Dongxiao Sun, PhD

    • 726 Citations
    • 16 h-Index
    20062019
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    Research Output 2006 2019

    • 726 Citations
    • 16 h-Index
    • 23 Article
    • 1 Conference contribution
    • 1 Review article
    2019

    Are Ergothioneine Levels in Blood Associated with Chronic Peripheral Neuropathy in Colorectal Cancer Patients Who Underwent Chemotherapy?

    Winkels, R., Van Brakel, L., Van Baar, H., Beelman, R. B., Van Duijnhoven, F. J. B., Geijsen, A., Van Halteren, H. K., Hansson, B. M. E., Richie, J., Sun, D., Wesselink, E., Van Zutphen, M., Kampman, E. & Kok, D. E., Jan 1 2019, In : Nutrition and cancer.

    Research output: Contribution to journalArticle

    Open Access
    Ergothioneine
    Peripheral Nervous System Diseases
    Colorectal Neoplasms
    Drug Therapy
    Sample Size
    4 Citations (Scopus)

    Brain cholesterol metabolism and Parkinson's disease

    Huang, X., Sterling, N. W., Du, G., Sun, D., Stetter, C., Kong, L., Zhu, Y., Neighbors, J., Lewis, M. M., Chen, H., Hohl, R. J. & Mailman, R. B., Mar 2019, In : Movement Disorders. 34, 3, p. 386-395 10 p.

    Research output: Contribution to journalArticle

    Parkinson Disease
    Cholesterol
    Brain
    Odds Ratio
    Logistic Models

    Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia

    Cury, N. M., Mühlethaler, T., Laranjeira, A. B. A., Canevarolo, R. R., Zenatti, P. P., Lucena-Agell, D., Barasoain, I., Song, C., Sun, D., Dovat, S., Yunes, R. A., Prota, A. E., Steinmetz, M. O., Díaz, J. F. & Yunes, J. A., Nov 22 2019, In : iScience. 21, p. 95-109 15 p.

    Research output: Contribution to journalArticle

    Open Access
    Colchicine
    Tubulin
    Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Tubulin Modulators
    ATP-Binding Cassette Transporters
    2018
    8 Citations (Scopus)

    Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice

    Peters, D. G., Pollack, A. N., Cheng, K., Sun, D., Saido, T., Haaf, M. P., Yang, Q., Connor, J. & Meadowcroft, M., Mar 1 2018, In : Metallomics. 10, 3, p. 426-443 18 p.

    Research output: Contribution to journalArticle

    Dietary Iron
    Alzheimer Disease
    Iron
    Brain
    Amyloid
    3 Citations (Scopus)

    Differences in nicotine dependence, smoke exposure and consumer characteristics between smokers of machine-injected roll-your-own cigarettes and factory-made cigarettes

    Joseph, S., Krebs, N. M., Zhu, J., Wert, Y., Goel, R., Reilly, S. M., Sun, D., Richie, J. P., Nikiforov, I., Cheriyath, P. & Muscat, J. E., Jun 1 2018, In : Drug and alcohol dependence. 187, p. 109-115 7 p.

    Research output: Contribution to journalArticle

    Tobacco Use Disorder
    Nicotine
    Smoke
    Tobacco Products
    Industrial plants
    2017
    3 Citations (Scopus)

    Sex/Gender Differences in Cotinine Levels among Daily Smokers in the Pennsylvania Adult Smoking Study

    Chen, A., Krebs, N. M., Zhu, J., Sun, D., Stennett, A. & Muscat, J. E., Nov 2017, In : Journal of Women's Health. 26, 11, p. 1222-1230 9 p.

    Research output: Contribution to journalArticle

    Cotinine
    Nicotine
    Sex Characteristics
    Smoking
    Tobacco Use Disorder
    14 Citations (Scopus)

    Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice

    Mattocks, D. A. L., Mentch, S. J., Shneyder, J., Ables, G. P., Sun, D., Richie, J. P., Locasale, J. W. & Nichenametla, S. N., Feb 1 2017, In : Experimental Gerontology. 88, p. 1-8 8 p.

    Research output: Contribution to journalArticle

    DNA Methylation
    Inbred C57BL Mouse
    Methionine
    Methylation
    Young Adult
    2016
    15 Citations (Scopus)

    Comparison of Puff Volume with Cigarettes per Day in Predicting Nicotine Uptake among Daily Smokers

    Krebs, N. M., Chen, A., Zhu, J., Sun, D., Liao, J. J., Stennett, A. L. & Muscat, J., Jul 1 2016, In : American Journal of Epidemiology. 184, 1, p. 48-57 10 p.

    Research output: Contribution to journalArticle

    Nicotine
    Tobacco Products
    Cotinine
    Smoking
    Inhalation
    2014
    51 Citations (Scopus)

    Regulation of UDP-glucuronosyltransferase 1A1 expression and activity by MicroRNA 491-3ps

    Dluzen, D. F., Sun, D., Salzberg, A. C., Jones, N., Bushey, R. T., Robertson, G. P. & Lazarus, P., Mar 1 2014, In : Journal of Pharmacology and Experimental Therapeutics. 348, 3, p. 465-477 13 p.

    Research output: Contribution to journalArticle

    MicroRNAs
    Messenger RNA
    Glucuronides
    Enzymes
    Liver
    2013
    22 Citations (Scopus)

    Characterization of raloxifene glucuronidation: Potential role of UGT1A8 genotype on raloxifene metabolism in vivo

    Sun, D., Jones, N. R., Manni, A. & Lazarus, P., Jul 2013, In : Cancer Prevention Research. 6, 7, p. 719-730 12 p.

    Research output: Contribution to journalArticle

    Genotype
    Glucuronides
    UGT1A8 UDP-glucuronosyltransferase
    Raloxifene Hydrochloride
    Selective Estrogen Receptor Modulators
    2012
    19 Citations (Scopus)
    norclozapine
    Clozapine
    Antipsychotic Agents
    Liver Microsomes
    Glucuronosyltransferase
    17 Citations (Scopus)
    Glucuronosyltransferase
    Exons
    Liver
    Messenger RNA
    Hep G2 Cells
    2011
    8 Citations (Scopus)

    Characterization of dibenzo[ a,l pyrene- trans -11,12-diol (dibenzo[ def,p chrysene) glucuronidation by UDP-glucuronosyltransferases

    Olson, K. C., Sun, D., Chen, G., Sharma, A., Amin, S., Ropson, I., Spratt, T. & Lazarus, P., Sep 19 2011, In : Chemical Research in Toxicology. 24, 9, p. 1549-1559 11 p.

    Research output: Contribution to journalArticle

    Glucuronosyltransferase
    Glucuronides
    Uridine Diphosphate
    Enantiomers
    Diphosphates
    2010
    45 Citations (Scopus)

    Characterization of 17-dihydroexemestane glucuronidation: Potential role of the UGT2B17 deletion in exemestane pharmacogenetics

    Sun, D., Chen, G., Dellinger, R. W., Sharma, A. K. & Lazarus, P., Oct 1 2010, In : Pharmacogenetics and Genomics. 20, 10, p. 575-585 11 p.

    Research output: Contribution to journalArticle

    exemestane
    Pharmacogenetics
    Aromatase
    Glucuronides
    Liver Microsomes
    33 Citations (Scopus)

    Potential role of UGT pharmacogenetics in cancer treatment and prevention: Focus on tamoxifen and aromatase inhibitors

    Lazarus, P. & Sun, D., Feb 2010, In : Drug Metabolism Reviews. 42, 1, p. 182-194 13 p.

    Research output: Contribution to journalReview article

    Aromatase Inhibitors
    Pharmacogenetics
    Tamoxifen
    exemestane
    Breast Neoplasms
    43 Citations (Scopus)

    Sex differences in UDP-glucuronosyltransferase 2B17 expression and activity

    Gallagher, C. J., Balliet, R. M., Sun, D., Chen, G. & Lazarus, P., Dec 1 2010, In : Drug Metabolism and Disposition. 38, 12, p. 2204-2209 6 p.

    Research output: Contribution to journalArticle

    Glucuronosyltransferase
    Sex Characteristics
    Liver Microsomes
    Human Activities
    Carcinogens
    2009
    45 Citations (Scopus)

    Characterization of UGTs active against SAHA and association between SAHA glucuronidation activity phenotype with UGT genotype

    Balliet, R. M., Chen, G., Gallagher, C. J., Dellinger, R. W., Sun, D. & Lazarusw, P., Apr 1 2009, In : Cancer Research. 69, 7, p. 2981-2989 9 p.

    Research output: Contribution to journalArticle

    Glucuronosyltransferase
    Genotype
    Phenotype
    Liver Microsomes
    vorinostat
    20 Citations (Scopus)

    Functional characterization of low-prevalence missense polymorphisms in the UDP-glucuronosyltransferase 1A9 gene

    Olson, K. C., Dellinger, R. W., Zhong, Q., Sun, D., Amin, S., Spratt, T. E. & Lazarus, P., Oct 1 2009, In : Drug Metabolism and Disposition. 37, 10, p. 1999-2007 9 p.

    Research output: Contribution to journalArticle

    Cheek
    HEK293 Cells
    Amino Acid Substitution
    Codon
    African Americans
    57 Citations (Scopus)

    Functional significance of UDP-Glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites

    Blevins-Primeau, A. S., Sun, D., Chen, G., Sharma, A. K., Gallagher, C. J., Amin, S. & Lazaru, P., Mar 1 2009, In : Cancer Research. 69, 5, p. 1892-1900 9 p.

    Research output: Contribution to journalArticle

    Glucuronosyltransferase
    Tamoxifen
    Genotype
    Selective Estrogen Receptor Modulators
    Liver
    38 Citations (Scopus)

    Potential role of UGT pharmacogenetics in cancer treatment and prevention: Focus on tamoxifen

    Lazarus, P., Blevins-Primeau, A. S., Zheng, Y. & Sun, D., Jan 1 2009, Steroid Enzymes and Cancer. Blackwell Publishing Inc., p. 99-111 13 p. (Annals of the New York Academy of Sciences; vol. 1155).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Oncology
    Pharmacogenetics
    Tamoxifen
    Neoplasms
    Breast Neoplasms
    2008
    50 Citations (Scopus)

    Glucuronidation of tobacco-specific nitrosamines by UGT2B10

    Chen, G., Dellinger, R. W., Sun, D., Spratt, T. E. & Lazarus, P., May 1 2008, In : Drug Metabolism and Disposition. 36, 5, p. 824-830 7 p.

    Research output: Contribution to journalArticle

    Nitrosamines
    Tobacco
    Glucuronosyltransferase
    N'-nitrosonornicotine
    Liver
    31 Citations (Scopus)

    Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines

    Chen, G., Dellinger, R. W., Gallagher, C. J., Sun, D. & Lazarus, P., Mar 1 2008, In : Pharmacogenetics and Genomics. 18, 3, p. 181-191 11 p.

    Research output: Contribution to journalArticle

    Nitrosamines
    Haplotypes
    Tobacco
    Liver Microsomes
    Genes
    2007
    44 Citations (Scopus)

    Elimination of antiestrogenic effects of active tamoxifen metabolites by glucuronidation

    Zheng, Y., Sun, D., Sharma, A. K., Chen, G., Amin, S. & Lazarus, P., Oct 1 2007, In : Drug Metabolism and Disposition. 35, 10, p. 1942-1948 7 p.

    Research output: Contribution to journalArticle

    Tamoxifen
    Progesterone Receptors
    Glucuronides
    Gene Expression
    Estrogen Receptor Modulators
    71 Citations (Scopus)

    Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases

    Sun, D., Sharma, A. K., Dellinger, R. W., Blevins-Primeau, A. S., Balliet, R. M., Chen, G., Boyiri, T., Amin, S. & Lazarus, P., Nov 1 2007, In : Drug Metabolism and Disposition. 35, 11, p. 2006-2014 9 p.

    Research output: Contribution to journalArticle

    Glucuronosyltransferase
    Tamoxifen
    hydroxide ion
    Estrogen Receptor Modulators
    4-hydroxy-N-desmethyltamoxifen
    2006
    83 Citations (Scopus)

    Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants

    Sun, D., Chen, G., Dellinger, R. W., Duncan, K., Fang, J. L. & Lazarus, P., Aug 2 2006, In : Breast Cancer Research. 8, 4, R50.

    Research output: Contribution to journalArticle

    Tamoxifen
    Glucuronides
    Microsomes
    afimoxifene
    bilirubin glucuronoside glucuronosyltransferase