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Research Output 1995 2019

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Article
2018
4 Citations (Scopus)

Peroxisomes support human herpesvirus 8 latency by stabilizing the viral oncogenic protein vFLIP via the MAVS-TRAF complex

Choi, Y. B., Choi, Y. & Harhaj, E. W., May 2018, In : PLoS pathogens. 14, 5, e1007058.

Research output: Contribution to journalArticle

CASP8 and FADD-Like Apoptosis Regulating Protein
Human Herpesvirus 8
Peroxisomes
Viral Proteins
Antiviral Agents
2017
9 Citations (Scopus)

TAX1BP1 restrains virus-induced apoptosis by facilitating itch-mediated degradation of the mitochondrial adaptor MAVS

Choi, Y. B., Shembade, N., Parvatiyar, K., Balachandran, S. & Harhaj, E. W., Jan 1 2017, In : Molecular and cellular biology. 37, 1, e00422-16.

Research output: Contribution to journalArticle

RNA Virus Infections
Apoptosis
Viruses
Sendai virus
Virus Activation
2016
10 Citations (Scopus)

Monoubiquitination of survival motor neuron regulates its cellular localization and Cajal body integrity

Han, K. J., Foster, D., Harhaj, E. W., Dzieciatkowska, M., Hansen, K. & Liu, C. W., Apr 1 2016, In : Human molecular genetics. 25, 7, p. 1392-1405 14 p., ddw021.

Research output: Contribution to journalArticle

Motor Neurons
Ubiquitin
Small Nuclear Ribonucleoproteins
Cytoplasm
Spinal Muscular Atrophy
2015
7 Citations (Scopus)

Aryl hydrocarbon receptor interacting protein targets IRF7 to suppress antiviral signaling and the induction of type I interferon

Zhou, Q., Lavorgna, A., Bowman, M., Hiscott, J. & Harhaj, E. W., Jun 5 2015, In : Journal of Biological Chemistry. 290, 23, p. 14729-14739 11 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-7
Interferon Type I
Antiviral Agents
Virus Diseases
Viruses
3 Citations (Scopus)

Elucidating dynamic protein–protein interactions and ubiquitination in NF-κB signaling pathways

Shembade, N. & Harhaj, E. W., Jan 1 2015, In : Methods in Molecular Biology. 1280, p. 283-295 13 p.

Research output: Contribution to journalArticle

Ubiquitination
Ubiquitin
TNF Receptor-Associated Factor 6
Autoimmune Diseases
Polyubiquitin
5 Citations (Scopus)

Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing complex between Tax and CREB

Jain, P., Lavorgna, A., Sehgal, M., Gao, L., Ginwala, R., Sagar, D., Harhaj, E. W. & Khan, Z. K., Feb 27 2015, In : Retrovirology. 12, 1, 23.

Research output: Contribution to journalArticle

Deltaretrovirus Infections
MEF2 Transcription Factors
Human T-lymphotropic virus 1
T-Lymphocytes
Terminal Repeat Sequences
13 Citations (Scopus)

Oncogenic human T-cell lymphotropic virus type 1 tax suppression of primary innate immune signaling pathways

Hyun, J., Ramos, J. C., Toomey, N., Balachandran, S., Lavorgna, A., Harhaj, E. & Barber, G. N., Jan 1 2015, In : Journal of virology. 89, 9, p. 4880-4893 14 p.

Research output: Contribution to journalArticle

Primate T-lymphotropic virus 1
Human T-lymphotropic virus 1
taxes
T-Lymphocytes
Interferon Regulatory Factor-7
2014
15 Citations (Scopus)

A Critical Role for IL-17RB Signaling in HTLV-1 Tax-Induced NF-κB Activation and T-Cell Transformation

Lavorgna, A., Matsuoka, M. & Harhaj, E. W., Oct 1 2014, In : PLoS pathogens. 10, 10

Research output: Contribution to journalArticle

Deltaretrovirus
T-Lymphocytes
Adult T Cell Leukemia Lymphoma
tax Gene Products
Interleukin-9
26 Citations (Scopus)
TNF Receptor-Associated Factor 6
Deltaretrovirus
Cell Survival
Ubiquitin
Lysine
2013
20 Citations (Scopus)
Deltaretrovirus
HSP90 Heat-Shock Proteins
Oncogene Proteins
taxes
Virus Replication
26 Citations (Scopus)

RING Finger Protein 11 Targets TBK1/IKKi Kinases to Inhibit Antiviral Signaling

Charoenthongtrakul, S., Gao, L., Parvatiyar, K., Lee, D. & Harhaj, E. W., Jan 15 2013, In : PloS one. 8, 1, e53717.

Research output: Contribution to journalArticle

interferons
Antiviral Agents
phosphotransferases (kinases)
Phosphotransferases
virus replication
2012
25 Citations (Scopus)
Deltaretrovirus
Cell Nucleus Active Transport
taxes
RNA Interference
RNA interference
2 Citations (Scopus)

The NLRP4-DTX4 axis: A key suppressor of TBK1 and innate antiviral signaling

Charoenthongtrakul, S., Gao, L. & Harhaj, E., Nov 1 2012, In : Cellular and Molecular Immunology. 9, 6, p. 431-433 3 p.

Research output: Contribution to journalArticle

Repressor Proteins
Interferon Type I
Ubiquitin-Protein Ligases
Protein-Serine-Threonine Kinases
Antiviral Agents
2011
42 Citations (Scopus)

ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling

Gao, L., Coope, H., Grant, S., Averil, M., Ley, S. C. & Harhaj, E. W., Oct 21 2011, In : Journal of Biological Chemistry. 286, 42, p. 36592-36602 11 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Virus Diseases
Viruses
Poly I-C
Antiviral Agents
47 Citations (Scopus)

Human T cell leukemia virus type 1 tax inhibits innate antiviral signaling via NF-κB-dependent induction of SOCS1

Charoenthongtrakul, S., Zhou, Q., Shembade, N., Harhaj, N. S. & Harhaj, E. W., Jul 1 2011, In : Journal of virology. 85, 14, p. 6955-6962 8 p.

Research output: Contribution to journalArticle

Deltaretrovirus
taxes
Antiviral Agents
Interferons
Transformed Cell Line
3 Citations (Scopus)

IKKi: A novel regulator of Act1, IL-17 signaling and pulmonary inflammation

Shembade, N. & Harhaj, E., Nov 1 2011, In : Cellular and Molecular Immunology. 8, 6, p. 447-449 3 p.

Research output: Contribution to journalArticle

I-kappa B Kinase
TNF Receptor-Associated Factor 6
Interleukin Receptors
Proto-Oncogene Proteins c-akt
Interleukin-17
3 Citations (Scopus)

Outfoxing FoxO transcription factors: HTLV-1 Tax oncoprotein inactivates FoxO4 via the ubiquitin-proteasome pathway

Shembade, N. & Harhaj, E., Oct 1 2011, In : Future Virology. 6, 10, p. 1165-1168 4 p.

Research output: Contribution to journalArticle

Deltaretrovirus
Ubiquitination
Oncogene Proteins
Proteasome Endopeptidase Complex
Ubiquitin
69 Citations (Scopus)

The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1

Shembade, N., Pujari, R., Harhaj, N. S., Abbott, D. W. & Harhaj, E., Sep 1 2011, In : Nature Immunology. 12, 9, p. 834-843 10 p.

Research output: Contribution to journalArticle

Ubiquitin
Transcription Factors
Phosphotransferases
Phosphorylation
Cytokines
2010
365 Citations (Scopus)

Inhibition of nf-kb signaling by a20 through disruption of ubiquitin enzyme complexes

Shembade, N., Ma, A. & Harhaj, E., Feb 26 2010, In : Science. 327, 5969, p. 1135-1139 5 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Ubiquitin
TNF Receptor-Associated Factor 2
TNF Receptor-Associated Factor 6
Ubiquitin-Conjugating Enzymes
3 Citations (Scopus)

Role of the proteasome in the downregulation of transcription factors NFκB and C/EBP in macrophages from tumor hosts

Perry, G., Iragavarapu-Charyulu, V., Harhaj, E. & Torroella-Kouri, M., Mar 1 2010, In : Oncology Reports. 23, 3, p. 875-881 7 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Proteasome Endopeptidase Complex
Transcription Factors
Down-Regulation
Macrophages
88 Citations (Scopus)

TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases

Parvatiyar, K., Barber, G. N. & Harhaj, E. W., May 14 2010, In : Journal of Biological Chemistry. 285, 20, p. 14999-15009 11 p.

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 3
Antiviral Agents
Phosphotransferases
Fibroblasts
Phosphorylation
2009
93 Citations (Scopus)

ITCH K63-Ubiquitinates the NOD2 Binding Protein, RIP2, to Influence Inflammatory Signaling Pathways

Tao, M. F., Scacheri, P. C., Marinis, J. M., Harhaj, E., Matesic, L. E. & Abbott, D. W., Aug 11 2009, In : Current Biology. 19, 15, p. 1255-1263 9 p.

Research output: Contribution to journalArticle

Crohn disease
binding proteins
Carrier Proteins
cytokines
Ubiquitin-Protein Ligases
141 Citations (Scopus)

The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-κB signalling

Shembade, N., Parvatiyar, K., Harhaj, N. S. & Harhaj, E., Mar 4 2009, In : EMBO Journal. 28, 5, p. 513-522 10 p.

Research output: Contribution to journalArticle

Ubiquitin
Down-Regulation
Tumor Necrosis Factor-alpha
Lipopolysaccharides
Intercellular Signaling Peptides and Proteins
2008
194 Citations (Scopus)

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

Shembade, N., Harhaj, N. S., Parvatiyar, K., Copeland, N. G., Jenkins, N. A., Matesic, L. E. & Harhaj, E., Mar 1 2008, In : Nature Immunology. 9, 3, p. 254-262 9 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Ubiquitin
Human T-lymphotropic virus 1
Tumor Necrosis Factor Receptors
Oncogene Proteins
2007
55 Citations (Scopus)
Deltaretrovirus
Human T-lymphotropic virus 1
T-cells
Oncogene Proteins
Ubiquitin
13 Citations (Scopus)

Deregulated expression of CD40 ligand in HTLV-I infection: Distinct mechanisms of downregulation in HTLV-I-transformed cell lines and ATL patients

Harhaj, N. S., Janic, B., Ramos, J. C., Harrington, W. J. & Harhaj, E. W., May 25 2007, In : Virology. 362, 1, p. 99-108 10 p.

Research output: Contribution to journalArticle

HTLV-I Infections
Adult T Cell Leukemia Lymphoma
CD40 Ligand
Transformed Cell Line
Human T-lymphotropic virus 1
129 Citations (Scopus)

Essential role for TAX1BP1 in the termination of TNF-α-, IL-1- and LPS-mediated NF-κB and JNK signaling

Shembade, N., Harhaj, N. S., Liebl, D. J. & Harhaj, E. W., Sep 5 2007, In : EMBO Journal. 26, 17, p. 3910-3922 13 p.

Research output: Contribution to journalArticle

Interleukin-1
Lipopolysaccharides
Carrier Proteins
Chemical activation
TNF Receptor-Associated Factor 6
50 Citations (Scopus)

IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia/lymphoma

Ramos, J. C., Ruiz, P., Ratner, L., Reis, I. M., Brites, C., Pedroso, C., Byrne, G. E., Toomey, N. L., Andela, V., Harhaj, E. W., Lossos, I. S. & Harrington, W. J., Apr 1 2007, In : Blood. 109, 7, p. 3060-3068 9 p.

Research output: Contribution to journalArticle

Adult T Cell Leukemia Lymphoma
T-cells
Antiviral Agents
Tumors
Neoplasms
83 Citations (Scopus)

The human T-cell leukemia virus type 1 tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-κB activation

Shembade, N., Harhaj, N. S., Yamamoto, M., Akira, S. & Harhaj, E. W., Dec 1 2007, In : Journal of virology. 81, 24, p. 13735-13742 8 p.

Research output: Contribution to journalArticle

Deltaretrovirus
Ubiquitin-Conjugating Enzymes
ubiquitin-protein ligase
Ubiquitination
Oncogene Proteins
2006
253 Citations (Scopus)

Expression of Interleukin-10 in Intestinal Lymphocytes Detected by an Interleukin-10 Reporter Knockin tiger Mouse

Kamanaka, M., Kim, S. T., Wan, Y. Y., Sutterwala, F. S., Lara-Tejero, M., Galán, J. E., Harhaj, E. & Flavell, R. A., Dec 1 2006, In : Immunity. 25, 6, p. 941-952 12 p.

Research output: Contribution to journalArticle

Interleukin-10
Lymphocytes
Fluorescence
Regulatory T-Lymphocytes
Polyadenylation
6 Citations (Scopus)

Regulation of human T-cell leukemia virus type 1 gene expression by Sp1 and Sp3 interaction with TRE-1 repeat III

Yao, J., Grant, C., Harhaj, E., Nonnemacher, M., Alefantis, T., Martin, J., Jain, P. & Wigdahl, B., May 1 2006, In : DNA and Cell Biology. 25, 5, p. 262-276 15 p.

Research output: Contribution to journalArticle

Deltaretrovirus
Terminal Repeat Sequences
Gene Expression
Binding Sites
Sp Transcription Factors
2005
24 Citations (Scopus)

Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway

Harhaj, E. W., Harhaj, N. S., Grant, C., Mostoller, K., Alefantis, T., Sun, S. C. & Wigdahl, B., Mar 1 2005, In : Virology. 333, 1, p. 145-158 14 p.

Research output: Contribution to journalArticle

Human T-lymphotropic virus 1
NF-kappa B
Gene Expression
T-Lymphocytes
Ligation
50 Citations (Scopus)

Secretion of the human T cell leukemia virus type I transactivator protein tax

Alefantis, T., Mostoller, K., Jain, P., Harhaj, E., Grant, C. & Wigdahl, B., Apr 29 2005, In : Journal of Biological Chemistry. 280, 17, p. 17353-17362 10 p.

Research output: Contribution to journalArticle

tax Gene Products
Trans-Activators
T-cells
Taxation
Viruses
2004
316 Citations (Scopus)

Regulation of the NF-κB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation

Liao, G., Zhang, M., Harhaj, E. W. & Sun, S. C., Jun 18 2004, In : Journal of Biological Chemistry. 279, 25, p. 26243-26250 8 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Phosphotransferases
Degradation
Chemical activation
Biological Phenomena
2003
80 Citations (Scopus)

Characterization of a nuclear export signal within the human T cell leukemia virus type I transactivator protein Tax

Alefantis, T., Barmak, K., Harhaj, E., Grant, C. & Wigdahl, B., Jun 13 2003, In : Journal of Biological Chemistry. 278, 24, p. 21814-21822 9 p.

Research output: Contribution to journalArticle

tax Gene Products
Nuclear Export Signals
Trans-Activators
T-cells
Taxation
2001
577 Citations (Scopus)

NF-κB-inducing kinase regulates the processing of NF-κB2 p100

Xiao, G., Harhaj, E. W. & Sun, S. C., Jan 1 2001, In : Molecular cell. 7, 2, p. 401-409 9 p.

Research output: Contribution to journalArticle

Phosphotransferases
Protein Precursors
Ubiquitination
Knockout Mice
Genes
238 Citations (Scopus)

Retroviral oncoprotein tax induces processing of NF-κB2/p100 in T cells: Evidence for the involvement of IKKα

Xiao, G., Cvijic, M. E., Fong, A., Harhaj, E., Uhlik, M. T., Waterfield, M. & Sun, S. C., Dec 3 2001, In : EMBO Journal. 20, 23, p. 6805-6815 11 p.

Research output: Contribution to journalArticle

Deltaretrovirus
T-cells
Oncogene Proteins
Taxation
T-Lymphocytes
2000
33 Citations (Scopus)

Activation of I-κB kinase by the HTLV type 1 Tax protein: Mechanistic insights into the adaptor function of IKKγ

Sun, S. C., Harhaj, E. W., Xiao, G. & Good, L., Nov 1 2000, In : AIDS Research and Human Retroviruses. 16, 16, p. 1591-1596 6 p.

Research output: Contribution to journalArticle

tax Gene Products
Human T-lymphotropic virus 1
Phosphotransferases
T-Lymphocytes
Deltaretrovirus
84 Citations (Scopus)

Domain-specific interaction with the IκB kinase (IKK) regulatory subunit IKKγ is an essential step in tax-mediated activation of IKK

Xiao, G., Harhaj, E. W. & Sun, S. C., Nov 3 2000, In : Journal of Biological Chemistry. 275, 44, p. 34060-34067 8 p.

Research output: Contribution to journalArticle

Leucine Zippers
Taxation
Phosphotransferases
Chemical activation
Deltaretrovirus
90 Citations (Scopus)

Somatic mutagenesis studies of NF-κB signaling in human T cells: Evidence for an essential role of IKKγ, in NP-κB activation by T-cell costimulatory signals and HTLV-I Tax protein

Harhaj, E. W., Good, L. F., Xiao, G., Uhlik, M., Cvijic, M. E., Rivera-Walsh, I. & Sun, S. C., Mar 9 2000, In : Oncogene. 19, 11, p. 1448-1456 9 p.

Research output: Contribution to journalArticle

Mutagenesis
T-Lymphocytes
Deltaretrovirus
JNK Mitogen-Activated Protein Kinases
Cell Line
1999
15 Citations (Scopus)

Binding of c-Rel to STAT5 target sequences in HTLV-I-transformed T cells

Sun, S. C., Maggirwar, S. B., Harhaj, E. W. & Uhlik, M., Feb 18 1999, In : Oncogene. 18, 7, p. 1401-1409 9 p.

Research output: Contribution to journalArticle

Deltaretrovirus
T-Lymphocytes
Interleukin-2
Growth
Transcription Factors
75 Citations (Scopus)

Gene expression profiles in HTLV-I-immortalized T cells: Deregulated expression of genes involved in apoptosis regulation

Harhaj, E. W., Good, L. F., Xiao, G. & Sun, S. C., Feb 11 1999, In : Oncogene. 18, 6, p. 1341-1349 9 p.

Research output: Contribution to journalArticle

Human T-lymphotropic virus 1
Transcriptome
Apoptosis
T-Lymphocytes
Gene Expression
189 Citations (Scopus)
tax Gene Products
Deltaretrovirus
T-cells
Taxation
Viruses
82 Citations (Scopus)

Regulation of RelA subcellular localization by a putative nuclear export signal and p50

Harhaj, E. W. & Shao-Cong, S., Oct 1999, In : Molecular and cellular biology. 19, 10, p. 7088-7095 8 p.

Research output: Contribution to journalArticle

Nuclear Export Signals
Cell Nucleus Active Transport
Cytoplasm
DNA-Binding Proteins
Sequence Homology
33 Citations (Scopus)

Thermolabile H-2Kb molecules expressed by transporter associated with antigen processing-deficient RMA-S cells are occupied by low-affinity peptides

De Silva, A. D., Boesteanu, A., Song, R., Nagy, N., Harhaj, E., Harding, C. V. & Joyce, S., Jan 1 1999, In : Journal of Immunology. 163, 8, p. 4413-4420 8 p.

Research output: Contribution to journalArticle

Antigen Presentation
Peptides
T-Lymphocytes
Temperature
1998
46 Citations (Scopus)

Bcl-3 expression and nuclear translocation are induced by granulocyte- macrophage colony-stimulating factor and erythropoietin in proliferating human erythroid precursors

Zhang, M. Y., Harhaj, E. W., Bell, L., Sun, S. C. & Miller, B. A., Aug 15 1998, In : Blood. 92, 4, p. 1225-1234 10 p.

Research output: Contribution to journalArticle

Granulocyte-Macrophage Colony-Stimulating Factor
Erythropoietin
Plasmids
Genes
Messenger RNA
30 Citations (Scopus)

Involvement of NF-AT in type I human T-cell leukemia virus tax-mediated fas ligand promoter transactivation

Rivera, I., Harhaj, E. W. & Sun, S. C., Aug 28 1998, In : Journal of Biological Chemistry. 273, 35, p. 22382-22388 7 p.

Research output: Contribution to journalArticle

Human T-lymphotropic virus 1
Fas Ligand Protein
T-cells
Taxation
Viruses
59 Citations (Scopus)

IκB kinases serve as a target of CD28 signaling

Harhaj, E. & Sun, S. C., Sep 25 1998, In : Journal of Biological Chemistry. 273, 39, p. 25185-25190 6 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Interleukin-2
Phosphotransferases
Chemical activation
Mitogens
135 Citations (Scopus)

NF-κB-inducing kinase and IκB kinase participate in human T-cell leukemia virus I tax-mediated NF-κB activation

Uhlik, M., Good, L. F., Xiao, G., Harhaj, E. W., Zandi, E., Karin, M. & Sun, S. C., Aug 14 1998, In : Journal of Biological Chemistry. 273, 33, p. 21132-21136 5 p.

Research output: Contribution to journalArticle

Human T-lymphotropic virus 1
T-cells
Taxation
Viruses
Phosphotransferases
1997
27 Citations (Scopus)
NFATC Transcription Factors
Human T-lymphotropic virus 1
T-cells
Taxation
Viruses