Projects per year
Personal profile
Research interests
The worldwide prevalence of esophageal cancer varies greatly, with the highest rates found in Asia. In the United States, the two most common types of esophageal cancers are squamous cell carcinoma (ESCC) and adenocarcinoma (EAC). Since patients are typically diagnosed at a late stage of the disease, overall five-year survival is approximately 18 percent. Given the poor survival rate, the advanced stage of the disease at diagnosis and the increasing frequency of ESCC (worldwide) and EAC (U.S.), it is increasingly important to understand the molecular mechanisms of initiation of these tumors as well as the genes and pathways involved, which is what Dr. Douglas Stairs' work focuses on.
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Projects
- 2 Finished
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Role of p120ctn in Esophageal Cancer
Stairs, D. & STAIRS, D.
7/1/07 → 6/30/10
Project: Research project
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The environmental pollutant and tobacco smoke constituent dibenzo[def,p]chrysene is a co-factor for malignant progression of mouse oral papillomavirus infections
Christensen, N. D., Chen, K. M., Hu, J., Stairs, D. B., Sun, Y. W., Aliaga, C., Balogh, K. K., Atkins, H., Shearer, D., Li, J., Brendle, S. A., Gowda, K., Amin, S., Walter, V., Viscidi, R. & El-Bayoumy, K., Jan 5 2021, In: Chemico-Biological Interactions. 333, 109321.Research output: Contribution to journal › Article › peer-review
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An integrated approach for preventing oral cavity and oropharyngeal cancers: Two etiologies with distinct and shared mechanisms of carcinogenesis
El-Bayoumy, K., Christensen, N. D., Hu, J., Viscidi, R., Stairs, D. B., Walter, V., Chen, K. M., Sun, Y. W., Muscat, J. E. & Richie, J. P., Aug 1 2020, In: Cancer Prevention Research. 13, 8, p. 649-660 12 p.Research output: Contribution to journal › Review article › peer-review
3 Scopus citations -
Loss of p120ctn causes EGFR-targeted therapy resistance and failure
Landmesser, M. E., Raup-Konsavage, W. M., Lehman, H. L. & Stairs, D. B., Oct 2020, In: PloS one. 15, 10 October, e0241299.Research output: Contribution to journal › Article › peer-review
Open Access -
Twist2 is NFkB-responsive when p120-catenin is inactivated and EGFR is overexpressed in esophageal keratinocytes
Lehman, H. L., Kidacki, M. & Stairs, D. B., Dec 1 2020, In: Scientific reports. 10, 1, 18829.Research output: Contribution to journal › Article › peer-review
Open Access -
E-cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions
Nelson, A. M., Cong, Z., Gettle, S. L., Longenecker, A. L., Kidacki, M., Kirby, J. S., Adams, D. R., Stairs, D. B. & Danby, F. W., Jul 2019, In: Experimental Dermatology. 28, 7, p. 867-871 5 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations