Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Dive into the research topics where Edward P. O'Brien, Jr. is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Machine Learning Guided Biophysical Model Development of Amino Acid and tRNA Effects on Translation-Elongation Speed
1/1/21 → 12/31/23
Project: Research project
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CC* Team: Research Innovation with Scientists and Engineers (RISE)
Hanna, C. C., O'Brien, Jr., E. P. & Evans, J.
7/1/20 → 6/30/23
Project: Research project
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EAGER: Measuring transcriptome-wide translation initiation rates from a single experiment
O'Brien, Jr., E. P. & Ingolia, N. N. T.
5/1/19 → 4/30/23
Project: Research project
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ABI INNOVATION: Physical Bioinformatics Tools for Measuring Translation Rates from Next-Generation Sequencing Data
7/15/18 → 6/30/23
Project: Research project
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CAREER: The origins of codon translation rates and their consequences for nascent protein behavior
6/1/16 → 5/31/23
Project: Research project
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How synonymous mutations alter enzyme structure and function over long timescales
Jiang, Y., Neti, S. S., Sitarik, I., Pradhan, P., To, P., Xia, Y., Fried, S. D., Booker, S. J. & O’Brien, E. P., Mar 2023, In: Nature Chemistry. 15, 3, p. 308-318 11 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments
Zhao, B., Rao, Y., Leighow, S., O’Brien, E. P., Gilbert, L. & Pritchard, J. R., Dec 2022, In: Nature communications. 13, 1, 625.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Cocktail of REGN Antibodies Binds More Strongly to SARS-CoV-2 Than Its Components, but the Omicron Variant Reduces Its Neutralizing Ability
Nguyen, H., Lan, P. D., Nissley, D. A., O'Brien, E. P. & Li, M. S., Apr 21 2022, In: Journal of Physical Chemistry B. 126, 15, p. 2812-2823 12 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Erratum: Ribosome Elongation Kinetics of Consecutively Charged Residues Are Coupled to Electrostatic Force (Biochemistry (2021) 60:43 (3223−3235) DOI:10.1021/acs.biochem.1c00507)
Leininger, S. E., Rodriguez, J., Vu, Q. V., Jiang, Y., Li, M. S., Deutsch, C. & O’Brien, E. P., Jan 18 2022, In: Biochemistry. 61, 2, p. 125 1 p.Research output: Contribution to journal › Comment/debate › peer-review
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Modeling Ensembles of Enzyme Reaction Pathways with Hi-MSM Reveals the Importance of Accounting for Pathway Diversity
Persichetti, J. R., Jiang, Y., Hudson, P. S. & O'Brien, E. P., Dec 1 2022, In: Journal of Physical Chemistry B. 126, 47, p. 9748-9758 11 p.Research output: Contribution to journal › Article › peer-review