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Douglas Stairs, PhD

 https://orcid.org/0000-0002-4875-6582
    • 1912 Citations
    • 17 h-Index
    19982020

    Research output per year

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    Personal profile

    Research interests

    The worldwide prevalence of esophageal cancer varies greatly, with the highest rates found in Asia. In the United States, the two most common types of esophageal cancers are squamous cell carcinoma (ESCC) and adenocarcinoma (EAC). Since patients are typically diagnosed at a late stage of the disease, overall five-year survival is approximately 18 percent. Given the poor survival rate, the advanced stage of the disease at diagnosis and the increasing frequency of ESCC (worldwide) and EAC (U.S.), it is increasingly important to understand the molecular mechanisms of initiation of these tumors as well as the genes and pathways involved, which is what Dr. Douglas Stairs' work focuses on.

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    Projects

    Regulation of p120-catenin tumor supressor activities

    Stairs, D.

    National Cancer Institute

    9/29/09 → 8/31/10

    Project: Research project

    • Role of p120ctn in Esophageal Cancer

    Stairs, D.

    National Cancer Institute

    7/1/07 → 6/30/08

    Project: Research project

    • Research Output

    • 1912 Citations
    • 17 h-Index
    • 24 Article
    • 2 Review article
    • 1 Chapter
    • 1 Comment/debate

    An Integrated Approach for Preventing Oral Cavity and Oropharyngeal Cancers: Two Etiologies with Distinct and Shared Mechanisms of Carcinogenesis

    El-Bayoumy, K., Christensen, N. D., Hu, J., Viscidi, R., Stairs, D., Walter, V., Chen, K. M., Sun, Y. W., Muscat, J. & Richie, J. P., Aug 1 2020, In : Cancer prevention research (Philadelphia, Pa.). 13, 8, p. 649-660 12 p.

    Research output: Contribution to journal › Review article

    • E-cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions

    Nelson, A. M., Cong, Z., Gettle, S. L., Longenecker, A. L., Kidacki, M., Kirby, J. S., Adams, D. R., Stairs, D. B. & Danby, F. W., Jul 2019, In : Experimental Dermatology. 28, 7, p. 867-871 5 p.

    Research output: Contribution to journal › Article

    • 1 Scopus citations

    NFkB hyperactivation causes invasion of esophageal squamous cell carcinoma with EGFR overexpression and p120-catenin down-regulation

    Lehman, H. L., Kidacki, M., Warrick, J. I. & Stairs, D. B., 2018, In : Oncotarget. 9, 13, p. 11180-11196 17 p.

    Research output: Contribution to journal › Article

    • 4 Scopus citations

    p120-catenin downregulation and PIK3CA mutations cooperate to induce invasion through MMP1 in HNSCC

    Kidacki, M., Lehman, H. L., Green, M. V., Warrick, J. I. & Stairs, D. B., Oct 1 2017, In : Molecular Cancer Research. 15, 10, p. 1398-1409 12 p.

    Research output: Contribution to journal › Article

    • 7 Scopus citations

    Increasing diagnostic accuracy to grade dysplasia in Barrett's esophagus using an immunohistochemical panel for CDX2, p120ctn, c-Myc and Jagged1

    Karamchandani, D. M., Lehman, H. L., Ohanessian, S. E., Massé, J., Welsh, P. A., Odze, R. D., Goldblum, J. R., Berg, A. S. & Stairs, D. B., Feb 29 2016, In : Diagnostic Pathology. 11, 1, 23.

    Research output: Contribution to journal › Article

    • 4 Scopus citations