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Research Output 1990 2018

2018

Exaggerated cardiovascular responses to treadmill running in rats with peripheral arterial insufficiency

Kuczmarski, J. M., Unrath, K. & Thomas, G., Jan 1 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 314, 1, p. H114-H121

Research output: Contribution to journalArticle

Running
Peripheral Arterial Disease
Arterial Pressure
Femoral Artery
Heart Rate
2017
3 Citations (Scopus)

The role played by oxidative stress in evoking the exercise pressor reflex in health and simulated peripheral artery disease

Harms, J. E., Kuczmarski, J. M., Kim, J. S., Thomas, G. & Kaufman, M., Jul 1 2017, In : Journal of Physiology. 595, 13, p. 4365-4378 14 p.

Research output: Contribution to journalArticle

Peripheral Arterial Disease
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt
Reflex
Oxidative Stress
Exercise
2015
12 Citations (Scopus)

Functional sympatholysis in hypertension

Thomas, G., Jan 1 2015, In : Autonomic Neuroscience: Basic and Clinical. 188, p. 64-68 5 p.

Research output: Contribution to journalArticle

Hypertension
Muscles
Vasoconstriction
Perfusion
Exercise
2013
20 Citations (Scopus)

Differential effects of nebivolol versus metoprolol on functional sympatholysis in hypertensive humans

Price, A., Raheja, P., Wang, Z., Arbique, D., Adams-Huet, B., Mitchell, J. H., Victor, R. G., Thomas, G. & Vongpatanasin, W., Apr 3 2013, In : Hypertension. 61, 6, p. 1263-1269 7 p.

Research output: Contribution to journalArticle

Nebivolol
Metoprolol
Forearm
Lower Body Negative Pressure
Adrenergic Receptors
49 Citations (Scopus)

Dual AAV therapy ameliorates exercise-induced muscle injury and functional ischemia in murine models of duchenne muscular dystrophy

Zhang, Y., Yue, Y., Li, L., Hakim, C. H., Zhang, K., Thomas, G. & Duan, D., Sep 1 2013, In : Human Molecular Genetics. 22, 18, p. 3720-3729 10 p., ddt224.

Research output: Contribution to journalArticle

Exercise Therapy
Dependovirus
Duchenne Muscular Dystrophy
Nitric Oxide Synthase Type I
Dystrophin
36 Citations (Scopus)

Functional muscle ischemia in Duchenne and Becker muscular dystrophy

Thomas, G., Dec 1 2013, In : Frontiers in Physiology. 4 DEC, Article 381.

Research output: Contribution to journalShort survey

Duchenne Muscular Dystrophy
Ischemia
Muscles
Dystrophin
Nitric Oxide Synthase Type I
2012
28 Citations (Scopus)

Oxidative stress and enhanced sympathetic vasoconstriction in contracting muscles of nitrate-tolerant rats and humans

Fadel, P. J., Farias, M., Gallagher, K. M., Wang, Z. & Thomas, G., Jan 1 2012, In : Journal of Physiology. 590, 2, p. 395-407 13 p.

Research output: Contribution to journalArticle

Vasoconstriction
Nitrates
Oxidative Stress
Muscles
Nitroglycerin
64 Citations (Scopus)

Tadalafil alleviates muscle ischemia in patients with becker muscular dystrophy

Martin, E. A., Barresi, R., Byrne, B. J., Tsimerinov, E. I., Scott, B. L., Walker, A. E., Gurudevan, S. V., Anene, F., Elashoff, R. M., Thomas, G. & Victor, R. G., Nov 28 2012, In : Science Translational Medicine. 4, 162, 162ra155.

Research output: Contribution to journalArticle

Duchenne Muscular Dystrophy
Ischemia
Nitric Oxide Synthase Type I
Muscles
Dystrophin
23 Citations (Scopus)

Treatment with a Nitric Oxide-Donating NSAID Alleviates Functional Muscle Ischemia in the Mouse Model of Duchenne Muscular Dystrophy

Thomas, G., Ye, J., de Nardi, C., Monopoli, A., Ongini, E. & Victor, R. G., Nov 5 2012, In : PloS one. 7, 11, e49350.

Research output: Contribution to journalArticle

muscular dystrophy
Duchenne Muscular Dystrophy
nonsteroidal anti-inflammatory agents
Non-Steroidal Anti-Inflammatory Agents
thighs
2011
91 Citations (Scopus)

Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2

Ramesh, S., Morrell, C. N., Tarango, C., Thomas, G., Yuhanna, I. S., Girardi, G., Herz, J., Urbanus, R. T., De Groot, P. G., Thorpe, P. E., Salmon, J. E., Shaul, P. W. & Mineo, C., Jan 4 2011, In : Journal of Clinical Investigation. 121, 1, p. 120-131 12 p.

Research output: Contribution to journalArticle

Antiphospholipid Antibodies
Cell Adhesion
Glycoproteins
Thrombosis
Leukocytes
62 Citations (Scopus)

Functional sympatholysis is impaired in hypertensive humans

Vongpatanasin, W., Wang, Z., Arbique, D., Arbique, G., Adams-Huet, B., Mitchell, J. H., Victor, R. G. & Thomas, G., Mar 1 2011, In : Journal of Physiology. 589, 5, p. 1209-1220 12 p.

Research output: Contribution to journalArticle

Forearm
Lower Body Negative Pressure
Muscles
irbesartan
Angiotensins
65 Citations (Scopus)

Neural control of the circulation

Thomas, G., Jan 1 2011, In : American Journal of Physiology - Advances in Physiology Education. 35, 1, p. 28-32 5 p.

Research output: Contribution to journalArticle

Sensory Feedback
Baroreflex
Aldosterone
Medical Students
Constriction
2010
6 Citations (Scopus)

Adenovirus-mediated leptin expression normalises hypertension associated with diet-induced obesity

Zhang, W., Telemaque, S., Augustyniak, R. A., Anderson, P., Thomas, G., An, J., Wang, Z., Newgard, C. B. & Victor, R. G., Mar 1 2010, In : Journal of Neuroendocrinology. 22, 3, p. 175-180 6 p.

Research output: Contribution to journalArticle

Leptin
Adenoviridae
Obesity
Diet
Hypertension
161 Citations (Scopus)

Non-nuclear estrogen receptor α signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice

Chambliss, K. L., Wu, Q., Oltmann, S., Konaniah, E. S., Umetani, M., Korach, K. S., Thomas, G., Mineo, C., Yuhanna, I. S., Kim, S. H., Madak-Erdogan, Z., Maggi, A., Dineen, S. P., Roland, C. L., Hui, D. Y., Brekken, R. A., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & Shaul, P. W., Jul 1 2010, In : Journal of Clinical Investigation. 120, 7, p. 2319-2330 12 p.

Research output: Contribution to journalArticle

Uterine Neoplasms
Dendrimers
Estrogen Receptors
Estrogens
Breast Neoplasms
1 Citation (Scopus)

Ready, set, flow! But how does the flow know where to go?

Thomas, G., Oct 1 2010, In : Journal of Physiology. 588, 19, p. 3633-3634 2 p.

Research output: Contribution to journalComment/debate

Receptors, Adrenergic, alpha
Sympathetic Nervous System
Skeletal Muscle Fibers
Regional Blood Flow
Muscle Contraction
2009
225 Citations (Scopus)

Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy

Lai, Y., Thomas, G., Yue, Y., Yang, H. T., Li, D., Long, C., Judge, L., Bostick, B., Chamberlain, J. S., Terjung, R. L. & Duan, D., Mar 2 2009, In : Journal of Clinical Investigation. 119, 3, p. 624-635 12 p.

Research output: Contribution to journalArticle

Spectrin
Sarcolemma
Dystrophin
Muscular Dystrophies
Duchenne Muscular Dystrophy
35 Citations (Scopus)

Inhibition of nitric oxide synthase evokes central sympatho-excitation in healthy humans

Young, C. N., Fisher, J. P., Gallagher, K. M., Whaley-Connell, A., Chaudhary, K., Victor, R. G., Thomas, G. & Fadel, P. J., Oct 1 2009, In : Journal of Physiology. 587, 20, p. 4977-4986 10 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase
Skin
Baroreflex
Nitric Oxide
Blood Pressure
2007
67 Citations (Scopus)

C-reactive protein causes downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice

Vongpatanasin, W., Thomas, G., Schwartz, R., Cassis, L. A., Osborne-Lawrence, S., Hahner, L., Gibson, L. L., Black, S., Samols, D. & Shaul, P. W., Feb 1 2007, In : Circulation. 115, 8, p. 1020-1028 9 p.

Research output: Contribution to journalArticle

Angiotensins
C-Reactive Protein
Blood Vessels
Down-Regulation
Hypertension
2006
59 Citations (Scopus)

Reactive oxygen species impair sympathetic vasoregulation in skeletal muscle in angiotensin II-dependent hypertension

Zhao, W., Swanson, S. A., Ye, J., Li, X., Shelton, J. M., Zhang, W. & Thomas, G., Oct 1 2006, In : Hypertension. 48, 4, p. 637-643 7 p.

Research output: Contribution to journalArticle

Angiotensin II
Reactive Oxygen Species
Skeletal Muscle
Hypertension
Vasoconstriction

Reply [16]

Davis, S. L., Fadel, P. J., Cui, J., Thomas, G. & Crandall, C. G., Apr 1 2006, In : Journal of Applied Physiology. 100, 4, 1 p.

Research output: Contribution to journalLetter

110 Citations (Scopus)

Skin blood flow influences near-infrared spectroscopy-derived measurements of tissue oxygenation during heat stress

Davis, S. L., Fadel, P. J., Cui, J., Thomas, G. & Crandall, C. G., Jan 1 2006, In : Journal of Applied Physiology. 100, 1, p. 221-224 4 p.

Research output: Contribution to journalArticle

Near-Infrared Spectroscopy
Heating
Hot Temperature
Skin
Muscles
42 Citations (Scopus)

Smooth muscle-specific dystrophin expression improves aberrant vasoregulation in mdx mice

Ito, K., Kimura, S., Ozasa, S., Matsukura, M., Ikezawa, M., Yoshioka, K., Ueno, H., Suzuki, M., Araki, K., Yamamura, K. I., Miwa, T., Dickson, G., Thomas, G. & Miike, T., Jul 15 2006, In : Human Molecular Genetics. 15, 14, p. 2266-2275 10 p.

Research output: Contribution to journalArticle

Inbred mdx Mouse
Dystrophin
Duchenne Muscular Dystrophy
Smooth Muscle
Adrenergic Agents
2005
85 Citations (Scopus)

FcγRIIB mediates C-reactive protein inhibition of endothelial NO synthase

Mineo, C., Gormley, A. K., Yuhanna, I. S., Osborne-Lawrence, S., Gibson, L. L., Hahner, L., Shohet, R. V., Black, S., Salmon, J. E., Samols, D., Karp, D. R., Thomas, G. & Shaul, P. W., Nov 1 2005, In : Circulation research. 97, 11, p. 1124-1131 8 p.

Research output: Contribution to journalArticle

Reactive Inhibition
Nitric Oxide Synthase
C-Reactive Protein
Endothelium
Okadaic Acid
2 Citations (Scopus)

Flow-mediated dilation and biological variability.

Thomas, G., Jan 1 2005, In : Journal of applied physiology (Bethesda, Md. : 1985). 99, 4, 1 p.

Research output: Contribution to journalComment/debate

Regional Blood Flow
Vascular Endothelium
Vasodilation
Dilatation
Analysis of Variance
21 Citations (Scopus)

Nitric oxide pathway as new drug targets for refractory hypertension

Augustyniak, R. A., Thomas, G., Victor, R. G. & Zhang, W., Sep 23 2005, In : Current Pharmaceutical Design. 11, 25, p. 3307-3315 9 p.

Research output: Contribution to journalReview article

Nitric Oxide Synthase
Nitric Oxide
Hypertension
Pharmaceutical Preparations
Hydroxymethylglutaryl-CoA Reductase Inhibitors
9 Citations (Scopus)

α-Adrenoceptor constrictor responses and their modulation in slow-twitch and fast-twitch mouse skeletal muscle

Lambert, D. G. & Thomas, G., Mar 15 2005, In : Journal of Physiology. 563, 3, p. 821-829 9 p.

Research output: Contribution to journalArticle

Adrenergic Receptors
Skeletal Muscle
Muscles
KATP Channels
Smooth Muscle Myosins
2004
61 Citations (Scopus)

Augmented sympathetic vasoconstriction in exercising forearms of postmenopausal women is reversed by oestrogen therapy

Fadel, P. J., Wang, Z., Watanabe, H., Arbique, D., Vongpatanasin, W. & Thomas, G., Dec 15 2004, In : Journal of Physiology. 561, 3, p. 893-901 9 p.

Research output: Contribution to journalArticle

Vasoconstriction
Forearm
Estrogens
Lower Body Negative Pressure
Muscles
147 Citations (Scopus)

Neural control of muscle blood flow during exercise

Thomas, G. & Segal, S. S., Aug 1 2004, In : Journal of Applied Physiology. 97, 2, p. 731-738 8 p.

Research output: Contribution to journalReview article

Muscles
Vasoconstriction
Vasodilation
Arterial Pressure
Neurophysiological Recruitment
68 Citations (Scopus)

Noninvasive assessment of sympathetic vasoconstriction in human and rodent skeletal muscle using near-infrared spectroscopy and Doppler ultrasound

Fadel, P. J., Keller, D. M., Watanabe, H., Raven, P. B. & Thomas, G., Apr 1 2004, In : Journal of Applied Physiology. 96, 4, p. 1323-1330 8 p.

Research output: Contribution to journalArticle

Doppler Ultrasonography
Near-Infrared Spectroscopy
Vasoconstriction
Rodentia
Skeletal Muscle
2003
28 Citations (Scopus)

Having it both ways? Vasoconstriction in contracting muscles

Joyner, M. J. & Thomas, G., Jul 15 2003, In : Journal of Physiology. 550, 2, 1 p.

Research output: Contribution to journalComment/debate

Vasoconstriction
Muscles
40 Citations (Scopus)

Impaired vasomodulation is associated with reduced neuronal nitric oxide synthase in skeletal muscle of ovariectomized rats

Fadel, P. J., Zhao, W. & Thomas, G., May 15 2003, In : Journal of Physiology. 549, 1, p. 243-253 11 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Skeletal Muscle
Nitric Oxide Synthase
Protein Isoforms
Estrogens
4 Citations (Scopus)

In favor of a role of lactic acid on the generation of the exercise pressor reflex

Thomas, G. & Victor, R. G., Feb 1 2003, In : Clinical Autonomic Research. 13, 1, p. 5-6 2 p.

Research output: Contribution to journalEditorial

Sympathetic Nervous System
Regional Blood Flow
Reflex
Lactic Acid
Skeletal Muscle
25 Citations (Scopus)

Reflex sympathetic activation during static exercise is severely impaired in patients with myophosphorylase deficiency

Fadel, P. J., Wang, Z., Tuncel, M., Watanabe, H., Abbas, A., Arbique, D., Vongpatanasin, W., Haley, R. W., Victor, R. G. & Thomas, G., May 1 2003, In : Journal of Physiology. 548, 3, p. 983-993 11 p.

Research output: Contribution to journalReview article

Glycogen Storage Disease Type V
Reflex
Exercise
Muscles
Lactic Acid
100 Citations (Scopus)

Vasomodulation by skeletal muscle-derived nitric oxide requires α-syntrophin-mediated sarcolemmal localization of neuronal nitric oxide synthase

Thomas, G., Shaul, P. W., Yuhanna, I. S., Froehner, S. C. & Adams, M. E., Mar 21 2003, In : Circulation research. 92, 5, p. 554-560 7 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Nitric Oxide
Skeletal Muscle
Transgenic Mice
PDZ Domains
2002
90 Citations (Scopus)

Nitric oxide-dependent modulation of sympathetic neural control of oxygenation in exercising human skeletal muscle

Chavoshan, B., Sander, M., Sybert, T. E., Hansen, J., Victor, R. G. & Thomas, G., Apr 1 2002, In : Journal of Physiology. 540, 1, p. 377-386 10 p.

Research output: Contribution to journalArticle

NG-Nitroarginine Methyl Ester
Lower Body Negative Pressure
Nitric Oxide
Skeletal Muscle
Muscles
2001
68 Citations (Scopus)

Impaired modulation of sympathetic vasoconstriction in contracting skeletal muscle of rats with chronic myocardial infarctions: Role of oxidative stress

Thomas, G., Zhang, W. & Victor, R. G., Apr 27 2001, In : Circulation research. 88, 8, p. 816-823 8 p.

Research output: Contribution to journalArticle

Vasoconstriction
Skeletal Muscle
Oxidative Stress
Myocardial Infarction
Hindlimb
66 Citations (Scopus)

Nitric oxide deficiency as a cause of clinical hypertension: Promising new drug targets for refractory hypertension

Thomas, G., Zhang, W. & Victor, R. G., Apr 25 2001, In : Journal of the American Medical Association. 285, 16, p. 2055-2057 3 p.

Research output: Contribution to journalShort survey

Vasomotor System
Superoxides
Antihypertensive Agents
Nitric Oxide
Blood Pressure
2000
303 Citations (Scopus)

Functional muscle ischemia in neuronal nitric oxide synthase-deficient skeletal muscle of children with Duchenne muscular dystrophy

Sander, M., Chavoshan, B., Harris, S. A., Iannaccone, S. T., Stull, J. T., Thomas, G. & Victor, R. G., Dec 5 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 25, p. 13818-13823 6 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Dystrophin
Duchenne Muscular Dystrophy
Skeletal Muscle
Ischemia
54 Citations (Scopus)

Metabolic modulation of sympathetic vasoconstriction in exercising skeletal muscle

Hansen, J., Sander, M. & Thomas, G., Apr 20 2000, In : Acta Physiologica Scandinavica. 168, 4, p. 489-503 15 p.

Research output: Contribution to journalArticle

Vasoconstriction
Skeletal Muscle
Muscles
Cardiac Output
Perfusion
61 Citations (Scopus)

Metabolic modulation of sympathetic vasoconstriction in human skeletal muscle: Role of tissue hypoxia

Hansen, J., Sander, M., Hald, C. F., Victor, R. G. & Thomas, G., Sep 1 2000, In : Journal of Physiology. 527, 2, p. 387-396 10 p.

Research output: Contribution to journalArticle

Vasoconstriction
Skeletal Muscle
Muscles
Lower Body Negative Pressure
Forearm
1999
13 Citations (Scopus)

Exercise-induced attenuation of alpha-adrenoceptor mediated vastconstriction in humans: Evidence from phase-contrast MRI

Hansen, J., Sayad, D., Thomas, G., Clarke, G. D., Peshock, R. M. & Victor, R. G., Jan 1 1999, In : Cardiovascular Research. 41, 1, p. 220-228 9 p.

Research output: Contribution to journalArticle

Adrenergic Receptors
Brachial Artery
Norepinephrine
Skeletal Muscle
Arteries
118 Citations (Scopus)

Magnetic resonance imaging and invasive evaluation of development of heart failure in transgenic mice with myocardial expression of tumor necrosis factor-α

Franco, F., Thomas, G., Giroir, B., Bryant, D., Bullock, M. C., Chwialkowski, M. C., Victor, R. G. & Peshock, R. M., Jan 26 1999, In : Circulation. 99, 3, p. 448-454 7 p.

Research output: Contribution to journalArticle

Transgenic Mice
Heart Failure
Tumor Necrosis Factor-alpha
Magnetic Resonance Imaging
Thermodilution
1998
302 Citations (Scopus)

Impaired metabolic modulation of α-adrenergic vasoconstriction in dystrophin-deficient skeletal muscle

Thomas, G., Sander, M., Lau, K. S., Huang, P. L., Stull, J. T. & Victor, R. G., Dec 8 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 25, p. 15090-15095 6 p.

Research output: Contribution to journalArticle

Dystrophin
Nitric Oxide Synthase Type I
Vasoconstriction
Adrenergic Agents
Skeletal Muscle
4 Citations (Scopus)

Invited editorial on "Effect of arterial occlusion on responses of group III and IV afferents to dynamic exercise".

Thomas, G., Chavoshan, B., Sander, M. & Victor, R. G., Jun 1998, In : Journal of Applied Physiology. 84, 6, p. 1825-1826 2 p.

Research output: Contribution to journalArticle

Afferent Neurons
Arterial Occlusive Diseases
Cats
170 Citations (Scopus)

Nitric oxide mediates contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscle

Thomas, G. & Victor, R. G., Feb 1 1998, In : Journal of Physiology. 506, 3, p. 817-826 10 p.

Research output: Contribution to journalArticle

Vasoconstriction
Nitric Oxide
Skeletal Muscle
Adenosine Triphosphate
Hindlimb
1997
73 Citations (Scopus)

ATP-sensitive potassium channels mediate contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscle

Thomas, G., Hansen, J. & Victor, R. G., Jun 1 1997, In : Journal of Clinical Investigation. 99, 11, p. 2602-2609 8 p.

Research output: Contribution to journalArticle

KATP Channels
Vasoconstriction
Skeletal Muscle
Adenosine Triphosphate
Hindlimb
5 Citations (Scopus)

Differential modulation of cortical synaptic activity by calcineurin (phosphatase 2B) versus phosphatases 1 and 2A

Thomas, G., O'Rourke, B., Sikkink, R., Rusnak, F., Marban, E. & Victor, R. G., Feb 21 1997, In : Brain research. 749, 1, p. 101-108 8 p.

Research output: Contribution to journalArticle

Calcineurin
Phosphoric Monoester Hydrolases
Synaptic Transmission
Synaptic Potentials
Neurons
18 Citations (Scopus)

Oxidation of lactate and acetate in rat skeletal muscle: Analysis by 13C-nuclear magnetic resonance spectroscopy

Bertocci, L. A., Jones, J. G., Malloy, C. R., Victor, R. G. & Thomas, G., Jan 1 1997, In : Journal of Applied Physiology. 83, 1, p. 32-39 8 p.

Research output: Contribution to journalArticle

Lactic Acid
Skeletal Muscle
Acetates
Magnetic Resonance Spectroscopy
Hindlimb

Sympathetic vasoconstriction is attenuated by nitric oxide in contracting rat hindlimb

Thomas, G. & Victor, R. G., 1997, In : FASEB Journal. 11, 3

Research output: Contribution to journalArticle

vasoconstriction
NG-Nitroarginine Methyl Ester
adenosine
Hindlimb
Vasoconstriction
1996

ARK KATP channels involved in the contraction-induced attenuation oh alpha 2 adrenergic vasoconstriction in rat hindlimb?

Thomas, G., Hansen, J. & Victor, R., Dec 1 1996, In : FASEB Journal. 10, 3

Research output: Contribution to journalArticle

KATP Channels
Hindlimb
Vasoconstriction
Adrenergic Agents
Diazoxide