• 673 Citations
  • 12 h-Index
20042020

Research output per year

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Personal profile

Research interests

The laboratory of Dr. Fadia Kamal studies cellular pathways that control chondrocyte homeostasis in healthy tissue and the key processes that transform them to pathological cells, which leads to cartilage damage and loss in osteoarthritis.

Osteoarthritis is a debilitating disease with no disease-modifying treatment available. Osteoarthritis is characterized by continuous and progressive cartilage loss leading to joint dysfunction. Chondrocyte, the functional cell of cartilage controls cartilage homeostasis by secreting cartilage matrix components and matrix degrading enzymes. In osteoarthritis, the chondrocyte acquires an aberrant phenotype, it differentiates to become hypertrophic and secretes higher levels of matrix degrading enzymes, ultimately leading to cartilage matrix degradation and cartilage loss.

The Kamal lab’s research focuses on discovering new pathways and drugs that target these disease pathways, and control chondrocyte behavior to delay or even reverse osteoarthritis disease process.

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Research Output

  • 673 Citations
  • 12 h-Index
  • 16 Article
  • 4 Review article
  • 1 Chapter

Aberrant structure of fibrillar collagen and elevated levels of advanced glycation end products typify delayed fracture healing in the diet-induced obesity mouse model

Khajuria, D. K., Soliman, M., Elfar, J. C., Lewis, G. S., Abraham, T., Kamal, F. & Elbarbary, R. A., Aug 2020, In : Bone. 137, 115436.

Research output: Contribution to journalArticle

  • Standardized histomorphometric evaluation of osteoarthritis in a surgical mouse model

    Pinamont, W. J., Yoshioka, N. K., Young, G. M., Karuppagounder, V., Carlson, E. L., Ahmad, A., Elbarbary, R. & Kamal, F., May 2020, In : Journal of Visualized Experiments. 2020, 159, e60991.

    Research output: Contribution to journalArticle

  • Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats

    Karuppagounder, V., Bajpai, A., Meng, S., Arumugam, S., Sreedhar, R., Giridharan, V. V., Guha, A., Bhimaraj, A., Youker, K. A., Palaniyandi, S. S., Karmouty-Quintana, H., Kamal, F., Spiller, K. L., Watanabe, K. & Thandavarayan, R. A., Jul 2018, In : PloS one. 13, 7, e0200697.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Targeting the gut microbiome to treat the osteoarthritis of obesity

    Schott, E. M., Farnsworth, C. W., Grier, A., Lillis, J. A., Soniwala, S., Dadourian, G. H., Bell, R. D., Doolittle, M. L., Villani, D. A., Awad, H., Ketz, J. P., Kamal, F., Ackert-Bicknell, C., Ashton, J. M., Gill, S. R., Mooney, R. A. & Zuscik, M. J., Apr 19 2018, In : JCI Insight. 3, 8

    Research output: Contribution to journalArticle

    Open Access
  • 34 Scopus citations

    Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and antiinflammatory in murine posttraumatic osteoarthritis

    Dar, Q. A., Schott, E. M., Catheline, S. E., Maynard, R. D., Liu, Z., Kamal, F., Farnsworth, C. W., Ketz, J. P., Mooney, R. A., Hilton, M. J., Jonason, J. H., Prawitt, J. & Zuscik, M. J., Apr 2017, In : PloS one. 12, 4, e0174705.

    Research output: Contribution to journalArticle

  • 14 Scopus citations