunable microchip toolkit to study mutations in the breast cancer susceptibility protein, BRCA1. Using this new tools, the Kelly lab expects to determine strategic insights for the molecular detection and prevention of BRCA1-related cancers. Her team is on the cutting edge of the burgeoning new field they call structural oncology.
Teaching and educational interests
As part of her academic appointment and throughout her career, Dr. Deb Kelly has had the privilege of teaching and training the next generation of physician-scientists. Prior to joining Penn State, she mentored four medical students, four graduate students and numerous undergraduates. Her medical students have published their findings in peer-reviewed journals, contributing to 10 original research articles.
Education/Academic qualification
Cell Biology, Post-doctoral Training, Harvard Medical School
… → 2010
Molecular Biophysics, PhD, Florida State University
… → 2003
External positions
Vice Chair, Gordon Research Conference in Liquid Phase EM
2019
Director of Biological Sciences, Microscopy Society of America
Jan 1 2017 → …
Session Chair, Gordon Research Conference in 3D-EM
2017
Director of Biological Sciences, Microscopy Society of America
2017 → …
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Collaborative Research: Infection mechanisms of bacteriophages targeting motile bacteria
6/1/21 → 5/31/24
Project: Research project
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Cyclic di-GMP Regulation of PilB in Motility and Biofilm
Yang, Z. & Kelly, D.
8/1/19 → 7/31/23
Project: Research project
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Hot Spot Analysis of the Breast Cancer Susceptibility Protein
Kelly, D. & Kelly, D.
3/1/18 → 2/28/23
Project: Research project
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Cryo-EM analysis of PI3K signaling complexes in glioblastoma
Kelly, D. & Kelly, D.
12/1/19 → 11/30/21
Project: Research project
Research output
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Automated Tools to Advance High-Resolution Imaging in Liquid
Jonaid, G. M., Casasanta, M. A., Dearnaley, W. J., Berry, S., Kaylor, L., Dressel-Dukes, M. J., Spilman, M. S., Gray, J. L. & Kelly, D. F., Apr 11 2022, In: Microscopy and Microanalysis. 28, 2, p. 361-370 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Connexin 43 confers chemoresistance through activating PI3K
Pridham, K. J., Shah, F., Hutchings, K. R., Sheng, K. L., Guo, S., Liu, M., Kanabur, P., Lamouille, S., Lewis, G., Morales, M., Jourdan, J., Grek, C. L., Ghatnekar, G. G., Varghese, R., Kelly, D. F., Gourdie, R. G. & Sheng, Z., Dec 2022, In: Oncogenesis. 11, 1, 2.Research output: Contribution to journal › Article › peer-review
Open Access -
High-Resolution Imaging of Human Viruses in Liquid Droplets
Jonaid, G. M., Dearnaley, W. J., Casasanta, M. A., Kaylor, L., Berry, S., Dukes, M. J., Spilman, M. S., Gray, J. L. & Kelly, D. F., Sep 16 2021, In: Advanced Materials. 33, 37, 2103221.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Microchip-based structure determination of low-molecular weight proteins using cryo-electron microscopy
Casasanta, M. A., Jonaid, G. M., Kaylor, L., Luqiu, W. Y., Solares, M. J., Schroen, M. L., Dearnaley, W. J., Wilson, J., Dukes, M. J. & Kelly, D. F., Apr 21 2021, In: Nanoscale. 13, 15, p. 7285-7293 9 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Liquid cell TEM imaging techniques and optimization for biological samples
Dukes, M., Kelly, D. & Varano, C., 2020, (Accepted/In press) In: Microscopy and Microanalysis.Research output: Contribution to journal › Comment/debate › peer-review
Open Access