• 4349 Citations
  • 36 h-Index
1986 …2020

Research output per year

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Research Output

  • 4349 Citations
  • 36 h-Index
  • 154 Article
  • 3 Review article
  • 2 Comment/debate
  • 1 Short survey
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Article
2020

Ceramide analogue SACLAC modulates sphingolipid levels and MCL-1 splicing to induce apoptosis in acute myeloid leukemia

Pearson, J. M., Tan, S. F., Sharma, A., Annageldiyev, C., Fox, T. E., Abad, J. L., Fabrias, G., Desai, D., Amin, S., Wang, H. G., Cabot, M. C., Claxton, D. F., Kester, M., Feith, D. J. & Loughran, T. P., Jan 1 2020, In : Molecular Cancer Research. 18, 3, p. 352-363 12 p.

Research output: Contribution to journalArticle

Regulation of small GTPase Rab20 by ikaros in B-cell acute lymphoblastic leukemia

Payne, J. L., Song, C., Ding, Y., Dhanyamraju, P. K., Bamme, Y., Schramm, J. W., Desai, D., Sharma, A., Gowda, C. & Dovat, S., Mar 1 2020, In : International journal of molecular sciences. 21, 5, 1718.

Research output: Contribution to journalArticle

Open Access

The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia

Annageldiyev, C., Gowda, K., Patel, T., Bhattacharya, P., Tan, S. F., Iyer, S., Desai, D., Dovat, S., Feith, D. J., Loughran, T. P., Amin, S., Claxton, D. & Sharma, A., Mar 1 2020, In : Haematologica. 105, 3, p. 687-696 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia

Annageldiyev, C., Tan, S. F., Thakur, S., Dhanyamraju, P. K., Ramisetti, S. R., Bhadauria, P., Schick, J., Zeng, Z., Sharma, V., Dunton, W., Dovat, S., Desai, D., Zheng, H., Feith, D. J., Loughran, T. P., Amin, S., Sharma, A. K., Claxton, D. & Sharma, A., Apr 1 2020, In : Frontiers in Oncology. 10, 393.

Research output: Contribution to journalArticle

Open Access
2019

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Tan, S. F., Dunton, W., Liu, X., Fox, T. E., Morad, S. A. F., Desai, D., Doi, K., Conaway, M. R., Amin, S., Claxton, D. F., Wang, H. G., Kester, M., Cabot, M. C., Feith, D. J. & Loughran, T. P., Jan 1 2019, In : Journal of Lipid Research. 60, 6, p. 1078-1086 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresposiveness by inhibiting UPR transducers

Nakada, E. M., Bhakta, N. R., Korwin-Mihavics, B. R., Kumar, A., Chamberlain, N., Bruno, S. R., Chapman, D. G., Hoffman, S. M., Daphtary, N., Aliyeva, M., Irvin, C. G., Dixon, A. E., Woodruff, P. G., Amin, S., Poynter, M. E., Desai, D. H. & Anathy, V., Jan 1 2019, In : JCI Insight. 4, 9, e98101.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2 Scopus citations

Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity

Ding, Y., Zhang, B., Payne, J. L., Song, C., Ge, Z., Gowda, C., Iyer, S., Dhanyamraju, P. K., Dorsam, G., Reeves, M. E., Desai, D., Huang, S., Payne, K. J., Yue, F. & Dovat, S., Nov 1 2019, In : Leukemia. 33, 11, p. 2720-2731 12 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors

Desai, D., Lauver, M., Ostman, A., Cruz, L., Ferguson, K., Jin, G., Roper, B., Brosius, D., Lukacher, A., Amin, S. & Buchkovich, N., May 1 2019, In : Bioorganic and Medicinal Chemistry. 27, 9, p. 1795-1803 9 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Monoclonal Antibodies for the Detection of a Specific Cyclic DNA Adduct Derived from ω-6 Polyunsaturated Fatty Acids

Dyba, M., Da Silva, B., Coia, H., Hou, Y., Noguchi, S., Pan, J., Berry, D., Creswell, K., Krzeminski, J., Desai, D., Amin, S., Yang, D. & Chung, F. L., Aug 20 2018, In : Chemical research in toxicology. 31, 8, p. 772-783 12 p.

Research output: Contribution to journalArticle

2017

AFB1 hepatocarcinogenesis is via lipid peroxidation that inhibits DNA repair, sensitizes mutation susceptibility and induces aldehyde-DNA adducts at p53 mutational hotspot codon 249

Weng, M. W., Lee, H. W., Choi, B., Wang, H. T., Hu, Y., Mehta, M., Desai, D., Amin, S., Zheng, Y. & Tang, M. S., Jan 1 2017, In : Oncotarget. 8, 11, p. 18213-18226 14 p.

Research output: Contribution to journalArticle

15 Scopus citations

Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin

Smith, K. J., Boyer, J. A., Muku, G. E., Murray, I. A., Gowda, K., Desai, D., Amin, S. G., Glick, A. B. & Perdew, G. H., Jan 1 2017, In : Toxicological Sciences. 160, 1, p. 83-94 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Inhibition of retrograde transport limits polyomavirus infection in vivo

Maru, S., Jin, G., Desai, D., Amin, S., Shwetank, Lauver, M. D. & Lukacher, A. E., Nov 1 2017, In : mSphere. 2, 6, e00494-17.

Research output: Contribution to journalArticle

8 Scopus citations

Potent inhibition of human cytomegalovirus by modulation of cellular SNARE syntaxin 5

Cruz, L., Streck, N. T., Ferguson, K., Desai, T., Desai, D. H., Amin, S. G. & Buchkovich, N. J., Jan 1 2017, In : Journal of virology. 91, 1, e01637-16.

Research output: Contribution to journalArticle

11 Scopus citations

Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer

Morad, S. A. F., Davis, T. S., MacDougall, M. R., Tan, S. F., Feith, D. J., Desai, D. H., Amin, S. G., Kester, M., Loughran, T. P. & Cabot, M. C., Apr 15 2017, In : Biochemical Pharmacology. 130, p. 21-33 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models

Hengst, J., Dick, T. E., Sharma, A., Doi, K., Hegde, S., Tan, S. F., Geffert, L., Fox, T. E., Sharma, A. K., Desai, D., Amin, S., Kester, M., Loughran, T. P., Paulson, R., Claxton, D., Wang, H-G. & Yun, J., 2017, In : Cancer Translational Medicine. 3, 4, p. 109-121

Research output: Contribution to journalArticle

2016

Acid ceramidase is upregulated in AML and represents a novel therapeutic target

Tan, S. F., Liu, X., Fox, T. E., Barth, B. M., Sharma, A., Turner, S. D., Awwad, A., Dewey, A., Doi, K., Spitzer, B., Shah, M. V., Morad, S. A. F., Desai, D., Amin, S., Zhu, J., Liao, J., Yun, J., Kester, M., Claxton, D. F., Wang, H. G. & 5 others, Cabot, M. C., Schuchman, E. H., Levine, R. L., Feith, D. J. & Loughran, T. P., Jan 1 2016, In : Oncotarget. 7, 50, p. 83208-83222 15 p.

Research output: Contribution to journalArticle

32 Scopus citations

A selenium containing inhibitor for the treatment of hepatocellular cancer

Tagaram, H. R. S., Desai, D., Li, G., Liu, D., Rountree, C. B., Gowda, K., Berg, A., Amin, S., Staveley-O’carroll, K. F. & Kimchi, E. T., Mar 24 2016, In : Pharmaceuticals. 9, 2, 18.

Research output: Contribution to journalArticle

6 Scopus citations

Effect of a chemical chaperone, tauroursodeoxycholic acid, on HDM-induced allergic airway disease

Siddesha, J. M., Nakada, E. M., Mihavics, B. R., Hoffman, S. M., Rattu, G. K., Chamberlain, N., Cahoon, J. M., Lahue, K. G., Daphtary, N., Aliyeva, M., Chapman, D. G., Desai, D. H., Poynter, M. E. & Anathy, V., Jun 1 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 310, 11, p. L1243-L1259

Research output: Contribution to journalArticle

15 Scopus citations
6 Scopus citations

Radon exposure, IL-6 promoter variants, and lung squamous cell carcinoma in former uranium miners

Leng, S., Thomas, C. L., Snider, A. M., Picchi, M. A., Chen, W., Willis, D. G., Carr, T. G., Krzeminski, J., Desai, D., Shantu, A., Lin, Y., Jacobson, M. R. & Belinsky, S. A., Apr 2016, In : Environmental health perspectives. 124, 4, p. 445-451 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Severe Babesia microti Infection in an Immunocompetent Host in Pennsylvania

Genda, J., Negron, EA., Lotfipour, M., Balabhadra, S., Desai, D., Craft, D. & Katzman, M., Aug 22 2016, In : Journal of Investigative Medicine High Impact Case Reports. 4, 3

Research output: Contribution to journalArticle

Open Access
13 Scopus citations
2015

Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation

Van Den Bogaard, E. H., Podolsky, M. A., Smits, J. P., Cui, X., John, C., Gowda, K., Desai, D., Amin, S. G., Schalkwijk, J., Perdew, G. H. & Glick, A. B., May 22 2015, In : Journal of Investigative Dermatology. 135, 5, p. 1320-1328 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Implication of a chromosome 15q15.2 locus in regulating UBR1 and predisposing smokers to MGMT methylation in lung

Leng, S., Wu, G., Collins, L. B., Thomas, C. L., Tellez, C. S., Jauregui, A. R., Picchi, M. A., Zhang, X., Juri, D. E., Desai, D., Amin, S. G., Crowell, R. E., Stidley, C. A., Liu, Y., Swenberg, J. A., Lin, Y., Wathelet, M. G., Gilliland, F. D. & Belinsky, S. A., Aug 1 2015, In : Cancer Research. 75, 15, p. 3108-3117 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Jiang, C., Xie, C., Li, F., Zhang, L., Nichols, R. G., Krausz, K. W., Cai, J., Qi, Y., Fang, Z. Z., Takahashi, S., Tanaka, N., Desai, D., Amin, S. G., Albert, I., Patterson, A. D. & Gonzalez, F. J., Jan 2 2015, In : Journal of Clinical Investigation. 125, 1, p. 386-402 17 p.

Research output: Contribution to journalArticle

241 Scopus citations

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Jiang, C., Xie, C., Lv, Y., Li, J., Krausz, K. W., Shi, J., Brocker, C. N., Desai, D., Amin, S. G., Bisson, W. H., Liu, Y., Gavrilova, O., Patterson, A. D. & Gonzalez, F. J., Dec 15 2015, In : Nature communications. 6, 10166.

Research output: Contribution to journalArticle

173 Scopus citations

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia

Song, C., Gowda, C., Pan, X., Ding, Y., Tong, Y., Tan, B. H., Wang, H., Muthusami, S., Ge, Z., Sachdev, M., Amin, S. G., Desai, D., Gowda, K., Gowda, R., Robertson, G. P., Schjerven, H., Muschen, M., Payne, K. J. & Dovat, S., Oct 8 2015, In : Blood. 126, 15, p. 1813-1822 10 p.

Research output: Contribution to journalArticle

52 Scopus citations
2014

A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion

Kale, V. P., Hengst, J. A., Desai, D. H., Dick, T. E., Choe, K. N., Colledge, A. L., Takahashi, Y., Sung, S. S., Amin, S. G. & Yun, J. K., Nov 28 2014, In : Cancer Letters. 354, 2, p. 299-310 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Crucial role of macrophage selenoproteins in experimental colitis

Kaushal, N., Kudva, A. K., Patterson, A. D., Chiaro, C., Kennett, M. J., Desai, D., Amin, S., Carlson, B. A., Cantorna, M. T. & Prabhu, K. S., Oct 1 2014, In : Journal of Immunology. 193, 7, p. 3683-3692 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

In vivo detection of a novel endogenous etheno-DNA adduct derived from arachidonic acid and the effects of antioxidants on its formation

Fu, Y., Nath, R. G., Dyba, M., Cruz, I. M., Pondicherry, S. R., Fernandez, A., Schultz, C. L., Yang, P., Pan, J., Desai, D., Krzeminski, J., Amin, S., Christov, P. P., Hara, Y. & Chung, F. L., Aug 2014, In : Free Radical Biology and Medicine. 73, p. 12-20 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
2013

Chemoprevention of prostate cancer by D,L-sulforaphane is augmented by pharmacological inhibition of autophagy

Vyas, A. R., Hahm, E. R., Arlotti, J. A., Watkins, S., Stolz, D. B., Desai, D., Amin, S. & Singh, S. V., Oct 1 2013, In : Cancer Research. 73, 19, p. 5985-5995 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Chemopreventive effects of PBI-Se, a selenium-containing analog of PBIT, on AOM-induced aberrant crypt foci in F344 rats

Janakiram, N. B., Mohammed, A., Ravillah, D., Choi, C. I., Zhang, Y., Desai, D., Amin, S. & Rao, C. V., Aug 1 2013, In : Oncology reports. 30, 2, p. 952-960 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Chemopreventive effects of the p53-modulating agents CP-31398 and prima-1 in tobacco carcinogen-induced lung tumorigenesis in A/J mice

Rao, C. V., Patlolla, J. M. R., Qian, L., Zhang, Y., Brewer, M., Mohammed, A., Desai, D., Amin, S., Lightfoot, S. & Kopelovich, L., Sep 2013, In : Neoplasia (United States). 15, 9, p. 1018-1027 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Simultaneous targeting of COX-2 and AKT using selenocoxib-1-GSH to inhibit melanoma

Gowda, R., Madhunapantula, S. V., Desai, D., Amin, S. & Robertson, G. P., Jan 1 2013, In : Molecular cancer therapeutics. 12, 1, p. 3-15 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

β-escin inhibits NNK-induced lung adenocarcinoma and ALDH1A1 and RhoA/Rock expression in A/J mice and growth of H460 human lung cancer cells

Patlolla, J. M. R., Qian, L., Biddick, L., Zhang, Y., Desai, D., Amin, S., Lightfoot, S. & Rao, C. V., Oct 1 2013, In : Cancer Prevention Research. 6, 10, p. 1140-1149 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
2012
9 Scopus citations

Notch Activation Is Dispensable for D, L-Sulforaphane-Mediated Inhibition of Human Prostate Cancer Cell Migration

Hahm, E. R., Chandra-Kuntal, K., Desai, D., Amin, S. & Singh, S. V., Sep 7 2012, In : PloS one. 7, 9, e44957.

Research output: Contribution to journalArticle

21 Scopus citations

Phenylalkyl isoselenocyanates vs phenylalkyl isothiocyanates: Thiol reactivity and its implications

Crampsie, M. A., Pandey, M. K., Desai, D., Spallholz, J., Amin, S. & Sharma, A. K., Oct 25 2012, In : Chemico-Biological Interactions. 200, 1, p. 28-37 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Selenium-containing histone deacetylase inhibitors for melanoma management

Gowda, R., Madhunapantula, S. R. V., Desai, D., Amin, S. & Robertson, G. P., Jul 1 2012, In : Cancer Biology and Therapy. 13, 9, p. 756-765 10 p.

Research output: Contribution to journalArticle

31 Scopus citations
2011
6 Scopus citations

Melanoma chemoprevention in skin reconstructs and mouse xenografts using isoselenocyanate-4

Nguyen, N., Sharma, A., Nguyen, N., Sharma, A. K., Desai, D., Huh, S. J., Amin, S., Meyers, C. & Robertson, G. P., Feb 1 2011, In : Cancer Prevention Research. 4, 2, p. 248-258 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Melanoma prevention using topical PBISe

Chung, C. Y., Madhunapantula, S. R. V., Desai, D., Amin, S. & Robertson, G. P., Jun 1 2011, In : Cancer Prevention Research. 4, 6, p. 935-948 14 p.

Research output: Contribution to journalArticle

21 Scopus citations
16 Scopus citations

Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia

Liao, A., Broeg, K., Fox, T., Tan, S. F., Watters, R., Shah, M. V., Zhang, L. Q., Li, Y., Ryland, L., Yang, J., Aliaga, C., Dewey, A., Rogers, A., Loughran, K., Hirsch, L., Jarbadan, N. R., Baab, K. T., Liao, J., Wang, H. G., Kester, M. & 4 others, Desai, D., Amin, S., Loughran, T. P. & Liu, X., Sep 8 2011, In : Blood. 118, 10, p. 2793-2800 8 p.

Research output: Contribution to journalArticle

33 Scopus citations
2010

Bid mediates anti-apoptotic COX-2 induction through the IKKβ/NFκB pathway due to 5-MCDE exposure

Luo, W., Li, J., Zhang, D., Cai, T., Song, L., Yin, X. M., Desai, D., Amin, S., Chen, J. & Huang, C., Feb 1 2010, In : Current Cancer Drug Targets. 10, 1, p. 96-106 11 p.

Research output: Contribution to journalArticle

12 Scopus citations
37 Scopus citations

Selenium-containing analogs of SAHA induce cytotoxicity in lung cancer cells

Karelia, N., Desai, D., Hengst, J. A., Amin, S., Rudrabhatla, S. V. & Yun, J., Nov 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 22, p. 6816-6819 4 p.

Research output: Contribution to journalArticle

26 Scopus citations

SelSA, selenium analogs of SAHA as potent histone deacetylase inhibitors

Desai, D., Salli, U., Vrana, K. E. & Amin, S., Mar 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 6, p. 2044-2047 4 p.

Research output: Contribution to journalArticle

37 Scopus citations

Synthesis and antitumor properties of selenocoxib-1 against rat prostate adenocarcinoma cells

Desai, D., Sinha, I., Null, K., Wolter, W., Suckow, M. A., King, T., Amin, S. & Sinha, R., Jul 1 2010, In : International Journal of Cancer. 127, 1, p. 230-238 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
30 Scopus citations