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Personal profile

Research interests

Dr. Dhimant Desai’s research interest is to study the structural activity relationship of organic chemopreventive and chemotherapeutic agents against cancers of colon, lung, melanoma and leukemia. He specializes in micro- and macro-scale organic and bio-organic syntheses of carbocyclic nucleosides, carcinogens, chemopreventive and chemotherapeutic agents including organoselenium compounds, cytodifferentiating agents and nitric oxide inhibitors.

The focus of Dr. Desai's research is on the synthesis of carcinogenic polycyclic aromatic hydrocarbons, tobacco-specific N-nitrosamines and their metabolites and adducts. It further extends his research in animal bioassays (studies in mice, rats, hamsters); isotopic and radiochemical preparations; animal tissue distribution studies; and in vitro studies with synthetic standards, including 14C, 2H and 3H-labeled compounds.

Dr. Desai has focused on the prevention and treatment of colon cancer by selenium-containing COX-2 inhibitors. In another recently funded project, Dr. Desai has investigated PK/PD studies of PAN-antiviral agent in the treatment of HCMV infections. He is also involved in the research on gut microbiota and metabolomics studies with bile acid analogs in the treatment of non-fatty liver disease, COPD and asthma.

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Selenium Medicine & Life Sciences
Lung Medicine & Life Sciences
Carcinogenesis Medicine & Life Sciences
Tobacco Medicine & Life Sciences
Nitrosamines Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Metabolites Chemical Compounds
Carcinogens Medicine & Life Sciences

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Projects 2009 2016

Celecoxib
Cyclooxygenase 2 Inhibitors
Chemoprevention
Colonic Neoplasms
Inbred F344 Rats
Chemoprevention
Colonic Neoplasms
Phosphatidylinositol 3-Kinases
Neoplasms
Selenium

Research Output 1986 2019

  • 4052 Citations
  • 35 h-Index
  • 148 Article
  • 3 Review article
  • 2 Comment/debate
  • 1 Short survey

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Tan, S. F., Dunton, W., Liu, X., Fox, T. E., Morad, S. A. F., Desai, D., Doi, K., Conaway, M. R., Amin, S., Claxton, D., Wang, H. G., Kester, M., Cabot, M. C., Feith, D. J. & Loughran, T. P., Jan 1 2019, In : Journal of Lipid Research. 60, 6, p. 1078-1086 9 p.

Research output: Contribution to journalArticle

Acid Ceramidase
P-Glycoprotein
Drug Resistance
Acute Myeloid Leukemia
Up-Regulation

Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity

Ding, Y., Zhang, B., Payne, J. L., Song, C., Ge, Z., Gowda, C., Iyer, S., Dhanyamraju, P. K., Dorsam, G., Reeves, M. E., Desai, D., Huang, S., Payne, K. J., Yue, F. & Dovat, S., Jan 1 2019, In : Leukemia.

Research output: Contribution to journalArticle

Open Access
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
T-Lymphocytes
Epigenomics
Chromatin
Cell Differentiation

Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors

Desai, D., Lauver, M., Ostman, A., Cruz, L., Ferguson, K., Jin, G., Roper, B., Brosius, D., Lukacher, A., Amin, S. & Buchkovich, N., May 1 2019, In : Bioorganic and Medicinal Chemistry. 27, 9, p. 1795-1803 9 p.

Research output: Contribution to journalArticle

Viruses
Polyomavirus
Stem Cell Transplantation
Stem cells
Cytomegalovirus

Monoclonal Antibodies for the Detection of a Specific Cyclic DNA Adduct Derived from ω-6 Polyunsaturated Fatty Acids

Dyba, M., Da Silva, B., Coia, H., Hou, Y., Noguchi, S., Pan, J., Berry, D., Creswell, K., Krzeminski, J., Desai, D., Amin, S., Yang, D. & Chung, F. L., Aug 20 2018, In : Chemical Research in Toxicology. 31, 8, p. 772-783 12 p.

Research output: Contribution to journalArticle

DNA Adducts
Unsaturated Fatty Acids
Monoclonal Antibodies
Deoxyguanosine
Tissue
8 Citations (Scopus)

AFB1 hepatocarcinogenesis is via lipid peroxidation that inhibits DNA repair, sensitizes mutation susceptibility and induces aldehyde-DNA adducts at p53 mutational hotspot codon 249

Weng, M. W., Lee, H. W., Choi, B., Wang, H. T., Hu, Y., Mehta, M., Desai, D., Amin, S., Zheng, Y. & Tang, M. S., Jan 1 2017, In : Oncotarget. 8, 11, p. 18213-18226 14 p.

Research output: Contribution to journalArticle

Aflatoxin B1
DNA Adducts
Aldehydes
Codon
DNA Repair