Diane Thiboutot, MD

    • 8938 Citations
    • 51 h-Index
    1990 …2019
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    Research Output 1990 2019

    108 Citations (Scopus)

    13-cis retinoic acid induces apoptosis and cell cycle arrest in human SEB-1 sebocytes

    Nelson, A. M., Gilliland, K. L., Cong, Z. & Thiboutot, D. M., Oct 30 2006, In : Journal of Investigative Dermatology. 126, 10, p. 2178-2189 12 p.

    Research output: Contribution to journalArticle

    Isotretinoin
    Cell Cycle Checkpoints
    Cells
    Apoptosis
    Retinoids
    7 Citations (Scopus)

    A 3-step acne system containing solubilized benzoyl peroxide versus clindamycin-benzoyl peroxide

    Thiboutot, D., Eichenfield, L., Shalita, A., Del Rosso, J. Q., Swinyer, L., Tanghetti, E., Tschen, E. & Parr, L., Jul 1 2009, In : Cutis. 84, 1, p. 48-55 8 p.

    Research output: Contribution to journalArticle

    Benzoyl Peroxide
    Clindamycin
    Acne Vulgaris
    Salicylic Acid
    Gels
    18 Citations (Scopus)

    A call to limit antibiotic use in acne

    Thiboutot, D., Dreno, B., Gollnick, H., Bettoli, V., Kang, S., Leyden, J. J., Shalita, A. & Torres, V., Dec 1 2013, In : Journal of Drugs in Dermatology. 12, 12, 1 p.

    Research output: Contribution to journalEditorial

    Bacterial Drug Resistance
    Physicians' Practice Patterns
    Acne Vulgaris
    Dermatology
    Anti-Bacterial Agents
    15 Citations (Scopus)

    A clinical overview of azelaic acid

    Elewski, B. & Thiboutot, D., Feb 1 2006, In : Cutis. 77, 2 SUPPL., p. 12-16 5 p.

    Research output: Contribution to journalReview article

    Rosacea
    Gels
    Metronidazole
    azelaic acid
    94 Citations (Scopus)

    Acne: Hormonal concepts and therapy

    Thiboutot, D., Jan 1 2004, In : Clinics in Dermatology. 22, 5, p. 419-428 10 p.

    Research output: Contribution to journalArticle

    Acne Vulgaris
    Hormones
    Sebaceous Glands
    Therapeutics
    Dehydroepiandrosterone Sulfate
    15 Citations (Scopus)

    Acne: Acute or chronic disease?

    Thiboutot, D. M. & Lookingbill, D. P., Jan 1 1995, In : Journal of the American Academy of Dermatology. 32, 5 PART 3

    Research output: Contribution to journalArticle

    Postmenopause
    Acne Vulgaris
    Acute Disease
    Preschool Children
    Chronic Disease
    16 Citations (Scopus)

    Acne: 1991-2001.

    Thiboutot, D., Jan 1 2002, In : Journal of the American Academy of Dermatology. 47, 1, p. 109-117 9 p.

    Research output: Contribution to journalArticle

    Acne Vulgaris
    68 Citations (Scopus)

    Acne: An overview of clinical research findings

    Thiboutot, D. M., Jan 1 1997, In : Dermatologic Clinics. 15, 1, p. 97-109 13 p.

    Research output: Contribution to journalArticle

    Acne Vulgaris
    Research
    Safety
    Isotretinoin
    Retinoids

    Acné: 1991-2001

    Translated title of the contribution: Acne: 1991-2001Thiboutot, D., Jan 1 2004, In : EMC - Dermatologie-Cosmetologie. 1, 4, p. 188-198 11 p.

    Research output: Contribution to journalShort survey

    Acne Vulgaris
    47 Citations (Scopus)

    Acne and rosacea: New and emerging therapies

    Thiboutot, D. M., Jan 1 2000, In : Dermatologic Clinics. 18, 1, p. 63-71 9 p.

    Research output: Contribution to journalArticle

    Rosacea
    Metronidazole
    Acne Vulgaris
    Therapeutics
    Isotretinoin
    26 Citations (Scopus)

    Acne counseling to improve adherence

    Thiboutot, D., Dréno, B. & Layton, A., Jan 2008, In : Cutis. 81, 1, p. 81-86 6 p.

    Research output: Contribution to journalArticle

    Acne Vulgaris
    Counseling
    Therapeutics
    Asymptomatic Diseases
    Life Style
    20 Citations (Scopus)

    Acne rosacea

    Thiboutot, D. M., 1994, In : American Family Physician. 50, 8, p. 1691-1697 7 p.

    Research output: Contribution to journalReview article

    Rosacea
    Rhinophyma
    Telangiectasis
    Anti-Bacterial Agents
    Dye Lasers
    34 Citations (Scopus)

    Acne severity grading: Determining essential clinical components and features using a Delphi consensus

    Tan, J., Wolfe, B., Weiss, J., Stein-Gold, L., Bikowski, J., Del Rosso, J., Webster, G. F., Lucky, A., Thiboutot, D., Wilkin, J., Leyden, J. & Chren, M. M., Aug 1 2012, In : Journal of the American Academy of Dermatology. 67, 2, p. 187-193 7 p.

    Research output: Contribution to journalArticle

    Acne Vulgaris
    Research
    35 Citations (Scopus)

    A combined oral contraceptive containing 3-mg drospirenone/20-μg ethinyl estradiol in the treatment of acne vulgaris: A randomized, double-blind, placebo-controlled study evaluating lesion counts and participant self-assessment

    Lucky, A. W., Koltun, W., Thiboutot, D., Niknian, M., Sampson-Landers, C., Korner, P. & Marr, J., Aug 1 2008, In : Cutis. 82, 2, p. 143-150 8 p.

    Research output: Contribution to journalArticle

    Contraceptives, Oral, Combined
    Ethinyl Estradiol
    Acne Vulgaris
    Placebos
    Odds Ratio
    12 Citations (Scopus)

    Activity-guided purification identifies lupeol, a pentacyclic triterpene, as a therapeutic agent targeting multiple pathogenic factors of acne

    Kwon, H. H., Yoon, J. Y., Park, S. Y., Min, S., Kim, Y. I., Park, J. Y., Lee, Y. S., Thiboutot, D. M. & Suh, D. H., Jan 1 2015, In : Journal of Investigative Dermatology. 135, 6, p. 1491-1500 10 p.

    Research output: Contribution to journalArticle

    Pentacyclic Triterpenes
    Acne Vulgaris
    Purification
    Therapeutics
    Solanum melongena
    59 Citations (Scopus)

    Activity of 5-alpha-reductase and 17-beta-hydroxysteroid dehydrogenase in the infrainfundibulum of subjects with and without acne vulgaris

    Thiboutot, D., Knaggs, H., Gilliland, K. & Lin, G., Mar 26 1998, In : Dermatology. 196, 1, p. 38-42 5 p.

    Research output: Contribution to journalArticle

    17-Hydroxysteroid Dehydrogenases
    Cholestenone 5 alpha-Reductase
    Acne Vulgaris
    Keratinocytes
    Androgens
    192 Citations (Scopus)

    Activity of the type 1 5α-reductase exhibits regional differences in isolated sebaceous glands and whole skin

    Thiboutot, D., Harris, G., Iles, V., Cimis, G., Gilliland, K. & Hagari, S., Jan 1 1995, In : Journal of Investigative Dermatology. 105, 2, p. 209-214 6 p.

    Research output: Contribution to journalArticle

    Sebaceous Glands
    Skin
    Oxidoreductases
    Scalp
    Acne Vulgaris
    99 Citations (Scopus)

    Activity of type 1 5α-reductase is greater in the follicular infrainfundibulum compared with the epidermis

    Thiboutot, D. M., Knaggs, H., Gilliland, K. & Hagari, S., Jan 1 1997, In : British Journal of Dermatology. 136, 2, p. 166-171 6 p.

    Research output: Contribution to journalArticle

    Epidermis
    Oxidoreductases
    Keratinocytes
    Dihydrotestosterone
    Acne Vulgaris
    146 Citations (Scopus)

    Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: Results of a multicenter, randomized double-blind, controlled study

    Thiboutot, D. M., Weiss, J., Bucko, A., Eichenfield, L., Jones, T., Clark, S., Liu, Y., Graeber, M. & Kang, S., Nov 1 2007, In : Journal of the American Academy of Dermatology. 57, 5, p. 791-799 9 p.

    Research output: Contribution to journalArticle

    Benzoyl Peroxide
    Acne Vulgaris
    Double-Blind Method
    Gels
    Adapalene
    85 Citations (Scopus)

    Adapalene gel, 0.1%, as maintenance therapy for acne vulgaris: A randomized, controlled, investigator-blind follow-up of a recent combination study

    Thiboutot, D. M., Shalita, A. R., Yamauchi, P. S., Dawson, C., Kerrouche, N., Arsonnaud, S. & Kang, S., May 1 2006, In : Archives of dermatology. 142, 5, p. 597-602 6 p.

    Research output: Contribution to journalArticle

    Acne Vulgaris
    Gels
    Research Personnel
    Doxycycline
    Maintenance
    69 Citations (Scopus)

    Adapalene gel 0.3% for the treatment of acne vulgaris: A multicenter, randomized, double-blind, controlled, phase III trial

    Thiboutot, D., Pariser, D. M., Egan, N., Flores, J., Herndon, J. H., Kanof, N. B., Kempers, S. E., Maddin, S., Poulin, Y. P., Wilson, D. C., Hwa, J., Liu, Y. & Graeber, M., Feb 1 2006, In : Journal of the American Academy of Dermatology. 54, 2, p. 242-250 9 p.

    Research output: Contribution to journalArticle

    Acne Vulgaris
    Gels
    Therapeutics
    Adapalene
    Random Allocation
    26 Citations (Scopus)

    A double-blinded, randomized, vehicle-controlled, multicenter, parallel-group study to assess the safety and efficacy of tretinoin gel microsphere 0.04% in the treatment of acne vulgaris in adults

    Berger, R., Barba, A., Fleischer, A., Leyden, J. J., Lucky, A., Pariser, D., Rafal, E., Thiboutot, D., Wilson, D., Grossman, R. & Nighland, M., Aug 1 2007, In : Cutis. 80, 2, p. 152-157 6 p.

    Research output: Contribution to journalArticle

    Acne Vulgaris
    Tretinoin
    Microspheres
    Gels
    Safety
    73 Citations (Scopus)

    American Academy of Dermatology Consensus Conference on the safe and optimal use of isotretinoin: Summary and recommendations

    Goldsmith, L. A., Bolognia, J. L., Callen, J. P., Chen, S. C., Feldman, S. R., Lim, H. W., Lucky, A. W., Reed, B. R., Siegfried, E. C., Thiboutot, D. M. & Wheeland, R. G., Jan 1 2004, In : Journal of the American Academy of Dermatology. 50, 6, p. 900-906 7 p.

    Research output: Contribution to journalArticle

    Isotretinoin
    7 Citations (Scopus)

    A multicenter, double-blind study to evaluate the efficacy and safety of 2 treatments in participants with mild to moderate acne vulgaris

    Draelos, Z. D., Shalita, A. R., Thiboutot, D., Oresajo, C., Yatskayer, M. & Raab, S., Jun 1 2012, In : Cutis. 89, 6, p. 287-293 7 p.

    Research output: Contribution to journalArticle

    Benzoyl Peroxide
    Acne Vulgaris
    Double-Blind Method
    Safety
    Prescriptions
    47 Citations (Scopus)

    A multicenter study of topical azelaic acid 15% gel in combination with oral doxycycline as initial therapy and azelaic acid 15% gel as maintenance monotherapy

    Thiboutot, D. M., Fleischer, A. B., Del Rosso, J. Q. & Rich, P., Jul 2009, In : Journal of Drugs in Dermatology. 8, 7, p. 639-648 10 p.

    Research output: Contribution to journalArticle

    Doxycycline
    Multicenter Studies
    Gels
    Maintenance
    Research Personnel
    92 Citations (Scopus)
    Acne Vulgaris
    Benzoyl Peroxide
    Clindamycin
    Gels
    Safety
    127 Citations (Scopus)

    Androgen metabolism in sebaceous glands from subjects with and without acne

    Thiboutot, D., Gilliland, K., Light, J. & Lookingbill, D., Jan 1 1999, In : Archives of dermatology. 135, 9, p. 1041-1045 5 p.

    Research output: Contribution to journalArticle

    Sebaceous Glands
    Acne Vulgaris
    Androgens
    Oxidoreductases
    Dihydrotestosterone
    30 Citations (Scopus)

    An evaluation of potential correlations between pathophysiologic mechanisms, clinical manifestations, and management of rosacea

    Del Rosso, J. Q., Gallo, R. L., Tanghetti, E., Webster, G. & Thiboutot, D., Mar 1 2013, In : Cutis. 91, 3, p. 1-8 8 p.

    Research output: Contribution to journalReview article

    Rosacea
    Facial Dermatoses
    Acne Vulgaris
    27 Citations (Scopus)

    An overview of acne and its treatment.

    Thiboutot, D. M., Jan 1 1996, In : Cutis; cutaneous medicine for the practitioner. 57, 1 Suppl, p. 8-12 5 p.

    Research output: Contribution to journalReview article

    Acne Vulgaris
    Tretinoin
    Benzoyl Peroxide
    Intralesional Injections
    Sebum
    51 Citations (Scopus)

    Antibiotic stewardship in dermatology: Limiting antibiotic use in acne

    Dreno, B., Thiboutot, D., Gollnick, H., Bettoli, V., Kang, S., Leyden, J. J., Shalita, A. & Torres, V., Jan 1 2014, In : European Journal of Dermatology. 24, 3, p. 330-334 5 p.

    Research output: Contribution to journalArticle

    Acne Vulgaris
    Dermatology
    Anti-Bacterial Agents
    Therapeutics
    Benzoyl Peroxide
    31 Citations (Scopus)

    Antibiotic use in acne vulgaris and rosacea: Clinical considerations and resistance issues of significance to dermatologists

    Del Rosso, J. Q., Leyden, J. J., Thiboutot, D. & Webster, G. F., Aug 1 2008, In : Cutis. 82, 2 SUPPL., p. 5-12 8 p.

    Research output: Contribution to journalArticle

    Rosacea
    Acne Vulgaris
    Anti-Bacterial Agents
    Dermatology
    Mupirocin

    Antimicrobial Activity of Sebocytes against Propionibacterium acnes via Toll-Like Receptor 2 and Lysosomal Pathway

    Hisaw, L. D., Qin, M., Park, A., Agak, G. W., Pirouz, A., Phan, J., Fernandez, C., Garbán, H. J., Nelson, A., Thiboutot, D. & Kim, J., Oct 1 2016, In : Journal of Investigative Dermatology. 136, 10, p. 2098-2101 4 p.

    Research output: Contribution to journalArticle

    Toll-Like Receptor 2
    Sebaceous Glands
    Propionibacterium acnes
    Lysosomes
    Innate Immunity
    10 Citations (Scopus)

    A phase IV, open-label study evaluating the use of triple-combination therapy with minocycline HCl extended-release tablets, a topical antibiotic/retinoid preparation and benzoyl peroxide in patients with moderate to severe acne vulgaris

    Zaenglein, A. L., Shamban, A., Webster, G., Del Rosso, J., Dover, J. S., Swinyer, L., Stein, L., Lin, X., Draelos, Z., Gold, M. & Thiboutot, D., Jun 1 2013, In : Journal of Drugs in Dermatology. 12, 6, p. 619-625 7 p.

    Research output: Contribution to journalArticle

    Benzoyl Peroxide
    Minocycline
    Retinoids
    Acne Vulgaris
    Tablets
    90 Citations (Scopus)

    A randomized, controlled trial of a low-dose contraceptive containing 20 μg of ethinyl estradiol and 100 μg of levonorgestrel for acne treatment

    Thiboutot, D., Archer, D. F., Lemay, A., Washenik, K., Roberts, J. & Harrison, D. D., Sep 3 2001, In : Fertility and sterility. 76, 3, p. 461-468 8 p.

    Research output: Contribution to journalArticle

    Levonorgestrel
    Ethinyl Estradiol
    Acne Vulgaris
    Contraceptive Agents
    Randomized Controlled Trials
    11 Citations (Scopus)

    A randomized, parallel, vehicle-controlled comparison of two erythromycin/benzoyl peroxide preparations for acne vulgaris

    Thiboutot, D., Jarratt, M., Rich, P., Rist, T., Rodriguez, D. & Levy, S., Jan 1 2002, In : Clinical therapeutics. 24, 5, p. 773-785 13 p.

    Research output: Contribution to journalArticle

    Acne Vulgaris
    Therapeutics
    Physicians
    erythromycin drug combination benzoyl peroxide
    Refrigeration
    30 Citations (Scopus)
    Cost Savings
    Acne Vulgaris
    Anti-Bacterial Agents
    Retinoids
    Therapeutics
    4 Citations (Scopus)

    Artificial intelligence for the objective evaluation of Acne investigator global assessment

    Melina, A., Dinh, N. N., Tafuri, B., Schipani, G., Nisticò, S., Cosentino, C., Amato, F., Thiboutot, D. & Cherubini, A., Jan 1 2018, In : Journal of Drugs in Dermatology. 17, 9, p. 1006-1009 4 p.

    Research output: Contribution to journalArticle

    Artificial Intelligence
    Acne Vulgaris
    Research Personnel
    Ethnic Groups
    Physicians
    1 Citation (Scopus)

    Assessing effectiveness in acne clinical trials: steps towards a core outcome measure set

    Thiboutot, D., Layton, A. M., Chren, M. M., Eady, E. A. & Tan, J., Oct 1 2019, In : British Journal of Dermatology. 181, 4, p. 700-706 7 p.

    Research output: Contribution to journalReview article

    Acne Vulgaris
    Outcome Assessment (Health Care)
    Clinical Trials
    Skin Diseases
    Dermatitis
    35 Citations (Scopus)

    A systemic type I 5 α-reductase inhibitor is ineffective in the treatment of acne vulgaris

    Leyden, J., Bergfeld, W., Drake, L., Dunlap, F., Goldman, M. P., Gottlieb, A. B., Heffernan, M. P., Hickman, J. G., Hordinsky, M., Jarrett, M., Kang, S., Lucky, A., Peck, G., Phillips, T., Rapaport, M., Roberts, J., Savin, R., Sawaya, M. E., Shalita, A., Shavin, J. & 14 others, Shaw, J. C., Stein, L., Stewart, D., Strauss, J., Swinehart, J., Swinyer, L., Thiboutot, D., Washenik, K., Weinstein, G., Whiting, D., Pappas, F., Sanchez, M., Terranella, L. & Waldstreicher, J., Jan 1 2004, In : Journal of the American Academy of Dermatology. 50, 3, p. 443-447 5 p.

    Research output: Contribution to journalArticle

    Acne Vulgaris
    Sebaceous Glands
    Oxidoreductases
    Minocycline
    Androgens
    1 Citation (Scopus)

    A three-step acne system containing solubilized benzoyl peroxide versus benzoyl peroxide/clindamycin in pediatric patients with acne

    Eichenfield, L. F., Thibouto, D., Shalita, A., Swinyert, L., Tanghetti, E., Tschen, E. & Parr, L., Nov 1 2009, In : Journal of Clinical and Aesthetic Dermatology. 2, 11, p. 19-27 9 p.

    Research output: Contribution to journalArticle

    Benzoyl Peroxide
    Clindamycin
    Acne Vulgaris
    Pediatrics
    Salicylic Acid
    39 Citations (Scopus)

    Azelaic acid 15% gel once daily versus twice daily in papulopustular rosacea

    Thiboutot, D. M., Fleischer, A. B., Del Rosso, J. Q. & Graupe, K., Jun 2008, In : Journal of Drugs in Dermatology. 7, 6, p. 541-546 6 p.

    Research output: Contribution to journalArticle

    Rosacea
    Gels
    Therapeutics
    Telangiectasis
    Erythema
    14 Citations (Scopus)

    Azelaic acid gel 15%: Clinical versatility in the treatment of rosacea

    Del Rosso, J. Q., Baum, E. W., Draelos, Z. D., Elewski, B. E., Fleischer, A. B., Kakita, L. S. & Thiboutot, D., Nov 1 2006, In : Cutis. 78, 5 SUPPL., p. 6-19 14 p.

    Research output: Contribution to journalReview article

    Rosacea
    Gels
    Therapeutics
    Skin Care
    Compliance
    41 Citations (Scopus)

    Can sebum reduction predict acne outcome?

    Janiczek-Dolphin, N., Cook, J., Thiboutot, D., Harness, J. & Clucas, A., Oct 1 2010, In : British Journal of Dermatology. 163, 4, p. 683-688 6 p.

    Research output: Contribution to journalReview article

    Sebum
    Acne Vulgaris
    33 Citations (Scopus)

    Changing the face of acne therapy.

    Ghali, F., Kang, S., Leyden, J., Shalita, A. R. & Thiboutot, D. M., Jan 1 2009, In : Cutis; cutaneous medicine for the practitioner. 83, 2 Suppl, p. 4-15 12 p.

    Research output: Contribution to journalReview article

    Acne Vulgaris
    Retinoids
    Therapeutics
    Anti-Bacterial Agents
    Artificial Receptors
    45 Citations (Scopus)

    Circulating tumor cells in melanoma patients

    Clawson, G. A., Kimchi, E., Patrick, S. D., Xin, P., Harouaka, R., Zheng, S., Berg, A., Schell, T., Staveley-O'Carroll, K. F., Neves, R. I., Mosca, P. J. & Thiboutot, D., Jul 19 2012, In : PloS one. 7, 7, e41052.

    Research output: Contribution to journalArticle

    Circulating Neoplastic Cells
    melanoma
    Tumors
    Melanoma
    Cells
    39 Citations (Scopus)

    Clinical review 74: Dermatological manifestations of endocrine disorders

    Thiboutot, D. M., Jan 1 1995, In : Journal of Clinical Endocrinology and Metabolism. 80, 10, p. 3082-3087 6 p.

    Research output: Contribution to journalArticle

    66 Citations (Scopus)

    Combination therapy with adapalene gel 0.1% and doxycycline for severe acne vulgaris: a multicenter, investigator-blind, randomized, controlled study.

    Thiboutot, D. M., Shalita, A. R., Yamauchi, P. S., Dawson, C., Arsonnaud, S. & Kang, S., Jan 1 2005, In : Skinmed. 4, 3, p. 138-146 9 p.

    Research output: Contribution to journalArticle

    Doxycycline
    Acne Vulgaris
    Gels
    Research Personnel
    Anti-Bacterial Agents
    11 Citations (Scopus)

    Comparing a novel solubilized benzoyl peroxide gel with benzoyl peroxide/clindamycin: Final data from a multicenter, investigator-blind, randomized study

    Kircik, L., Green, L., Thiboutot, D., Tanghetti, E., Wilson, D., Dhawan, S. & Parr, L., Sep 1 2009, In : Journal of Drugs in Dermatology. 8, 9, p. 812-818 7 p.

    Research output: Contribution to journalArticle

    Benzoyl Peroxide
    Clindamycin
    Gels
    Research Personnel
    Acne Vulgaris
    59 Citations (Scopus)

    Comparison of tazarotene and minocycline maintenance therapies in acne vulgaris: A multicenter, double-blind, randomized, parallel-group study

    Leyden, J., Thiboutot, D. M., Shalita, A. R., Webster, G., Washenik, K., Strober, B. E. & Shupack, J., May 1 2006, In : Archives of dermatology. 142, 5, p. 605-612 8 p.

    Research output: Contribution to journalArticle

    Minocycline
    Acne Vulgaris
    Maintenance
    Capsules
    Gels