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Personal profile

Research interests

Dr. Deb Kelly's research focuses on innovative approaches to study biological systems, ranging from human viruses to cancer. Central to her work is high-resolution imaging, primarily cryo-Electron Microscopy (EM). Invasive breast cancer threatens the lives of women everywhere and there is no precise treatment for the disease. Her team has developed a tunable microchip toolkit to study mutations in the breast cancer susceptibility protein, BRCA1. Using this new tools, the Kelly lab expects to determine strategic insights for the molecular detection and prevention of BRCA1-related cancers. Her team is on the cutting edge of the burgeoning new field they call structural oncology.

Teaching and educational interests

As part of her academic appointment and throughout her career, Dr. Deb Kelly has had the privilege of teaching and training the next generation of physician-scientists. Prior to joining Penn State, she mentored four medical students, four graduate students and numerous undergraduates. Her medical students have published their findings in peer-reviewed journals, contributing to 10 original research articles.

Education/Academic qualification

Cell Biology, Post-doctoral Training, Harvard Medical School

… → 2010

Molecular Biophysics, PhD, Florida State University

… → 2003

External positions

Director of Biological Sciences, Microscopy Society of America

Jan 1 2017 → …

Director of Biological Sciences, Microscopy Society of America

2017 → …

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Electron Microscopy Medicine & Life Sciences
Cryoelectron Microscopy Medicine & Life Sciences
Electron microscopy Chemical Compounds
Proteins Medicine & Life Sciences
Rotavirus Medicine & Life Sciences
Glioblastoma Medicine & Life Sciences
Liquids Engineering & Materials Science
Lipids Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2014 2023

DNA Repair
Breast Neoplasms
Mutation
BRCA1 Protein
Proteins
Breast Neoplasms
Neoplasms
Proteins
DNA Repair
Mutation

UVA molecular electron microscopy core for the Mid-Atlantic region

Kelly, D., Zhang, P., Samso, M., Taylor, D. J., Yeager, M., Galkin, V. & Melanie Diane, O.

National Institutes of Health

9/1/177/31/22

Project: Research project

electron microscopy
Titan
life sciences
medicine
electron microscopes

The Southeastern Consortium for Microscopy of MacroMolecular Machines

Kelly, D., Moiseenkova-Bell, V., Bullitt, E., Liu, J. U. N., Taylor, K. A., Dokland, T., Sindelar, C. V., Schmidt-Krey, I., Melanie Diane, O., Radermacher, M., Jiang, Q. X., Stewart, P. & Wright, E.

National Institutes of Health

7/18/166/30/21

Project: Research project

electron counters
Titan
viruses
microscopy
high resolution

CryoEM Data Collection Facility Consortium at NCMI

Kelly, D., Chiu, W. A. H., Sherman, M., Stewart, P., Bullitt, E., Gogol, E. P., Huilin, L., Zhang, J. & Xiao, C.

National Institutes of Health

7/15/166/30/21

Project: Research project

Electron microscopy
Tomography
Microscopes
Imaging techniques
Macromolecules

Research Output 1995 2019

  • 668 Citations
  • 16 h-Index
  • 43 Article
  • 3 Chapter
  • 1 Conference article
  • 1 Review article

Correcting errors in the BRCA1 warning system

Liang, Y., Dearnaley, W. J., Alden, N. A., Solares, M. J., Gilmore, B. L., Pridham, K. J., Varano, C., Sheng, Z., Alli, E. & Kelly, D., Jan 1 2019, In : DNA Repair. 73, p. 120-128 9 p.

Research output: Contribution to journalArticle

BRCA1 Protein
Alarm systems
Repair
Biochemical Phenomena
Cells

Cryo-EM-On-a-Chip: Custom-Designed Substrates for the 3D Analysis of Macromolecules

Alden, N. A., Varano, C., Dearnaley, W., Solares, M. J., Luqiu, W. Y., Liang, Y., Sheng, Z., McDonald, S. M., Damiano, J., McConnell, J., Dukes, M. J. & Kelly, D., May 24 2019, In : Small. 15, 21, 1900918.

Research output: Contribution to journalArticle

Cryoelectron Microscopy
Macromolecules
Electron microscopy
Tumors
Cells

Cryo-EM Reveals Architectural Diversity in Active Rotavirus Particles

Hauser, M., Dearnaley, W., Varano, C., Casasanta, M., McDonald, S. M. & Kelly, D., Jan 1 2019, In : Computational and Structural Biotechnology Journal. 17, p. 1178-1183 6 p.

Research output: Contribution to journalArticle

Open Access
Rotavirus
Transcription
RNA
Proteins
Messenger RNA

Liquid-Cell Electron Tomography of Biological Systems

Dearnaley, W., Schleupner, B., Varano, C., Alden, N. A., Gonzalez, F., Casasanta, M. A., Scharf, B. E., Dukes, M. J. & Kelly, D., Oct 9 2019, In : Nano letters. 19, 10, p. 6734-6741 8 p.

Research output: Contribution to journalArticle

Biological systems
Tomography
Bacteriophages
pathogens
tomography
2 Citations (Scopus)

Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival

Varghese, R. T., Young, S., Pham, L., Liang, Y., Pridham, K. J., Guo, S., Murphy, S., Kelly, D. F. & Sheng, Z., Dec 1 2018, In : Scientific reports. 8, 1, 13621.

Research output: Contribution to journalArticle

Open Access
Casein Kinase Iepsilon
Glioblastoma
Cell Survival
Catenins
Stem Cells

Prizes

Innovator of the Year

Deb Kelly (Recipient), 2019

Prize

Session Chair

Deb Kelly (Recipient), 2017

Prize: Other distinction

Vice Chair

Deb Kelly (Recipient), 2019

Prize: Other distinction