• 536 Citations
  • 11 h-Index
20042018
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Personal profile

Research interests

The laboratory of Dr. Fadia Kamal studies cellular pathways that control chondrocyte homeostasis in healthy tissue and the key processes that transform them to pathological cells, which leads to cartilage damage and loss in osteoarthritis.

Osteoarthritis is a debilitating disease with no disease-modifying treatment available. Osteoarthritis is characterized by continuous and progressive cartilage loss leading to joint dysfunction. Chondrocyte, the functional cell of cartilage controls cartilage homeostasis by secreting cartilage matrix components and matrix degrading enzymes. In osteoarthritis, the chondrocyte acquires an aberrant phenotype, it differentiates to become hypertrophic and secretes higher levels of matrix degrading enzymes, ultimately leading to cartilage matrix degradation and cartilage loss.

The Kamal lab’s research focuses on discovering new pathways and drugs that target these disease pathways, and control chondrocyte behavior to delay or even reverse osteoarthritis disease process.

Fingerprint Dive into the research topics where Fadia Kamal is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Heart Failure Medicine & Life Sciences
G-Protein-Coupled Receptors Medicine & Life Sciences
Myocarditis Medicine & Life Sciences
Fibrosis Medicine & Life Sciences
Osteoarthritis Medicine & Life Sciences
Protein Subunits Medicine & Life Sciences
Angiotensin Receptor Antagonists Medicine & Life Sciences
GTP-Binding Proteins Medicine & Life Sciences

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Research Output 2004 2018

  • 536 Citations
  • 11 h-Index
  • 14 Article
  • 4 Review article
  • 1 Chapter
2 Citations (Scopus)

Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats

Karuppagounder, V., Bajpai, A., Meng, S., Arumugam, S., Sreedhar, R., Giridharan, V. V., Guha, A., Bhimaraj, A., Youker, K. A., Palaniyandi, S. S., Karmouty-Quintana, H., Kamal, F., Spiller, K. L., Watanabe, K. & Thandavarayan, R. A., Jul 1 2018, In : PloS one. 13, 7, e0200697.

Research output: Contribution to journalArticle

myocarditis
Macrophages
Myocarditis
Protein Subunits
heart failure
21 Citations (Scopus)

Targeting the gut microbiome to treat the osteoarthritis of obesity

Schott, E. M., Farnsworth, C. W., Grier, A., Lillis, J. A., Soniwala, S., Dadourian, G. H., Bell, R. D., Doolittle, M. L., Villani, D. A., Awad, H., Ketz, J. P., Kamal, F., Ackert-Bicknell, C., Ashton, J. M., Gill, S. R., Mooney, R. A. & Zuscik, M. J., Apr 19 2018, In : JCI insight. 3, 8

Research output: Contribution to journalArticle

Open Access
Osteoarthritis
Obesity
Bifidobacterium
Knee Osteoarthritis
Inflammation
10 Citations (Scopus)

Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and antiinflammatory in murine posttraumatic osteoarthritis

Dar, Q. A., Schott, E. M., Catheline, S. E., Maynard, R. D., Liu, Z., Kamal, F., Farnsworth, C. W., Ketz, J. P., Mooney, R. A., Hilton, M. J., Jonason, J. H., Prawitt, J. & Zuscik, M. J., Apr 1 2017, In : PLoS One. 12, 4, e0174705.

Research output: Contribution to journalArticle

osteoarthritis
Chondrocytes
Collagen Type I
Osteoarthritis
chondrocytes
6 Citations (Scopus)

Extraction of high-quality RNA from human articular cartilage

Le Bleu, H. K., Kamal, F., Kelly, M., Ketz, J. P., Zuscik, M. J. & Elbarbary, R., Feb 1 2017, In : Analytical Biochemistry. 518, p. 134-138 5 p.

Research output: Contribution to journalArticle

Cartilage
Articular Cartilage
RNA
RNA Sequence Analysis
RNA Stability
12 Citations (Scopus)

Pharmacological and Activated Fibroblast Targeting of Gβγ-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression

Travers, J. G., Kamal, F., Valiente-Alandi, I., Nieman, M. L., Sargent, M. A., Lorenz, J. N., Molkentin, J. D. & Blaxall, B. C., Aug 22 2017, In : Journal of the American College of Cardiology. 70, 8, p. 958-971 14 p.

Research output: Contribution to journalArticle

Phosphotransferases
Ischemia
Heart Failure
Pharmacology
Myofibroblasts