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Personal profile

Research interests

As a Professor of Orthopaedic Surgery specializing in Musculoskeletal Oncology Surgery, Dr. Edward Fox has seen firsthand the limitations of current medical technology in managing traumatic and tumor-related segmental bone loss. Off-the-shelf medical endoprosthetic implants do not meet the demands mechanically, biologically or even durably that patients' simple activities of daily living require. This results in failure to fully restore patient anatomic motor function and/or premature implant failure via wear, loosening or infection. That, in turn, requires additional surgeries to correct these deficits, resulting in additional patient morbidity and mortality and increased healthcare expenditures.

Other areas of Dr. Fox's research include osteosarcoma, a malignant neoplasm of mesenchymal origin that is presumed to arise from osteoblasts; hip fractures that are common in the elderly; patients with hip fractures who frequently have comorbid illnesses; and osteoporosis.

Dr. Fox's experience and qualifications as an orthopaedic musculoskeletal oncology surgeon give him clinical and biologic knowledge of bone segmental defects. He has publications relating to tumor segmental bone defects and has had collaborative MD and PhD research projects with successful research grants.

Education/Academic qualification

MD, University of Rochester

… → 1995

BA, University of Rochester

… → 1991

Fingerprint Dive into the research topics where Edward Fox is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Neoplasms Medicine & Life Sciences
Differential Diagnosis Medicine & Life Sciences
Spontaneous Fractures Medicine & Life Sciences
Thigh Medicine & Life Sciences
Femur Medicine & Life Sciences
Osteoporosis Medicine & Life Sciences
Bone and Bones Medicine & Life Sciences
Orthopedics Medicine & Life Sciences

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Research Output 1996 2019

  • 786 Citations
  • 15 h-Index
  • 40 Article
  • 4 Review article

Parametric Finite Element Analysis of Intramedullary Nail Fixation of Proximal Femur Fractures

Tucker, S. M., Wee, H., Fox, E., Reid, J. & Lewis, G., Nov 1 2019, In : Journal of Orthopaedic Research. 37, 11, p. 2358-2366 9 p.

Research output: Contribution to journalArticle

Finite Element Analysis
Fracture Fixation
Intramedullary Fracture Fixation

Zoledronic Acid Improves Muscle Function in Healthy Mice Treated with Chemotherapy

Hain, B. A., Jude, B., Xu, H., Smuin, D. M., Fox, E. J., Elfar, J. C. & Waning, D. L., Jan 1 2019, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

zoledronic acid
Muscle Weakness
Bone and Bones
Drug Therapy

Comparison of osteoporosis pharmacotherapy fracture rates: Analysis of a marketScan® claims database cohort

Reynolds, A. W., Liu, G., Kocis, P. T., Skowronski, J. N., Leslie, D. L. & Fox, E. J., Jul 1 2018, In : International Journal of Endocrinology and Metabolism. 16, 3, e12104.

Research output: Contribution to journalArticle

Drug Therapy

Hospitalizations for fracture in patients with metastatic disease: Primary source lesions in the United States

Nikkel, L. E., Mahmood, B., Lander, S., Maceroli, M., Fox, E. J., Tyler, W., Karbach, L. & Elfar, J. C., Feb 2018, In : Journal of Community and Supportive Oncology. 16, 1, p. e14-e20

Research output: Contribution to journalArticle

Spontaneous Fractures
Organized Financing
Kidney Neoplasms
Costs and Cost Analysis

Isolated limb infusion as a treatment option for malignant granular cell tumour

Tian, Y., Fox, E., Drabick, J. & Pameijer, C., Jan 1 2018, In : BMJ case reports. 2018, 224618.

Research output: Contribution to journalArticle

Granular Cell Tumor