• 601 Citations
  • 13 h-Index
20072019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 2007 2019

  • 601 Citations
  • 13 h-Index
  • 27 Article
  • 2 Review article
  • 1 Comment/debate
Filter
Article
2019
2 Citations (Scopus)

Computational translation of genomic responses from experimental model systems to humans

Brubaker, D. K., Proctor, E. A., Haigis, K. M. & Lauffenburger, D. A., Jan 1 2019, In : PLoS computational biology. 15, 1, e1006286.

Research output: Contribution to journalArticle

translation (genetics)
Genomics
Mouse
genomics
Theoretical Models
3 Citations (Scopus)

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes

Nicholas, D. A., Proctor, E. A., Agrawal, M., Belkina, A. C., Van Nostrand, S. C., Panneerseelan-Bharath, L., Jones, A. R., Raval, F., Ip, B. C., Zhu, M., Cacicedo, J. M., Habib, C., Sainz-Rueda, N., Persky, L., Sullivan, P. G., Corkey, B. E., Apovian, C. M., Kern, P. A., Lauffenburger, D. A. & Nikolajczyk, B. S., Sep 3 2019, In : Cell Metabolism. 30, 3, p. 447-461.e5

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Fatty Acids
Inflammation
Glycolysis
Cytokines

β-Methylamino-L-alanine substitution of serine in SOD1 suggests a direct role in ALS etiology

Proctor, E. A., Mowrey, D. D. & Dokholyan, N. V., Jul 2019, In : PLoS computational biology. 15, 7, e1007225.

Research output: Contribution to journalArticle

Open Access
etiology
Amyotrophic Lateral Sclerosis
Alanine
alanine
serine
2018
3 Citations (Scopus)

Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD-1, TIGIT, and TIM-3 in Lymphocytes From Patients With Systemic Sclerosis

Fleury, M., Belkina, A. C., Proctor, E. A., Zammitti, C., Simms, R. W., Lauffenburger, D. A., Snyder-Cappione, J. E., Lafyatis, R. & Dooms, H., Apr 1 2018, In : Arthritis and Rheumatology. 70, 4, p. 566-577 12 p.

Research output: Contribution to journalArticle

Programmed Cell Death 1 Receptor
Systemic Scleroderma
Lymphocytes
T-Lymphocytes
Cytokines
2 Citations (Scopus)

Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator

Wang, C., Aleksandrov, A. A., Yang, Z., Forouhar, F., Proctor, E. A., Kota, P., An, J., Kaplan, A., Khazanov, N., Boël, G., Stockwell, B. R., Senderowitz, H., Dokholyan, N. V., Riordan, J. R., Brouillette, C. G. & Hunt, J. F., Jan 1 2018, In : Journal of Biological Chemistry. 293, 46, p. 17685-17704 20 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Ligands
Mutation
Nucleotides
Molecules
3 Citations (Scopus)

Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging

Belkina, A. C., Starchenko, A., Drake, K. A., Proctor, E. A., Pihl, R. M. F., Olson, A., Lauffenburger, D. A., Lin, N. & Snyder-Cappione, J. E., Jan 1 2018, In : Frontiers in immunology. 9, 1 p.

Research output: Contribution to journalArticle

Antigen Receptors, T-Cell, gamma-delta
Multivariate Analysis
HIV
HIV Infections
Least-Squares Analysis
2017
5 Citations (Scopus)

Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis

Nicholas, D., Proctor, E. A., Raval, F. M., Ip, B. C., Habib, C., Ritou, E., Grammatopoulos, T. N., Steenkamp, D., Dooms, H., Apovian, C. M., Lauffenburger, D. A. & Nikolajczyk, B. S., Feb 2017, In : PloS one. 12, 2, e0170975.

Research output: Contribution to journalArticle

Lymphocytes
Fluxes
data analysis
lymphocytes
Organized Financing
10 Citations (Scopus)

Genital-systemic chemokine gradients and the risk of HIV acquisition in women

Liebenberg, L. J. P., Masson, L., Arnold, K. B., McKinnon, L. R., Werner, L., Proctor, E., Archary, D., Mansoor, L. E., Lauffenburger, D. A., Karim, Q. A., Karim, S. S. A. & Passmore, J. A. S., Mar 1 2017, In : Journal of Acquired Immune Deficiency Syndromes. 74, 3, p. 318-325 8 p.

Research output: Contribution to journalArticle

Chemokines
HIV
Odds Ratio
Interleukin-8
Confidence Intervals
2016
1 Citation (Scopus)

A hidden aggregation-prone structure in the heart of hypoxia inducible factor prolyl hydroxylase

Hadi-Alijanvand, H., Proctor, E. A., Ding, F., Dokholyan, N. V. & Moosavi-Movahedi, A. A., May 1 2016, In : Proteins: Structure, Function and Bioinformatics. 84, 5, p. 611-623 13 p.

Research output: Contribution to journalArticle

Prolyl Hydroxylases
Agglomeration
Protein Unfolding
Proteins
Molecular Dynamics Simulation
11 Citations (Scopus)

A Phosphomimetic Mutation Stabilizes SOD1 and Rescues Cell Viability in the Context of an ALS-Associated Mutation

Fay, J. M., Zhu, C., Proctor, E. A., Tao, Y., Cui, W., Ke, H. & Dokholyan, N. V., Nov 1 2016, In : Structure. 24, 11, p. 1898-1906 9 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Cell Survival
Mutation
Poisons
Motor Neurons
42 Citations (Scopus)

Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis

Proctor, E. A., Fee, L., Tao, Y., Redler, R. L., Fay, J. M., Zhang, Y., Lv, Z., Mercer, I. P., Deshmukh, M., Lyubchenko, Y. L. & Dokholyan, N. V., Jan 19 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 3, p. 614-619 6 p.

Research output: Contribution to journalArticle

Poisons
Amyotrophic Lateral Sclerosis
Motor Neurons
Mutation
Disease Progression
2015
20 Citations (Scopus)

Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening

Wood, L. B., Winslow, A. R., Proctor, E. A., McGuone, D., Mordes, D. A., Frosch, M. P., Hyman, B. T., Lauffenburger, D. A. & Haigis, K. M., Nov 2015, In : Scientific reports. 5, 16622.

Research output: Contribution to journalArticle

Alzheimer Disease
Cytokines
Neurons
Vascular Endothelial Growth Factor A
Amyloid
25 Citations (Scopus)

Rational coupled dynamics network manipulation rescues disease-relevant mutant cystic fibrosis transmembrane conductance regulator

Proctor, E. A., Kota, P., Aleksandrov, A. A., He, L., Riordan, J. R. & Dokholyan, N. V., Feb 1 2015, In : Chemical Science. 6, 2, p. 1237-1246 10 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Proteins
Ion Channels
Nucleotides
2014
23 Citations (Scopus)

Cu,Zn-superoxide dismutase without Zn is folded but catalytically inactive

Nedd, S., Redler, R. L., Proctor, E. A., Dokholyan, N. V. & Alexandrova, A. N., Dec 12 2014, In : Journal of Molecular Biology. 426, 24, p. 4112-4124 13 p.

Research output: Contribution to journalArticle

Protein Unfolding
Amyotrophic Lateral Sclerosis
Molecular Dynamics Simulation
Mechanics
Superoxides
11 Citations (Scopus)

Traffic within the cytochrome b6f lipoprotein complex: Gating of the quinone portal

Hasan, S. S., Proctor, E. A., Yamashita, E., Dokholyan, N. V. & Cramer, W. A., Oct 7 2014, In : Biophysical journal. 107, 7, p. 1620-1628 9 p.

Research output: Contribution to journalArticle

Cytochrome b6f Complex
Hydroquinones
Lipoproteins
Superoxides
Oxidation-Reduction
2013
4 Citations (Scopus)

Highly covarying residues have a functional role in antibody constant domains

Proctor, E. A., Kota, P., Demarest, S. J., Caravella, J. A. & Dokholyan, N. V., May 1 2013, In : Proteins: Structure, Function and Bioinformatics. 81, 5, p. 884-895 12 p.

Research output: Contribution to journalArticle

Antibodies
Mutation
Proteins
Antibody Specificity
Immunoglobulin Isotypes

Metric to distinguish closely related domain families using sequence information

Proctor, E. A., Kota, P., Demarest, S. J., Caravella, J. A. & Dokholyan, N., Feb 8 2013, In : Journal of Molecular Biology. 425, 3, p. 475-478 4 p.

Research output: Contribution to journalArticle

Antibodies
Immunoglobulin Variable Region
Immunoglobulin Isotypes
Histocompatibility Antigens Class II
Entropy
2 Citations (Scopus)

Protein HP1028 from the human pathogen Helicobacter pylori belongs to the lipocalin family

Barison, N., Cendron, L., Loconte, V., Proctor, E. A., Dokholyan, N. V. & Zanotti, G., Aug 1 2013, In : Acta Crystallographica Section D: Biological Crystallography. 69, 8, p. 1387-1394 8 p.

Research output: Contribution to journalArticle

Lipocalins
Helicobacter pylori
Periplasm
Proteins
Bacteria
2012
25 Citations (Scopus)

Discrete molecular dynamics distinguishes nativelike binding poses from decoys in difficult targets

Proctor, E. A., Yin, S., Tropsha, A. & Dokholyan, N., Jan 4 2012, In : Biophysical Journal. 102, 1, p. 144-151 8 p.

Research output: Contribution to journalArticle

Molecular Dynamics Simulation
Ligands
Small Molecule Libraries
Drug Discovery
Proteins
3 Citations (Scopus)

Thermal Unfolding Pathway of PHD2 Catalytic Domain in Three Different PHD2 Species: Computational Approaches

Hadi-Alijanvand, H., Proctor, E. A., Goliaei, B., Dokholyan, N. V. & Moosavi-Movahedi, A. A., Oct 15 2012, In : PloS one. 7, 10, e47061.

Research output: Contribution to journalArticle

procollagen-proline dioxygenase
Prolyl Hydroxylases
active sites
Catalytic Domain
Hot Temperature
2011
1 Citation (Scopus)

A folding pathway-dependent score to recognize membrane proteins

Hadi-Alijanvand, H., Rouhani, M., Proctor, E. A., Dokholyan, N. V. & Moosavi-Movahedi, A. A., Mar 10 2011, In : PloS one. 6, 3, e16778.

Research output: Contribution to journalArticle

membrane proteins
Membrane Proteins
Membranes
proteins
Proteins
49 Citations (Scopus)

Discrete molecular dynamics

Proctor, E. A., Ding, F. & Dokholyan, N. V., Jan 1 2011, In : Wiley Interdisciplinary Reviews: Computational Molecular Science. 1, 1, p. 80-92 13 p.

Research output: Contribution to journalArticle

Discrete Dynamics
Molecular Dynamics Simulation
Molecular Dynamics
Molecular dynamics
molecular dynamics
53 Citations (Scopus)

Glutathionylation at Cys-111 induces dissociation of wild type and FALS mutant SOD1 dimers

Redler, R. L., Wilcox, K. C., Proctor, E. A., Fee, L., Caplow, M. & Dokholyan, N. V., Aug 16 2011, In : Biochemistry. 50, 32, p. 7057-7066 10 p.

Research output: Contribution to journalArticle

Dimers
Agglomeration
Mutation
Oxidative stress
Surface Plasmon Resonance
61 Citations (Scopus)

Structural and dynamic determinants of protein-peptide recognition

Dagliyan, O., Proctor, E. A., D'Auria, K. M., Ding, F. & Dokholyan, N., Dec 7 2011, In : Structure. 19, 12, p. 1837-1845 9 p.

Research output: Contribution to journalArticle

Peptides
Proteins
Static Electricity
Protein Conformation
Molecular Dynamics Simulation
35 Citations (Scopus)
Post Translational Protein Processing
Thermodynamics
Amyotrophic Lateral Sclerosis
Human Body
Disease Progression
2009
30 Citations (Scopus)

Fast screening of protein surfaces using geometric invariant fingerprints

Yin, S., Proctor, E. A., Lugovskoy, A. A. & Dokholyan, N. V., Sep 29 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 39, p. 16622-16626 5 p.

Research output: Contribution to journalArticle

Dermatoglyphics
Membrane Proteins
Proteins
Molecular Sequence Annotation
Databases
2007
132 Citations (Scopus)

Effect of surface treatment on diffusion and domain formation in supported lipid bilayers

Seu, K. J., Pandey, A. P., Haque, F., Proctor, E. A., Ribbe, A. E. & Hovis, J. S., Apr 2007, In : Biophysical journal. 92, 7, p. 2445-2450 6 p.

Research output: Contribution to journalArticle

Lipid Bilayers
Lipids