Projects per year
Personal profile
Research interests
Dr. Deb Kelly's research focuses on innovative approaches to study biological systems, ranging from human viruses to cancer. Central to her work is high-resolution imaging, primarily cryo-Electron Microscopy (EM). Invasive breast cancer threatens the lives of women everywhere and there is no precise treatment for the disease. Her team has developed a tunable microchip toolkit to study mutations in the breast cancer susceptibility protein, BRCA1. Using this new tools, the Kelly lab expects to determine strategic insights for the molecular detection and prevention of BRCA1-related cancers. Her team is on the cutting edge of the burgeoning new field they call structural oncology.
Teaching and educational interests
As part of her academic appointment and throughout her career, Dr. Deb Kelly has had the privilege of teaching and training the next generation of physician-scientists. Prior to joining Penn State, she mentored four medical students, four graduate students and numerous undergraduates. Her medical students have published their findings in peer-reviewed journals, contributing to 10 original research articles.
Education/Academic qualification
Cell Biology, Post-doctoral Training, Harvard Medical School
… → 2010
Molecular Biophysics, PhD, Florida State University
… → 2003
External positions
Director of Biological Sciences, Microscopy Society of America
Jan 1 2017 → …Director of Biological Sciences, Microscopy Society of America
2017 → …Fingerprint Dive into the research topics where Deb Kelly is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Projects
Cryo-EM analysis of PI3K signaling complexes in glioblastoma
Kelly, D. & Sheng, Z. H. I.
12/1/19 → 11/30/21
Project: Research project
Multi-scale imaging of breast cancer proteins during DNA repair
6/1/18 → 5/31/23
Project: Research project
Hot Spot Analysis of the Breast Cancer Susceptibility Protein
3/1/18 → 2/28/23
Project: Research project
UVA molecular electron microscopy core for the Mid-Atlantic region
Kelly, D., Zhang, P., Samso, M., Taylor, D. J., Yeager, M., Galkin, V., Melanie Diane, O. & Unger, V.
9/1/17 → 7/31/22
Project: Research project
The Southeastern Consortium for Microscopy of MacroMolecular Machines
Kelly, D., Moiseenkova-Bell, V., Bullitt, E., Liu, J. U. N., Taylor, K. A., Dokland, T., Sindelar, C. V., Schmidt-Krey, I., Melanie Diane, O., Radermacher, M., Jiang, Q. X., Stewart, P., Wright, E., Galkin, V., Zhang, W. E. I. & Liang, B. O.
7/18/16 → 6/30/21
Project: Research project
Research Output
Correcting errors in the BRCA1 warning system
Liang, Y., Dearnaley, W. J., Alden, N. A., Solares, M. J., Gilmore, B. L., Pridham, K. J., Varano, C., Sheng, Z., Alli, E. & Kelly, D., Jan 2019, In : DNA Repair. 73, p. 120-128 9 p.Research output: Contribution to journal › Article
Cryo-EM-On-a-Chip: Custom-Designed Substrates for the 3D Analysis of Macromolecules
Alden, N. A., Varano, A. C., Dearnaley, W. J., Solares, M. J., Luqiu, W. Y., Liang, Y., Sheng, Z., McDonald, S. M., Damiano, J., McConnell, J., Dukes, M. J. & Kelly, D. F., May 24 2019, In : Small. 15, 21, 1900918.Research output: Contribution to journal › Article
Cryo-EM Reveals Architectural Diversity in Active Rotavirus Particles
Hauser, M., Dearnaley, W. J., Varano, A. C., Casasanta, M., McDonald, S. M. & Kelly, D. F., 2019, In : Computational and Structural Biotechnology Journal. 17, p. 1178-1183 6 p.Research output: Contribution to journal › Article
Open Access
Liquid-Cell Electron Tomography of Biological Systems
Dearnaley, W., Schleupner, B., Varano, C., Alden, N. A., Gonzalez, F., Casasanta, M. A., Scharf, B. E., Dukes, M. J. & Kelly, D., Oct 9 2019, In : Nano letters. 19, 10, p. 6734-6741 8 p.Research output: Contribution to journal › Article
1
Scopus
citations
Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival
Varghese, R. T., Young, S., Pham, L., Liang, Y., Pridham, K. J., Guo, S., Murphy, S., Kelly, D. F. & Sheng, Z., Dec 1 2018, In : Scientific reports. 8, 1, 13621.Research output: Contribution to journal › Article
Open Access
4
Scopus
citations