Dongxiao Sun, PhD

    • 722 Citations
    • 16 h-Index
    20062019
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    Personal profile

    Research interests

    Dr. Dongxiao Sun's research interest is focused on small molecule analysis in different matrices by HPLC-MS/mass spectrometry as well as drug and carcinogen metabolism and pharmacogenetics study, including samples from cells, tissues, blood, urine, saliva, food, soil and many other sources.

    The mass spectrometry systems in Dr. Sun's lab include Waters Acquity UPLC-Sciex 4000 QTRAP, Sciex ExionLC-Sciex QTRAP 6500+ and Sciex ExionLC-Sciex Q TOF 5600.

    The Sun lab develops and validates method for each assay, including sample pretreatment, instrument performance and data process. Sample pretreatment includes solid-phase extraction, liquid-liquid extraction, etc., and the small molecules analyzed are in wide varieties, including amino acids, keto acids, steroids, vitamins, neurotransmitters, peptides, different drugs and their metabolites, carcinogens, natural compounds, synthetic compounds and many other biomarkers.

    The lab also conducts metabolism pathway studies focused on phase I and phase II enzyme metabolizing of small molecules, especially for pharmacogenetics.

    Education/Academic qualification

    Analytical Chemistry, PhD, University of Hong Kong

    19962002

    Environmental Engineering, MS, East China University of Science and Technology

    19911994

    Applied Chemistry, BS, East China University of Science and Technology

    … → 1991

    Fingerprint Dive into the research topics where Dongxiao Sun is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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    Research Output 2006 2019

    • 722 Citations
    • 16 h-Index
    • 23 Article
    • 1 Conference contribution
    • 1 Review article

    Are Ergothioneine Levels in Blood Associated with Chronic Peripheral Neuropathy in Colorectal Cancer Patients Who Underwent Chemotherapy?

    Winkels, R., Van Brakel, L., Van Baar, H., Beelman, R. B., Van Duijnhoven, F. J. B., Geijsen, A., Van Halteren, H. K., Hansson, B. M. E., Richie, J., Sun, D., Wesselink, E., Van Zutphen, M., Kampman, E. & Kok, D. E., Jan 1 2019, In : Nutrition and cancer.

    Research output: Contribution to journalArticle

    Open Access
    Ergothioneine
    Peripheral Nervous System Diseases
    Colorectal Neoplasms
    Drug Therapy
    Sample Size
    3 Citations (Scopus)

    Brain cholesterol metabolism and Parkinson's disease

    Huang, X., Sterling, N. W., Du, G., Sun, D., Stetter, C., Kong, L., Zhu, Y., Neighbors, J., Lewis, M., Chen, H., Hohl, R. & Mailman, R., Mar 1 2019, In : Movement Disorders. 34, 3, p. 386-395 10 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Cholesterol
    Brain
    Odds Ratio
    Logistic Models

    Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia

    Cury, N. M., Mühlethaler, T., Laranjeira, A. B. A., Canevarolo, R. R., Zenatti, P. P., Lucena-Agell, D., Barasoain, I., Song, C., Sun, D., Dovat, S., Yunes, R. A., Prota, A. E., Steinmetz, M. O., Díaz, J. F. & Yunes, J. A., Nov 22 2019, In : iScience. 21, p. 95-109 15 p.

    Research output: Contribution to journalArticle

    Open Access
    Colchicine
    Tubulin
    Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Tubulin Modulators
    ATP-Binding Cassette Transporters
    8 Citations (Scopus)

    Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice

    Peters, D. G., Pollack, A. N., Cheng, K., Sun, D., Saido, T., Haaf, M. P., Yang, Q., Connor, J. & Meadowcroft, M., Mar 1 2018, In : Metallomics. 10, 3, p. 426-443 18 p.

    Research output: Contribution to journalArticle

    Dietary Iron
    Alzheimer Disease
    Iron
    Brain
    Amyloid
    3 Citations (Scopus)

    Differences in nicotine dependence, smoke exposure and consumer characteristics between smokers of machine-injected roll-your-own cigarettes and factory-made cigarettes

    Joseph, S., Krebs, N. M., Zhu, J., Wert, Y., Goel, R., Reilly, S. M., Sun, D., Richie, J., Nikiforov, I., Cheriyath, P. & Muscat, J., Jun 1 2018, In : Drug and Alcohol Dependence. 187, p. 109-115 7 p.

    Research output: Contribution to journalArticle

    Tobacco Use Disorder
    Nicotine
    Smoke
    Tobacco Products
    Industrial plants