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Personal profile

Research interests

Dr. Dhimant Desai’s research interest is to study the structural activity relationship of organic chemopreventive and chemotherapeutic agents against cancers of colon, lung, melanoma, and leukemia. He specializes in micro- and macro-scale organic and bio-organic syntheses of carbocyclic nucleosides, carcinogens, chemopreventive and chemotherapeutic agents including organoselenium compounds, cytodifferentiating agents and nitric oxide inhibitors. The focus of his research is on the synthesis of carcinogenic polycyclic aromatic hydrocarbons (PAH’s), tobacco-specific N-nitrosamines, their metabolites, and adducts and further extends his research in the Animal Bioassays (studies in mice, rats, hamster), and isotopic and radiochemical preparations, animal tissue distribution studies, in vitro studies with synthetic standards, including 14C, 2H and 3H-labeled compounds. Dr. Desai has published more than 161 publications in peer reviewed journals. Recently completed NCI funded project as PI, Dr. Desai has focused on the prevention and treatment of colon cancer by selenium containing COX-2 inhibitor. In another recently funded project by Tobacco settlement fund, Dr. Desai has investigated PK/PD studies of PAN-antiviral agent in the treatment of HCMV infections. Dr. Desai is also involved in the research on gut microbiota and metabolomics studies with bile acid analogs in the treatment of non-fatty liver disease, COPD and asthma.

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Projects 2009 2016

Celecoxib
Cyclooxygenase 2 Inhibitors
Chemoprevention
Colonic Neoplasms
Inbred F344 Rats
Chemoprevention
Colonic Neoplasms
Phosphatidylinositol 3-Kinases
Neoplasms
Selenium

Research Output 1986 2019

  • 4009 Citations
  • 35 h-Index
  • 147 Article
  • 3 Review article
  • 2 Comment/debate
  • 1 Short survey

Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity

Ding, Y., Zhang, B., Payne, J. L., Song, C., Ge, Z., Gowda, C., Iyer, S., Dhanyamraju, P. K., Dorsam, G., Reeves, M. E., Desai, D., Huang, S., Payne, K. J., Yue, F. & Dovat, S., Jan 1 2019, In : Leukemia.

Research output: Contribution to journalArticle

Open Access
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
T-Lymphocytes
Epigenomics
Chromatin
Cell Differentiation

Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors

Desai, D., Lauver, M., Ostman, A., Cruz, L., Ferguson, K., Jin, G., Roper, B., Brosius, D., Lukacher, A., Amin, S. & Buchkovich, N., May 1 2019, In : Bioorganic and Medicinal Chemistry. 27, 9, p. 1795-1803 9 p.

Research output: Contribution to journalArticle

Viruses
Polyomavirus
Stem Cell Transplantation
Stem cells
Cytomegalovirus

Monoclonal Antibodies for the Detection of a Specific Cyclic DNA Adduct Derived from ω-6 Polyunsaturated Fatty Acids

Dyba, M., Da Silva, B., Coia, H., Hou, Y., Noguchi, S., Pan, J., Berry, D., Creswell, K., Krzeminski, J., Desai, D., Amin, S., Yang, D. & Chung, F. L., Aug 20 2018, In : Chemical Research in Toxicology. 31, 8, p. 772-783 12 p.

Research output: Contribution to journalArticle

DNA Adducts
Unsaturated Fatty Acids
Monoclonal Antibodies
Deoxyguanosine
Tissue
7 Citations (Scopus)

AFB1 hepatocarcinogenesis is via lipid peroxidation that inhibits DNA repair, sensitizes mutation susceptibility and induces aldehyde-DNA adducts at p53 mutational hotspot codon 249

Weng, M. W., Lee, H. W., Choi, B., Wang, H. T., Hu, Y., Mehta, M., Desai, D., Amin, S., Zheng, Y. & Tang, M. S., Jan 1 2017, In : Oncotarget. 8, 11, p. 18213-18226 14 p.

Research output: Contribution to journalArticle

Aflatoxin B1
DNA Adducts
Aldehydes
Codon
DNA Repair
5 Citations (Scopus)

Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin

Smith, K. J., Boyer, J. A., Muku, G. E., Murray, I. A., Gowda, K., Desai, D., Amin, S., Glick, A. B. & Perdew, G. H., Jan 1 2017, In : Toxicological Sciences. 160, 1, p. 83-94 12 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Neutrophil Activation
Chemotactic Factors
Keratinocytes
Skin