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Personal profile

Research interests

As a Professor of Orthopaedic Surgery specializing in Musculoskeletal Oncology Surgery, Dr. Edward Fox has seen firsthand the limitations of current medical technology in managing traumatic and tumor-related segmental bone loss. Off-the-shelf medical endoprosthetic implants do not meet the demands mechanically, biologically or even durably that patients' simple activities of daily living require. This results in failure to fully restore patient anatomic motor function and/or premature implant failure via wear, loosening or infection. That, in turn, requires additional surgeries to correct these deficits, resulting in additional patient morbidity and mortality and increased healthcare expenditures.

Other areas of Dr. Fox's research include osteosarcoma, a malignant neoplasm of mesenchymal origin that is presumed to arise from osteoblasts; hip fractures that are common in the elderly; patients with hip fractures who frequently have comorbid illnesses; and osteoporosis.

Dr. Fox's experience and qualifications as an orthopaedic musculoskeletal oncology surgeon give him clinical and biologic knowledge of bone segmental defects. He has publications relating to tumor segmental bone defects and has had collaborative MD and PhD research projects with successful research grants.

Education/Academic qualification

MD, University of Rochester

… → 1995

BA, University of Rochester

… → 1991

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Research Output 1996 2018

  • 722 Citations
  • 14 h-Index
  • 37 Article
  • 3 Review article

Comparison of osteoporosis pharmacotherapy fracture rates: Analysis of a marketScan® claims database cohort

Reynolds, A. W., Liu, G., Kocis, P. T., Skowronski, J. N., Leslie, D. L. & Fox, E. J., Jul 1 2018, In : International Journal of Endocrinology and Metabolism. 16, 3, e12104.

Research output: Contribution to journalArticle

Osteoporosis
Databases
Drug Therapy
Diphosphonates
Teriparatide

Hospitalizations for fracture in patients with metastatic disease: Primary source lesions in the United States

Nikkel, L. E., Mahmood, B., Lander, S., Maceroli, M., Fox, E., Tyler, W., Karbach, L. & Elfar, J., Feb 1 2018, In : Journal of Community and Supportive Oncology. 16, 1, p. e14-e20

Research output: Contribution to journalArticle

Spontaneous Fractures
Hospitalization
Organized Financing
Kidney Neoplasms
Costs and Cost Analysis

Isolated limb infusion as a treatment option for malignant granular cell tumour

Tian, Y., Fox, E., Drabick, J. & Pameijer, C., Jan 1 2018, In : BMJ Case Reports. 2018, 224618.

Research output: Contribution to journalArticle

Granular Cell Tumor
Extremities
Amputation
Knee
Polyps

Intraoperative catastrophic failure of a Mizuho OSI orthopedic trauma table top

Andrews, C. R., Stapinski, B. & Fox, E., Jan 1 2016, In : JBJS Case Connector. 6, 1, e14.

Research output: Contribution to journalArticle

Operating Tables
Orthopedics
Fatigue
Equipment Failure
Wounds and Injuries
1 Citations

Management of nerve compression in multiple hereditary exostoses: a report of two cases and review of the literature

Payne, R., Sieg, E., Fox, E., Harbaugh, K. & Rizk, E., Dec 1 2016, In : Child's Nervous System. 32, 12, p. 2453-2458 6 p.

Research output: Contribution to journalArticle

Multiple Hereditary Exostoses
Exostoses
Pain
Wounds and Injuries
Decompression