• 565 Citations
  • 13 h-Index
20072019
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Personal profile

Research interests

Dr. Elizabeth Proctor’s laboratory aims to characterize the systems biology of neurodegenerative disease at multiple scales (molecular, cellular, tissue, and physiological), with the ultimate goal of providing tools for early diagnosis and identifying novel preventative and therapeutic strategies. Her laboratory combines multiplexing experiments with computational modeling and machine learning to identify patterns associated with neurodegenerative disease pathology, then manipulates the identified variables in cell culture and/or in animal models to test their ability to alter and control disease state.

Education/Academic qualification

Postdoctoral Fellowship, Massachusetts Institute of Technology

… → 2018

PhD, University of North Carolina at Chapel Hill

… → 2013

BS, BA, Purdue University

… → 2008

Fingerprint Dive into the research topics where Elizabeth Anne Proctor is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Molecular Dynamics Simulation Medicine & Life Sciences
Amyotrophic Lateral Sclerosis Medicine & Life Sciences
Proteins Medicine & Life Sciences
Mutation Medicine & Life Sciences
Prolyl Hydroxylases Medicine & Life Sciences
Cystic Fibrosis Transmembrane Conductance Regulator Chemical Compounds
Catalytic Domain Medicine & Life Sciences
Poisons Medicine & Life Sciences

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Projects 2010 2013

Amyotrophic Lateral Sclerosis
Drug Delivery Systems
Post Translational Protein Processing
Mutation
Pharmaceutical Preparations

Research Output 2007 2019

  • 565 Citations
  • 13 h-Index
  • 27 Article
  • 2 Review article
  • 1 Comment/debate

Computational translation of genomic responses from experimental model systems to humans

Brubaker, D. K., Proctor, E. A., Haigis, K. M. & Lauffenburger, D. A., Jan 1 2019, In : PLoS computational biology. 15, 1, e1006286.

Research output: Contribution to journalArticle

translation (genetics)
Genomics
Mouse
genomics
Theoretical Models
1 Citation (Scopus)

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes

Nicholas, D. A., Proctor, E. A., Agrawal, M., Belkina, A. C., Van Nostrand, S. C., Panneerseelan-Bharath, L., Jones, A. R., Raval, F., Ip, B. C., Zhu, M., Cacicedo, J. M., Habib, C., Sainz-Rueda, N., Persky, L., Sullivan, P. G., Corkey, B. E., Apovian, C. M., Kern, P. A., Lauffenburger, D. A. & Nikolajczyk, B. S., Sep 3 2019, In : Cell Metabolism. 30, 3, p. 447-461.e5

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Fatty Acids
Inflammation
Glycolysis
Cytokines

β-Methylamino-L-alanine substitution of serine in SOD1 suggests a direct role in ALS etiology

Proctor, E. A., Mowrey, D. D. & Dokholyan, N., Jul 1 2019, In : PLoS computational biology. 15, 7, e1007225.

Research output: Contribution to journalArticle

Open Access
etiology
Amyotrophic Lateral Sclerosis
Alanine
alanine
serine
3 Citations (Scopus)

Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD-1, TIGIT, and TIM-3 in Lymphocytes From Patients With Systemic Sclerosis

Fleury, M., Belkina, A. C., Proctor, E. A., Zammitti, C., Simms, R. W., Lauffenburger, D. A., Snyder-Cappione, J. E., Lafyatis, R. & Dooms, H., Apr 1 2018, In : Arthritis and Rheumatology. 70, 4, p. 566-577 12 p.

Research output: Contribution to journalArticle

Programmed Cell Death 1 Receptor
Systemic Scleroderma
Lymphocytes
T-Lymphocytes
Cytokines

Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator

Wang, C., Aleksandrov, A. A., Yang, Z., Forouhar, F., Proctor, E. A., Kota, P., An, J., Kaplan, A., Khazanov, N., Boël, G., Stockwell, B. R., Senderowitz, H., Dokholyan, N., Riordan, J. R., Brouillette, C. G. & Hunt, J. F., Jan 1 2018, In : Journal of Biological Chemistry. 293, 46, p. 17685-17704 20 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Ligands
Mutation
Nucleotides
Molecules