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Edward P. O'Brien, Jr., PhD

    • 1502 Citations
    • 24 h-Index
    20002019
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    Fingerprint Dive into the research topics where Edward P. O'Brien, Jr. is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

    • 4 Similar Profiles
    Protein folding Chemical Compounds
    Protein Folding Medicine & Life Sciences
    Ribosomes Medicine & Life Sciences
    Proteins Chemical Compounds
    Codon Medicine & Life Sciences
    proteins Physics & Astronomy
    folding Physics & Astronomy
    Tunnels Chemical Compounds

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    Research Output 2000 2019

    • 1502 Citations
    • 24 h-Index
    • 39 Article
    • 3 Review article
    • 1 Comment/debate
    1 Citation (Scopus)

    A chemical kinetic basis for measuring translation initiation and elongation rates from ribosome profiling data

    Sharma, A. K., Sormanni, P., Ahmed, N., Ciryam, P., Friedrich, U. A., Kramer, G. & O'Brien, Jr., E. P., Jan 1 2019, In : PLoS computational biology. 15, 5, e1007070.

    Research output: Contribution to journal › Article

    Open Access
    Chemical Kinetics
    Elongation
    Profiling
    ribosomes
    Stem cells
    2 Citations (Scopus)

    Domain topology, stability, and translation speed determine mechanical force generation on the ribosome

    Leininger, S. E., Trovato, F., Nissley, D. A. & O'Brien, Jr., E. P., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 12, p. 5523-5532 10 p.

    Research output: Contribution to journal › Article

    Ribosomes
    Proteins
    Statistical Models
    Proteome
    Phenotype

    Identifying A- and P-site locations on ribosome-protected mRNA fragments using Integer Programming

    Ahmed, N., Sormanni, P., Ciryam, P., Vendruscolo, M., Dobson, C. M. & O'Brien, Jr., E. P., Dec 1 2019, In : Scientific reports. 9, 1, 6256.

    Research output: Contribution to journal › Article

    Open Access
    Ribosomes
    Messenger RNA
    Codon
    Camellia
    Reading Frames

    Mechanochemistry in Translation

    Leininger, S. E., Narayan, K., Deutsch, C. & O'Brien, Jr., E. P., Jan 1 2019, In : Biochemistry.

    Research output: Contribution to journal › Article

    Peptidyl Transferases
    Protein folding
    Protein Folding
    Ribosomes
    Tunnels
    2 Citations (Scopus)

    Determinants of translation speed are randomly distributed across transcripts resulting in a universal scaling of protein synthesis times

    Sharma, A. K., Ahmed, N. & O'Brien, Jr., E. P., Feb 20 2018, In : Physical Review E. 97, 2, 022409.

    Research output: Contribution to journal › Article

    protein synthesis
    Protein Synthesis
    determinants
    Determinant
    Scaling