• 4284 Citations
  • 35 h-Index
1986 …2020

Research output per year

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Personal profile

Research interests

Dr. Dhimant Desai’s research interest is to study the structural activity relationship of organic chemopreventive and chemotherapeutic agents against cancers of colon, lung, melanoma and leukemia. He specializes in micro- and macro-scale organic and bio-organic syntheses of carbocyclic nucleosides, carcinogens, chemopreventive and chemotherapeutic agents including organoselenium compounds, cytodifferentiating agents and nitric oxide inhibitors.

The focus of Dr. Desai's research is on the synthesis of carcinogenic polycyclic aromatic hydrocarbons, tobacco-specific N-nitrosamines and their metabolites and adducts. It further extends his research in animal bioassays (studies in mice, rats, hamsters); isotopic and radiochemical preparations; animal tissue distribution studies; and in vitro studies with synthetic standards, including 14C, 2H and 3H-labeled compounds.

Dr. Desai has focused on the prevention and treatment of colon cancer by selenium-containing COX-2 inhibitors. In another recently funded project, Dr. Desai has investigated PK/PD studies of PAN-antiviral agent in the treatment of HCMV infections. He is also involved in the research on gut microbiota and metabolomics studies with bile acid analogs in the treatment of non-fatty liver disease, COPD and asthma.

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Projects

  • Research Output

    • 4284 Citations
    • 35 h-Index
    • 153 Article
    • 3 Review article
    • 2 Comment/debate
    • 1 Short survey

    Ceramide analogue SACLAC modulates sphingolipid levels and MCL-1 splicing to induce apoptosis in acute myeloid leukemia

    Pearson, J. M., Tan, S. F., Sharma, A., Annageldiyev, C., Fox, T. E., Abad, J. L., Fabrias, G., Desai, D., Amin, S., Wang, H. G., Cabot, M. C., Claxton, D. F., Kester, M., Feith, D. J. & Loughran, T. P., Jan 1 2020, In : Molecular Cancer Research. 18, 3, p. 352-363 12 p.

    Research output: Contribution to journalArticle

  • Regulation of small GTPase Rab20 by ikaros in B-cell acute lymphoblastic leukemia

    Payne, J. L., Song, C., Ding, Y., Dhanyamraju, P. K., Bamme, Y., Schramm, J. W., Desai, D., Sharma, A., Gowda, C. & Dovat, S., Mar 1 2020, In : International journal of molecular sciences. 21, 5, 1718.

    Research output: Contribution to journalArticle

    Open Access
  • The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia

    Annageldiyev, C., Gowda, K., Patel, T., Bhattacharya, P., Tan, S. F., Iyer, S., Desai, D., Dovat, S., Feith, D. J., Loughran, T. P., Amin, S., Claxton, D. & Sharma, A., Mar 1 2020, In : Haematologica. 105, 3, p. 687-696 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

    Tan, S. F., Dunton, W., Liu, X., Fox, T. E., Morad, S. A. F., Desai, D., Doi, K., Conaway, M. R., Amin, S., Claxton, D. F., Wang, H. G., Kester, M., Cabot, M. C., Feith, D. J. & Loughran, T. P., Jan 1 2019, In : Journal of Lipid Research. 60, 6, p. 1078-1086 9 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresposiveness by inhibiting UPR transducers

    Nakada, E. M., Bhakta, N. R., Korwin-Mihavics, B. R., Kumar, A., Chamberlain, N., Bruno, S. R., Chapman, D. G., Hoffman, S. M., Daphtary, N., Aliyeva, M., Irvin, C. G., Dixon, A. E., Woodruff, P. G., Amin, S., Poynter, M. E., Desai, D. H. & Anathy, V., Jan 1 2019, In : JCI Insight. 4, 9, e98101.

    Research output: Contribution to journalArticle

    Open Access
  • 4 Scopus citations