Diane Thiboutot, MD

    • 8938 Citations
    • 51 h-Index
    1990 …2019
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    Research Output 1990 2019

    2013
    60 Citations (Scopus)

    Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes

    Yoon, J. Y., Kwon, H. H., Min, S. U., Thiboutot, D. M. & Suh, D. H., Jan 1 2013, In : Journal of Investigative Dermatology. 133, 2, p. 429-440 12 p.

    Research output: Contribution to journalArticle

    Isotretinoin
    AMP-Activated Protein Kinases
    Transcription Factor AP-1
    Acne Vulgaris
    Polyphenols
    94 Citations (Scopus)

    Evidence-based recommendations for the diagnosis and treatment of pediatric acne

    Eichenfield, L. F., Krakowski, A. C., Piggott, C., Del Rosso, J., Baldwin, H., Friedlander, S. F., Levy, M., Lucky, A., Mancini, A. J., Orlow, S. J., Yan, A. C., Vaux, K. K., Webster, G., Zaenglein, A. L. & Thiboutot, D. M., May 1 2013, In : Pediatrics. 131, SUPPL. 3, p. S163-S186

    Research output: Contribution to journalReview article

    Acne Vulgaris
    Pediatrics
    Therapeutics
    Rosacea
    Benzoyl Peroxide
    6 Citations (Scopus)

    Isotretinoin and affective disorders: Thirty years later

    Thiboutot, D. & Zaenglein, A., Apr 1 2013, In : Journal of the American Academy of Dermatology. 68, 4, p. 675-676 2 p.

    Research output: Contribution to journalEditorial

    20th Century History
    Dermatologic Agents
    Isotretinoin
    Acne Vulgaris
    Mood Disorders
    2012
    34 Citations (Scopus)

    Acne severity grading: Determining essential clinical components and features using a Delphi consensus

    Tan, J., Wolfe, B., Weiss, J., Stein-Gold, L., Bikowski, J., Del Rosso, J., Webster, G. F., Lucky, A., Thiboutot, D., Wilkin, J., Leyden, J. & Chren, M. M., Aug 1 2012, In : Journal of the American Academy of Dermatology. 67, 2, p. 187-193 7 p.

    Research output: Contribution to journalArticle

    Acne Vulgaris
    Research
    7 Citations (Scopus)

    A multicenter, double-blind study to evaluate the efficacy and safety of 2 treatments in participants with mild to moderate acne vulgaris

    Draelos, Z. D., Shalita, A. R., Thiboutot, D., Oresajo, C., Yatskayer, M. & Raab, S., Jun 1 2012, In : Cutis. 89, 6, p. 287-293 7 p.

    Research output: Contribution to journalArticle

    Benzoyl Peroxide
    Acne Vulgaris
    Double-Blind Method
    Safety
    Prescriptions
    45 Citations (Scopus)

    Circulating tumor cells in melanoma patients

    Clawson, G. A., Kimchi, E., Patrick, S. D., Xin, P., Harouaka, R., Zheng, S., Berg, A., Schell, T., Staveley-O'Carroll, K. F., Neves, R. I., Mosca, P. J. & Thiboutot, D., Jul 19 2012, In : PloS one. 7, 7, e41052.

    Research output: Contribution to journalArticle

    Circulating Neoplastic Cells
    melanoma
    Tumors
    Melanoma
    Cells
    7 Citations (Scopus)

    Oral isotretinoin and pregnancy prevention programmes

    Thiboutot, D., Gollnick, H., Bettoli, V., Dréno, B., Kang, S., Leyden, J. J., Shalita, A. & Torres, V., Jan 10 2012, In : British Journal of Dermatology. 166, 2, p. 466-467 2 p.

    Research output: Contribution to journalLetter

    Drug-Induced Abnormalities
    Dermatologic Agents
    Guideline Adherence
    Teratogens
    Isotretinoin
    76 Citations (Scopus)

    Systemic isotretinoin therapy normalizes exaggerated TLR-2-mediated innate immune responses in acne patients

    Dispenza, M. C., Wolpert, E. B., Gilliland, K. L., Dai, J. P., Cong, Z., Nelson, A. M. & Thiboutot, D. M., Jan 1 2012, In : Journal of Investigative Dermatology. 132, 9, p. 2198-2205 8 p.

    Research output: Contribution to journalArticle

    Toll-Like Receptor 2
    Isotretinoin
    Acne Vulgaris
    Innate Immunity
    Propionibacterium acnes
    9 Citations (Scopus)

    The effects of isotretinoin on wisdom tooth extraction

    Sharma, J., Thiboutot, D. M. & Zaenglein, A. L., Jan 1 2012, In : Journal of the American Academy of Dermatology. 67, 4, p. 794-795 2 p.

    Research output: Contribution to journalArticle

    Dermatologic Agents
    Isotretinoin
    Tooth Extraction
    Third Molar
    Wound Healing
    36 Citations (Scopus)

    Why is rosacea considered to be an inflammatory disorder? The primary role, clinical relevance, and therapeutic correlations of abnormal innate immune response in rosacea-prone skin

    Del Rosso, J. Q., Gallo, R. L., Kircik, L., Thiboutot, D., Baldwin, H. E. & Cohen, D., Jun 1 2012, In : Journal of Drugs in Dermatology. 11, 6, p. 694-700 7 p.

    Research output: Contribution to journalReview article

    Rosacea
    Innate Immunity
    Skin
    Therapeutics
    Immune System
    2011
    8 Citations (Scopus)
    Bacterial Drug Resistance
    Acne Vulgaris
    Staphylococcus aureus
    Anti-Bacterial Agents
    Dermatologists
    3 Citations (Scopus)

    Hormonal treatment of acne in women

    Keri, J., Berson, D. S. & Thiboutot, D., Mar 21 2011, Acne Vulgaris. CRC Press, p. 146-155 10 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Acne Vulgaris
    Therapeutics

    Introduction. Challenges in managing acne patients.

    Thiboutot, D., Jun 1 2011, In : Journal of drugs in dermatology : JDD. 10, 6

    Research output: Contribution to journalEditorial

    Dermatologic Agents
    Bacterial Drug Resistance
    Cutaneous Administration
    Skin Pigmentation
    Acne Vulgaris
    9 Citations (Scopus)

    Isotretinoin increases skin-surface levels of neutrophil gelatinase-associated lipocalin in patients treated for severe acne

    Lumsden, K. R., Nelson, A. M., Dispenza, M. C., Gilliland, K. L., Cong, Z., Zaenglein, A. L. & Thiboutot, D. M., Aug 1 2011, In : British Journal of Dermatology. 165, 2, p. 302-310 9 p.

    Research output: Contribution to journalArticle

    Isotretinoin
    Acne Vulgaris
    Skin
    Propionibacterium acnes
    Sebum

    Journal of Drugs in Dermatology: Introduction

    Thiboutot, D., Jun 1 2011, In : Journal of Drugs in Dermatology. 10, 6

    Research output: Contribution to journalEditorial

    Dermatology
    Pharmaceutical Preparations
    23 Citations (Scopus)

    Pathogenesis of acne vulgaris: What's new, what's interesting and what may be clinically relevant

    Bellew, S., Thiboutot, D. & Del Rosso, J. Q., Jun 1 2011, In : Journal of Drugs in Dermatology. 10, 6, p. 582-585 4 p.

    Research output: Contribution to journalReview article

    Acne Vulgaris
    Sebum
    Sebaceous Glands
    Dermatology
    Primary Health Care
    2 Citations (Scopus)

    Rethinking treatment of acne in the severe patient

    Thiboutot, D., Jun 1 2011, In : Journal of Drugs in Dermatology. 10, 6

    Research output: Contribution to journalReview article

    Dermatologic Agents
    Severity of Illness Index
    Bacterial Drug Resistance
    Benzoyl Peroxide
    Cutaneous Administration
    1 Citation (Scopus)

    Sebum

    Nelson, A. & Thiboutot, D., Mar 21 2011, Acne Vulgaris. CRC Press, p. 3-11 9 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Sebum
    31 Citations (Scopus)

    TRAIL contributes to the apoptotic effect of 13-cis retinoic acid in human sebaceous gland cells

    Nelson, A. M., Cong, Z., Gilliland, K. L. & Thiboutot, D. M., Sep 1 2011, In : British Journal of Dermatology. 165, 3, p. 526-533 8 p.

    Research output: Contribution to journalArticle

    Sebaceous Glands
    Isotretinoin
    Tumor Necrosis Factor-alpha
    Apoptosis
    Ligands
    2010
    41 Citations (Scopus)

    Can sebum reduction predict acne outcome?

    Janiczek-Dolphin, N., Cook, J., Thiboutot, D., Harness, J. & Clucas, A., Oct 1 2010, In : British Journal of Dermatology. 163, 4, p. 683-688 6 p.

    Research output: Contribution to journalReview article

    Sebum
    Acne Vulgaris
    6 Citations (Scopus)

    Impact of a fixed combination of clindamycin phosphate 1.2%-benzoyl peroxide 2.5% aqueous gel on health-related quality of life in moderate to severe acne vulgaris

    Webster, G., Thiboutot, D. M., Chen, D. M. & Merikle, E., Nov 1 2010, In : Cutis. 86, 5, p. 263-267 5 p.

    Research output: Contribution to journalArticle

    Acne Vulgaris
    Gels
    Quality of Life
    Clindamycin
    Benzoyl Peroxide
    98 Citations (Scopus)

    Large-scale worldwide observational study of adherence with acne therapy

    Dréno, B., Thiboutot, D., Gollnick, H., Finlay, A. Y., Layton, A., Leyden, J. J., Leutenegger, E. & Perez, M., Jan 1 2010, In : International Journal of Dermatology. 49, 4, p. 448-456 9 p.

    Research output: Contribution to journalArticle

    Acne Vulgaris
    Observational Studies
    Therapeutics
    Isotretinoin
    Patient Satisfaction

    Over-the-Counter Acne Treatments

    Graber, E. M. & Thiboutot, D., Mar 10 2010, Cosmetic Dermatology: Products and Procedures. Wiley-Blackwell, p. 488-494 7 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Benzoyl Peroxide
    Salicylic Acid
    Acne Vulgaris
    Volatile Oils
    417 Citations (Scopus)

    Postmenopausal hormone therapy: An endocrine society scientific statement

    Santen, R. J., Allred, D. C., Ardoin, S. P., Archer, D. F., Boyd, N., Braunstein, G. D., Burger, H. G., Colditz, G. A., Davis, S. R., Gambacciani, M., Gower, B. A., Henderson, V. W., Jarjour, W. N., Karas, R. H., Kleerekoper, M., Lobo, R. A., Manson, J. E., Marsden, J., Martin, K. A., Martin, L. & 6 others, Pinkerton, J. V., Rubinow, D. R., Teede, H., Thiboutot, D. M., Utian, W. H. & Endocrine Society, S., Jan 1 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 7, p. s1-s66

    Research output: Contribution to journalArticle

    Hormones
    Advisory Committees
    Textbooks
    Menopause
    Endocrinology
    5 Citations (Scopus)

    The hypothetical role of FoxO1 in acne is interesting, but more study is needed before any conclusions can be drawn

    Leyden, J. J., Gollnick, H., Thiboutot, D., Dreno, B., Bettoli, V., Kang, S., Shalita, A. & Torres, V., Dec 1 2010, In : British Journal of Dermatology. 163, 6, p. 1365-1366 2 p.

    Research output: Contribution to journalLetter

    Dermatologic Agents
    Forkhead Transcription Factors
    Isotretinoin
    Acne Vulgaris
    Somatomedins
    2009
    7 Citations (Scopus)

    A 3-step acne system containing solubilized benzoyl peroxide versus clindamycin-benzoyl peroxide

    Thiboutot, D., Eichenfield, L., Shalita, A., Del Rosso, J. Q., Swinyer, L., Tanghetti, E., Tschen, E. & Parr, L., Jul 1 2009, In : Cutis. 84, 1, p. 48-55 8 p.

    Research output: Contribution to journalArticle

    Benzoyl Peroxide
    Clindamycin
    Acne Vulgaris
    Salicylic Acid
    Gels
    47 Citations (Scopus)

    A multicenter study of topical azelaic acid 15% gel in combination with oral doxycycline as initial therapy and azelaic acid 15% gel as maintenance monotherapy

    Thiboutot, D. M., Fleischer, A. B., Del Rosso, J. Q. & Rich, P., Jul 2009, In : Journal of Drugs in Dermatology. 8, 7, p. 639-648 10 p.

    Research output: Contribution to journalArticle

    Doxycycline
    Multicenter Studies
    Gels
    Maintenance
    Research Personnel
    1 Citation (Scopus)

    A three-step acne system containing solubilized benzoyl peroxide versus benzoyl peroxide/clindamycin in pediatric patients with acne

    Eichenfield, L. F., Thibouto, D., Shalita, A., Swinyert, L., Tanghetti, E., Tschen, E. & Parr, L., Nov 1 2009, In : Journal of Clinical and Aesthetic Dermatology. 2, 11, p. 19-27 9 p.

    Research output: Contribution to journalArticle

    Benzoyl Peroxide
    Clindamycin
    Acne Vulgaris
    Pediatrics
    Salicylic Acid
    33 Citations (Scopus)

    Changing the face of acne therapy.

    Ghali, F., Kang, S., Leyden, J., Shalita, A. R. & Thiboutot, D. M., Jan 1 2009, In : Cutis; cutaneous medicine for the practitioner. 83, 2 Suppl, p. 4-15 12 p.

    Research output: Contribution to journalReview article

    Acne Vulgaris
    Retinoids
    Therapeutics
    Anti-Bacterial Agents
    Artificial Receptors
    11 Citations (Scopus)

    Comparing a novel solubilized benzoyl peroxide gel with benzoyl peroxide/clindamycin: Final data from a multicenter, investigator-blind, randomized study

    Kircik, L., Green, L., Thiboutot, D., Tanghetti, E., Wilson, D., Dhawan, S. & Parr, L., Sep 1 2009, In : Journal of Drugs in Dermatology. 8, 9, p. 812-818 7 p.

    Research output: Contribution to journalArticle

    Benzoyl Peroxide
    Clindamycin
    Gels
    Research Personnel
    Acne Vulgaris

    Double-blind, randomized, prospective trial comparing a lipohydroxy acid cream with tretinoin cream for acne vulgaris

    Graber, E. M., Thiboutot, D. M., Seité, S., Rougier, A. & Shalita, A. R., Oct 1 2009, In : Cosmetic Dermatology. 22, 10, p. 517-520 4 p.

    Research output: Contribution to journalArticle

    Salicylic Acid
    Acne Vulgaris
    Tretinoin
    Acids
    Therapeutics
    74 Citations (Scopus)

    Histone H4 is a major component of the antimicrobial action of human sebocytes

    Lee, D. Y., Huang, C. M., Nakatsuji, T., Thiboutot, D., Kang, S. A., Monestier, M. & Gallo, R. L., Oct 1 2009, In : Journal of Investigative Dermatology. 129, 10, p. 2489-2496 8 p.

    Research output: Contribution to journalArticle

    Histones
    Sebaceous Glands
    Peptides
    Staphylococcus aureus
    Sebum
    13 Citations (Scopus)

    Isotretinoin temporally regulates distinct sets of genes in patient skin

    Nelson, A. M., Zhao, W., Gilliland, K. L., Zaenglein, A. L., Liu, W. & Thiboutot, D. M., Apr 1 2009, In : Journal of Investigative Dermatology. 129, 4, p. 1038-1042 5 p.

    Research output: Contribution to journalLetter

    Eye Proteins
    Type 6 Cyclic Nucleotide Phosphodiesterases
    Sebaceous Glands
    Isotretinoin
    Gene Expression Regulation
    501 Citations (Scopus)

    New insights into the management of acne: An update from the Global Alliance to Improve Outcomes in Acne Group

    Thiboutot, D., Gollnick, H., Bettoli, V., Dréno, B., Kang, S., Leyden, J. J., Shalita, A. R., Lozada, V. T., Berson, D., Finlay, A., Goh, C. L., Herane, M. I., Kaminsky, A., Kubba, R., Layton, A., Miyachi, Y., Perez, M., Martin, J. P., Ramos-e-Silva, M., See, J. A. & 2 others, Shear, N. & Wolf, J., May 1 2009, In : Journal of the American Academy of Dermatology. 60, 5 SUPPL. 1

    Research output: Contribution to journalArticle

    Acne Vulgaris
    Phototherapy
    R Factors
    Laser Therapy
    Therapeutics
    42 Citations (Scopus)

    Standard management options for rosacea, part 1: Overview and broad spectrum of care

    Odom, R., Dahl, M., Dover, J., Draelos, Z., Drake, L., Macsai, M., Powell, F., Thiboutot, D., Webster, G. F. & Wilkin, J., Jul 1 2009, In : Cutis. 84, 1, p. 43-47 5 p.

    Research output: Contribution to journalArticle

    Rosacea
    Information Storage and Retrieval
    Advisory Committees
    Terminology
    Signs and Symptoms
    35 Citations (Scopus)

    Standard management options for Rosacea, part 2: Options according to subtype

    Odom, R., Dahl, M., Dover, J., Draelos, Z., Drake, L., Macsai, M., Powell, F., Thiboutot, D., Webster, G. F. & Wilkin, J., Aug 1 2009, In : Cutis. 84, 2, p. 97-104 8 p.

    Research output: Contribution to journalArticle

    Rosacea
    Information Storage and Retrieval
    Advisory Committees
    Terminology
    Signs and Symptoms
    2008
    26 Citations (Scopus)

    Acne counseling to improve adherence

    Thiboutot, D., Dréno, B. & Layton, A., Jan 2008, In : Cutis. 81, 1, p. 81-86 6 p.

    Research output: Contribution to journalArticle

    Acne Vulgaris
    Counseling
    Therapeutics
    Asymptomatic Diseases
    Life Style
    35 Citations (Scopus)

    A combined oral contraceptive containing 3-mg drospirenone/20-μg ethinyl estradiol in the treatment of acne vulgaris: A randomized, double-blind, placebo-controlled study evaluating lesion counts and participant self-assessment

    Lucky, A. W., Koltun, W., Thiboutot, D., Niknian, M., Sampson-Landers, C., Korner, P. & Marr, J., Aug 1 2008, In : Cutis. 82, 2, p. 143-150 8 p.

    Research output: Contribution to journalArticle

    Contraceptives, Oral, Combined
    Ethinyl Estradiol
    Acne Vulgaris
    Placebos
    Odds Ratio
    92 Citations (Scopus)
    Acne Vulgaris
    Benzoyl Peroxide
    Clindamycin
    Gels
    Safety
    31 Citations (Scopus)

    Antibiotic use in acne vulgaris and rosacea: Clinical considerations and resistance issues of significance to dermatologists

    Del Rosso, J. Q., Leyden, J. J., Thiboutot, D. & Webster, G. F., Aug 1 2008, In : Cutis. 82, 2 SUPPL., p. 5-12 8 p.

    Research output: Contribution to journalArticle

    Rosacea
    Acne Vulgaris
    Anti-Bacterial Agents
    Dermatology
    Mupirocin
    39 Citations (Scopus)

    Azelaic acid 15% gel once daily versus twice daily in papulopustular rosacea

    Thiboutot, D. M., Fleischer, A. B., Del Rosso, J. Q. & Graupe, K., Jun 2008, In : Journal of Drugs in Dermatology. 7, 6, p. 541-546 6 p.

    Research output: Contribution to journalArticle

    Rosacea
    Gels
    Therapeutics
    Telangiectasis
    Erythema
    65 Citations (Scopus)

    Efficacy and safety of 3 mg drospirenone/20 mcg ethinylestradiol oral contraceptive administered in 24/4 regimen in the treatment of acne vulgaris: a randomized, double-blind, placebo-controlled trial

    Koltun, W., Lucky, A. W., Thiboutot, D., Niknian, M., Sampson-Landers, C., Korner, P. & Marr, J., Apr 1 2008, In : Contraception. 77, 4, p. 249-256 8 p.

    Research output: Contribution to journalArticle

    Contraceptives, Oral, Combined
    Ethinyl Estradiol
    Acne Vulgaris
    Oral Contraceptives
    Placebos
    24 Citations (Scopus)

    Efficacy and tolerability of adapalene 0.3% gel compared to tazarotene 0.1% gel in the treatment of acne vulgaris

    Thiboutot, D., Arsonnaud, S., Soto, P. & Johnson, L. A., Jun 2008, In : Journal of Drugs in Dermatology. 7, 6

    Research output: Contribution to journalArticle

    Acne Vulgaris
    Gels
    Therapeutics
    Retinoids
    tazarotene
    67 Citations (Scopus)

    Hormonal Therapy for Acne

    George, R., Clarke, S. & Thiboutot, D., Sep 1 2008, In : Seminars in Cutaneous Medicine and Surgery. 27, 3, p. 188-196 9 p.

    Research output: Contribution to journalReview article

    Acne Vulgaris
    Androgens
    Therapeutics
    Hormones
    Flutamide
    128 Citations (Scopus)

    IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase/Akt pathway

    Smith, T. M., Gilliland, K., Clawson, G. A. & Thiboutot, D., Jan 1 2008, In : Journal of Investigative Dermatology. 128, 5, p. 1286-1293 8 p.

    Research output: Contribution to journalArticle

    Lipogenesis
    1-Phosphatidylinositol 4-Kinase
    Response Elements
    Sterols
    Phosphatidylinositols
    2 Citations (Scopus)

    Improving outcomes through collaboration

    Thiboutot, D. M., Harper, J. C., O'Connell, K., Rich, P. & Sondheimer, S. J., Jan 1 2008, In : Cutis. 81, 1 SUPPL., p. 26-31 6 p.

    Research output: Contribution to journalArticle

    Oral Contraceptives
    Acne Vulgaris
    Polycystic Ovary Syndrome
    Uterine Cervical Neoplasms
    Breast Neoplasms
    15 Citations (Scopus)

    Long-term safety and efficacy study of adapalene 0.3% gel

    Weiss, J. S., Thiboutot, D. M., Hwa, J., Liu, Y. & Graeber, M., Jun 1 2008, In : Journal of Drugs in Dermatology. 7, 6

    Research output: Contribution to journalArticle

    Gels
    Safety
    Acne Vulgaris
    Skin
    Adapalene
    90 Citations (Scopus)

    Neutrophil gelatinase-associated lipocalin mediates 13-cis retinoic acid-induced apoptosis of human sebaceous gland cells

    Nelson, A. M., Zhao, W., Gilliland, K. L., Zaenglein, A. L., Liu, W. & Thiboutot, D. M., Apr 1 2008, In : Journal of Clinical Investigation. 118, 4, p. 1468-1478 11 p.

    Research output: Contribution to journalArticle

    Sebaceous Glands
    Isotretinoin
    Apoptosis
    Acne Vulgaris
    Skin
    31 Citations (Scopus)

    Overview of acne and its treatment

    Thiboutot, D. M., Jan 1 2008, In : Cutis. 81, 1 SUPPL., p. 3-7 5 p.

    Research output: Contribution to journalReview article

    Acne Vulgaris
    Pregnant Women
    Sebum
    Isotretinoin
    Stevens-Johnson Syndrome
    15 Citations (Scopus)

    Patient experiences with oily skin: The qualitative development of content for two new patient reported outcome questionnaires

    Arbuckle, R., Atkinson, M. J., Clark, M., Abetz, L., Lohs, J., Kuhagen, I., Harness, J., Draelos, Z., Thiboutot, D., Blume-Peytavi, U. & Copley-Merriman, K., Oct 16 2008, In : Health and Quality of Life Outcomes. 6, 80.

    Research output: Contribution to journalArticle

    Skin
    Focus Groups
    Internet
    Patient Reported Outcome Measures
    Surveys and Questionnaires