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Personal profile

Research interests

The Plastic Surgery Research Laboratory at Penn State is directed by Dr. Dino Ravnic and managed by Dr. Srinivas Koduru.

The laboratory's primary research effort is toward the creation of autologous vascularized engineered tissue that is suitable for microsurgical implantation and immediate reperfusion. Composite tissue defects are a common manifestation after tumor resection or traumatic injury. Reconstructive microsurgery involves the transfer of autologous tissue (free-flap) for correction of these injuries. However, flap harvest may not be an option in all individuals and can be associated with significant donor-site morbidity. Tissue engineering is the practice of combining cells, scaffolds and biologically active molecules to create functional tissue. The lab attempts to optimize these factors to craft bioengineered vascularized tissue that is patient-specific.

Adipose tissue has long been thought to be nothing more than an energy reservoir. However, it is rich in mesenchymal stem cells and endothelial cells which can serve as the cellular starting material for tissue engineering approaches. The lab has been successful in differentiating adipose derived stem cells (ADSCs) into multiple cell lines and recombining them in vitro with endothelial cells derived from the same adipose fraction. When cultured in three-dimension (3D) this cellular composition allows for adjacent microvasculature development. Furthermore, the isolation of various proteins and molecules from adipose tissue can be used in scaffold fabrication. The lab believes that the complete "deconstruction" of adipose tissue can provide most of the elements used in tissue "reconstruction."

To achieve its goals, the lab collaborates with experts in materials science for scaffold fabrication, biomedical engineers for 3D bioprinting assembly of cells/scaffolds/proteins and vascular biologists for optimization of microvascular development, integration and function.

This cross-collaborative environment has led to additional projects in tissue repair (e.g. hernia, bone) and the investigation of small RNAs for both clinical implementation and integration into tissue engineering approaches.

Fingerprint Dive into the research topics where Dino Ravnic is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Microcirculation Medicine & Life Sciences
Bioprinting Medicine & Life Sciences
Colitis Medicine & Life Sciences
Tissue Chemical Compounds
Inflammation Medicine & Life Sciences
Long Noncoding RNA Medicine & Life Sciences
Colon Medicine & Life Sciences
Microvessels Medicine & Life Sciences

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Research Output 2001 2019

  • 407 Citations
  • 14 h-Index
  • 29 Article
  • 5 Review article
  • 1 Conference contribution
  • 1 Letter
1 Citation (Scopus)

Bioprinting functional tissues

Leberfinger, A. N., Dinda, S., Wu, Y., Koduru, S., Ozbolat, V., Ravnic, D. & Ozbolat, I. T., Jan 1 2019, (Accepted/In press) In : Acta Biomaterialia.

Research output: Contribution to journalArticle

Bioprinting
Tissue
Transplants
Mechanics
Cell Count

Cellular Based Strategies for Microvascular Engineering

Koduru, S., Leberfinger, A. N., Pasic, D., Forghani, A., Lince, S., Hayes, D. J., Ozbolat, I. T. & Ravnic, D., Apr 15 2019, In : Stem Cell Reviews and Reports. 15, 2, p. 218-240 23 p.

Research output: Contribution to journalReview article

Blood Vessels
Tissue Engineering
Microvessels
Microtechnology
Microfluidics

Differentiation of Adipose Tissue–Derived CD34+/CD31− Cells into Endothelial Cells In Vitro

Forghani, A., Koduru, S., Chen, C., Leberfinger, A. N., Ravnic, D. & Hayes, D. J., Jan 1 2019, In : Regenerative Engineering and Translational Medicine.

Research output: Contribution to journalArticle

Endothelial cells
Endothelial Cells
Tissue
Vascular Endothelial Growth Factor A
Cells
1 Citation (Scopus)

Porous tissue strands: Avascular building blocks for scalable tissue fabrication

Wu, Y., Hospodiuk, M., Peng, W., Gudapati, H., Neuberger, T., Koduru, S., Ravnic, D. & Ozbolat, I. T., Jan 1 2019, In : Biofabrication. 11, 1, 015009.

Research output: Contribution to journalArticle

Tissue
Fabrication
Porosity
Cartilage
Self assembly
2 Citations (Scopus)

Development of Citrate-Based Dual-Imaging Enabled Biodegradable Electroactive Polymers

Shan, D., Kothapalli, S-R., Ravnic, D., Gerhard, E., Kim, J. P., Guo, J., Ma, C., Guo, J., Gui, L., Sun, L., Lu, D. & Yang, J., Aug 22 2018, In : Advanced Functional Materials. 28, 34, 1801787.

Research output: Contribution to journalArticle

electroactive polymers
citrates
Citric Acid
Polymers
Photoacoustic effect