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Research Output

2019

MEF-2 isoforms' (A-D) roles in development and tumorigenesis

Madugula, K., Mulherkar, R., Khan, Z. K., Chigbu, D. G. I., Patel, D., Harhaj, E. W. & Jain, P., Apr 12 2019, In : Oncotarget. 10, 28, p. 2755-2787 33 p.

Research output: Contribution to journalReview article

Open Access
2018

NF-κB signaling mechanisms in HTLV-1-induced adult T-cell leukemia/lymphoma

Harhaj, E. W. & Giam, C. Z., Sep 2018, In : FEBS Journal. 285, 18, p. 3324-3336 13 p.

Research output: Contribution to journalReview article

6 Scopus citations

Peroxisomes support human herpesvirus 8 latency by stabilizing the viral oncogenic protein vFLIP via the MAVS-TRAF complex

Choi, Y. B., Choi, Y. & Harhaj, E. W., May 2018, In : PLoS pathogens. 14, 5, e1007058.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Regnase-1, a rapid response ribonuclease regulating inflammation and stress responses

Mao, R., Yang, R., Chen, X., Harhaj, E. W., Wang, X. & Fan, Y., May 1 2017, In : Cellular and Molecular Immunology. 14, 5, p. 412-422 11 p.

Research output: Contribution to journalReview article

10 Scopus citations

TAX1BP1 restrains virus-induced apoptosis by facilitating itch-mediated degradation of the mitochondrial adaptor MAVS

Choi, Y. B., Shembade, N., Parvatiyar, K., Balachandran, S. & Harhaj, E. W., Jan 1 2017, In : Molecular and cellular biology. 37, 1, e00422-16.

Research output: Contribution to journalArticle

10 Scopus citations
2016

Monoubiquitination of survival motor neuron regulates its cellular localization and Cajal body integrity

Han, K. J., Foster, D., Harhaj, E. W., Dzieciatkowska, M., Hansen, K. & Liu, C. W., Apr 1 2016, In : Human molecular genetics. 25, 7, p. 1392-1405 14 p., ddw021.

Research output: Contribution to journalArticle

10 Scopus citations

SHARPINing the knowledge of TCR signal control

Bowman, M., Pan, F. & Harhaj, E., Feb 1 2016, In : Nature Immunology. 17, 3, p. 221-222 2 p.

Research output: Contribution to journalShort survey

2015

Aryl hydrocarbon receptor interacting protein targets IRF7 to suppress antiviral signaling and the induction of type I interferon

Zhou, Q., Lavorgna, A., Bowman, M., Hiscott, J. & Harhaj, E. W., Jun 5 2015, In : Journal of Biological Chemistry. 290, 23, p. 14729-14739 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Elucidating dynamic protein–protein interactions and ubiquitination in NF-κB signaling pathways

Shembade, N. & Harhaj, E. W., Jan 1 2015, In : Methods in Molecular Biology. 1280, p. 283-295 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing complex between Tax and CREB

Jain, P., Lavorgna, A., Sehgal, M., Gao, L., Ginwala, R., Sagar, D., Harhaj, E. W. & Khan, Z. K., Feb 27 2015, In : Retrovirology. 12, 1, 23.

Research output: Contribution to journalArticle

5 Scopus citations

Oncogenic human T-cell lymphotropic virus type 1 tax suppression of primary innate immune signaling pathways

Hyun, J., Ramos, J. C., Toomey, N., Balachandran, S., Lavorgna, A., Harhaj, E. & Barber, G. N., Jan 1 2015, In : Journal of virology. 89, 9, p. 4880-4893 14 p.

Research output: Contribution to journalArticle

13 Scopus citations
2014

A Critical Role for IL-17RB Signaling in HTLV-1 Tax-Induced NF-κB Activation and T-Cell Transformation

Lavorgna, A., Matsuoka, M. & Harhaj, E. W., Oct 1 2014, In : PLoS pathogens. 10, 10

Research output: Contribution to journalArticle

16 Scopus citations

Functional implications of mitochondrial reactive oxygen species generated by oncogenic viruses

Choi, Y. B. & Harhaj, E. W., Dec 5 2014, In : Frontiers in Biology. 9, 6, p. 423-436 14 p.

Research output: Contribution to journalReview article

5 Scopus citations
26 Scopus citations

Regulation of HTLV-1 tax stability, cellular trafficking and NF-κB activation by the ubiquitin-proteasome pathway

Lavorgna, A. & Harhaj, E. W., Oct 23 2014, In : Viruses. 6, 10, p. 3925-3943 19 p.

Research output: Contribution to journalReview article

17 Scopus citations
2013
20 Scopus citations

Is there a role for ubiquitin or SUMO in human T-cell leukemia virus type 2 Tax-induced NF-κB activation?

Lavorgna, A. & Harhaj, E., Mar 1 2013, In : Future Virology. 8, 3, p. 223-227 5 p.

Research output: Contribution to journalComment/debate

RING Finger Protein 11 Targets TBK1/IKKi Kinases to Inhibit Antiviral Signaling

Charoenthongtrakul, S., Gao, L., Parvatiyar, K., Lee, D. & Harhaj, E. W., Jan 15 2013, In : PloS one. 8, 1, e53717.

Research output: Contribution to journalArticle

26 Scopus citations
25 Scopus citations

EBV LMP1: New and shared pathways to NF-κB activation

Lavorgna, A. & Harhaj, E. W., Feb 14 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 7, p. 2188-2189 2 p.

Research output: Contribution to journalComment/debate

16 Scopus citations

Regulation of NF-κB by deubiquitinases

Harhaj, E. W. & Dixit, V. M., Mar 1 2012, In : Immunological Reviews. 246, 1, p. 107-124 18 p.

Research output: Contribution to journalReview article

162 Scopus citations

Regulation of NF-κB signaling by the A20 deubiquitinase

Shembade, N. & Harhaj, E. W., Mar 1 2012, In : Cellular and Molecular Immunology. 9, 2, p. 123-130 8 p.

Research output: Contribution to journalReview article

95 Scopus citations

The NLRP4-DTX4 axis: A key suppressor of TBK1 and innate antiviral signaling

Charoenthongtrakul, S., Gao, L. & Harhaj, E., Nov 1 2012, In : Cellular and Molecular Immunology. 9, 6, p. 431-433 3 p.

Research output: Contribution to journalArticle

3 Scopus citations
2011

ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling

Gao, L., Coope, H., Grant, S., Averil, M., Ley, S. C. & Harhaj, E. W., Oct 21 2011, In : Journal of Biological Chemistry. 286, 42, p. 36592-36602 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Deubiquitinases in the regulation of NF-κB signaling

Harhaj, E. W. & Dixit, V. M., Jan 1 2011, In : Cell Research. 21, 1, p. 22-39 18 p.

Research output: Contribution to journalReview article

153 Scopus citations

Human T cell leukemia virus type 1 tax inhibits innate antiviral signaling via NF-κB-dependent induction of SOCS1

Charoenthongtrakul, S., Zhou, Q., Shembade, N., Harhaj, N. S. & Harhaj, E. W., Jul 1 2011, In : Journal of virology. 85, 14, p. 6955-6962 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

IKKi: A novel regulator of Act1, IL-17 signaling and pulmonary inflammation

Shembade, N. & Harhaj, E., Nov 1 2011, In : Cellular and Molecular Immunology. 8, 6, p. 447-449 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Outfoxing FoxO transcription factors: HTLV-1 Tax oncoprotein inactivates FoxO4 via the ubiquitin-proteasome pathway

Shembade, N. & Harhaj, E., Oct 1 2011, In : Future Virology. 6, 10, p. 1165-1168 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Regulation of inflammatory and antiviral signaling by A20

Parvatiyar, K. & Harhaj, E. W., Mar 1 2011, In : Microbes and Infection. 13, 3, p. 209-215 7 p.

Research output: Contribution to journalShort survey

24 Scopus citations

The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1

Shembade, N., Pujari, R., Harhaj, N. S., Abbott, D. W. & Harhaj, E. W., Sep 1 2011, In : Nature Immunology. 12, 9, p. 834-843 10 p.

Research output: Contribution to journalArticle

70 Scopus citations
2010

A20 inhibition of NFκB and inflammation: Targeting E2:E3 ubiquitin enzyme complexes

Shembade, N. & Harhaj, E., Jul 1 2010, In : Cell Cycle. 9, 13, p. 2481-2482 2 p.

Research output: Contribution to journalEditorial

18 Scopus citations

Anchors away for ubiquitin chains

Parvatiyar, K. & Harhaj, E., Jun 4 2010, In : Science. 328, 5983, p. 1244-1245 2 p.

Research output: Contribution to journalShort survey

5 Scopus citations

Inhibition of nf-kb signaling by a20 through disruption of ubiquitin enzyme complexes

Shembade, N., Ma, A. & Harhaj, E., Feb 26 2010, In : Science. 327, 5969, p. 1135-1139 5 p.

Research output: Contribution to journalArticle

367 Scopus citations

Role of the proteasome in the downregulation of transcription factors NFκB and C/EBP in macrophages from tumor hosts

Perry, G., Iragavarapu-Charyulu, V., Harhaj, E. W. & Torroella-Kouri, M., Mar 1 2010, In : Oncology reports. 23, 3, p. 875-881 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases

Parvatiyar, K., Barber, G. N. & Harhaj, E. W., May 14 2010, In : Journal of Biological Chemistry. 285, 20, p. 14999-15009 11 p.

Research output: Contribution to journalArticle

89 Scopus citations
2009

ITCH K63-Ubiquitinates the NOD2 Binding Protein, RIP2, to Influence Inflammatory Signaling Pathways

Tao, M. F., Scacheri, P. C., Marinis, J. M., Harhaj, E. W., Matesic, L. E. & Abbott, D. W., Aug 11 2009, In : Current Biology. 19, 15, p. 1255-1263 9 p.

Research output: Contribution to journalArticle

93 Scopus citations

The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-κB signalling

Shembade, N., Parvatiyar, K., Harhaj, N. S. & Harhaj, E. W., Mar 4 2009, In : EMBO Journal. 28, 5, p. 513-522 10 p.

Research output: Contribution to journalArticle

142 Scopus citations
2008

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

Shembade, N., Harhaj, N. S., Parvatiyar, K., Copeland, N. G., Jenkins, N. A., Matesic, L. E. & Harhaj, E., Mar 1 2008, In : Nature Immunology. 9, 3, p. 254-262 9 p.

Research output: Contribution to journalArticle

194 Scopus citations
2007
55 Scopus citations

Deregulated expression of CD40 ligand in HTLV-I infection: Distinct mechanisms of downregulation in HTLV-I-transformed cell lines and ATL patients

Harhaj, N. S., Janic, B., Ramos, J. C., Harrington, W. J. & Harhaj, E. W., May 25 2007, In : Virology. 362, 1, p. 99-108 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Essential role for TAX1BP1 in the termination of TNF-α-, IL-1- and LPS-mediated NF-κB and JNK signaling

Shembade, N., Harhaj, N. S., Liebl, D. J. & Harhaj, E. W., Sep 5 2007, In : EMBO Journal. 26, 17, p. 3910-3922 13 p.

Research output: Contribution to journalArticle

130 Scopus citations

IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia/lymphoma

Ramos, J. C., Ruiz, P., Ratner, L., Reis, I. M., Brites, C., Pedroso, C., Byrne, G. E., Toomey, N. L., Andela, V., Harhaj, E. W., Lossos, I. S. & Harrington, W. J., Apr 1 2007, In : Blood. 109, 7, p. 3060-3068 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

The human T-cell leukemia virus type 1 tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-κB activation

Shembade, N., Harhaj, N. S., Yamamoto, M., Akira, S. & Harhaj, E. W., Dec 1 2007, In : Journal of virology. 81, 24, p. 13735-13742 8 p.

Research output: Contribution to journalArticle

83 Scopus citations
2006

Expression of Interleukin-10 in Intestinal Lymphocytes Detected by an Interleukin-10 Reporter Knockin tiger Mouse

Kamanaka, M., Kim, S. T., Wan, Y. Y., Sutterwala, F. S., Lara-Tejero, M., Galán, J. E., Harhaj, E. & Flavell, R. A., Dec 1 2006, In : Immunity. 25, 6, p. 941-952 12 p.

Research output: Contribution to journalArticle

253 Scopus citations

Regulation of human T-cell leukemia virus type 1 gene expression by Sp1 and Sp3 interaction with TRE-1 repeat III

Yao, J., Grant, C., Harhaj, E., Nonnemacher, M., Alefantis, T., Martin, J., Jain, P. & Wigdahl, B., May 1 2006, In : DNA and Cell Biology. 25, 5, p. 262-276 15 p.

Research output: Contribution to journalArticle

6 Scopus citations
2005

Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway

Harhaj, E. W., Harhaj, N. S., Grant, C., Mostoller, K., Alefantis, T., Sun, S. C. & Wigdahl, B., Mar 1 2005, In : Virology. 333, 1, p. 145-158 14 p.

Research output: Contribution to journalArticle

24 Scopus citations

Mechanisms of persistent NF-κB activation by HTLV-I tax

Harhaj, E. & Harhaj, N. S., Feb 1 2005, In : IUBMB Life. 57, 2, p. 83-91 9 p.

Research output: Contribution to journalReview article

35 Scopus citations

Secretion of the human T cell leukemia virus type I transactivator protein tax

Alefantis, T., Mostoller, K., Jain, P., Harhaj, E., Grant, C. & Wigdahl, B., Apr 29 2005, In : Journal of Biological Chemistry. 280, 17, p. 17353-17362 10 p.

Research output: Contribution to journalArticle

50 Scopus citations
2004

Regulation of the NF-κB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation

Liao, G., Zhang, M., Harhaj, E. W. & Sun, S. C., Jun 18 2004, In : Journal of Biological Chemistry. 279, 25, p. 26243-26250 8 p.

Research output: Contribution to journalArticle

317 Scopus citations