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Personal profile

Research interests

The worldwide prevalence of esophageal cancer varies greatly, with the highest rates found in Asia. In the United States, the two most common types of esophageal cancers are squamous cell carcinoma (ESCC) and adenocarcinoma (EAC). Since patients are typically diagnosed at a late stage of the disease, overall five-year survival is approximately 18 percent. Given the poor survival rate, the advanced stage of the disease at diagnosis and the increasing frequency of ESCC (worldwide) and EAC (U.S.), it is increasingly important to understand the molecular mechanisms of initiation of these tumors as well as the genes and pathways involved, which is what Dr. Douglas Stairs' work focuses on.

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  • 9 Similar Profiles
Barrett Esophagus Medicine & Life Sciences
Human Mammary Glands Medicine & Life Sciences
Epithelium Medicine & Life Sciences
Breast Medicine & Life Sciences
Epidermal Growth Factor Receptor Medicine & Life Sciences
Esophageal Neoplasms Medicine & Life Sciences
Down-Regulation Medicine & Life Sciences
Neoplasms Medicine & Life Sciences

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Projects 2007 2014

Neoplasms
Cadherins
Esophageal Neoplasms
Adherens Junctions
Cell Movement
Esophageal Neoplasms
Cadherins
Phosphorylation
Aptitude
Catenins

Research Output 1998 2019

  • 1763 Citations
  • 17 h-Index
  • 24 Article
  • 1 Chapter
  • 1 Comment/debate
  • 1 Review article

E-cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions

Nelson, A., Cong, Z., Gettle, S. L., Longenecker, A. L., Kidacki, M., Sciacca Kirby, J., Adams, D., Stairs, D. & Danby, F. W., Jul 1 2019, In : Experimental Dermatology. 28, 7, p. 867-871 5 p.

Research output: Contribution to journalArticle

Hidradenitis Suppurativa
Cadherins
Skin
Catenins
Proteins
3 Citations (Scopus)

NFkB hyperactivation causes invasion of esophageal squamous cell carcinoma with EGFR overexpression and p120-catenin down-regulation

Lehman, H. L., Kidacki, M., Warrick, J. & Stairs, D., Jan 1 2018, In : Oncotarget. 9, 13, p. 11180-11196 17 p.

Research output: Contribution to journalArticle

Down-Regulation
rho-Associated Kinases
Esophageal Squamous Cell Carcinoma
delta catenin
Keratinocytes
6 Citations (Scopus)

p120-catenin downregulation and PIK3CA mutations cooperate to induce invasion through MMP1 in HNSCC

Kidacki, M., Lehman, H. L., Green, M. V., Warrick, J. & Stairs, D., Oct 1 2017, In : Molecular Cancer Research. 15, 10, p. 1398-1409 12 p.

Research output: Contribution to journalArticle

Down-Regulation
Mutation
Phosphatidylinositol 3-Kinases
Neoplasm Metastasis
Neoplasms
4 Citations (Scopus)

Increasing diagnostic accuracy to grade dysplasia in Barrett's esophagus using an immunohistochemical panel for CDX2, p120ctn, c-Myc and Jagged1

Karamchandani, D., Lehman, H. L., Ohanessian, S. E., Massé, J., Welsh, P. A., Odze, R. D., Goldblum, J. R., Berg, A. & Stairs, D., Feb 29 2016, In : Diagnostic Pathology. 11, 1, 23.

Research output: Contribution to journalArticle

Barrett Esophagus
Proto-Oncogene Proteins c-myc
Adenocarcinoma
Principal Component Analysis
ROC Curve
6 Citations (Scopus)

Proteomic and metabolic signatures of esophageal squamous cell carcinoma

Karagoz, K., Lehman, H. L., Stairs, D., Sinha, R. & Arga, K. Y., Oct 1 2016, In : Current Cancer Drug Targets. 16, 8, p. 721-736 16 p.

Research output: Contribution to journalArticle

Proteomics
Biomarkers
dimethylaniline monooxygenase (N-oxide forming)
Genes
Esophageal Squamous Cell Carcinoma