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Research Output 1995 2019

  • 673 Citations
  • 16 h-Index
  • 43 Article
  • 3 Chapter
  • 1 Conference article
  • 1 Review article
2019

Correcting errors in the BRCA1 warning system

Liang, Y., Dearnaley, W. J., Alden, N. A., Solares, M. J., Gilmore, B. L., Pridham, K. J., Varano, C., Sheng, Z., Alli, E. & Kelly, D., Jan 1 2019, In : DNA Repair. 73, p. 120-128 9 p.

Research output: Contribution to journalArticle

BRCA1 Protein
Alarm systems
Repair
Biochemical Phenomena
Cells

Cryo-EM-On-a-Chip: Custom-Designed Substrates for the 3D Analysis of Macromolecules

Alden, N. A., Varano, A. C., Dearnaley, W. J., Solares, M. J., Luqiu, W. Y., Liang, Y., Sheng, Z., McDonald, S. M., Damiano, J., McConnell, J., Dukes, M. J. & Kelly, D. F., May 24 2019, In : Small. 15, 21, 1900918.

Research output: Contribution to journalArticle

Cryoelectron Microscopy
Macromolecules
Electron microscopy
Tumors
Cells

Cryo-EM Reveals Architectural Diversity in Active Rotavirus Particles

Hauser, M., Dearnaley, W., Varano, C., Casasanta, M., McDonald, S. M. & Kelly, D., Jan 1 2019, In : Computational and Structural Biotechnology Journal. 17, p. 1178-1183 6 p.

Research output: Contribution to journalArticle

Open Access
Rotavirus
Transcription
RNA
Proteins
Messenger RNA

Liquid-Cell Electron Tomography of Biological Systems

Dearnaley, W., Schleupner, B., Varano, C., Alden, N. A., Gonzalez, F., Casasanta, M. A., Scharf, B. E., Dukes, M. J. & Kelly, D., Oct 9 2019, In : Nano letters. 19, 10, p. 6734-6741 8 p.

Research output: Contribution to journalArticle

Biological systems
Tomography
Bacteriophages
pathogens
tomography
2018
2 Citations (Scopus)

Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival

Varghese, R. T., Young, S., Pham, L., Liang, Y., Pridham, K. J., Guo, S., Murphy, S., Kelly, D. F. & Sheng, Z., Dec 1 2018, In : Scientific reports. 8, 1, 13621.

Research output: Contribution to journalArticle

Open Access
Casein Kinase Iepsilon
Glioblastoma
Cell Survival
Catenins
Stem Cells
11 Citations (Scopus)

PIK3CB/p110β is a selective survival factor for glioblastoma

Pridham, K. J., Le, L., Guo, S., Varghese, R. T., Algino, S., Liang, Y., Fajardin, R., Rodgers, C. M., Simonds, G. R., Kelly, D. & Sheng, Z., Mar 27 2018, In : Neuro-oncology. 20, 4, p. 494-505 12 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Glioblastoma
Survival
Protein Isoforms
Cell Survival
1 Citation (Scopus)

Preparation of tunable microchips to visualize native protein complexes for single-particle electron microscopy

Gilmore, B. L., Varano, C., Dearnaley, W., Liang, Y., Marcinkowski, B. C., Dukes, M. J. & Kelly, D., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 45-58 14 p. (Methods in Molecular Biology; vol. 1764).

Research output: Chapter in Book/Report/Conference proceedingChapter

Electron Microscopy
Proteins
Technology
Lipids
silicon nitride
2017
6 Citations (Scopus)

Molecular Analysis of BRCA1 in Human Breast Cancer Cells under Oxidative Stress

Gilmore, B. L., Liang, Y., Winton, C. E., Patel, K., Karageorge, V., Varano, A. C., Dearnaley, W., Sheng, Z. & Kelly, D. F., Mar 6 2017, In : Scientific reports. 7, 43435.

Research output: Contribution to journalArticle

Open Access
Oxidative Stress
Breast Neoplasms
BRCA1 Protein
Molecular Imaging
Genomic Instability

Preparation of disease-related protein assemblies for single particle electron microscopy

Cameron Varano, A., Harafuji, N., Dearnaley, W., Guay-Woodford, L. & Kelly, D. F., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 185-196 12 p. (Methods in Molecular Biology; vol. 1647).

Research output: Chapter in Book/Report/Conference proceedingChapter

Electron Microscopy
Proteins
Histidine
Cell Line
7 Citations (Scopus)

Real-time observation of protein aggregates in pharmaceutical formulations using liquid cell electron microscopy

DiMemmo, L. M., Cameron Varano, A., Haulenbeek, J., Liang, Y., Patel, K., Dukes, M. J., Zheng, S., Hubert, M., Piccoli, S. P. & Kelly, D. F., Jan 1 2017, In : Lab on a Chip. 17, 2, p. 315-322 8 p.

Research output: Contribution to journalArticle

Drug Compounding
Drug products
Electron microscopy
Electron Microscopy
Observation
3 Citations (Scopus)

Structural analysis of BRCA1 reveals modification hotspot

Liang, Y., Dearnaley, W. J., Cameron Varano, A., Winton, C. E., Gilmore, B. L., Alden, N. A., Sheng, Z. & Kelly, D. F., Jan 1 2017, In : Science Advances. 3, 9, 1701386.

Research output: Contribution to journalArticle

Open Access
BRCA1 Protein
Breast Neoplasms
Genomic Instability
Ubiquitination
Ubiquitin
2016
5 Citations (Scopus)

A microchip platform for structural oncology applications

Winton, C. E., Gilmore, B. L., Demmert, A. C., Karageorge, V., Sheng, Z. & Kelly, D., Dec 14 2016, In : npj Breast Cancer. 2, 1, 16016.

Research output: Contribution to journalArticle

Open Access
BRCA1 Protein
BRCA1 Gene
Cryoelectron Microscopy
Mutation
RNA Polymerase II
16 Citations (Scopus)

Patient-derived glioblastoma stem cells respond differentially to targeted therapies

Kanabur, P., Guo, S., Simonds, G. R., Kelly, D. F., Gourdie, R. G., Verbridge, S. S. & Sheng, Z., Jan 1 2016, In : Oncotarget. 7, 52, p. 86406-86419 14 p.

Research output: Contribution to journalArticle

Open Access
Glioblastoma
Stem Cells
Therapeutics
temozolomide
Cell Line
12 Citations (Scopus)

Prolonged particulate hexavalent chromium exposure suppresses homologous recombination repair in human lung cells

Browning, C. L., Qin, Q., Kelly, D. F., Prakash, R., Vanoli, F., Jasin, M. & Wise, J. P., Sep 1 2016, In : Toxicological Sciences. 153, 1, p. 70-78 9 p.

Research output: Contribution to journalArticle

Open Access
Recombinational DNA Repair
Repair
Lung
Chromosomal Instability
Double-Stranded DNA Breaks
22 Citations (Scopus)

Survival kinase genes present prognostic significance in glioblastoma

Varghese, R. T., Liang, Y., Guan, T., Franck, C. T., Kelly, D. F. & Sheng, Z., Apr 12 2016, In : Oncotarget. 7, 15, p. 20140-20151 12 p.

Research output: Contribution to journalArticle

Open Access
Glioblastoma
Phosphotransferases
Genes
temozolomide
Recurrence
2015
6 Citations (Scopus)

A Molecular Toolkit to Visualize Native Protein Assemblies in the Context of Human Disease

Gilmore, B. L., Winton, C. E., Demmert, A. C., Tanner, J. R., Bowman, S., Karageorge, V., Patel, K., Sheng, Z. & Kelly, D. F., Sep 23 2015, In : Scientific reports. 5, 14440.

Research output: Contribution to journalArticle

Open Access
BRCA1 Gene
Microscopy
Proteins
Neoplasms
57 Citations (Scopus)

A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications

Guo, S., Liang, Y., Murphy, S. F., Huang, A., Shen, H., Kelly, D. F., Sobrado, P. & Sheng, Z., Jan 1 2015, In : Autophagy. 11, 3, p. 560-572 13 p.

Research output: Contribution to journalArticle

Open Access
Autophagy
Fluorescence
RNA Interference
Coloring Agents
Endosomes
8 Citations (Scopus)

Electron microscopic analysis of rotavirus assembly-replication intermediates

Boudreaux, C. E., Kelly, D. & McDonald, S. M., Mar 1 2015, In : Virology. 477, p. 32-41 10 p.

Research output: Contribution to journalArticle

Open Access
Rotavirus
Viral RNA
Electrons
Proteins
Subcellular Fractions
2 Citations (Scopus)

Real-time imaging of lead nanoparticles in solution-determination of the growth mechanism

Delach, D. L., Dukes, M. J., Varano, C., Kelly, D. & Dukes, A. D., Jan 1 2015, In : RSC Advances. 5, 126, p. 104193-104197 5 p.

Research output: Contribution to journalArticle

Nanoparticles
Imaging techniques
Lead
Ostwald ripening
Electron microscopy
23 Citations (Scopus)

Real-Time Visualization of Nanoparticles Interacting with Glioblastoma Stem Cells

Pohlmann, E. S., Patel, K., Guo, S., Dukes, M. J., Sheng, Z. & Kelly, D., Apr 8 2015, In : Nano letters. 15, 4, p. 2329-2335 7 p.

Research output: Contribution to journalArticle

stem cells
Stem cells
Visualization
Nanoparticles
nanoparticles
13 Citations (Scopus)

Visualizing virus particle mobility in liquid at the nanoscale

Cameron Varano, A., Rahimi, A., Dukes, M. J., Poelzing, S., McDonald, S. M. & Kelly, D. F., Sep 4 2015, In : Chemical Communications. 51, 90, p. 16176-16179 4 p.

Research output: Contribution to journalArticle

Open Access
Viruses
Imaging techniques
Liquids
Electron microscopes
2014
1 Citation (Scopus)

Applications and design of reinforced silicon nitride windows for in situ liquid transmission electron microscopy

Dukes, M. J., Dukes, A. D., Klein, K. L., Thomas, R., Kelly, D. F. & Damiano, J., Aug 1 2014, In : Microscopy and Microanalysis. 20, 3, p. 1090-1091 2 p.

Research output: Contribution to journalConference article

Open Access
Silicon nitride
silicon nitrides
Transmission electron microscopy
transmission electron microscopy
Liquids
8 Citations (Scopus)

Capturing enveloped viruses on affinity grids for downstream cryo-electron microscopy applications

Kiss, G., Chen, X., Brindley, M. A., Campbell, P., Afonso, C. L., Ke, Z., Holl, J. M., Guerrero-Ferreira, R. C., Byrd-Leotis, L. A., Steel, J., Steinhauer, D. A., Plemper, R. K., Kelly, D. F., Spearman, P. W. & Wright, E. R., Feb 2014, In : Microscopy and Microanalysis. 20, 1, p. 164-174 11 p.

Research output: Contribution to journalArticle

viruses
Viruses
Electron microscopy
affinity
electron microscopy
11 Citations (Scopus)

Improved microchip design and application for in situ transmission electron microscopy of macromolecules

Dukes, M. J., Thomas, R., Damiano, J., Klein, K. L., Balasubramaniam, S., Kayandan, S., Riffle, J. S., Davis, R. M., McDonald, S. M. & Kelly, D., Jan 1 2014, In : Microscopy and Microanalysis. 20, 2, p. 338-345 8 p.

Research output: Contribution to journalArticle

Macromolecules
macromolecules
Transmission electron microscopy
transmission electron microscopy
reagents
7 Citations (Scopus)

Manganese graft ionomer complexes (MaGICs) for dual imaging and chemotherapy

Pothayee, N., Pothayee, N., Hu, N., Zhang, R., Kelly, D., Koretsky, A. P. & Riffle, J. S., Feb 28 2014, In : Journal of Materials Chemistry B. 2, 8, p. 1087-1099 13 p.

Research output: Contribution to journalArticle

Chemotherapy
Ionomers
Manganese
Grafts
Imaging techniques
40 Citations (Scopus)

Toward design of magnetic nanoparticle clusters stabilized by biocompatible diblock copolymers for T 2-weighted MRI contrast

Balasubramaniam, S., Kayandan, S., Lin, Y. N., Kelly, D. F., House, M. J., Woodward, R. C., St. Pierre, T. G., Riffle, J. S. & Davis, R. M., Feb 18 2014, In : Langmuir. 30, 6, p. 1580-1587 8 p.

Research output: Contribution to journalArticle

Iron oxides
Magnetic resonance imaging
Block copolymers
copolymers
iron oxides
2013
21 Citations (Scopus)

Affinity grid-based cryo-EM of PKC binding to RACK1 on the ribosome

Sharma, G., Pallesen, J., Das, S., Grassucci, R., Langlois, R., Hampton, C. M., Kelly, D., des Georges, A. & Frank, J., Feb 1 2013, In : Journal of Structural Biology. 181, 2, p. 190-194 5 p.

Research output: Contribution to journalArticle

Ribosomes
Small Ribosome Subunits
Macromolecular Substances
Proteins
4 Citations (Scopus)

In situ TEM of biological assemblies in liquid.

Dukes, M. J., Gilmore, B. L., Tanner, J. R., McDonald, S. M. & Kelly, D., Jan 1 2013, In : Journal of visualized experiments : JoVE. 82, 1 p.

Research output: Contribution to journalArticle

Microfluidics
Electron microscopes
Electrons
Virus Assembly
Rotavirus
2 Citations (Scopus)

Molecular surveillance of viral processes using silicon nitride membranes

Gilmore, B. L., Tanner, J. R., McKell, A. O., Boudreaux, C. E., Dukes, M. J., McDonald, S. M. & Kelly, D. F., Oct 14 2013, In : Micromachines. 4, 1, p. 90-102 13 p.

Research output: Contribution to journalArticle

Open Access
Silicon nitride
Membranes
Electron microscopy
Carbon films
RNA
10 Citations (Scopus)

Rotavirus core shell subdomains involved in polymerase encapsidation into virus-like particles

Boudreaux, C. E., Vile, D. C., Gilmore, B. L., Tanner, J. R., Kelly, D. F. & McDonald, S. M., Aug 1 2013, In : Journal of General Virology. 94, PART8, p. 1818-1826 9 p.

Research output: Contribution to journalArticle

Open Access
Rotavirus
Virion
Product Packaging
Genome
RNA
17 Citations (Scopus)

Visualizing nanoparticle mobility in liquid at atomic resolution

Dukes, M. J., Jacobs, B. W., Morgan, D. G., Hegde, H. & Kelly, D. F., Apr 14 2013, In : Chemical Communications. 49, 29, p. 3007-3009 3 p.

Research output: Contribution to journalArticle

Open Access
Nanorods
Nanoparticles
Liquids
High resolution transmission electron microscopy
Gold
28 Citations (Scopus)

Visualizing viral assemblies in a nanoscale biosphere

Gilmore, B. L., Showalter, S. P., Dukes, M. J., Tanner, J. R., Demmert, A. C., McDonald, S. M. & Kelly, D., Jan 21 2013, In : Lab on a Chip. 13, 2, p. 216-219 4 p.

Research output: Contribution to journalArticle

Virus Assembly
Microfluidics
Rotavirus
Fluidics
Vacuum
2012
3 Citations (Scopus)

Capturing RNA-dependent pathways for cryo-EM analysis

Tanner, J. R., Degen, K., Gilmore, B. L. & Kelly, D. F., Apr 2012, In : Computational and Structural Biotechnology Journal. 1, 1, p. e201204003 a7.

Research output: Contribution to journalArticle

Open Access
Cryoelectron Microscopy
Biological Phenomena
Molecular Imaging
Bacterial Proteins
RNA
16 Citations (Scopus)

The development of affinity capture devices - A nanoscale purification platform for biological in situ transmission electron microscopy

Degen, K., Dukes, M., Tanner, J. R. & Kelly, D., Mar 14 2012, In : RSC Advances. 2, 6, p. 2408-2412 5 p.

Research output: Contribution to journalArticle

Purification
Transmission electron microscopy
Molecular imaging
Imaging techniques
Silicon nitride
2011
1 Citation (Scopus)

Fast and easy protocol for the purification of recombinant S-layer protein for synthetic biology applications

Norville, J. E., Kelly, D., Knight, T. F., Belcher, A. M. & Walz, T., Jul 1 2011, In : Biotechnology Journal. 6, 7, p. 807-811 5 p.

Research output: Contribution to journalArticle

Synthetic Biology
Divalent Cations
Biocompatible Materials
Proteins
S-layer proteins
11 Citations (Scopus)

The use of trehalose in the preparation of specimens for molecular electron microscopy

Chiu, P. L., Kelly, D. & Walz, T., Dec 1 2011, In : Micron. 42, 8, p. 762-772 11 p.

Research output: Contribution to journalReview article

Trehalose
Electron Microscopy
Electrons
Multiprotein Complexes
Negative Staining
2010
17 Citations (Scopus)

A practical guide to the use of monolayer purification and affinity grids

Kelly, D., Dukovski, D. & Walz, T., Jan 1 2010, Methods in Enzymology. C ed. Academic Press Inc., p. 83-107 25 p. (Methods in Enzymology; vol. 481, no. C).

Research output: Chapter in Book/Report/Conference proceedingChapter

Purification
Monolayers
Electron Microscopy
Lipids
Electron microscopy
25 Citations (Scopus)

Molecular structure and dimeric organization of the notch extracellular domain as revealed by electron microscopy

Kelly, D. F., Lake, R. J., Middelkoop, T. C., Fan, H. Y., Artavanis-Tsakonas, S. & Walz, T., Sep 14 2010, In : PloS one. 5, 5, e10532.

Research output: Contribution to journalArticle

Open Access
Molecular Structure
chemical structure
Molecular structure
Electron microscopy
Conformations
24 Citations (Scopus)

Strategy for the use of affinity grids to prepare non-his-tagged macromolecular complexes for single-particle electron microscopy

Kelly, D. F., Dukovski, D. & Walz, T., Jul 1 2010, In : Journal of Molecular Biology. 400, 4, p. 675-681 7 p.

Research output: Contribution to journalArticle

Macromolecular Substances
Electron Microscopy
Cell Extracts
Staphylococcal Protein A
HEK293 Cells
2009
6 Citations (Scopus)

Structural and functional studies on the stalk of the transferrin receptor

Dukovski, D., Li, Z., Kelly, D., Mack, E. & Walz, T., Apr 17 2009, In : Biochemical and Biophysical Research Communications. 381, 4, p. 712-716 5 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Transferrin
Iron
Electron microscopy
Electron Microscopy
2008
49 Citations (Scopus)
Open Access
Ribosome Subunits
Electron Microscopy
Transferrin Receptors
Transferrin
Macromolecular Substances
41 Citations (Scopus)

The Affinity Grid: A Pre-fabricated EM Grid for Monolayer Purification

Kelly, D., Abeyrathne, P. D., Dukovski, D. & Walz, T., Oct 3 2008, In : Journal of Molecular Biology. 382, 2, p. 423-433 11 p.

Research output: Contribution to journalArticle

Ribosome Subunits
Electron Microscopy
Lipids
Detergents
Escherichia coli
2007
36 Citations (Scopus)

7 Å projection map of the S-layer protein sbpA obtained with trehalose-embedded monolayer crystals

Norville, J. E., Kelly, D., Knight, T. F., Belcher, A. M. & Walz, T., Dec 1 2007, In : Journal of Structural Biology. 160, 3, p. 313-323 11 p.

Research output: Contribution to journalArticle

Trehalose
Lipids
Electron Microscopy
Protein Array Analysis
Nanotechnology
9 Citations (Scopus)

Conformational variability of the intracellular domain of Drosophila Notch and its interaction with Suppressor of Hairless

Kelly, D., Lake, R. J., Walz, T. & Artavanis-Tsakonas, S., Jun 5 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 23, p. 9591-9596 6 p.

Research output: Contribution to journalArticle

Open Access
Notch Receptors
Intracellular Membranes
Divalent Cations
Drosophila
Signal Transduction
16 Citations (Scopus)

On the freezing and identification of lipid monolayer 2-D arrays for cryoelectron microscopy

Taylor, D. W., Kelly, D., Cheng, A. & Taylor, K. A., Dec 1 2007, In : Journal of Structural Biology. 160, 3, p. 305-312 8 p.

Research output: Contribution to journalArticle

Cryoelectron Microscopy
Freezing
Lipids
Three-Dimensional Imaging
Protein Array Analysis
2006
31 Citations (Scopus)

Structure of the α-actinin-vinculin head domain complex determined by cryo-electron microscopy

Kelly, D. F., Taylor, D. W., Bakolitsa, C., Bobkov, A. A., Bankston, L., Liddington, R. C. & Taylor, K. A., Mar 24 2006, In : Journal of Molecular Biology. 357, 2, p. 562-573 12 p.

Research output: Contribution to journalArticle

Vinculin
Cryoelectron Microscopy
Actinin
Calmodulin
Binding Sites
2005
27 Citations (Scopus)

Identification of the β1-integrin binding site on α-actinin by cryoelectron microscopy

Kelly, D. F. & Taylor, K. A., Mar 2005, In : Journal of Structural Biology. 149, 3, p. 290-302 13 p.

Research output: Contribution to journalArticle

Cryoelectron Microscopy
Actinin
Integrins
Binding Sites
Nickel
1995
18 Citations (Scopus)

Activation of transfer RNA-guanine ribosyltransferase by protein kinase C

Morris, R. C., Brooks, B. J., Eriotou, P., Kelly, D. F., Sagar, S., Lenore Hart, K. & Elliott, M. S., Jul 11 1995, In : Nucleic acids research. 23, 13, p. 2492-2498 7 p.

Research output: Contribution to journalArticle

Guanine
Transfer RNA
Protein Kinase C
Phosphoric Monoester Hydrolases
Phosphorylation