Dongxiao Sun, PhD

    • 744 Citations
    • 17 h-Index

    Research output per year

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    Personal profile

    Research interests

    Dr. Dongxiao Sun's research interest is focused on small molecule analysis in different matrices by HPLC-MS/mass spectrometry as well as drug and carcinogen metabolism and pharmacogenetics study, including samples from cells, tissues, blood, urine, saliva, food, soil and many other sources.

    The mass spectrometry systems in Dr. Sun's lab include Waters Acquity UPLC-Sciex 4000 QTRAP, Sciex ExionLC-Sciex QTRAP 6500+ and Sciex ExionLC-Sciex Q TOF 5600.

    The Sun lab develops and validates method for each assay, including sample pretreatment, instrument performance and data process. Sample pretreatment includes solid-phase extraction, liquid-liquid extraction, etc., and the small molecules analyzed are in wide varieties, including amino acids, keto acids, steroids, vitamins, neurotransmitters, peptides, different drugs and their metabolites, carcinogens, natural compounds, synthetic compounds and many other biomarkers.

    The lab also conducts metabolism pathway studies focused on phase I and phase II enzyme metabolizing of small molecules, especially for pharmacogenetics.

    Education/Academic qualification

    Analytical Chemistry, PhD, University of Hong Kong


    Environmental Engineering, MS, East China University of Science and Technology


    Applied Chemistry, BS, East China University of Science and Technology

    … → 1991

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    Research Output

    • 744 Citations
    • 17 h-Index
    • 24 Article
    • 1 Conference contribution
    • 1 Review article

    Are Ergothioneine Levels in Blood Associated with Chronic Peripheral Neuropathy in Colorectal Cancer Patients Who Underwent Chemotherapy?

    Winkels, R. M., van Brakel, L., van Baar, H., Beelman, R. B., van Duijnhoven, F. J. B., Geijsen, A., van Halteren, H. K., Hansson, B. M. E., Richie, J. P., Sun, D., Wesselink, E., van Zutphen, M., Kampman, E. & Kok, D. E., Apr 2 2020, In : Nutrition and cancer. 72, 3, p. 451-459 9 p.

    Research output: Contribution to journalArticle

    Open Access
  • Pharmacokinetic Profile of Spectrum Reduced Nicotine Cigarettes

    Kamens, H. M., Silva, C. P., Nye, R. T., Miller, C. N., Singh, N., Sipko, J., Trushin, N., Sun, D., Branstetter, S. A., Muscat, J. E., Richie, J. P. & Foulds, J., Feb 6 2020, In : Nicotine and Tobacco Research. 22, 2, p. 273-279 7 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Brain cholesterol metabolism and Parkinson's disease

    Huang, X., Sterling, N. W., Du, G., Sun, D., Stetter, C., Kong, L., Zhu, Y., Neighbors, J., Lewis, M. M., Chen, H., Hohl, R. J. & Mailman, R. B., Mar 2019, In : Movement Disorders. 34, 3, p. 386-395 10 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations

    Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia

    Cury, N. M., Mühlethaler, T., Laranjeira, A. B. A., Canevarolo, R. R., Zenatti, P. P., Lucena-Agell, D., Barasoain, I., Song, C., Sun, D., Dovat, S., Yunes, R. A., Prota, A. E., Steinmetz, M. O., Díaz, J. F. & Yunes, J. A., Nov 22 2019, In : iScience. 21, p. 95-109 15 p.

    Research output: Contribution to journalArticle

    Open Access
  • Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice

    Peters, D. G., Pollack, A. N., Cheng, K. C., Sun, D., Saido, T., Haaf, M. P., Yang, Q. X., Connor, J. R. & Meadowcroft, M. D., Mar 2018, In : Metallomics. 10, 3, p. 426-443 18 p.

    Research output: Contribution to journalArticle

  • 9 Scopus citations