• 507 Citations
  • 13 h-Index
1976 …2018
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Personal profile

Research interests

Dr. Elizabeth Proctor’s laboratory aims to characterize the systems biology of neurodegenerative disease at multiple scales (molecular, cellular, tissue, and physiological), with the ultimate goal of providing tools for early diagnosis and identifying novel preventative and therapeutic strategies. Her laboratory combines multiplexing experiments with computational modeling and machine learning to identify patterns associated with neurodegenerative disease pathology, then manipulates the identified variables in cell culture and/or in animal models to test their ability to alter and control disease state.

Education/Academic qualification

Postdoctoral Fellowship, Massachusetts Institute of Technology

… → 2018

PhD, University of North Carolina at Chapel Hill

… → 2013

BS, BA, Purdue University

… → 2008

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Prolyl Hydroxylases Chemical Compounds
Cystic Fibrosis Transmembrane Conductance Regulator Chemical Compounds
Mutation Medicine & Life Sciences
Poisons Medicine & Life Sciences
Procollagen-Proline Dioxygenase Chemical Compounds

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Projects 2010 2013

Identification of drug leads targeting SOD1 dissociation for the treatment of ALS

Proctor, E. A.

National Institutes of Health

12/1/1011/30/13

Project: Research projectPredoctoral Individual National Research Service Award

Amyotrophic Lateral Sclerosis
Drug Delivery Systems
Post Translational Protein Processing
Mutation
Pharmaceutical Preparations

Research Output 1976 2018

  • 507 Citations
  • 13 h-Index
  • 24 Article
  • 3 Review article
  • 1 Comment/debate
1 Citations

Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD-1, TIGIT, and TIM-3 in Lymphocytes From Patients With Systemic Sclerosis

Fleury, M., Belkina, A. C., Proctor, E. A., Zammitti, C., Simms, R. W., Lauffenburger, D. A., Snyder-Cappione, J. E., Lafyatis, R. & Dooms, H., Apr 1 2018, In : Arthritis and Rheumatology. 70, 4, p. 566-577 12 p.

Research output: Contribution to journalArticle

Programmed Cell Death 1 Receptor
Systemic Scleroderma
Lymphocytes
T-Lymphocytes
Cytokines

Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator

Wang, C., Aleksandrov, A. A., Yang, Z., Forouhar, F., Proctor, E. A., Kota, P., An, J., Kaplan, A., Khazanov, N., Boël, G., Stockwell, B. R., Senderowitz, H., Dokholyan, N., Riordan, J. R., Brouillette, C. G. & Hunt, J. F., Jan 1 2018, In : Journal of Biological Chemistry. 293, 46, p. 17685-17704 20 p.

Research output: Contribution to journalArticle

Electrophysiology
Cystic Fibrosis Transmembrane Conductance Regulator
Nucleotides
Stabilization
Ligands
1 Citations

Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis

Nicholas, D., Proctor, E. A., Raval, F. M., Ip, B. C., Habib, C., Ritou, E., Grammatopoulos, T. N., Steenkamp, D., Dooms, H., Apovian, C. M., Lauffenburger, D. A. & Nikolajczyk, B. S., Feb 1 2017, In : PloS one. 12, 2, e0170975.

Research output: Contribution to journalArticle

Lymphocytes
Fluxes
data analysis
lymphocytes
Organized Financing
3 Citations

Genital-systemic chemokine gradients and the risk of HIV acquisition in women

Liebenberg, L. J. P., Masson, L., Arnold, K. B., McKinnon, L. R., Werner, L., Proctor, E. A., Archary, D., Mansoor, L. E., Lauffenburger, D. A., Karim, Q. A., Karim, S. S. A. & Passmore, J. A. S., Mar 1 2017, In : Journal of Acquired Immune Deficiency Syndromes. 74, 3, p. 318-325 8 p.

Research output: Contribution to journalArticle

Chemokines
HIV
Odds Ratio
Interleukin-8
Confidence Intervals

A hidden aggregation-prone structure in the heart of hypoxia inducible factor prolyl hydroxylase

Hadi-Alijanvand, H., Proctor, E. A., Ding, F., Dokholyan, N. & Moosavi-Movahedi, A. A., May 1 2016, In : Proteins: Structure, Function and Bioinformatics. 84, 5, p. 611-623 13 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor-Proline Dioxygenases
Prolyl Hydroxylases
Calorimetry
Amyloid
Agglomeration