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Personal profile

Research interests

The worldwide prevalence of esophageal cancer varies greatly, with the highest rates found in Asia. In the United States, the two most common types of esophageal cancers are squamous cell carcinoma (ESCC) and adenocarcinoma (EAC). Since patients are typically diagnosed at a late stage of the disease, overall five-year survival is approximately 18 percent. Given the poor survival rate, the advanced stage of the disease at diagnosis and the increasing frequency of ESCC (worldwide) and EAC (U.S.), it is increasingly important to understand the molecular mechanisms of initiation of these tumors as well as the genes and pathways involved, which is what Dr. Douglas Stairs' work focuses on.

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  • 12 Similar Profiles
Barrett Esophagus Medicine & Life Sciences
Human Mammary Glands Medicine & Life Sciences
Epithelium Medicine & Life Sciences
Breast Medicine & Life Sciences
Epidermal Growth Factor Receptor Medicine & Life Sciences
Esophageal Neoplasms Medicine & Life Sciences
Down-Regulation Medicine & Life Sciences
Neoplasms Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2007 2014

Esophageal Neoplasms
Adherens Junctions
Cell Movement
Esophageal Neoplasms

Research Output 1998 2019

  • 1822 Citations
  • 17 h-Index
  • 24 Article
  • 1 Chapter
  • 1 Comment/debate
  • 1 Review article

E-cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions

Nelson, A., Cong, Z., Gettle, S. L., Longenecker, A. L., Kidacki, M., Sciacca Kirby, J., Adams, D., Stairs, D. & Danby, F. W., Jul 1 2019, In : Experimental Dermatology. 28, 7, p. 867-871 5 p.

Research output: Contribution to journalArticle

Hidradenitis Suppurativa
4 Citations (Scopus)

NFkB hyperactivation causes invasion of esophageal squamous cell carcinoma with EGFR overexpression and p120-catenin down-regulation

Lehman, H. L., Kidacki, M., Warrick, J. I. & Stairs, D. B., Jan 1 2018, In : Oncotarget. 9, 13, p. 11180-11196 17 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Esophageal Squamous Cell Carcinoma
delta catenin
6 Citations (Scopus)

p120-catenin downregulation and PIK3CA mutations cooperate to induce invasion through MMP1 in HNSCC

Kidacki, M., Lehman, H. L., Green, M. V., Warrick, J. I. & Stairs, D. B., Oct 1 2017, In : Molecular Cancer Research. 15, 10, p. 1398-1409 12 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Neoplasm Metastasis
4 Citations (Scopus)

Increasing diagnostic accuracy to grade dysplasia in Barrett's esophagus using an immunohistochemical panel for CDX2, p120ctn, c-Myc and Jagged1

Karamchandani, D., Lehman, H. L., Ohanessian, S. E., Massé, J., Welsh, P. A., Odze, R. D., Goldblum, J. R., Berg, A. & Stairs, D., Feb 29 2016, In : Diagnostic Pathology. 11, 1, 23.

Research output: Contribution to journalArticle

Barrett Esophagus
Proto-Oncogene Proteins c-myc
Principal Component Analysis
ROC Curve
9 Citations (Scopus)

Proteomic and metabolic signatures of esophageal squamous cell carcinoma

Karagoz, K., Lehman, H. L., Stairs, D. B., Sinha, R. & Arga, K. Y., Oct 1 2016, In : Current Cancer Drug Targets. 16, 8, p. 721-736 16 p.

Research output: Contribution to journalArticle

dimethylaniline monooxygenase (N-oxide forming)
Esophageal Squamous Cell Carcinoma