Dongxiao Sun, PhD

    • 666 Citations
    • 15 h-Index
    20062018
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    Personal profile

    Research interests

    Dr. Dongxiao Sun's research interest is focused on small molecule analysis in different matrices by HPLC-MS/mass spectrometry as well as drug and carcinogen metabolism and pharmacogenetics study, including samples from cells, tissues, blood, urine, saliva, food, soil and many other sources.

    The mass spectrometry systems in Dr. Sun's lab include Waters Acquity UPLC-Sciex 4000 QTRAP, Sciex ExionLC-Sciex QTRAP 6500+ and Sciex ExionLC-Sciex Q TOF 5600.

    The Sun lab develops and validates method for each assay, including sample pretreatment, instrument performance and data process. Sample pretreatment includes solid-phase extraction, liquid-liquid extraction, etc., and the small molecules analyzed are in wide varieties, including amino acids, keto acids, steroids, vitamins, neurotransmitters, peptides, different drugs and their metabolites, carcinogens, natural compounds, synthetic compounds and many other biomarkers.

    The lab also conducts metabolism pathway studies focused on phase I and phase II enzyme metabolizing of small molecules, especially for pharmacogenetics.

    Education/Academic qualification

    Analytical Chemistry, PhD, University of Hong Kong

    19962002

    Environmental Engineering, MS, East China University of Science and Technology

    19911994

    Applied Chemistry, BS, East China University of Science and Technology

    … → 1991

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    Research Output 2006 2018

    • 666 Citations
    • 15 h-Index
    • 20 Article
    • 1 Conference contribution
    • 1 Review article
    5 Citations (Scopus)

    Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice

    Peters, D. G., Pollack, A. N., Cheng, K., Sun, D., Saido, T., Haaf, M. P., Yang, Q., Connor, J. & Meadowcroft, M., Mar 1 2018, In : Metallomics. 10, 3, p. 426-443 18 p.

    Research output: Contribution to journalArticle

    Dietary Iron
    Alzheimer Disease
    Iron
    Brain
    Amyloid
    1 Citation (Scopus)

    Differences in nicotine dependence, smoke exposure and consumer characteristics between smokers of machine-injected roll-your-own cigarettes and factory-made cigarettes

    Joseph, S., Krebs, N. M., Zhu, J., Wert, Y., Goel, R., Reilly, S. M., Sun, D., Richie, J., Nikiforov, I., Cheriyath, P. & Muscat, J., Jun 1 2018, In : Drug and Alcohol Dependence. 187, p. 109-115 7 p.

    Research output: Contribution to journalArticle

    Tobacco Use Disorder
    Nicotine
    Smoke
    Tobacco Products
    Industrial plants
    1 Citation (Scopus)

    Sex/Gender Differences in Cotinine Levels among Daily Smokers in the Pennsylvania Adult Smoking Study

    Chen, A., Krebs, N. M., Zhu, J., Sun, D., Stennett, A. & Muscat, J., Nov 1 2017, In : Journal of Women's Health. 26, 11, p. 1222-1230 9 p.

    Research output: Contribution to journalArticle

    Cotinine
    Nicotine
    Sex Characteristics
    Smoking
    Tobacco Use Disorder
    9 Citations (Scopus)

    Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice

    Mattocks, D. A. L., Mentch, S. J., Shneyder, J., Ables, G. P., Sun, D., Richie, J., Locasale, J. W. & Nichenametla, S. N., Feb 1 2017, In : Experimental Gerontology. 88, p. 1-8 8 p.

    Research output: Contribution to journalArticle

    DNA Methylation
    Inbred C57BL Mouse
    Methionine
    Methylation
    Young Adult
    10 Citations (Scopus)

    Comparison of Puff Volume with Cigarettes per Day in Predicting Nicotine Uptake among Daily Smokers

    Krebs, N. M., Chen, A., Zhu, J., Sun, D., Liao, J. J., Stennett, A. L. & Muscat, J., Jul 1 2016, In : American Journal of Epidemiology. 184, 1, p. 48-57 10 p.

    Research output: Contribution to journalArticle

    Nicotine
    Tobacco Products
    Cotinine
    Smoking
    Inhalation